Open Access

Giant dedifferentiated liposarcoma of small bowel mesentery: a case report

  • Susanta Meher1,
  • Tushar Subhadarshan Mishra1Email author,
  • Satyajit Rath1,
  • Prakash Kumar Sasmal1,
  • Pritinanda Mishra2 and
  • Susama Patra2
World Journal of Surgical Oncology201614:250

https://doi.org/10.1186/s12957-016-1007-1

Received: 26 January 2016

Accepted: 13 September 2016

Published: 21 September 2016

Abstract

Background

Dedifferentiated liposarcoma is an uncommon variant of liposarcoma, with poor prognosis and higher preponderance to local recurrence. Only nine cases of dedifferentiated liposarcoma of small bowel mesentery have been reported till now. This is a case of giant dedifferentiated liposarcoma of the small bowel mesentery, weighing nearly 9 kg (19.8 lbs), with synchronous lesions in the extraperitoneal space, which is the first such case to be reported.

Case presentation

We report a case of a 62-year-old man, who presented with a huge abdominal mass occupying nearly the entire abdomen. A contrast enhanced computed tomography of abdomen and pelvis revealed a large, poorly enhancing, heterogeneous, lobulated mass of size 27 × 16 cm, displacing the bowel loops peripherally. At laparotomy, a large mass arising from the small bowel mesentery was found. In addition, many other smaller synchronous lesions were studded in the entire small bowel mesentery and a couple more in the extraperitoneal space. A palliative excision of the giant mass along with the adjacent small bowel was done. The other smaller swellings were not causing any mass effect and were left behind as they were numerous, virtually ruling out any possibility of a curative excision. The histopathological examination suggested the diagnosis of dedifferentiated liposarcoma. On immunohistochemistry, S-100 was positive in the well-differentiated sarcomatous areas. The CD 117 and SMA were strongly negative ruling out the possibility of a gastrointestinal stromal tumour. The CD 34 however was positive in the tumour cells.

Conclusions

Dedifferentiated liposarcoma of the small bowel mesentery is rare. Involvement of nearly whole of the small bowel mesentery in the disease process virtually rules out the possibility of a curative resection, the mainstay of management. This report would add to the knowledge of this rare disease and the possible therapeutic problem that may be encountered in case of multifocal disease.

Keywords

Dedifferentiated liposarcoma Small bowel Mesentery

Background

Liposarcoma is the most common soft tissue sarcoma in adults [1]. Evans, in 1979, was the first to identify the dedifferentiated variant of liposarcoma [2]. Dedifferentiated liposarcomas (DDLPS) have features of well-differentiated as well as poorly differentiated liposarcoma along with nonlipomatous sarcoma in the same tumour. The prognosis of DDLPS variant of liposarcoma is worse than the well-differentiated ones, but better than the pleomorphic type. The retroperitoneum is the most frequent site of its occurrence [1, 2]. DDLPS affecting the small bowel mesentery is a rarity [2]. This case of dedifferentiated liposarcoma of small bowel mesentery is being reported for the therapeutic problem posed by the presence of a large number of nodules in the mesentery as well as a few in the extraperitoneal space. Multiple DDLPS of the small bowel mesentery with synchronous lesions in the extraperitoneal space is the first such case to be reported, to the best of our knowledge.

Case presentation

A 62-year-old man presented to us with history of a palpable abdominal mass, vague left side abdominal pain and loss of appetite for 2 months. The bowel habits were normal, and there was no history of weight loss. He was a known hypertensive on medications. On examination, the patient was thin built and had a huge abdominal mass extending from the epigastrium to the hypogastrium including both the flanks.

The routine hematogical and biochemical parameters were within normal limits. The tumour markers including CA19-9, carcinoembryonic antigen (CEA) and CA-125 levels were also within normal limits. Abdominal sonography revealed a heterogeneous, nodular, soft tissue mass nearly filling the abdominal cavity. Computed tomography showed a large, poorly enhancing, lobulated soft tissue mass of size 27 × 16 cm with fluid densities. The mass was displacing the bowel loops peripherally (Fig. 1). There was no evidence of calcification or ascites.
Fig. 1

CECT abdomen and pelvis, showing a large poorly enhancing heterogeneous mass

On laparotomy, a huge well-circumscribed lobulated mass was identified arising from the jejunal mesentery 20 cm away from the ligament of Trietz. Multiple nodular lesions were found adjacent to the main tumour mass, largest measuring 3.5 × 2.5 × 3 cm (Fig. 2). There were two extraperitoneal nodules measuring 2.5 cm × 2.5 cm in size in maximum dimensions, present one at the right deep inguinal ring, and the other near the right iliac vessels. Segmental resection of the small bowel was done including the tumour mass and the mesenteric nodules.
Fig. 2

a Post operative specimen showing a huge, well-circumscribed lobulated mass with multiple mesenteric nodules. b The well-differentiated areas showing lipoblasts. c The nonlipomatous areas showing spindle cells, arranged in long and short fascicles and in storiform pattern. d Tumour cell showing CD 34 positivity

Gross examination revealed a large lobulated mass of size 35 × 25 × 25 cm, weighing 9 kg (19.8 lbs). Cut section showed a greyish yellow, soft to firm tumour with solid components along with myxoid area in less than 50 % area. The attached small bowel with mesentery measured 40 cm. There were multiple nodules over the mesentery, largest measuring 3.5 × 2.5 × 3 cm and smallest measuring 0.5 × 0.5 cm.

Histopathological examination showed a partially encapsulated tumour composed of spindle cells, arranged in long and short fascicles and in storiform pattern. The neoplastic cells were oval to spindloid with round to oval pleomorphic hyperchromatic nuclei, with prominent nucleoli. Binucleated and multinucleated giant cells were seen. Round cells with nucleus pushed laterally with vacuolated cytoplasm resembling lipoblasts were present interspersed in between the tumour cells. There was a zone of transition between the well-differentiated area to a high-grade sarcomatous area with extensive coagulative necrosis, hyalinisation and myxoid changes. Mononuclear cell infiltration including lymphocytes and plasma cells were present. Mitotic rate was 8–10/10 per high power field. A diagnosis of dedifferentiated liposarcoma was made based on the basis of histological features. On immunohistochemistry, S-100 was positive in the well-differentiated sarcomatous areas. The CD 117 and SMA were strongly negative ruling out the possibility of a gastrointestinal stromal tumour (GIST). The CD 34 however was positive in the tumour cells. In the first follow-up after 1 month, the patient had gained weight and had regained his appetite. He had a general overall feeling of well-being. There was no significant problem at 10 months post surgery.

Discussion

According to the WHO, lipomatous tumours are classified into benign, intermediate and malignant types. The well-differentiated liposarcoma belongs to the intermediate variety being locally aggressive. The malignant type includes the dedifferentiated, myxoid, round cell, pleomorphic, mixed and liposarcoma not otherwise specified types. The dedifferentiated variant of liposarcoma is thrice more common in the retroperitoneum than in the extremities, where well-differentiated liposarcomas are more usual [1]. DDLPS primarily arising from the gastrointestinal tract or its secondary involvement is very unusual [2, 3]. DDLPS involving small bowel mesentery is a rare entity, with nine such cases having been described in the literature as of now (Table 1).
Table 1

Dedifferentiated liposarcoma of small bowel mesentery reported in the literature

Reference

Age (in years)/gender

Multifocality

Maximum size (in cm)

Primary treatment

Adjuvant therapy

Hasegawa et al. [10]

59/M

Unifocal

14

Surgery

No

Hasegawa et al. [10]

58/F

Unifocal

20

Surgery

No

Hasegawa et al. [10]

56/F

Unifocal

20

Surgery

No

Hasegawa et al. [10]

52/F

Unifocal

40

Surgery

No

Hasegawa et al. [10]

63/F

Unifocal

10

Surgery

No

Korukluoglu et al. [11]

61/F

Bifocal

25 and 16

Surgery

Chemotherapy

Grifasi et al. [4]

59/F

Unifocal

25

Surgery

Ifosfamide (on recurrence)

Cha et al. [2]

76/F

Unifocal

5

Surgery

No

Vats M [12]

36/F

Multifocal

25

Surgery

Chemotherapy (doxorubicin, dacarbazine, ifosfamide)

Present case

62/M

Multifocal

35

Surgery

No

The early symptoms of this disease are nonspecific; they present as abdominal lumps when they attain large sizes and may cause pressure symptoms [2, 3]. X-ray, ultrasonography, computed tomography and MRI can be used for radiological assessment of the tumour [4]. Mesenteric angiography has been used to ascertain the location of the tumour preoperatively [5]. Needle biopsy can be fallacious due to inadequate sampling, making it difficult to distinguish from high-grade sarcomas [2, 3]. Thorough sampling from different sites of the tumour is mandatory as it is as important to identify the nonlipogenic component as it to see the well-differentiated areas to reach at the diagnosis [3]. Hence, post operative histopathology is the only reliable method of stamping the diagnosis of DDLPS. Histological DDLPS is characterised by a mixture of atypical lipoma (ALT)/well-differentiated liposarcoma (WDLPS) and a high-grade nonlipogenic sarcomatous component, usually with an abrupt transition between the two components [13]. Dedifferentiated areas exhibit a wide morphological spectrum and often show a high-grade sarcoma resembling a malignant fibrous histiocytoma (MFH) or low-grade spindle cell sarcoma [13].

Distinction of different subtypes of liposarcoma on histopathological examination and immunohistochemistry is important because DDLPS is the variant of liposarcoma having worse prognosis than the well-differentiated variety. Its clinical course however is less aggressive than other types of high-grade sarcoma. [13]. Due to its proximity to the bowel, it becomes imperative to distinguish DDLPS from GIST. CD117 (c-kit) and CD34 which are expressed in GIST are usually negative in DDLPS [2, 3]. In our case, CD117 and SMA were negative. The CD 34 however was positive in our case. It is worth emphasising that CD 34 expression is not specific to GIST, and it may also be positive in tumours like solitary fibrous tumour, inflammatory fibrous polyps and dedifferentiated liposarcoma [6]. MDM2 amplification demonstrated by florescent in situ hybridisation (FISH) technique, immunohistochemistry, and quantitative PCR help in the diagnosis of lipomatous tumours. Hence, it may have a role in differentiating these tumours from the poorly differentiated sarcomas [4]. p53 has a tumour suppression role. Mutations of this gene therefore are associated with carcinogenesis and tumours with poor prognosis. Karaman et al. found p53 gene mutation in nonlipomatous component of dedifferentiated sarcomas and not in the well-differentiated areas [7].

Complete surgical resection is the only effective treatment option available [4]. Efforts to remove the tumour completely often require the removal of an organ or part of an organ to which it is adherent [3, 4]. Even palliative resection is sometimes helpful to treat troublesome symptoms of recurrence [5, 8]. The negative margins of surgical resection are associated with disease-free survival and overall survival [4]. Although the evidence supporting the use of chemotherapy and radiotherapy is limited [3, 4], they may be of benefit in poorly differentiated sarcomas more than 10 cm in size or if there is residual disease after a palliative surgery [9]. Ifosfamide in high doses has been tried in recurrent DDLPS, after recurrence [4]. However, approximately 40 % of DDLPS will have local recurrence, 17 % will metastasize and 28 % will have tumour-related mortality [1].

Conclusions

Dedifferentiated liposarcoma is a variant of liposarcoma having worse prognosis and higher risk of local recurrence than the well-differentiated variety. Hence, accurate histopathological diagnosis is essential for prognostication and closer follow-up. Complete surgical excision with negative margin is associated with overall survival and disease-free survival. However, DDLPS at multiple locations in the mesentery is a possibility which may exclude the chance of curative resection. Palliative resection upfront, of large offending masses, or upon recurrence will have the benefit by relieving pressure symptoms due to the tumour. The scope of adjuvant chemotherapy and radiotherapy is limited to recurrent, residual or poorly differentiated liposarcomas.

Abbreviations

ALT: 

Atypical lipoma

CEA: 

Carcinoembryonic antigen

DDLPS: 

Dedifferentiated liposarcomas

FISH: 

Fluorescence in situ hybridization

GIST: 

Gastrointestinal stromal tumour

MFH: 

Malignant fibrous histiocytoma

WDLPS: 

Well-differentiated liposarcomas

Declarations

Acknowledgements

Not applicable.

Funding

None.

Availability of data and materials

Not applicable.

Authors’ contributions

SM and SR prepared the initial draft of the manuscript. TSM critically reviewed and revised the article and prepared the manuscript. PKS critically reviewed the manuscript. PM and SP gave the histopathological input of the patient and reviewed the manuscript. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Written informed consent obtained from the patient for publication of this case report and the accompanying images.

Ethics approval and consent to participate

Not applicable.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of General Surgery, All India Institute of Medical Sciences
(2)
Department of Pathology, All India Institute of Medical Sciences

References

  1. Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of tumours, Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 10–46.Google Scholar
  2. Cha EJ. Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass. World J Gastrointest Oncol. 2011;3(7):116–8.View ArticlePubMedPubMed CentralGoogle Scholar
  3. Winn B, Gao J, Akbari H, Bhattacharya B. Dedifferentiated liposarcoma arising from the sigmoid mesocolon: a case report. World J Gastroenterol. 2007;13(30):4147–8.View ArticlePubMedPubMed CentralGoogle Scholar
  4. Grifasi C, Calogero A, Carlomagno N, Campione S, D’Armiento FP, Renda A. Intraperitoneal dedifferentiated liposarcoma showing MDM2 amplification: case report. World J Surg Oncol. 2013;11:305. doi:https://doi.org/10.1186/1477-7819-11-305.View ArticlePubMedPubMed CentralGoogle Scholar
  5. Takeda K, Aimoto T, Yoshioka M, Nakamura Y, Yamahatsu K, Ishiwata T, Naito Z, Miyashita M, Uchida E. Dedifferentiated liposarcoma arising from the mesocolon ascendens: report of a case. J Nippon Med Sch. 2012;79(5):385–90.View ArticlePubMedGoogle Scholar
  6. Krasinskas AM, Goldsmith JD. Immunohistology of the gastrointestinal tract. In: Diagnostic Immunohistochemistry Theranostic and Genomic Applications. 3rd ed. Philadelphia: Elsevier; 2010. p. 500–40.Google Scholar
  7. Karaman A, Kabalar ME, Özcan Ö, Koca T, Binici DN. Intraperitoneal dedifferentiated liposarcoma: a case report. World J Gastroenterol. 2008;14(38):5927–9.View ArticlePubMedPubMed CentralGoogle Scholar
  8. Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C, Thomas JM. Surgical management of primary and recurrent retroperitoneal liposarcoma. Br J Surg. 2005;92:246–52.View ArticlePubMedGoogle Scholar
  9. Kim ES, Jang SH, Park HC, Jung EH, Moon GB. Dedifferentiated liposarcoma of the retroperitoneum. Cancer Res Treat. 2010;42(1):57–60.View ArticlePubMedPubMed CentralGoogle Scholar
  10. Hasegawa T, Seki K, Hasegawa F, Matsuno Y, Shimodo T, Hirose T, Sano T, Hirohashi S. Dedifferentiated liposarcoma of retroperitoneum and mesentery: varied growth patterns and histological grades—a clinicopathologic study of 32 cases. Hum Pathol. 2000;31:717–27.View ArticlePubMedGoogle Scholar
  11. Korukluoglu B, Ergul E, Sisman IC, Yalcin S, Kusdemir A. Giant primary synchronously bilateral mesenteric dedifferentiated liposarcoma with hyperparathyroidism, hyperthyroidism, type-2 diabetes mellitus and hypertension. J Pak Med Assoc. 2009;59(8):563–5.PubMedGoogle Scholar
  12. Vats M, Pandey D, Ahlawat H, Akhtar A, Singh N. Multiple Primary Dedifferentiated Liposarcoma of the Jejunal Mesentery: A Case Report and Review of Literature. J Clin Diagn Res.: JCDR. 2016;10(1):XD01–XD04.PubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2016

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