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How does lesion size affect the pooled effect of traction-assisted endoscopic submucosal dissection on procedure time? A meta-regression
World Journal of Surgical Oncologyvolume 17, Article number: 157 (2019)
The purpose of this letter was to explore how lesion size affects the pooled effect of traction-assisted endoscopic submucosal dissection on procedure time. Our meta-regression showed that lesion size negatively associated with the effect of traction-assisted endoscopic submucosal dissection on procedure time (estimate point = − 1.02; 95% confidence interval, from − 1.58 to − 0.46). We also confirmed this result in different statistical models including fixed effect regression and two mixed effects regression models.
We read with interest the study published in World Journal of Surgical Oncology which synthesized seven randomized clinical trials with 964 cases for examining the effectiveness of traction assistance on endoscopic submucosal dissection (ESD) . The research found that traction-assisted ESD (TA-ESD) has two advantages including shorter procedure time and lower perforation rate, and TA-ESD reaches similar en bloc resection rate and complete resection rate to traditional ESD (T-ESD). However, there is an extremely high heterogeneity (I2 = 87%) in their pooled result of procedure time (main outcome). We completely agree with them about conducting subgroup analysis for exploring the source of the heterogeneity according to anatomy, yet their result still reflected a high heterogeneity (I2 = 60%). As we know, an important factor affecting procedure time is lesion size. Unfortunately, they did not explore how lesion size affects procedure time. Thus, we wrote this letter to improve the understanding about the role of lesion size in the effects of TA-ESD on procedure time through using appropriate data and meta-regression.
Six out of the seven trials in the previous meta-analysis reported lesion size, and mean lesion size ranged from 15.6 mm to 36.25 mm. Based on relevant data in the previous meta-analysis, we checked that the result was not seriously affected by each single trial (Additional file 1: Figure S1), and conducted meta-regression. Our meta-regression showed that lesion size negatively associated with the effect of TA-ESD on procedure time (estimate point = − 1.02; 95% confidence interval, from − 1.58 to − 0.46; Fig. 1). This result indicated that TA-ESD needs lesser time than T-ESD for a treating bigger lesion. To be specific, TA-ESD reduces about 1 min/mm lesion when it is compared with T-ESD. We confirmed this result in different statistical models including fixed effect regression and two mixed effects regression models (Additional file 1: Table S1). Moreover, no evidence detected serious small study bias in this result (Egger’s test = − 2.85, p = 0.30; Additional file 1: Figure S2).
In summary, we successfully identified an important factor causing heterogeneity in the pooled mean difference of procedure time between TA-ESD and T-ESD. This meaningful finding fosters the understanding of the impact of lesion size on the effectiveness of TA-ESD. Based on the previous synthesis and our meta-regression, TA-ESD is worth to be considered for patients deciding to receive ESD, especially in patients with large-size lesions. Lesion size is associated with fibrosis, and fibrosis is an important factor predicting perforation after ESD [2, 3]. Nevertheless, our evidence is limited to explore the impact of TA-ESD on lesions with fibrosis because current reports presented insufficient information about baseline fibrosis. We suggest future studies to examine how traction-assisted methods influence the ESD outcomes in those having fibrosis. Furthermore, the authors presented different effects on procedure time in the stomach, colorectum, and esophagus through subgroup analysis, but they did not clarify en bloc resection rate, complete resection rate, perforation rate, and delayed bleeding rate in different lesion location. As we know, procedure view and complexity in the stomach may differ from the colorectum and esophagus [4,5,6,7]. Therefore, we anticipate further studies exploring those results with stratifications of upper gastrointestinal tract lesions and lower gastrointestinal tract lesions in the future. These further analyses will improve TA-ESD application in clinical practice.
Availability of data and materials
All data generated or analyzed during this study are included in this published article
Endoscopic submucosal dissection
Traction-assisted endoscopic submucosal dissection
Traditional endoscopic submucosal dissection
Xia M, Zhou Y, Yu J, Chen W, Huang X, Liao J. Short-term outcomes of traction-assisted versus conventional endoscopic submucosal dissection for superficial gastrointestinal neoplasms: a systematic review and meta-analysis of randomized controlled studies. World J Surg Oncol. 2019;17:94.
Chiba H, Tachikawa J, Arimoto J, Ashikari K, Kuwabara H, Nakaoka M, Goto T, Ohata K, Nakajima A. Predictive factors of mild and severe fibrosis in colorectal endoscopic submucosal dissection. Dig Dis Sci. 2019. https://doi.org/10.1007/s10620-019-05735-y.
Hayashi N, Tanaka S, Nishiyama S, Terasaki M, Nakadoi K, Oka S, Yoshihara M, Chayama K. Predictors of incomplete resection and perforation associated with endoscopic submucosal dissection for colorectal tumors, Gastrointest Endosc. 2014;79:427–35.
Ban H, Sugimoto M, Otsuka T, Murata M, Nakata T, Hasegawa H, Inatomi O, Bamba S, Andoh A. Usefulness of the clip-flap method of endoscopic submucosal dissection: a randomized controlled trial. World Journal of Gastroenterology. 2018;24:4077–85.
Yamasaki Y, Takeuchi Y, Uedo N, Kanesaka T, Kato M, Hamada K, Tonai Y, Matsuura N, Akasaka T, Hanaoka N, et al. Efficacy of traction-assisted colorectal endoscopic submucosal dissection using a clip-and-thread technique: a prospective randomized study. Digestive Endoscopy. 2018;30:467–76.
Koike Y, Hirasawa D, Fujita N, Maeda Y, Ohira T, Harada Y, Suzuki K, Yamagata T, Tanaka M. Usefulness of thread-traction-method in esophageal endoscopic submucosal dissection: randomised control trial. Gastroenterological Endoscopy. 2015;57:66–74.
Yoshida M, Takizawa K, Suzuki S, Koike Y, Nonaka S, Yamasaki Y, Minagawa T, Sato C, Takeuchi C, Watanabe K, et al. Conventional versus traction-assisted endoscopic submucosal dissection for gastric neoplasms: a multicenter, randomized controlled trial (with video). Gastrointestinal Endoscopy. 2018;87:1231–40.
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Table S1. Meta-regression of lesion size on procedure time. Figure S1. Forest plot of procedure time between traction-assisted endoscopic submucosal dissection and traditional endoscopic submucosal dissection. Figure S2. Small study effect of procedure time between traction-assisted endoscopic submucosal dissection and traditional endoscopic submucosal dissection. (PDF 63 kb)