Glioblastoma multiform with ipsilateral carotid artery stenosis: carotid artery stent promote tumor growth?
© Xu et al. 2016
Received: 5 October 2015
Accepted: 26 January 2016
Published: 6 February 2016
Ischemic stroke and glioblastoma multiforme have similar features on anatomic magnetic resonance imaging (MRI) and thus may require a surgical biopsy for a definitive diagnosis.
A 55-year-old male complained of dysphasia for 4 weeks and continuous deterioration for 5 days. Cerebral infarction was considered based on MRI, which showed hyperintensity at the border zone of the left hemisphere, and computed tomography angiography (CTA) showed left carotid artery severe stenosis. The patient underwent placement of a left carotid artery stent, and his symptoms recurred 2 months after carotid artery stent (CAS). MRI showed multiple ring-enhanced lesions in the left temporal, parietal, and occipital lobes accompanied by massive brain edema. The final pathologic diagnosis was glioblastoma multiforme.
Although there is no evidence that stent therapy for carotid artery stenosis will worsen an ipsilateral glioblastoma, we should be careful to perform surgeries involving carotid artery stents when the patient has a glioblastoma.
Ischemic stroke is a leading health problem in China, and is the most common disease in elderly people . Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV tumor with a dismal prognosis; <10 % of patients are alive after 2 years . Co-existing ischemic stroke with carotid artery stenosis and GBM is rare. The patient described herein presented three times with ischemic strokes complicated by left carotid artery severe stenosis. Magnetic resonance imaging (MRI) showed an infarct pattern consistent with a watershed infarction. Two months after left carotid artery stent (CAS), multiple lesions were noted in the left cerebral hemisphere with massive edema, and a GBM was diagnosed post-operatively. There are some issues worthy of discussion about the clinical diagnosis, therapy, and blood flow after CAS-induced deterioration.
GBM is a malignant tumor with a dismal prognosis that is often associated with extensive angiogenesis due to tumor secretion and local effects exerted by vascular endothelial growth factor, a major regulator of angiogenesis and other cytokines . The patient described herein initially presented with ischemic stroke and severe ipsilateral carotid artery stenosis and an intracranial massive lesion worsened after CAS. Cerebral hyperfusion syndrome was suspected due to headaches, cerebral edema, focal neurologic deficits, serial images, and a pathologic diagnosis of a GBM. Hyperperfusion syndrome is a relatively rare complication of carotid artery revascularization procedures and may have adverse clinical consequences in 1.1–25.0 % of patients after CAS . Delayed hyperperfusion syndrome has been reported , which may be related to prolonged impairment of cerebrovascular autoregulation. Some questions remain which should be addressed. The course of the disease was approximately 2 years, and the patient had numerous atherosclerotic risks, including hypertension, smoking, and coronary artery disease. The patient had right limb weakness and numbness, amaurosis, and mild dysphasia. MRI showed a left internal border zone cerebral infarction and severe left carotid artery stenosis. Thus, an ischemic stroke was not only misdiagnosed, but CAS was reasonable. Imaging features of GBM have no special characteristics. Multiple model MRI images are useful in the diagnosis of GBM and its tumor grade [2, 5–7]. The characteristic MRI findings of GBM include enhanced heterogeneous ring mass lesions with significant peritumoral cerebral edema, necrosis, or hemorrhage [5, 7]. These features also occur in patients with ischemic strokes [8, 9]. GBMs often pose a diagnostic dilemma on anatomic MRI and may require a surgical biopsy for a definitive diagnosis. In the current patient, whole-body PET/CT revealed no systemic tumor and brain metastasis was ruled out.
Did CAS prompt the growth of the GBM? The left cerebral hemisphere was ischemic secondary to severe carotid artery stenosis, while the GBM was dependent on the blood supply. Brain ischemia and the GBM were improved when the left carotid artery stenosis was recanalized, which may induce tumor growth. Relative cerebral blood volume (rCBV) maps and measurements have been shown to correlate reliably with tumor grade and histologic findings of increased tumor vascularity [5, 7, 10]. In addition, a study has proved that if the rCBV is >1.75, there is a high probability that the tumor will be a high-grade glioma . GBM complicated with carotid artery stenosis is rarely reported, and there is insufficient evidence to prove a relationship between a worsening tumor and CAS.
A GBM is a high-grade tumor with a dismal prognosis; complication with severe ipsilateral carotid artery stenosis is rare. Although ischemic stroke is a common disease, we should make the diagnosis cautiously to avoid misdiagnosis. There is insufficient evidence that stent therapy for carotid artery stenosis will aggravate an ipsilateral GBM. Thus, we should be careful in performing CAS when a patient has a concomitant GBM.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
This work was supported by the project of educational bureau of Zhejiang Province (Y200909841) and Zhejiang administration of traditional Chinese medicine(2014ZQ018).
This was supported by administration of Traditional Chinese Medicine of Zhejiang Province (2014ZQ018).
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