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Table 3 Predictive factors for recurrence-free survival

From: Prognosis of papillary thyroid cancer in patients with Graves’ disease: a propensity score-matched analysis

Covariates Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
Clinical features
 Graves’ disease 0.329 (0.046–2.371) 0.270 1.299 (0.170–9.941) 0.801
 Age at surgery (years) 0.981 (0.962–1.001) 0.068 0.983 (0.964–1.001) 0.067
 Male sex 1.092 (0.585–2.037) 0.782 0.669 (0.350–1.277) 0.223
Pathological features
 Tumor size 2.132 (1.822–2.496) < 0.001 1.585 (1.245–2.018) < 0.001
 Extrathyroidal extension
  Microscopic 3.146 (1.644–6.021) 0.001 1.674 (0.814–3.441) 0.161
  Gross 10.22 (4.920–21.21) < 0.001 2.030 (0.931–4.958) 0.120
 Lymphatic invasion 5.520 (3.112–9.793) < 0.001 1.440 (0.763–2.718) 0.261
 Vascular invasion 4.990 (1.817–13.70) 0.002 1.536 (0.540–4.371) 0.421
 Margin involvement 2.238 (1.144–4.378) 0.019 0.881 (0.400–1.642) 0.560
 LN metastasis
  N1a 3.331 (1.192–7.435) 0.003 3.067 (1.160–8.111) 0.024
  N1b 22.76 (11.76–44.08) < 0.001 15.65 (6.404–38.25) < 0.001
131I remnant ablation 4.858 (2.323–10.16) < 0.001 0.622 (0.223–1.739) 0.366
  1. Data presented as mean and standard deviation if not noted otherwise. Cox proportional hazard model was used for univariate and multivariate analysis for recurrence-free survival
  2. HR hazard ratio, CI confidence interval, LN lymph node