Percutaneous transhepatic and endoscopic biliary drainage for malignant biliary tract obstruction: a meta-analysis
© Leng et al. 2014
Received: 13 May 2014
Accepted: 6 August 2014
Published: 23 August 2014
Various malignant tumors can obstruct the extrahepatic biliary tract. Two major techniques for restoring bile flow in this circumstance are endoscopic biliary drainage (EBD) and percutaneous transhepatic biliary drainage (PTBD).We conducted a meta-analysis to compare the effectiveness and safety of the two techniques.
Medline, EMBASE and the Cochrane Library database were searched for articles published between January 1980 and December 2013. The outcome measures were therapeutic success rate (primary), 30-day mortality rate and overall complications.
Of 264 screened articles, 3 randomized controlled trials comprising an aggregate total of 183 cancer patients were included in the meta-analysis. Our analysis showed no significant difference in restoration of bile flow between patients treated with EBD and those treated with PTBD (odds ratio (OR) = 2.34, 95% confidence interval (CI) = 0.32 to 17.16, P = 0.401). However, the result of sensitivity analysis indicated that the study conducted by Speer et al. influenced the pooled estimates. After the Speer et al. study was excluded, the therapeutic success rate of patients treated with PTBD was significantly greater than that of those who underwent EBD (OR = 5.48, 95% CI: 2.26 to 13.28, P < 0.001). The 30-day mortality and complication rates were similar in the EBD and PTBD groups.
The results of our meta-analysis indicate that PTBD had a higher therapeutic success rate than EBD in the treatment of malignancy-induced biliary obstruction. The mortality and complication rates of the two techniques were similar.
KeywordsBiliary tract neoplasms Biliary tract surgical procedures Cholangiocarcinoma Endoscopic biliary drainage Extrahepatic biliary ducts Malignancy-induced biliary obstruction Obstructive jaundice Percutaneous transhepatic biliary drainage
Malignant tumors that obstruct bile flow usually carry a very poor prognosis . Tumor-induced obstructive jaundice can be caused by Klatskin tumors (hilar cholangiocarcinoma), pancreatic adenocarcinoma, gallbladder carcinoma, metastases in theporta hepatis lymph nodes, distal cholangiocarcinoma orhepatocellular carcinoma (HCC) [2–5]. Jaundice occurs in 5% to 44% of patients withHCC . Symptoms include jaundice and pruritus, which can significantly impair patients’ quality of life. The major goal of palliative treatment for obstructing biliary tumors is the restoration of bile flow to the intestine . Median survival has been found to be significantly longer in patients with restored bile drainage (4.8 to 11.8 months), regardless of technique, than in patients with failed attempts at biliary drainage (1.3 to 1.8 months) [3, 6, 7]. Restoration of bile drainage also improves the patient’s quality of life.
Treatment modalities that can restore adequate bile duct drainage in malignant biliary obstruction cases include surgical biliary bypass, endoscopic biliary drainage (EBD) and percutaneous transhepatic biliary drainage (PTBD) [1–15]. None of these procedures has been proven superior to the others, and the most effective procedure for decompression of bile obstruction remains controversial. Cholangitis and pancreatitis are common complications of all the biliary decompression procedures .
It has been difficult to compare the effectiveness and safety of surgical bypass to endoscopic stenting in the treatment of malignant biliary duct obstruction, because many variables can influence the results: heterogeneity of patient populations studied, variations in tumor type, improvement in endoscopic and surgical techniques and differences in study design [2–4, 6–8, 12–15]. Nonetheless, the results of some comparative studies are available.Randomized clinical trials (RCTs) have shown no significant difference in overall survival rates between patients who were treated with endoscopic stenting and those who underwent surgical bypass [9–11]. However, stenting was associated with a significantly lower early complication rate  and shorter initial hospital stay , whereas the surgical bypass group had a significantly lower late complication rate . The comparative results of the EBD and PTBD procedures in RCTs have varied from a significant benefit for the EBD procedure  to a significant benefit for the PTBD technique [4, 13].
The comparative effectiveness of EBD and PTBD in the treatment of the various types of malignancy that can obstruct the bile duct remains unclear. Therefore, we conducted a meta-analysis of studies published through January 1980 and December 2013 to try to clarify this issue.
This article is in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines . This study doesn’t involve human subjects and does not require IRB review or consent. The population, intervention, comparator, outcomesand study design (PICOS) components are as follows: P: patients with malignant biliary tract obstruction; I: percutaneous transhepatic biliary drainage; C: endoscopic biliary drainage; OS: therapeutic success rate, 30-day mortality rate and complications.
Search strategy and data sources
Two reviewers independently searched Medline, EMBASE, Cochrane Library (CENTRAL), from January 1980 to December 2013, for articles with these keywords: malignant biliary obstruction, percutaneous endoscopic biliary drainage, cholangiocarcinoma, Klatskin tumor, duodenal cancer, ampullary cancer, pancreatic cancer and hepatocellular carcinoma. Searches were conducted using these specific keyword combinations: percutaneous AND malignant biliary obstruction; endoscopic AND malignant biliary obstruction; and percutaneous AND endoscopic AND biliary drainage.
Inclusion criteria in the meta-analysis were original RCTs that compared the efficacy and safety of PTBD and EBD used for treatment of malignant biliary obstruction. The meta-analysis excluded review articles, case reports, retrospective studies, cohort studies, single-arm prospective studies, letters, comments, editorials, non-English-language publications and trials of patients with biliary obstruction that was not caused by malignancy. Two reviewers (LJJ and ZN) screened and selected the articles independently. In case of disagreement on inclusion of an article, a third reviewer (DJH) was consulted.
Data extraction and quality assessment
The reviewers extracted the following information in a blinded manner from the included articles: the number of cases, patients’ ages (in years as a continuous variable), sex (male or female), type of stent placed (plastic or metal stent), follow-up period (in months as a continuous variable), type of malignancy (carcinoma of the gallbladder, primary carcinoma of the pancreas or bile ducts), use of prophylactic antibiotics (types of antibiotics), therapeutic success rate (successful drainage in the short term), 30-day mortality rate (in percentage), complications (overall, cholangitis and pancreatitis) and reference citation. All extracted data were checked by a third reviewer (DJH). The primary outcome for this study was the therapeutic success rate. Secondary outcomes were 30-day mortality rates and overall complication rates.
Two reviewers (LJJ and ZN) assessed the risk of bias in the studies, as described in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0) . They assigned a low risk, high risk or unclear risk to the attributes of each included article: (1) random sequence generation, (2) allocation concealment, (3) blinding (patients, personnel and assessor), (4) adequate assessment of each outcome, (5) avoidance of selective outcome reporting and (6) intention-to-treat analysis.
Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for binary outcome data and were compared between PTBD and EBD groups. A χ2test was used to assess the presence of heterogeneity across studies, and I2 was used to assess the degree of heterogeneity. An OR >1 for the therapeutic success rate indicated that PTBD was favored. In contrast, an OR <1 for the 30-day mortality rate and overall complication rate indicated that PTBD was favored. If heterogeneity existed between studies (Q-statistic with P < 0.1  or I2 > 50% ), we used the random-effects model (DerSimonian-Laird method) . Otherwise, the fixed-effects model was recommended (Mantel-Haenszel method). Statistical significance was set at a two-sided P-value <0.05. The small number of the selected studies negated assessment of publication bias by the funnel plot method . Sensitivity analysis was performed for primary outcomes based on the leave-one-out approach. All analyses were performed with Comprehensive Meta-Analysis statistical software, version 2.0 (Biostat, Englewood, NJ, USA).
Identification of relevant studies and risk of bias
Description of studies
Summary of studies included in the meta-analysis a
Number of cases
Malignancy causing biliary obstruction
Type of stent placed
PTBD vs. EBD
27 vs. 27
Carcinoma of the gallbladder
51 vs. 50
37% vs. 30%
Cefoperazone + sulbactam
PTBD vs. EBD
28 vs. 26
Primary carcinoma of the pancreas, gallbladder, or bile ducts, or to regional lymph node metastases
75 vs. 70
43% vs. 42%
Median: 2.5 months
PTBD vs. EBD
36 vs. 39
Primary carcinoma of the pancreas, gallbladder, or bile ducts
73 vs. 72.5
Summary of primary and secondary outcomes and complications
Definition of therapeutic success
Incidence of cholangitisa,%
Incidence of pancreatitisa,%
Bilirubin declined to <50% of the pretreatment value within 7 days after drainage
89 vs. 41b
4 vs. 8
18 vs. 52b
11 vs. 48b
0 vs. 3.7
Bilirubin declined by ≥ 20% of the pretreatment value
71 vs. 42b
36 vs. 42
61 vs. 35
0 vs. 3.8
Bilirubin declined by ≥20% of the pretreatment value during the initial admission
61 vs. 81
67 vs. 19b
13.9 vs. 17.9
Primary outcome: therapeutic success rate
Secondary outcome: 30-day mortality
Incidence of overall complications
In this meta-analysis, we found no significant difference in the therapeutic success rate, 30-day survival rate or rate of complications between patients treated with EBD and those treated with PTBD for malignant biliary obstruction in three RCTs reviewed [4, 12, 13]. However, sensitivity analysis was performed for primary outcomes based on the leave-one-out approach, with the therapeutic response in two of the studies was separately calculated. That revision revealed a significantly higher therapeutic response for PTBD than for EBD, although there was much heterogeneity in the reported success rates.
The heterogeneity could have resulted from various factors, such as variability in the types of stents (self-expanding metal  vs. plastic [12, 13]) and instrumentation used, causes of the biliary obstructionand location and extent of the tumors. The lower success rate of PTBD in the study of Speer et al.  may have been related to the use of less-advanced instrumentation. In the study of Garcarek et al. , a significantly lower rate of pericapsular bile leak in procedures performed from 2000 to 2006 compared to 2007 and 2011 may have been due to the use of novel instrumentation in the latter period . Self-expanding metal stents have several advantages over plastic stents, including larger internal diameter, lower risk for stent occlusion, need for additional surgical interventions, and relatively long patency (about 10 months) . The various causes of biliary obstruction described in the studies were cancers of the gallbladder [4, 12, 13], pancreas [4, 12] and bile ducts [4, 12], as well as metastases . Another technical consideration is that one or the other of the two techniques may be more efficacious for treatment of a specific type of tumor, such as hilar cholangiocarcinoma. In this regard, hilar cholangiocarcinoma (Klatskin tumor) was the cause of biliary obstruction in four of the five trials [2, 6, 8, 15, 24], and PTBD had a higher therapeutic success rate than EBD in those. The rates of complication with the two treatments were either similar [2, 6] or lower [8, 15] with PTBD.
With respect to the possible influence of location of the tumor and its extent on the therapeutic success of the drainage technique, tumor infiltration in the second portion of the duodenum and major papilla may prevent cannulation of the bile duct during EBD. In that case, an alternative strategy, such as surgical bypass or PTBD , may be needed. Also, patients with proximal biliary obstruction may have a higher incidence of cholangitis and bacteribilia than do those with distal biliary obstruction .
The reported incidence of early cholangitis associated with PTBD and EBD ranges from 11% to 48% [12, 13]. Multivariate logistic regression analysis identified the following statistically significant predictive factors for the immediate development of cholangitis after PTBD: history of cholangitis, recent biliary drainage (≤6 months), elevated C-reactive protein and low serum albumin concentration . In one study of PTBD-treated patients , the presence of fever was significantly associated with increased the risk for bacteremia and shock, leading the authors to suggest that prophylactic antibiotics should be administered to patients undergoing PTBD.
Our meta-analysis has some limitations. First, relatively few RCTs have been conductedin which investigators compared the outcomes and complication rates of cancer patients treated with PTBD or EBD. Second, both Speer et al.  and Piñolet al.  used relatively less stringent criteria for therapeutic success (20% decline in serum biliary concentration), in contrast to the 50% decline in the study of Saluja et al. . As mentioned above, the diverse array of tumors and their locations may also have affected the heterogeneity of our meta-analyses. Third, language bias is present because the studies published in languages other than English were excluded. Fourth, technical advances in intensive care made during the period of the studies could have affected the results.
The results of our meta-analysis indicate that PTBD had a higher therapeutic success rate than EBD in the treatment of malignancy-induced biliary obstruction. We found that the mortality and complication rates of the two techniques were similar.
This work was supported by National Key Technology Research and Development Program of China (2012BAI06B01).
- van Delden OM, Laméris JS: Percutaneous drainage and stenting for palliation of malignant bile duct obstruction. Eur Radiol. 2008, 18: 448-456. 10.1007/s00330-007-0796-6.View ArticlePubMedGoogle Scholar
- Walter T, Ho CS, Horgan AM, Warkentin A, Gallinger S, Greig PD, Kortan P, Knox JJ: Endoscopic or percutaneous biliary drainage for Klatskin tumors?. J Vasc Interv Radiol. 2013, 24: 113-121. 10.1016/j.jvir.2012.09.019.View ArticlePubMedGoogle Scholar
- Choi J, Ryu JK, Lee SH, Ahn DW, Hwang JH, Kim YT, Yoon YB, Han JK: Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach. Hepatobiliary Pancreat Dis Int. 2012, 11: 636-642. 10.1016/S1499-3872(12)60237-9.View ArticlePubMedGoogle Scholar
- Piñol V, Castells A, Bordas JM, Real MI, Llach J, Montañà X, Feu F, Navarro S: Percutaneous self-expanding metal stents versus endoscopic polyethylene endoprostheses for treating malignant biliary obstruction: randomized clinical trial. Radiology. 2002, 225: 27-34. 10.1148/radiol.2243011517.View ArticlePubMedGoogle Scholar
- Ahn S, Lee YS, Lim KS, Lee JL: Malignant biliary obstructions: Can we predict immediate postprocedural cholangitis after percutaneous biliary drainage?. Support Care Cancer. 2013, 21: 2321-2326. 10.1007/s00520-013-1796-5.View ArticlePubMedGoogle Scholar
- Paik WH, Park YS, Hwang JH, Lee SH, Yoon CJ, Kang SG, Lee JK, Ryu JK, Kim YT, Yoon YB: Palliative treatment with self-expandable metallic stents in patients with advanced type III or IV hilar cholangiocarcinoma: a percutaneous versus endoscopic approach. Gastrointest Endosc. 2009, 69: 55-62. 10.1016/j.gie.2008.04.005.View ArticlePubMedGoogle Scholar
- Ho CS, Warkentin AE: Evidence-based decompression in malignant biliary obstruction. Korean J Radiol. 2012, 13 (Suppl 1): S56-S61. 10.3348/kjr.2012.13.S1.S56.PubMed CentralView ArticlePubMedGoogle Scholar
- Kloek JJ, van der Gaag NA, Aziz Y, Rauws EA, van Delden OM, Lameris JS, Busch OR, Gouma DJ, van Gulik TM: Endoscopic and percutaneous preoperative biliary drainage in patients with suspected hilar cholangiocarcinoma. J Gastrointest Surg. 2010, 14: 119-125. 10.1007/s11605-009-1009-1.PubMed CentralView ArticlePubMedGoogle Scholar
- Andersen JR, Sorensen SM, Kruse A, Rokkjaer M, Matzen P: Randomised trial of endoscopic endoprosthesis versus operative bypass in malignant obstructive jaundice. Gut. 1989, 30: 1132-1135. 10.1136/gut.30.8.1132.PubMed CentralView ArticlePubMedGoogle Scholar
- Smith AC, Dowsett JF, Russell RC, Hatfield AR, Cotton PB: Randomised trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction. Lancet. 1994, 344: 1655-1660. 10.1016/S0140-6736(94)90455-3.View ArticlePubMedGoogle Scholar
- Shepherd HA, Royle G, Ross AP, Diba A, Arthur M, Colin-Jones D: Endoscopic biliary endoprosthesis in the palliation of malignant obstruction of the distal common bile duct: a randomized trial. Br J Surg. 1988, 75: 1166-1168. 10.1002/bjs.1800751207.View ArticlePubMedGoogle Scholar
- Speer AG, Cotton PB, Russell RC, Mason RR, Hatfield AR, Leung JW, MacRae KD, Houghton J, Lennon CA: Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice. Lancet. 1987, 2: 57-62.View ArticlePubMedGoogle Scholar
- Saluja SS, Gulati M, Garg PK, Pal H, Pal S, Sahni P, Chattopadhyay TK: Endoscopic or percutaneous biliary drainage for gallbladder cancer: a randomized trial and quality of life assessment. Clin Gastroenterol Hepatol. 2008, 6: 944-950. 10.1016/j.cgh.2008.03.028. e3View ArticlePubMedGoogle Scholar
- Bin OY, Zeng KW, Hua HW, Zhang XQ, Chen FL: Endoscopic nasobiliary drainage and percutaneous transhepatic biliary drainage for the treatment of acute obstructive suppurative cholangitis: a retrospective study of 37 cases. Hepatogastroenterology. 2012, 59: 2454-2456.PubMedGoogle Scholar
- Lee SH, Park JK, Yoon WJ, Lee JK, Ryu JK, Yoon YB, YT K: Optimal biliary drainage for inoperable Klatskin’s tumor based on Bismuth type. World J Gastroenterol. 2007, 13: 3948-3955. 10.3748/wjg.v13.i29.3948.PubMed CentralView ArticlePubMedGoogle Scholar
- Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009, 151: W65-W94.View ArticlePubMedGoogle Scholar
- Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Edited by: Higgins JPT, Green S. 2011, The Cochrane Collaboration, Available from http://www.cochrane-handbook.org. (accessed 16 August 2014)Google Scholar
- Lau J, Ioannidis JP, Schmid CH: Quantitative synthesis in systematic reviews. Ann Intern Med. 1997, 127: 820-826. 10.7326/0003-4819-127-9-199711010-00008.View ArticlePubMedGoogle Scholar
- Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21: 1539-1558. 10.1002/sim.1186.View ArticlePubMedGoogle Scholar
- DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials. 1986, 7: 177-188. 10.1016/0197-2456(86)90046-2.View ArticlePubMedGoogle Scholar
- Sutton AJ, Duval SJ, Tweedie RL, Abrams KR, Jones DR: Empirical assessment of effect of publication bias on meta-analyses. BMJ. 2000, 320: 1574-1577. 10.1136/bmj.320.7249.1574.PubMed CentralView ArticlePubMedGoogle Scholar
- Garcarek J, Kurcz J, Guziński M, Janczak D, Sasiadek M: Ten years single center experience in percutaneous transhepatic decompression of biliary tree in patients with malignant obstructive jaundice. Adv Clin Exp Med. 2012, 21: 621-632.PubMedGoogle Scholar
- Park YJ, Kang DH: Endoscopic drainage in patients with inoperable hilar cholangiocarcinoma. Korean J Intern Med. 2013, 28: 8-18. 10.3904/kjim.2013.28.1.8.PubMed CentralView ArticlePubMedGoogle Scholar
- Blechacz BR, Gores GJ: Cholangiocarcinoma. Clin Liver Dis. 2008, 12: 131-150. 10.1016/j.cld.2007.11.003.View ArticlePubMedGoogle Scholar
- Artifon EL, Aparicio D, Paione JB, Lo SK, Bordini A, Rabello C, Otoch JP, Gupta K: Biliary drainage in patients with unresectable, malignant obstruction where ERCP fails: endoscopic ultrasonography-guided choledochoduodenostomy versus percutaneous drainage. J Clin Gastroenterol. 2012, 46: 768-774. 10.1097/MCG.0b013e31825f264c.View ArticlePubMedGoogle Scholar
- Nomura T, Shirai Y, Hatakeyama K: Bacteribilia and cholangitis after percutaneous transhepatic biliary drainage for malignant biliary obstruction. Dig Dis Sci. 1999, 44: 542-546. 10.1023/A:1026653306735.View ArticlePubMedGoogle Scholar
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