Skip to main content

Comment on “Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma”

The Original Article was published on 09 February 2021


This article is a commentary on an article published in World Journal of Surgical Oncology by Liu et al. With this study, authors evaluated diagnostic accuracy of Xpert bladder cancer monitor in detecting recurrences. With this article, we highlight the strengths and limitations of the study.


I read an article published by Liu et al. [1] in the February edition of World Journal of Surgical Oncology. I read this article with keen interest and would extend my best wishes to the study authors. This study aimed to “reviewing the performance of Xpert BC in the follow-up of bladder cancer and evaluating the role of Xpert BC in detecting NMIBC recurrence in the round”. The study has been well performed in my opinion; however there are certain issues which I would like to highlight.

  1. 1.

    I have reservations over inclusion of study by Valenberg et al. [2], as this study tested accuracy of Xpert bladder cancer (BC) in patients who presented with hematuria. Hence still study does not meet the primary aim of this study, which was to detect diagnostic accuracy of Xpert BC in patients with bladder cancer on follow-up.

  2. 2.

    Study authors have pooled overall data of study by Wallace et al. [3] that included patients with both known case of bladder cancers (on surveillance) and patients who presented with hematuria. Thus, in my opinion separate data for patients with BC on surveillance should be extracted and reanalyzed.

  3. 3.

    Lastly, use of different gold standard techniques by different studies is yet another limitation of this study which needs to be highlighted. Subgroup analysis according to the gold standard modality could also be performed.

To conclude, the results of this study need to interpret with caution due to abovementioned limitations and if possible needs revision for above mentioned points as they have potential to change the overall results.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.


  1. Liu Y-L, Wang X-L, Yang X-H, Wu X-H, He G-X, Xie L-M, et al. Pooled analysis of Xpert Bladder Cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma. World Journal of Surgical Oncology. 2021;19(1):42.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Valenberg F, Hiar AM, Wallace E, Bridge JA, Mayne DJ, Beqaj S, et al. Validation of an mRNA-based urine test for the detection of bladder cancer in patients with haematuria. European Urology Oncology. 2020.

  3. Wallace E, Higuchi R, Satya M, McCann L, Sin MLY, Bridge JA. Development of a 90-minute integrated noninvasive urinary assay for bladder cancer detection. J Urol. 2018;199(3):655–62.

    Article  PubMed  Google Scholar 

Download references





Author information

Authors and Affiliations



G Sharma - Protocol development, data collection and management, data analysis, and manuscript writing. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Gopal Sharma.

Ethics declarations

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable

Competing interests

The author declares no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharma, G. Comment on “Pooled analysis of Xpert bladder cancer based on the 5 mRNAs for rapid diagnosis of bladder carcinoma”. World J Surg Onc 19, 237 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: