- Open Access
Response to comment on “Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma”
World Journal of Surgical Oncology volume 20, Article number: 306 (2022)
This article is a response to “comment on ‘Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma’” by Gopal Sharma. With this comment, author highlighted the strengths and limitations of the study. With this response, we respond to this and make a comparison of the results and conclusions.
We thank Gopal Sharma for his interest and insightful comments  on our published work . The article seeks to make a pooled analysis of Xpert bladder cancer (Xpert BC) based on the five mRNAs for rapid diagnosis of bladder carcinoma, compared with cystoscopy and/or biopsy. In terms of clinical application prospects, Xpert BC is supposed to be used for tumor recurrences and the screening of patients with hematuria. Therefore, samples of hematuria patients were included in this study. However, due to the small number of hematuria patients, the study mainly included the patients with bladder cancer on follow-up. Consequently, the conclusion is more suitable for the follow-up of bladder cancer patients. We agree that Gopal Sharma’s suggestions are reasonable and find that Sharma et al. also pool the data regarding the diagnostic performance of Xpert BC in patients with non-muscle invasive bladder cancer (NMIBC) . The data of hematuria patients in the studies of Valenberg et al.  and Wallace et al.  were excluded, and 5 more articles from the updated literature search were added by Sharma et al.
The pooled sensitivity and specificity of Xpert BC in the diagnosis of bladder cancer were 0.71 and 0.81 in our research, which is little different from the sensitivity (0.73) and specificity (0.77) of Sharma et al. All articles used cystoscopy and/or biopsy as the gold standard, and the included studies did not get enough data for subgroup analysis of the gold standard, which is consistent with Sharma et al. Besides, our conclusions on the diagnostic performance of Xpert BC in follow-up patients are consistent with Sharma et al.; Xpert BC has acceptable diagnostic accuracy in monitoring patients with NMIBC. And the diagnostic accuracy of high-grade tumors was higher than that of low-grade tumors in subgroup analysis.
Our research still has limitations caused by factors such as heterogeneity. More studies in the future are supposed to contribute to subgroup analysis and heterogeneity resolution.
Availability of data and materials
All data analyzed during this study are included in this published article.
- Xpert BC:
Xpert bladder cancer
Non-muscle-invasive bladder cancer
Sharma G. Comment on “Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma”. World J Surg Oncol. 2021;19:237.
Liu YL, Wang XL, Yang XH, Wu XH, He GX, Xie LM, et al. Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma. World J Surg Oncol. 2021;19:42.
Sharma G, Sharma A, Krishna M, Devana SK, Singh SK. Xpert bladder cancer monitor in surveillance of bladder cancer: systematic review and meta-analysis. Urol Oncol. 2022;40:163 e161–9.
Valenberg F, Hiar AM, Wallace E, Bridge JA, Mayne DJ, Beqaj S, et al. Validation of an mRNA-based urine test for the detection of bladder cancer in patients with haematuria. Eur Urol Oncol. 2021;4:93–101.
Wallace E, Higuchi R, Satya M, McCann L, Sin MLY, Bridge JA, et al. Development of a 90-minute integrated noninvasive urinary assay for bladder cancer detection. J Urol. 2018;199:655–62.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Xie, YF., Liu, YL. & Guo, XG. Response to comment on “Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma”. World J Surg Onc 20, 306 (2022). https://doi.org/10.1186/s12957-022-02771-3
- Bladder cancer
- Xpert BC