Table 2 Clinicopathologic characteristics
Characteristic | Value | (n=14) |
|---|---|---|
Age, median (IQR), years | 74 | (67.5–78.5) |
Gender | ||
Male, No. (%) | 7 | (50%) |
Female, No. (%) | 7 | (50%) |
Preoperative diagnosis of pagetoid spread, No. (%) | ||
Diagnosed | 2 | (14%) |
Not diagnosed | 12 | (86%) |
Identification of underlying anorectal cancer, No. (%) | ||
Not found | 6 | (43%) |
Syncronous | 7 | (50%) |
Metachronous | 1 | (7%) |
Primary tumor site, No. (%) | ||
Anal canal | 7 | (50%) |
Lower rectum | 1 | (7%) |
Unknown | 6 | (43%) |
Immunohistochemistry, No. (%) | ||
Not confirmed | 2 | (14%) |
CK20+/CK7+ | 7 | (50%) |
CK20+/CK7− | 4 | (29%) |
CK20−/CK7+ | 0 | (0%) |
CK20−/CK7− | 1 | (7%) |
GCDFP15−a | 8 | (100%) |
CDX2+ | 11 | (92%) |
Histologya, No. (%) | ||
Adenocarcinoma (grade unknown) | 7 | (50%) |
Tub1/2 | 1 | (7%) |
Por/sig | 4 | (933%) |
Muc | 3 | (600%) |
Tumor size, median (IQR), cm | 53.5 | (26.3–87.5) |
Depth of invasion, No. (%) | ||
M | 3 | (21%) |
SM | 1 | (7%) |
MP | 2 | (14%) |
A | 1 | (7%) |
AI | 1 | (7%) |
Invasive (WLE) | 1 | (7%) |
Non-invasive (WLE) | 2 | (14%) |
Lymph node metastases at initial treatment, No. (%) | ||
Negative | 4 | (29%) |
Lateral lymph node | 1 | (7%) |
Inguinal lymph node | 2 | (14%) |
Unknown (clinically negative) | 7 | (50%) |
Initial treatment, No. (%) | ||
WLE (±transanal local excision | 7 | (50%) |
APR (±WLE) | 5 | (36%) |
Radiation | 1 | (7%) |
Unknownb | 1 | (7%) |
Mapping biopsyc, No. (%) | ||
Done | 5 | (42%) |
None | 7 | (58%) |
Resection statusc, No. (%) | ||
R0 | (0%) | |
R1 | (0%) | |
R2 | (0%) | |
Follow-up time, median (IQR), mo | 4.5 | (158.7–7.4) |
Recurrence, No (%) | 7 | (50%) |
Time to recurrence, median (IQR), mo | 34.6 | (18.2–81.7) |
5-year recurrence free survival | 55.9% | |
Mortality, No. (%) | 2 | (14%) |
5-year overall survival | 90.0% | |