Histopathologic tumor spreading in primary ovarian cancer with modified posterior exenteration
© Kato et al. 2015
Received: 5 May 2015
Accepted: 14 July 2015
Published: 31 July 2015
To achieve optimal cytoreduction for advanced-stage ovarian cancer, modified posterior exenteration is the most frequently performed bowel surgery. We assessed the extents of tumor spreading in the rectosigmoid wall and pelvic side wall in modified posterior exenteration specimens during primary debulking surgery (PDS) and interval debulking surgery (IDS) following neoadjuvant chemotherapy, and compared the validity of selecting this surgical procedure in the patients undergoing PDS with that in the patients undergoing IDS.
Clinicopathological data from consecutive patients who had undergone a modified posterior exenteration for primary ovarian, tubal, and peritoneal cancer at our institution between April 2008 and March 2013 was retrospectively reviewed.
A total of 75 patients (38 in PDS and 37 in IDS) were included in this study. Tumor involvement of the rectosigmoid was histopathologically confirmed in 65 % of the specimens. Though the extent of tumor spreading in the rectosigmoid was deeper in PDS than in IDS, the frequency of tumor involvement of the rectosigmoid in patients who had undergone modified posterior exenteration during PDS was equivalent to that in the IDS group. Lateral tumor spreading to the side wall(s) was histopathologically confirmed in 53 % of the patients in whom a pelvic side wall resection had been performed.
During both PDS and IDS for ovarian cancer presenting with tumor involvement of the cul-de-sac, close inspection and palpation by gynecologic oncologists may enable the extent of tumor spreading in the pelvis to be estimated, enabling valid decisions as to whether an en bloc resection of the pelvic tumors together with the rectosigmoid and the pelvic side wall might or might not be appropriate.
Effective cytoreduction at the time of primary surgery has been identified as the most important prognostic factor in the management of advanced-stage ovarian cancer [1, 2]. The goal of cytoreductive surgery is to obtain a macroscopic complete resection of the disease; such surgery is now considered to be the “real” optimal debulking surgery [3, 4]. Primary debulking surgery (PDS) followed by chemotherapy is the mainstay of treatment for advanced-stage ovarian cancer. However, for those unable to tolerate PDS or with an initial disease that is too extensive for optimal debulking, interval debulking surgery (IDS) following neoadjuvant chemotherapy (NAC) is considered to be a valuable alternative option for PDS. The usefulness of this strategy has been confirmed in a recent randomized trial performed by the European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group and National Cancer Institute of Canada Clinical Trials Group; comparing PDS with IDS reported that progression-free survival and overall survival were similar in both groups .
Because of the anatomic proximity of the rectosigmoid to the female pelvic organs and its frequent involvement in ovarian cancer, rectosigmoid resection is the most frequently performed bowel surgery to achieve optimal cytoreduction . Many investigators have studied the value of modified posterior exenteration, also known as low anterior en bloc resection or radical oophorectomy, during debulking surgery for ovarian cancer [6–9]. Although modified posterior exenteration has acceptable morbidity and mortality rates, anastomotic leakage after rectosigmoid resection remains a life-threatening potential complication .
If the tumor is suspected of having infiltrated the pelvic side wall, an en bloc resection of the pelvic side wall(s) together with the uterus, adnexa, and rectosigmoid should be performed to achieve optimal cytoreduction and to complete the surgical procedure safely [6, 11]. This surgical procedure is accompanied by the sacrifice of the ipsilateral autonomic nerves, resulting in postoperative bladder dysfunction to some extent . In addition, as a pelvic side wall resection involves the removal of connective tissue containing lymphatic tissue around the internal iliac vessels and/or the internal iliac vessels themselves, possibly resulting in severe bleeding.
In ovarian cancer patients with tumor involvement of the cul-de-sac in whom a modified posterior exenteration with or without pelvic side wall resection has been performed, the histopathologic evaluation of tumor spreading is useful for evaluating the validity of the selection of this type of surgery. In the present study, we assessed the extents of tumor spreading in the rectosigmoid wall and pelvic side wall in modified posterior exenteration specimens from patients with primary ovarian, tubal, and peritoneal cancer during PDS and IDS. Then, we compared the validity of selecting this surgical procedure in the patients undergoing PDS with that in the patients undergoing IDS.
The following data were retrieved from the patients’ medical records: patient age, primary site of disease, clinical stage, largest tumor size at the time of surgery, timing of surgery (PDS or IDS), type of surgery (modified posterior exenteration without pelvic side wall resection, with unilateral pelvic side wall resection, or bilateral pelvic side wall resection), final histopathologic results, and follow-up data. With respect to the histopathology, all the available information, including the histopathologic subtype of the tumor, the extent of tumor spreading in the rectosigmoid and pelvic side walls, and the margin status in the specimen, was recorded. Statistical analyses were performed using the Wilcoxon signed-rank test and the Fisher exact test. A value of P less than 0.05 was considered statistically significant.
This study protocol was approved by the Institutional Review Board of the Chiba University School of Medicine.
Patient and tumor characteristics
Age, median (range), y
Diagnosis and stage
Ovarian cancer (n = 53)
Tubal cancer (n = 17)
Peritoneal cancer (n = 5)
Histology, n (%)
Largest size of pelvic tumor at surgery, n (%)
Pelvic lymph node involvement, n (%)
No pelvic lymph nodes found
Differences in the extent of tumor spreading in the rectosigmoid wall between patients who underwent a modified posterior exenteration in the PDS group and those in the IDS group
PDS (n = 38)
IDS (n = 37)
Rectosigmoid wall involvement
Depth of tumor invasion
Mucosal or submucosal layer
Factor in rectosigmoid adhesion
Tumor involvement of the mesocolon
Tumor involvement of the peritoneum of the cul-de-sac
Fibrosis, necrosis, and/or granulation
No histopathologic finding
Differences in the extent of tumor spreading in the pelvic side wall between patients who underwent a modified posterior exenteration with pelvic side wall resection in the PDS group and those in the IDS group
PDS (n = 12)
IDS (n = 5)
Pelvic side wall involvement
Extent of tumor spread
Parametrium and/or paracolpium
Cardinal ligament and/or deep retroperitoneal space
Internal iliac vessels
Levator ani muscle
Pelvic lymph node involvement
The median duration of the follow-up period was 30.1 months (range, 6.2–74.5 months). Overall, 25 recurrences (33 %), 4 pelvic recurrences (5 %), and 12 deaths (16 %) occurred during the follow-up period. One of two patients who underwent PDS with positive resection margins in the rectosigmoid had multiple bone metastases as a recurrence. Among four patients who underwent IDS with positive or close resection margins in the rectosigmoid, one patient had a pelvic recurrence and additional two patients had distant metastases as a recurrence during this period.
The present study evaluated the histopathologic results of tumor spreading in surgical specimens obtained during modified posterior exenteration for primary ovarian cancer. Our results indicate that during surgery for ovarian cancer presenting with tumor involvement of the cul-de-sac, close inspection and palpation by gynecologic oncologists can enable the extent of tumor spreading in the pelvis to be estimated in most cases, enabling valid decisions as to whether an en bloc resection of the pelvic tumors together with the rectosigmoid and the pelvic side wall might or might not be appropriate.
Tumor involvement of the rectosigmoid wall was histopathologically confirmed in 65 % of the cases. A previous study reported that in 73 % of patients with suspected infiltration of the cul-de-sac (bulky tumor, disseminated tumor spread), the rectosigmoid wall was histopathologically infiltrated by the tumor . They argued that in the majority of ovarian cancer patients with intraoperatively suspected cul-de-sac infiltration, residual tumor is likely to be present in the wall of the rectosigmoid if only deperitonealization, and no en bloc resection of the uterus and rectosigmoid, is performed. In this study, histopathologic examinations suggested that in cases without tumor spreading in the rectosigmoid or cul-de-sac, a modified posterior exenteration was performed because of fibrosis, necrosis, granulation, and/or endometriosis. Macroscopic inspection may overestimate the tumor involvement in such cases. MRI is an anatomic, high-resolution imaging modality that is widely used to guide the management of patients with ovarian cancer [14, 15]. Of course, our surgical decisions were made based not only on macroscopic inspection, but also on dynamic contrast-enhanced and diffusion-weighted MRI findings. The extent of tumor spreading in the rectosigmoid wall was deeper in the patients who underwent PDS than in those who underwent IDS. This difference was likely due to the effect of neoadjuvant chemotherapy before surgery, which reduced the tumor volume and spreading. However, a histopathologic evaluation showed that the frequency of tumor involvement of the rectosigmoid in patients who have undergone modified posterior exenteration during PDS was equivalent to that in the patients who have undergone modified posterior exenteration during IDS.
In this study, histopathologic examinations showed that the resection margins in the rectosigmoid wall were positive in 5 % of the patients who had undergone PDS, and were positive in 5 % and close (surgical margins ≤5 mm) in an additional 5 % of the patients who had undergone IDS. The lower segment of the rectum lies retroperitoneally. In the greater part of ovarian cancer cases presenting with a confluent tumor in the cul-de-sac, the lower segment of the rectum is free of tumor, since ovarian cancer grows along the peritoneal lining. Despite an intent to remove all visible and palpable tumors, however, there are some cases in which the resection margins are microscopically positive. In PDS, tumor-free resection margins (R0) are associated with a significant reduction in pelvic recurrences among ovarian cancer patients undergoing modified posterior exenteration . It is not evident that all attempts should be made to achieve an R0 status during IDS. In the current series, the rate of positive resection margins in the rectosigmoid wall among the patients undergoing PDS was equivalent to that in patients undergoing IDS. Half of the patients with positive or close resection margins in the rectosigmoid experienced distant recurrence. This result may have been due to the wide-spread of tumor reflecting in positive or close resection margin in the rectosigmoid and microscopic residual disease remaining in extra-pelvic areas.
Gynecologic oncologists occasionally encounter cases with tumor spreading in the deep retroperitoneal space. Not only to secure negative surgical margins but to accomplish the procedures safely and securely for cases, the pelvic side wall resection is needed for these cases. In the current series, tumor involvement of the parametrium and/or the parametrium surrounding the uterus and vagina was frequent (75 % of the patients in the PDS group and 40 % of the patients in the IDS group). Lateral tumor spreading to the cardinal ligament and/or deep retroperitoneal space was histopathologically confirmed in 25 % of the patients in the PDS group and in 20 % of the patients in the IDS group. In addition, tumor spreading beyond the deep retroperitoneal space to the levator ani muscle was confirmed in only one patient in whom a pelvic side wall resection had been performed. Similarly, the previous study showed that though infiltration of the parametrium and paracolpium frequently occurred in patients who underwent a modified posterior exenteration with pelvic side wall resection, tumor involvement of the parietal pelvis, including the internal iliac vessels, levator ani muscle, and internal obturator muscle, was rare [11, 16]. Although nerve-sparing modified posterior exenteration on at least one side is useful, pelvic side wall resection results in the sacrifice of the pelvic autonomic nerves to some extent . The results of this study showing that none of the patients with pelvic side wall resection had positive or close circumferential margins in the specimens suggest the validity of this surgery.
From the results of this study, the presence of cancer cells within desmoplastic stroma was histopathologically demonstrated in the palpable masses under the pelvic peritoneum, and the visceral serous membrane appeared to be intact during IDS in many cases. The use of NAC before surgery induces tumor necrosis, fibrosis, macrophage infiltration, and tumor-induced inflammation in the peritoneal cavity. Then, residual cancer cells remain in deep visceral and retroperitoneal tissue. There is a report that among advanced ovarian cancer patients with residual disease of <1 cm, the size of the viable tumor in the operative specimens was inversely correlated with progression-free survival and overall survival . We supposed that the removal of as many palpable masses under the peritoneum as necessary was feasible. A recent report has suggested that microscopically carcinomatous areas often have a benign visual appearance after neoadjuvant chemotherapy in advanced ovarian cancer . Accordingly, intraoperative macroscopic evaluation of the extent of the tumor is more accurate in PDS than in IDS. It was stated that the removal of all peritoneal surfaces affected at the time of diagnosis should be considered in IDS. However, this approach would lead to more extensive debulking operations, with the consequent loss of some of the benefits that are presently linked with IDS. Thus, a study investigating whether the resection of sites involved by primary and metastatic tumors at the time of diagnosis are associated with a higher survival should be performed in larger prospective trials in the future.
There are some limitations that must be considered when interpreting these data. First, this was a retrospective study design. Second, the number of the patients whom pelvic side wall resection had been performed was small and further studies with the long follow-up period are needed to confirm the efficacy of this surgical procedure. Despite these limitations, study strengths consist of a report from one institution where the treatment approaches were not changed throughout the inclusion period.
The evaluation of whether the tumor involves the rectosigmoid wall and the pelvic side wall is critical, based on physical investigations performed during the modified posterior exenteration with or without pelvic side wall resection. As a close inspection and palpation by gynecologic oncologists to estimate the extent of tumor spreading in the pelvis seems to be appropriate, this procedure might be achieved under a conventional laparotomy. This approach may also be useful for the cytoreduction of the upper-abdominal spreading of disease in cases of advanced-stage ovarian cancer.
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
- Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 2002;20:1248–59.PubMedView ArticleGoogle Scholar
- Chi DS, Eisenhauer EL, Zivanovic O, Sonoda Y, Abu-Rustum NR, Levine DA, et al. Improved progression-free and overall survival in advanced ovarian cancer as a result of a change in surgical paradigm. Gynecol Oncol. 2009;114:26–31.PubMedView ArticleGoogle Scholar
- Du Bois A, Reuss A, Pujade-Lauraine E, Harter P, Ray-Coquard I, Pfisterer J. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d’Investigateurs Nationaux Pour les Etudes des Cancers de l’Ovaire (GINECO). Cancer. 2009;115:1234–44.PubMedView ArticleGoogle Scholar
- Thigpen T, duBois A, McAlpine J, DiSaia P, Fujiwara K, Hoskins W, et al. First-line therapy in ovarian cancer trials. Int J Gynecol Cancer. 2011;21:756–62.PubMedView ArticleGoogle Scholar
- Vergote I, Tropé CG, Amant F, Kristensen GB, Ehlen T, Johnson N, et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 2010;363:943–53.PubMedView ArticleGoogle Scholar
- Eisenkop SM, Nalick RH, Teng NN. Modified posterior exenteration for ovarian cancer. Obstet Gynecol. 1991;78:879–85.PubMedGoogle Scholar
- Aletti GD, Podratz KC, Jones MB, Cliby WA. Role of rectosigmoidectomy and stripping of pelvic peritoneum in outcomes of patients with advanced ovarian cancer. J Am Coll Surg. 2006;203:521–6.PubMedView ArticleGoogle Scholar
- Obermair A, Hagenauer S, Tamandl D, Clayton RD, Nicklin JL, Perrin LC, et al. Safety and efficacy of low anterior en bloc resection as part of cytoreductive surgery for patients with ovarian cancer. Gynecol Oncol. 2001;83:115–20.PubMedView ArticleGoogle Scholar
- Bristow RE, del Carmen MG, Kaufman HS, Montz FJ. Radical oophorectomy with primary stapled colorectal anastomosis for resection of locally advanced epithelial ovarian cancer. J Am Coll Surg. 2003;197:565–74.PubMedView ArticleGoogle Scholar
- Richardson DL, Mariani A, Cliby WA. Risk factors for anastomotic leak after recto-sigmoid resection for ovarian cancer. Gynecol Oncol. 2006;103:667–72.PubMedView ArticleGoogle Scholar
- Höckel M. Laterally extended endopelvic resection (LEER)—principles and practice. Gynecol Oncol. 2008;111:S13–7.PubMedView ArticleGoogle Scholar
- Kato K, Tate S, Nishikimi K, Shozu M. Bladder function after modified posterior exenteration for primary gynecological cancer. Gynecol Oncol. 2013;129:229–33.PubMedView ArticleGoogle Scholar
- Hertel H, Diebolder H, Herrmann J, Köhler C, Kühne-Heid R, Possover M, et al. Is the decision for colorectal resection justified by histopathologic findings: a prospective study of 100 patients with advanced ovarian cancer. Gynecol Oncol. 2001;83:481–4.PubMedView ArticleGoogle Scholar
- Sala E, Rockall A, Rangarajan D, Kubik-Huch RA. The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis. Eur J Radiol. 2010;76:367–85.PubMedView ArticleGoogle Scholar
- Nam EJ, Yun MJ, Oh YT, Kim JW, Kim JH, Kim S, et al. Diagnosis and staging of primary ovarian cancer: correlation between PET/CT, Doppler US, and CT or MRI. Gynecol Oncol. 2010;116:389–94.PubMedView ArticleGoogle Scholar
- Höckel M, Horn LC, Einenkel J. (Laterally) extended endopelvic resection: surgical treatment of locally advanced and recurrent cancer of the uterine cervix and vagina based on ontogenetic anatomy. Gynecol Oncol. 2012;127:297–302.PubMedView ArticleGoogle Scholar
- Muraji M, Sudo T, Iwasaki S, Ueno S, Wakahashi S, Yamaguchi S, et al. Histopathology predicts clinical outcome in advanced epithelial ovarian cancer patients treated with neoadjuvant chemotherapy and debulking surgery. Gynecol Oncol. 2013;131:531–4.PubMedView ArticleGoogle Scholar
- Hynninen J, Lavonius M, Oksa S, Grénman S, Carpén O, Auranen A. Is perioperative visual estimation of intra-abdominal tumor spread reliable in ovarian cancer surgery after neoadjuvant chemotherapy? Gynecol Oncol. 2013;128:229–32.PubMedView ArticleGoogle Scholar
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.