Unusual presentation of dermatofibrosarcoma protuberans in a male patient’s breast: a case report and review of the literature
© Al Tarakji et al.; licensee BioMed Central. 2015
Received: 23 September 2014
Accepted: 26 March 2015
Published: 22 April 2015
We herein present a case report and literature review of dermatofibrosarcoma protuberans in the breast of a male patient. A 27-year-old man presented with a painless lump in his right breast with areas of bluish skin discoloration. The diagnostic work-up comprised clinical examination, ultrasonography, core biopsy, mammography, and magnetic resonance imaging. After surgical excision, the preoperative diagnosis of dermatofibrosarcoma protuberans was proven by pathological examination and immunohistochemistry. The patient was still free of recurrence 1 year after surgical excision. This extremely rare case is, to the best of our knowledge, the fifth such case reported in the literature.
Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue neoplasm that was identified for the first time by Taylor in 1890 . It was described in 1924 by Darier and Ferrand  as a progressive recurrent dermatofibroma and was later termed dermatofibrosarcoma protuberans by Hoffmann in 1925 .
DFSP is a rare soft tissue sarcoma that represents less than 5% of all soft tissue sarcomas occurring in adults aged 30 to 40 years . The incidence of DFSP is five cases in every one million persons per year . The most common sites are the trunk and extremities . DFSP of the breast is extremely rare, especially in men. We herein provide a case report and literature review of DFSP in a male patient.
A previously healthy 27-year-old Pakistani man presented with a painless lump in his right breast that was first noticed about 1.5 years previously. He initially noticed a thickened patch of skin, which gradually increased in size with areas of bluish discoloration. During the most recent couple of months, however, this patch of skin had become a lumpy swelling. The patient had no family history of breast, prostate, or testicular cancer. He had no systemic signs or associated weight loss.
The patient underwent ultrasound-guided core biopsy of the lesion. Histopathological examination showed marked cellular proliferation comprising monomorphic spindle cells arranged into a tight storiform pattern (Figure 4). Immunohistochemically, the cells were positive for CD34, bc12, CD99, β-catenin, and vimentin. This morphology was very suggestive of dermatofibrosarcoma. Staging computed tomography and a bone scan showed no evidence of visceral or bone metastasis.
Primary breast sarcomas are rare mesenchymal tumors accounting for 0.2% to 1.0% of all breast malignancies  and less than 5% of all soft tissue sarcomas . DFSP has an annual incidence of only 0.8 cases per million people and typically presents in mid-adult life with female predominance. DFSP may develop in patients of all ages, but those aged 30 to 40 years are primarily affected .
The most common sites of development of DFSP are the trunk (42% to 72%) and extremities (16% to 30%) . However, Prabhu et al. reported rare sites including the hand, gluteal region, head and neck region, toe, vulva, and parotid gland. Localization in the breast is very rare .
DFSP is a soft tissue tumor of low-degree malignancy that arises in the dermis and spreads into the subcutaneous tissues and muscle . DFSP has a low malignant potential, representing more a slow growing, localized ‘benign’ entity, but in 5% of the cases, this only nominally sarcoma undergoes sarcomatous transformation, and from that point often, after serial insufficient surgical excisions and recurrences, DFSP transforms to real aggressive sarcoma, often presenting with pulmonary metastases and even causing death of the patient.
Histologically, it is distinctively composed of monomorphic spindle cells arranged in a storiform pattern. Positive CD34 staining helps in the diagnosis . Clinically, the lesion presents as a firm area of the skin, most commonly about 1 to 5 cm in diameter, with pink or violet-red plaques; the surrounding skin may be telangiectatic . The tumors are generally fixed to the dermis but move freely over the more deeply lying tissue. However, they are often fixed to more deeply seated structures in advanced and/or recurrent cases . DFSP tends to exhibit an indolent growth pattern and is usually less than 5 cm in size .
The morphology of the tumor requires a 3- to 4-cm surgical margin, and so, in most of the cases, a plastic surgical reconstruction is mandatory. The reason for the insufficient primary surgical care is often the fear from technical wound closure not involving the reconstructive plastic surgeon in the process.
Ultrasound exploration reveals an ovoid lesion with a circumscribed or microlobulated margin in the dermis or subcutaneous tissue, and the use of Doppler shows hypervascularization of the affected area . Mammography reveals a dense lesion without fat or calcification . Magnetic resonance imaging may be helpful to define the depth of infiltration of the tumor . Fine needle aspiration cytology has been recommended as the first-line evaluation technique for superficial soft tissue tumors .
According to the NCCN Clinical Practice Guidelines in Oncology, the gold standard treatment is complete surgical excision with appropriate reconstruction . Surgical excision with a margin of at least 2 to 3 cm is recommended for treatment because the local recurrence rate is 20% to 50% in cases of incomplete resection . An unresectable lesion or resected lesion with a positive margin should be treated with adjuvant radiotherapy. Adjuvant radiotherapy can reliably reduce the local recurrence rate and avoid the mutilation and functional deficits caused by repeated surgery . Chemotherapy in the form of imatinib has also been tried with encouraging results. Similar radiotherapy was attempted in a limited series, but the results did not favor its regular use .
Long-term follow-up requires strict ultrasonographic monitoring every 6 to 12 months with biopsy in cases of suspected recurrence. The 5-year survival rate of patients with DFSP is higher than 99% .
Our literature search revealed only four other cases of DFSP in the breast of a man. The mean age of these patients was 36.2 years, and the mean tumor size was 4.6 cm. To the best of our knowledge, the present case is the fifth.
DFSP is a soft tissue sarcoma that very rarely develops in the breast of male patients. The clinical presentation includes a painless, gradually enlarging nodule with a thickened patch of skin exhibiting telangiectasia. The diagnosis is based on ultrasonography, mammography, MRI, and fine needle aspiration cytology. Surgical excision with wide margins may reduce the risk of recurrence.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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