Table 1 Correlation of CDH1 and CTNNB1 expression by IHC with clinicopathological factors, including patient and tumor characteristics, in esophageal cancer
From: Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer
|  |  | No. of patients (n = 86) |  |  |  |
|---|---|---|---|---|---|
Characteristics | Case | CDH1(+) | p value | CTNNB1(+) | p value |
Age at surgery | |||||
 <65 years | 50 | 30 |  | 18 |  |
 >65 years | 36 | 15 | 0.009 | 13 | 0.991 |
Gender | |||||
 Male | 69 | 40 |  | 26 |  |
 Female | 17 | 5 | 0.035 | 5 | 0.525 |
Tumor status | |||||
 T1 | 17 | 13 |  | 10 |  |
 T2 | 8 | 5 |  | 5 |  |
 T3 | 37 | 17 |  | 9 |  |
 T4 | 24 | 10 |  | 7 |  |
 T1–2 vs T3–4 |  |  | 0.0088 |  | 0.0015 |
Lymph node status | |||||
 N0 | 18 | 11 |  | 10 |  |
 N1 | 68 | 34 |  | 21 |  |
 N0 vs N1 |  |  | 0.40 |  | 0.053 |
Pathological stage | |||||
 I | 13 | 9 |  | 8 |  |
 II | 11 | 8 |  | 5 |  |
 III | 28 | 15 |  | 8 |  |
 IV | 34 | 13 |  | 10 |  |
 I–II vs III–IV |  |  | 0.032 |  | 0.029 |
Lymphatic invasion | |||||
 Negative | 16 | 13 |  | 10 |  |
 Positive | 54 | 26 |  | 14 |  |
 Unknown | 16 |  | 0.019 |  | 0.007 |
Blood vessel invasion | |||||
 Negative | 30 | 19 |  | 13 |  |
 Positive | 40 | 20 |  | 11 |  |
 Unknown | 16 |  | 0.266 |  | 0.167 |