- Case Report
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Primary melanoma of the bladder: case report and review of the literature
World Journal of Surgical Oncology volume 20, Article number: 287 (2022)
Primary melanoma of the bladder is extremely rare and has been sporadically reported in case reports. Its incidence, diagnosis, treatment, and outcomes are still unclear.
We report a 67-year-old female patient who presented with hematuria and was diagnosed with primary melanoma of the bladder by transurethral resection. No distant metastasis was detected by fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT). After a multidisciplinary discussion, the patient received laparoscopic radical resection of the bladder tumor. There was no tumor recurrence or distant metastasis after 15 months of follow-up.
Primary melanoma of the bladder is easily confused with urothelium carcinoma in morphology. The immunohistochemical is crucial in diagnosis. Because of a lack of in-depth understanding of primary melanoma of the bladder, the “gold standard” treatment has not been set. We would like to provide some rare information about it and discuss the proper treatment strategy for this rare disease.
Primary melanoma of the bladder is extremely rare and accounts for less than 0.2% of all reported melanoma cases. It has been reported that 96–95% of all primary melanomas arise from the skin and have a lethal effect on patients. Thus far, up to 30 corresponding cases have been reported . However, no standard treatment has been established for local or advanced primary bladder melanoma.
Transurethral resection (TUR), partial cystectomy (PC), and radical cystectomy (RC) are ordinarily regarded as optional treatments for primary melanoma of the bladder. Although the tumor size and depth of invasion might determine the prognosis in primary disease, the overall survival time is less than 3 years. Because of the risk of recurrence in the bladder or systemic metastasis after local treatment in patients with primary bladder melanoma, RC is recommended in some cases . However, some studies reported that RC did not achieve the expected positive effect on survival . Thus, we report the positive effect of RC on survival in a patient with confirmed primary bladder malignant melanoma.
A 67-year-old female patient with a complaint of gross hematuria underwent a cystoscopy, and a mass lesion approximately 1 cm in size was detected on the left side of the bladder neck. A detailed outpatient consultation revealed that the non-smoker patient had no additional systematic diseases and was not taking any medications. A subtotal hysterectomy has been performed more than 10 years ago due to the myoma of the uterus. In addition, the physical examination did not show further positive findings. After all preoperational preparations were ready, a complete TUR of the bladder tumor was performed in the primary hospital. Based on the pathological evaluation by HE (hematoxylin-eosin) staining, a high-grade urothelial carcinoma was initially diagnosed (Fig. 1).
To prevent the recurrence of the bladder tumor, a bladder perfusion with gemcitabine was then performed. The hematuria reappeared after 4 circles of perfusion of the bladder. After routine laboratory tests, the following parameters were obtained: hemoglobin 13.7 g/dL; creatinine 49 umol/L; urine analysis, leukocytes 30/HPF; and erythrocytes 9/HPF. After all the needed preoperational preparations were completed, a TUR of the bladder tumor was performed again in our hospital (Fig. 2). After pathological evaluation by the HE staining method mentioned above, the tumor was then examined by immunohistochemical (IHC) staining. Mart-1, HMB-45, and S-100 were positive, while cytokeratin was negative (Fig. 3). The final pathology was reported as primary bladder malignant melanoma.
One month after TUR, fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) revealed no distant metastasis in the body of the patient (Supplemental figure 1). To make a treatment plan and prognosis assessment, the patient was discussed by members of the institutional multidisciplinary uro-oncologic disease management team, who proposed a treatment plan. By fully communicating with the patient and her family members regarding the patient’s condition and treatment plan, a RC with double cutaneous ureterostomy was performed. Fortunately, no tumor in the bladder was found after pathological evaluation (Fig. 4). Follow-up of the patient lasted 15 months, and no recurrence or metastasis was found.
Discussion and conclusion
Primary bladder malignant melanoma is extremely rare in the genitourinary tract, especially in the bladder. Since Wheelock and colleagues reported the first case of primary bladder malignant melanoma of the bladder in 1942, approximately 31 cases of primary bladder melanoma have been reported in the authoritative medical literature. All the reported cases are listed in Table 1. The median age of patients was 61 (from 7 to 87) years old, and 17/31 patients were male. In addition, the follow-up time varied from 0.5 to 144 months (a median of 14 months), during which only 13/31 (41.9%) patients were still alive. It has been reported that bladder metastasis of malignant melanoma is more common than primary bladder malignant melanoma. Furthermore, renal and bladder metastases have been reported in 45% and 18% of patients dying of melanoma, respectively .
The symptoms caused by this tumor vary and depend on its location . The patient in our report complained of hematuria for 1 month. Gross hematuria is one of the most frequent presenting symptoms, depending on the size and location of the tumor in the bladder. It was reported that recurrent urinary tract infections might be an initial symptom in some patients with primary bladder melanoma .
In ordinary clinical practice, the diagnosis of primary melanoma of the bladder is complicated. In this case, the tumor was originally misdiagnosed as a high-grade urothelial carcinoma. IHC staining is crucial to make an accurate diagnosis of this disease, and immunohistochemical staining such as HMB-45, Melan-A, and S-100 are helpful in diagnosis during the pathological examination. Thus far, some diagnostic criteria for primary melanoma in the bladder have been established as follows : (1) absence of any previous skin lesions, (2) cutaneous malignant melanoma, (3) primary visceral malignant melanoma, (4) recurrence pattern showing consistency with the primary tumor diagnosis, and (5) atypical melanocytes at the tumor margin upon microscopic examination.
It is generally known that no standard treatment has been established for primary melanoma in the bladder. The PC, RC, and TUR were potential surgical plans. TUR was always considered a conservative treatment for some patients. The tumor is apt to recurrence, and metastasis after TUR, therefore, refers to the treatment of urothelium carcinoma; BCG instillation was used to decrease the recurrence of carcinoma after TUR. There was only one patient treated with Bacillus of Calmette Guerin (BCG) after TUR; however, its effect after TUR still requires further explore . Some case studies revealed that chemotherapy could be considered a therapy for patients after surgery. For the two patients without distant metastasis, they were treated with chemotherapy after TUR, and the patients died after 18 and 6 months, respectively [ 14, 30]. RC was carried out on 10 patients, and the survival rate was 60% (6/10) at a median follow-up of 15.5 months.
Two patients with suspicious distant metastasis received immune checkpoint inhibitors (ICIs) after surgery, and one of the patients who received Nivolumab after RC was alive at 16 months . Nivolumab plus Ipilimumab or Nivolumab alone, blocking the interaction between the programmed cell death PD1, and its ligand PD-L1 have been reported to be effective in antitumor response in melanoma [31, 33, 34]. ICIs might be considered for the primay bladder melanoma patients with distant metastasis after surgery.
In this case report, the patient was informed regarding all corresponding treatment options in advance and was managed in a pre-emptive manner by carrying out RC following transurethral resection of the bladder tumor.
In conclusion, primary melanoma of the bladder is easily confused with urothelium carcinoma in morphology. The IHC is crucial in diagnosis. Because of the lack of adequate evidence about the treatment of patients with primary melanoma of the bladder, no “Gold standard” treatment has been set. We would like to provide some rare information about primary bladder melanoma and discuss the appropriate treatment strategy for this rare disease.
Availability of data and materials
Raw data for the figures are not publicly available to preserve individuals’ privacy under the European General Data Protection Regulation.
Bacillus of Calmette Guerin
Positron emission tomography-computed tomography
- H&E staining:
Immune checkpoint inhibitors
Hussein MR. Extracutaneous malignant melanomas. Cancer Investig. 2008;26(5):516–34. https://doi.org/10.1080/07357900701781762.
Mercimek MN, Ozden E. Bladder-sparing approach in a woman with muscle-invasive primary bladder melanoma. J Coll Phys Surg Pak. 2019;29(12):S154–s156. https://doi.org/10.29271/jcpsp.2019.12.S154.
Venyo AK. Melanoma of the urinary bladder: a review of the literature. Sur Res Pract. 2014;2014:605802. https://doi.org/10.1155/2014/605802.
Wheelock MC. Sarcoma of the urinary bladder. J Urol. 1942;48(6):628–34.
Su CT, Prince CL. Melanoma of the bladder. J Urol. 1962;87:365–7. https://doi.org/10.1016/s0022-5347(17)64965-6.
Ainsworth AM, Clark WH, Mastrangelo M, Conger KB. Primary malignant melanoma of the urinary bladder. Cancer. 1976;37(4):1928–36 https://doi.org/10.1002/1097-0142(197604)37:4<1928:aid-cncr2820370444>3.0.co;2-w.
Willis AJ, Huang AH, Carroll P. Primary melanoma of the bladder: a case report and review. J Urol. 1980;123(2):278–81. https://doi.org/10.1016/s0022-5347(17)55897-8.
Anichkov NM, Nikonov AA. Primary malignant melanomas of the bladder. J Urol. 1982;128(4):813–5. https://doi.org/10.1016/s0022-5347(17)53200-0.
Ironside JW, Timperley WR, Madden JW, Royds JA, Taylor CB. Primary melanoma of the urinary bladder presenting with intracerebral metastases. Br J Urol. 1985;57(5):593–4. https://doi.org/10.1111/j.1464-410x.1985.tb05880.x.
Goldschmidt P, Py JM, Kostakopoulos A, Jacqmin D, Grosshans E, Bollack C. Primary malignant melanomas of the urinary bladder. Br J Urol. 1988;61(4):359. https://doi.org/10.1111/j.1464-410x.1988.tb13975.x.
Philippe P, Volant A, Fournier G, Mangin P. Primary malignant melanoma of the bladder. Apropos of a case. J Urol. 1989;95(4):247–50.
Van Ahlen H, Nicolas V, Lenz W, Boldt I, Bockisch A, Vahlensieck W. Primary melanoma of urinary bladder. Urology. 1992;40(6):550–4. https://doi.org/10.1016/0090-4295(92)90414-r.
Lund L, Storgård L, Noer H. Primary malignant melanoma of the urinary bladder. Case report. Scand J Urol Nephrol. 1992;26(2):205–6. https://doi.org/10.1080/00365599.1992.11690458.
Kojima T, Tanaka T, Yoshimi N, Mori H. Primary malignant melanoma of the urinary bladder. Arch Pathol Lab Med. 1992;116(11):1213–6.
Lange-Welker U, Papadopoulos I, Wacker HH. Primary malignant melanoma of the bladder. A case report and literature review. Urol Int. 1993;50(4):226–8. https://doi.org/10.1159/000282490.
Mourad WA, Mackay B, Ordonez NG, Ro JY, Swanson DA. Clear cell melanoma of the bladder. Ultrastruct Pathol. 1993;17(3-4):463–8. https://doi.org/10.3109/01913129309027791.
Niederberger CS, Lome LG. Primary malignant melanoma of urinary bladder. Urology. 1993;41(1):72–4. https://doi.org/10.1016/0090-4295(93)90250-e.
De Torres I, Fortuño MA, Raventos A, Tarragona J, Banus JM, Vidal MT. Primary malignant melanoma of the bladder: immunohistochemical study of a new case and review of the literature. J Urol. 1995;154(2 Pt 1):525–7.
Tainio HM, Kylmälä TM, Haapasalo HK. Primary malignant melanoma of the urinary bladder associated with widespread metastases. Scand J Urol Nephrol. 1999;33(6):406–7. https://doi.org/10.1080/003655999750017086.
García Montes F, Lorenzo Gómez MF, Boyd J. Does primary melanoma of the bladder exist? Actas Urol Esp. 2000;24(5):433–6. https://doi.org/10.1016/s0210-4806(00)72477-6.
Khalbuss WE, Hossain M, Elhosseiny A. Primary malignant melanoma of the urinary bladder diagnosed by urine cytology: a case report. Acta Cytol. 2001;45(4):631–5. https://doi.org/10.1159/000327878.
Hsu T, Hsu YH. Primary malignant melanoma of the urinary bladder. Tzu Chi Med J. 2002;14(4):253–6.
Baudet C, Shell M, Bergeron C, Mollard P, Dijoud F, Bailly C, et al. Bladder melanoma in a 7-year-old girl. Prog Urol. 2005;15(1):67–70.
Pacella M, Gallo F, Gastaldi C, Ambruosi C, Carmignani G. Primary malignant melanoma of the bladder. Int J Urol. 2006;13(5):635–7. https://doi.org/10.1111/j.1442-2042.2006.01375.x.
Sundersingh S, Majhi U, Narayanaswamy K, Balasubramanian S. Primary spindle cell melanoma of the urinary bladder. Indian J Pathol Microbiol. 2011;54(2):422–4. https://doi.org/10.4103/0377-4929.81612.
El Ammari JE, Ahallal Y, El Fassi MJ, Farih MH. Primary malignant melanoma of the urinary bladder. Case Rep Urol. 2011;2011:932973. https://doi.org/10.1155/2011/932973.
Truong H, Sundi D, Sopko N, Xing D, Lipson EJ, Bivalacqua TJ. A case report of primary recurrent malignant melanoma of the urinary bladder. Urol Case Rep. 2013;1(1):2–4. https://doi.org/10.1016/j.eucr.2013.10.002.
Otto T, Barski D, Bug R. Malignant melanoma of the urinary bladder. Der Urologe Ausg A. 2017;56(7):861–3. https://doi.org/10.1007/s00120-017-0421-5.
Barillaro F, Camilli M, Dessanti P, Gorji N, Chiesa F, Villa A, et al. Primary melanoma of the bladder: case report and review of the literature. Arch Ital Urologia Androl. 2018;90(3):224–6. https://doi.org/10.4081/aiua.2018.3.224.
Bumbu GA, Berechet MC, Pop OL, Nacer K, Bumbu G, Maghiar OA, et al. Primary malignant melanoma of the bladder - case report and literature overview. Rom J Morphol Embryol. 2019;60(1):287–92.
Mahoney KM, Freeman GJ, McDermott DF. The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clin Ther. 2015;37(4):764–82. https://doi.org/10.1016/j.clinthera.2015.02.018.
Lamichhane N. Melanoma of urinary bladder presented as acute urine retention. J Urol Res. 2016;3:1054.
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320–30. https://doi.org/10.1056/NEJMoa1412082.
Monica I, Kumar LP, Uppin MS, Jagannath Rao Naidu KV. Neurocutaneous melanocytosis presenting in a teenager: a case report and review of the literature. J Cancer Res Ther. 2015;11(3):649. https://doi.org/10.4103/0973-1482.138201.
The authors thank the patient’s family for their cooperation. The authors thank those patients who contributed to the article but did not meet the criteria for authorship.
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Additional file 1: Supplemental Figure S1
: The patients’ preoperative PET/MRI scan. The red arrow marks the point of the tumor in neck of bladder.
Additional file 2: Supplemental Figure S2
: The pictures of patient’s hematuria sample.
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Dai, JD., He, B., Liu, ZH. et al. Primary melanoma of the bladder: case report and review of the literature. World J Surg Onc 20, 287 (2022). https://doi.org/10.1186/s12957-022-02753-5
- Bladder tumor
- Case report