Articles

Histiocytic pleural effusion: the strong clue to malignancy

There have been many studies on the clinical characteristics of neutrophilic, lymphocytic, and/or eosinophilic pleural effusion. While caring for patients with pleural effusion, we found that histiocytic pleur...

Authors: Ganghee Chae, Jae-Bum Jun, Hwa Sik Jung, Chui Yong Park, Jin Hyoung Kim, Byung Ju Kang, Hyeon Hui Kang, Seung Won Ra, Kwang Won Seo, Yangjin Jegal, Jong Joon Ahn, Sang Hyuk Park and Taehoon Lee

Tumor size measured by multidetector CT in resectable colon cancer: correlation with regional lymph node metastasis and N stage

Lymph node metastasis (LNM) is a risk factor for poor long-term outcomes and a prognostic factor for disease-free survival in colon cancer. Preoperative lymph node status evaluation remains a challenge. The pu...

Authors: Anna Mou, Hang Li, Xiao-li Chen, Yang-hua Fan and Hong Pu

Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study

Mistletoe extract, used as a complementary chemotherapeutic agent for cancer patients, has anticancer effects against various malignancies. The aim of the present study was to evaluate the effect of mistletoe ...

Authors: Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung and Kyung-Ok Kim

The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer

Colon cancer (CC) is a very common gastrointestinal tumor that is prone to invasion and metastasis in the late stage. This study aims to observe the expression of Na⁺/Ca²⁺ exchangers (NCXs) and analyze the correl...

Authors: Zhixiu Xia, Changliang Wang and Hong Zhang

CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205

Colorectal cancer (CRC) is a common aggressive tumor that poses a heavy burden to human health. An increasing number of studies have reported that circular RNA (circRNA) is involved in the progression of CRC. ...

Authors: Guojiu Fang, Yibin Wu and Xueli Zhang

Radiofrequency ablation versus repeat hepatectomy in the treatment of recurrent hepatocellular carcinoma in subcapsular location: a retrospective cohort study

Repeat hepatectomy and radiofrequency ablation (RFA) are widely used to treat early recurrent hepatocellular carcinoma (RHCC) located in the subcapsular region, but the optimal treatment strategy remains to be...

Authors: Fuqun Wei, Qizhen Huang, Yang Zhou, Liuping Luo and Yongyi Zeng

MiR-194-5p enhances the sensitivity of nonsmall-cell lung cancer to doxorubicin through targeted inhibition of hypoxia-inducible factor-1

Despite chemotherapy being a common treatment, an increase in chemoresistance over time is unavoidable. We therefore investigated the role of miR-194-5p in regulating chordoma cell behavior and examined the do...

Authors: Mengning Xia, Lili Sheng, Wei Qu, Xue Xue, Hucheng Chen, Guoyan Zheng and Weigang Chen

Significance of a preoperative systemic immune-inflammation index as a predictor of postoperative survival outcomes in gastric cancer

Since inflammation and the immune system contribute to the development and progression of malignancies, parameters that reflect a host’s immune-inflammatory status may be useful prognostic indicators of gastri...

Authors: Hiroyuki Inoue, Toshiyuki Kosuga, Takeshi Kubota, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara and Eigo Otsuji

Reply to the letter to the editor concerning the article “clinical outcomes of chondroblastoma treated using synthetic bone substitute: risk factors for developing radiographic joint degeneration”

Authors: Hidetatsu Outani, Shigeki Kakunaga, Yoshinori Imura and Takafumi Ueda

Letter to the Editor concerning the article “Clinical outcomes of chondroblastoma treated using synthetic bone substitute: risk factors for developing radiographic joint degeneration”

The purpose of this letter to the Editor is to report some shortcomings in the statistical analysis and variable grouping in the recent publication of the article “Clinical outcomes of chondroblastoma treated ...

Authors: Bo-Wen Zheng, Bo-Yv Zheng, Hua-Qing Niu, Xiao-Bin Wang and Jing Li

Impact of skeletal muscle mass in patients with recurrent gastric cancer

We retrospectively examined the relationship among skeletal muscle mass index (SMI), prognosis, and chemotherapy side effects in patients with recurrent gastric cancer (RGC).

Authors: Tomoyuki Matsunaga, Hiroaki Satio, Wataru Miyauchi, Yuji Shishido, Kozo Miyatani, Yuki Murakami, Takehiko Hanaki, Kyoichi Kihara, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Toshimichi Hasegawa and Yoshiyuki Fujiwara

Interstitial lung disease associated with adjuvant and neoadjuvant chemotherapy in early breast cancer

Interstitial lung disease (ILD) is a rare adverse event in patients receiving adjuvant or neoadjuvant chemotherapy (NAC) for breast cancer. Few studies have reported the frequency of ILD in detail, and only sm...

Authors: Kenji Tezuka, Kotaro Miura, Yusuke Nakano, Takahiro Ueda, Kyoko Yagyu, Shimako Matsuyama, Masami Shirai, Hiroshi Okuda, Miho Ujikawa and Takayo Ota

A meta-analysis of the efficacy and safety of adjuvant sorafenib for hepatocellular carcinoma after resection

Sorafenib was reported as a useful adjuvant treatment in patients with hepatocellular carcinoma who underwent surgical resection. However, its therapeutic value remains controversial. This meta-analysis examin...

Authors: Shenglan Huang, Dan Li, LingLing Zhuang, Liying Sun and Jianbing Wu

Does liver cirrhosis affect the surgical outcome of primary colorectal cancer surgery? A meta-analysis

The purpose of this meta-analysis was to evaluate the effect of liver cirrhosis (LC) on the short-term and long-term surgical outcomes of colorectal cancer (CRC).

Authors: Yu-Xi Cheng, Wei Tao, Hua Zhang, Dong Peng and Zheng-Qiang Wei

Preoperative plasma D-dimer independently predicts survival in patients with pancreatic ductal adenocarcinoma undergoing radical resection

Elevated plasma D-dimer levels have been reported as an unfavorable prognostic indicator in many solid tumors. However, there are limited relevant studies in pancreatic cancer patients following radical surger...

Authors: Haoda Chen, Fanlu Li, Siyi Zou, Junjie Xie, Jun Zhang, Xiaxing Deng, Hao Chen and Baiyong Shen

Long non-coding RNA XIST regulates ovarian cancer progression via modulating miR-335/BCL2L2 axis

X inactivation-specific transcript (XIST) is the long non-coding RNA (lncRNA) related to cancer, which is involved in the development and progression of various types of tumor. However, up to now, the exact ro...

Authors: Qingjuan Meng, Ningning Wang and Guanglan Duan

Feasibility and outcomes of cytoreductive surgery and HIPEC for peritoneal surface malignancies in low- and middle-income countries: a single-center experience of 232 cases

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has recently emerged as a viable management option for peritoneal surface malignancy (PSM). CRS and HIPEC is a complex, multidi...

Authors: Suryanarayana Deo, Mukurdipi Ray, Babul Bansal, Sandeep Bhoriwal, Sushma Bhatnagar, Rakesh Garg, Nishkarsh Gupta, Atul Sharma, Lalit Kumar, Sanjay Thulkar, Ekta Dhamija, Sandeep Mathur and Prasenjit Das

LncRNA TTN-AS1 acts as a tumor promoter in gallbladder carcinoma by regulating miR-107/HMGA1 axis

The incidence of gallbladder carcinoma (GBM) in China has increased in recent years. Here, the functional mechanism of lncRNA TTN-AS1 in GBC was preliminary elucidated.

Authors: Zhaoxia Lin, Yaosheng Li, Rongfeng Shao, Yuqing Hu and Han Gao

Research advances on the immune research and prospect of immunotherapy in pituitary adenomas

Pituitary adenomas are one type of intracranial tumor, which can be divided into microadenoma (≤ 1 cm), macroadenoma (> 1 cm), and giant adenoma (≥ 4 cm) according to their diametral sizes. They are benign, ty...

Authors: Ding Nie, Qiuyue Fang, Bin Li, Jianhua Cheng, Chuzhong Li, Songbai Gui, Yazhuo Zhang and Peng Zhao

Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia

Breast cancer (BC) is the most commonly malignant tumor among women worldwide. Many studies have reported that circular RNAs (circRNAs) were participated in the regulation of multiple cancers development. Howe...

Authors: Zhimin Qiu, Ling Wang and Huaidong Liu

The efficacy of cytoreductive surgery for oligometastatic prostate cancer: a meta-analysis

At present, the application of tumor reduction surgery in oligometastatic prostate cancer has aroused extensive discussion among urologists, but clinicians have not reached a consensus on this issue. The purpo...

Authors: Bisheng Cheng, Shuchao Ye and Peiming Bai

Correction to: Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study

Authors: Inge van den Berg, Robert R. J. Coebergh van den Braak, Jeroen L. A. van Vugt, Jan N. M. Ijzermans and Stefan Buettner

The Amplatzer device and pedicle muscle flap transposition for the treatment of bronchopleural fistula with chronic empyema after lobectomy: two case reports

Bronchopleural fistula (BPF) refers to an abnormal channel between the pleural space and the bronchial tree. It is a potentially fatal postoperative complication after pulmonary resection and a complex challen...

Authors: Yongyong Wu, Zhongliang He, Weihua Xu, Guoxing Chen, Zhijun Liu and Ziying Lu

Comparative efficacy of intraoperative extracorporeal irradiated and alcohol-inactivated autograft reimplantation for the management of osteosarcomas—a multicentre retrospective study

Biologic bone reconstruction in limb salvage surgery for the treatment of malignant bone tumours has always been controversial. The various inactivation methods, their convenience and stability, the curative e...

Authors: Meitao Xu, Ming Xu, Shuai Zhang, Hanqing Li, A. I. Qiuchi, Xiuchun Yu and Xu Quan Wang

Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma

Renal cell carcinoma (RCC) is a common malignant tumour of the genitourinary system. We aimed to analyse the potential value of metastasis-related biomarkers, circulating tumour cells (CTCs) and the proliferat...

Authors: Jinbo Song, Zhe Yu, Bingqi Dong, Mingkai Zhu, Xiaofeng Guo, Yongkang Ma, Shiming Zhao and Tiejun Yang

Improved perioperative outcomes and reduced inflammatory stress response in malignant robot-assisted colorectal resections: a retrospective cohort study of 298 patients

Robot-assisted surgery is increasingly implemented for the resection of colorectal cancer, although the scientific evidence for adopting this technique is still limited. This study’s main objective was to comp...

Authors: Pedja Cuk, Randi Maria Simonsen, Mirjana Komljen, Michael Festersen Nielsen, Per Helligsø, Andreas Kristian Pedersen, Christian Backer Mogensen and Mark Bremholm Ellebæk

The assessment of risk factors for long-term survival outcome in ypN0 patients with rectal cancer after neoadjuvant therapy and radical anterior resection

The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients sti...

Authors: Marcin Zeman, Marek Czarnecki, Ewa Chmielik, Adam Idasiak, Władysław Skałba, Mirosław Strączyński, Piotr J. Paul and Agnieszka Czarniecka

The expression of the GATA6 gene in oral carcinoma cell lines

This study aimed to investigate the expression level of the GATA6 gene in different oral cancer cells.

Authors: Cheng-Lin Xu, Wei-Qun Guan and Xue-Ying Wang

Pathological features of lymph nodes around inferior mesenteric artery in rectal cancer: a retrospective study

This study aimed to explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer and its risk factors and its impact on tumor staging.

Authors: Chunhui Jiang, Ye Liu, Chunjie Xu, Yanying Shen, Qing Xu and Lei Gu

Neoadjuvant chemotherapy followed by hyperthermic intraperitoneal chemotherapy for patients with colorectal peritoneal metastasis: a retrospective study of its safety and efficacy

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective routine treatments for colorectal peritoneal metastasis (PM). However, the safety and efficacy of neoadjuvant che...

Authors: Sicheng Zhou, Yujuan Jiang, Jianwei Liang, Wei Pei and Zhixiang Zhou

Prognostic value of regional lymph node involvement in patients with metastatic colorectal cancer: palliative versus curative resection

Approximately 20% of patients with colorectal cancer are initially diagnosed with stage IV disease. This study aims to examine the role of regional lymph node (LN) status in metastatic colorectal cancer (mCRC)...

Authors: Ya-Ting Kuo, Wen-Sy Tsai, Hsin-Yuan Hung, Pao-Shiu Hsieh, Sum-Fu Chiang, Cheng-Chou Lai, Yih-Jong Chern, Yu-Jen Hsu and Jeng-Fu You

Potential role of chimeric genes in pathway-related gene co-expression modules

Gene fusion has epigenetic modification functions. The novel proteins encoded by gene fusion products play a role in cancer development. Therefore, a better understanding of the novel protein products may prov...

Authors: Piaopiao Li, Yingxia Li and Lei Ma

Conventional suture with prolonged timing of drainage is as good as quilting suture in preventing seroma formation at pectoral area after mastectomy

The aim of this study was to compare conventional suture with prolonged timing of drainage with quilting suture on the formation of seroma at pectoral area after mastectomy (ME) with sentinel lymph node biopsy...

Authors: Juan Huang, Shouman Wang, Yuhui Wu, Jian Hai, Jie Mao, Xue Dong and Zhi Xiao

CT imaging-based machine learning model: a potential modality for predicting low-risk and high-risk groups of thymoma: “Impact of surgical modality choice”

Radiomics methods are used to analyze various medical images, including computed tomography (CT), magnetic resonance, and positron emission tomography to provide information regarding the diagnosis, patient ou...

Authors: Ayten Kayi Cangir, Kaan Orhan, Yusuf Kahya, Hilal Özakıncı, Betül Bahar Kazak, Buse Mine Konuk Balcı, Duru Karasoy and Çağlar Uzun

Radiologic findings that aid in the reduction of misdiagnoses of Langerhans cell histiocytosis of the bone: a retrospective study

This study aimed to identify the characteristic radiological signs for the diagnosis of Langerhans cell histiocytosis (LCH) of the bone.

Authors: Mimi Zhao, Limin Tang, Shiqing Sun, Jiufa Cui and Haisong Chen

Predictive value of pretreatment PD-L1 expression in EGFR-mutant non-small cell lung cancer: a meta-analysis

To investigate the predictive value of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR...

Authors: Zhiyu Peng, Huahang Lin, Ke Zhou, Senyi Deng and Jiandong Mei

Large intraperitoneal lipoleiomyoma in a pre-menopausal woman: a case report

Lipoleiomyoma is a rare, benign variant of the commonplace uterine leiomyoma. Unlike leiomyoma, these tumors are composed of smooth muscle cells admixed with mature adipose tissue. While rare, they are most fr...

Authors: Sara L. Schaefer, Amy L. Strong, Sheena Bahroloomi, Jichang Han, Michella K. Whisman, Jodi M. Wilkowski and Christina V. Angeles

HBME1 and CK19 expression in non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) vs other follicular patterned thyroid lesions

Thyroid neoplasms with follicular architecture can have overlapping morphologic features and pose diagnostic confusion among pathologists. Various immunohistochemical stains have been investigated as potential...

Authors: Qandeel Sadiq, Radhika Sekhri, Daniel T. Dibaba, Qi Zhao and Shweta Agarwal

A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2

No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC accordi...

Authors: Shoko Yamashita, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada

Meta-analysis of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced rectal cancer

With the advent of more intensive chemotherapy regimens, neoadjuvant chemoradiotherapy (NACRT) for patients with locally advanced rectal cancer (LARC) has always been questioned due to its inevitable radiation...

Authors: Huaqin Lin, Lei Wang, Xiaohong Zhong, Xueqing Zhang, Lingdong Shao and Junxin Wu

Intercalary prosthetic replacement is a reliable solution for metastatic humeral shaft fractures: retrospective, observational study of a single center series

Treatments for metastatic fracture of the humeral shaft continue to evolve as advances are made in both oncological and operative management. The purposes of this study were to critically evaluate the effectiv...

Authors: Zhiqing Zhao, Zhipeng Ye, Taiqiang Yan, Xiaodong Tang, Wei Guo and Rongli Yang

Prognostic value of the C-reactive protein to albumin ratio in colorectal cancer: an updated systematic review and meta-analysis

The inflammatory biomarker “C-reactive protein to albumin ratio (CAR)” has been reported to significantly correlate to a variety of human cancers. However, there are conflicting results regarding the prognosti...

Authors: Chun-Kai Liao, Yen-Lin Yu, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jy-Ming Chiang and Jeng-Fu You

Risk factors for central lymph node metastasis in the cervical region in papillary thyroid carcinoma: a retrospective study

To investigate the influence of different risk factors on central lymph node metastasis (CLNM) in the cervical region in patients with papillary thyroid carcinoma (PTC).

Authors: Xiang Li, Hanwen Zhang, Yu Zhou and Ruochuan Cheng

Human nuclear receptors (NRs) genes have prognostic significance in hepatocellular carcinoma patients

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality in the world.

Authors: Guangtao Sun, Kejian Sun and Chao Shen

Unclassified mesenchymal sarcoma with NTRK1-KHDRBS1 gene fusion: a case report of long-term tumor-free survival with crizotinib treatment

Mesenchymal sarcomas are tumors that originate from mesenchymal tissue. Most mesenchymal sarcomas can be accurately classified, but some are unclassifiable in clinical practice. Molecular detection methods ena...

Authors: Weijie Chen, Huimei Wang, Dongxian Jiang, Lijuan Luan, Yuhong Zhou and Yingyong Hou

Identification of a ferroptosis-related gene signature predictive model in colon cancer

The prognosis of colon cancer (CC) is challenging to predict due to its highly heterogeneous nature. Ferroptosis, an iron-dependent form of cell death, has roles in various cancers; however, the correlation be...

Authors: Ye Wang, Heng-bo Xia, Zhang-ming Chen, Lei Meng and A-man Xu

Clinical-MRI radiomics enables the prediction of preoperative cerebral spinal fluid dissemination in children with medulloblastoma

Medulloblastoma (MB) is the most common pediatric embryonal tumor. Accurate identification of cerebral spinal fluid (CSF) dissemination is important in prognosis prediction. Both MRI of the central nervous sys...

Authors: Hui Zheng, Jinning Li, Huanhuan Liu, Chenqing Wu, Ting Gui, Ming Liu, Yuzhen Zhang, Shaofeng Duan, Yuhua Li and Dengbin Wang

Overexpressed pseudogene MT1L associated with tumor immune infiltrates and indicates a worse prognosis in BLCA

BLCA is a common cancer worldwide, and it is both aggressive and fatal. Immunotherapy (ICT) has achieved an excellent curative effect in BLCA; however, only some BLCA patients can benefit from ICT. MT1L is a p...

Authors: Yanpeng Ding, Nuomin Liu, Mengge Chen, Yulian Xu, Sha Fang, Wenbin Xiang, Xinying Hua, Gaili Chen, Yahua Zhong and Haijun Yu

Salpingo-oophorectomy versus cystectomy in patients with borderline ovarian tumors: a systemic review and meta-analysis on postoperative recurrence and fertility

To compare the postoperative recurrence and fertility in patients with borderline ovarian tumors (BOTs) who underwent different surgical procedures: salpingo-oophorectomy versus cystectomy.

Authors: Peng Wang and Lei Fang

Safety and efficacy of side-to-end anastomosis versus colonic J-pouch anastomosis in sphincter-preserving resections: an updated meta-analysis of randomized controlled trials

The application of side-to-end anastomosis (SEA) in sphincter-preserving resection (SPR) is controversial. We performed a meta-analysis to compare the safety and efficacy of SEA with colonic J-pouch (CJP) anas...

Authors: Sen Hou, Quan Wang, Shidong Zhao, Fan Liu, Peng Guo and Yingjiang Ye