Primary adrenal leiomyosarcoma with lymph node metastasis: a case report
© The Author(s). 2016
Received: 25 December 2015
Accepted: 28 June 2016
Published: 2 July 2016
Leiomyosarcomas typically originate in smooth muscle cell. Leiomyosarcoma potentially arising from the adrenal gland is an extremely rare mesenchymal tumors associated with delayed diagnosis and poor prognosis.
A 34-year-old man visited our department complaining of right hypochondriac pain. Computed tomography demonstrated a solid mass measuring 5.2 cm in diameter above the right kidney, corresponding to the right adrenal gland, and a lymph node mass, which appeared to have invaded the IVC wall. Right adrenalectomy and lymphadenectomy were performed. A microscopic examination revealed primary adrenal leiomyosarcoma with lymph node metastasis. No adjuvant therapy was performed, and the patient remains recurrence-free at 10 months postoperatively.
We experienced a very rare case of primary adrenal leiomyosarcoma.
Aggressive surgical resection including vascular reconstruction may be associated with improved survival.
KeywordPrimary adrenal leiomyosarcoma IVC reconstruction Adrenalectomy
Primary adrenal leiomyosarcoma is exceptionally rare and represents 0.1–0.2 % of intra-abdominal soft tissue malignancies in adults . Its diagnosis is based entirely on the findings of both histological and immunohistochemical evaluations, which are indispensable not only for determining the tumor type but also for predicting the biological behavior. We herein report a rare case of leiomyosarcoma potentially arising from the right adrenal gland in a 34-year-old man who presented with hypochondriac pain.
A 34-year-old man visited another hospital complaining of right hypochondriac pain. The patient presented with a right adrenal tumor measuring 5.0 cm in diameter and a swollen lymph node measuring 3.5 cm in diameter, which were revealed on plain computed tomography (CT). He was therefore referred to our department for treatment.
Bilateral leg edema was seen right after surgery, which worsened when the patient left his sick-bed. A contrast-enhanced CT scan revealed that there were diffuse thrombi from the IVC to the vein of the lower extremity. Anticoagulant therapy was started to dissolve the thrombi, and the sign gradually improved. The patient remains recurrence-free as of the time of writing.
Leiomyosarcoma arise from various organs containing smooth muscle such as the uterus, alimentary canal, and blood vessels. However, primary adrenal leiomyosarcoma is extremely rare. To the best of our knowledge, only approximately 30 cases have been reported in the English literature . HIV and EBV are suggested to be factors related to its occurrence [1, 2], and it typically presents as a retroperitoneal mass with pain, mass effect, and pressure effect on the surrounding organs. The preoperative diagnosis is difficult. There are no radiologic features available for making the preoperative diagnosis, although imaging studies including CT and MRI are important for assessing the resectability of the tumor and possibility of metastasis. The size or growth rate is also helpful to differentiate malignant tumors from benign ones. In general, adrenal masses larger than 3 cm are suspicious of malignancy [3, 4]. A definitive biomarker for leiomyosarcoma is absent. Lastly, both histological and immunohistological evaluations of the excised tumor are mandatory to make an accurate diagnosis.
It was very difficult to identify the tumor origin in our case, because primary adrenal leiomyosarcoma is extremely rare and lymph node mass penetrated the IVC wall. The origin, leiomyosarcoma, is commonly presumed to be smooth muscle of the blood vessels. However, it was determined by clinical and pathological findings. The tumor which arose from the adrenal gland was bigger than that situated adjacent to IVC. The primary tumor is commonly thought to be bigger than metastatic tumor. In addition, the tumor cells and lymphatic cells were mixed in the mass penetrated the ICV wall. Thus, a final diagnosis of primary adrenal leiomyosarcoma with lymph node metastasis was made in the present case.
Radical surgery is the mainstay of therapy, and the survival depends on tumor size, location, and complete surgical resection with free margins as well as morphologic grading . Despite having slow growth and late metastasis, leiomyosarcomas carry a poor prognosis and unpredictable course with a high incidence of local recurrence . The most important prognostic factor is the ability to achieve a microscopically negative margin. Adjuvant therapy combined with surgery is often used. Strander et al.  showed that adjuvant radiotherapy was recommended for the treatment of locally advanced sarcomas. Other factors include the tumor size, location, morphological grading, venous thrombus, and distant metastasis [5, 7, 8]. In our case, dissection of the IVC was required to achieve complete resection. Thus, it was anticipated that the blood flow from the left renal vein bypass gonadal, suprarenal and lumbar veins, and the left renal vein was not reconstructed. Conversely, the right renal vein was re-anastomosed to the IVC. Though leg edema is occasionally problematic after surgery with dissection of the IVC, the development of collateral veins will often resolve it. Our patient also developed leg edema with diffuse thrombi from the IVC to the vein of the lower extremity according to the CT findings. To dissolve the thrombi, anticoagulant therapy was added.
This is a rare case of primary adrenal leiomyosarcoma with lymph node metastasis. For the time being, early and complete surgical resection is the mainstay management. In our case, dissection of the IVC was required to achieve complete resection. This surgical procedure for dissection of IVC and reconstruction of the right renal vein has been shown to be safe and useful. This case is considered to be useful for future treatment.
IVC, inferior vena cava
Written consent was obtained from the patient for publication of the study.
This received no specific grant from any funding agency in pubic, commercial, or not-for-profit sectors. Furthermore, none of the authors have any commercial or financial involvement in connection with this study that represent or appear to represent any conflict of interest.
Availability of data and materials
Informed consent was obtained from the patient prior to initiating the study. The datasets supporting the conclusions of this article are available in the repository of Ethics Committee for Clinical Research of Ehime University Hospital.
TO, YY, TK, NM, and TK participated in the care of the patient. TO, YY, TN, and NT performed the literature review and drafted the manuscript. RK obtained the pathological data. YY was the surgeon-of-record. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
A copy of the written consent is available for review by Editor-in-Chief of this journal.
Ethics approval and consent to participate
The clinical study of the abovementioned case report was approved by the Ethics Committee for Clinical Research of Ehime University Hospital concerning the publication of this manuscript and any accompanying images.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
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