Skip to main content

A small Askin’s tumor presenting with early onset of chest pain

Abstract

Most primitive neuroectodermal tumor of the chest wall destroy the rib, chest wall muscles, diaphragm, and lung or extend into the spinal compartment, resulting in a large-sized tumor and symptoms. In contrast, we recently encountered a rare case of Askin’s tumor presenting with early-onset chest pain despite the small size. After resection of the tumor and adjuvant chemotherapy, the patient remains disease-free over 3 years of follow-up.

Correspondence

We read with great interest the article by Benbrahim et al. [1], which reported two cases of rare primitive neuroectodermal tumor (PNET) developing from the soft tissues of the chest wall (Askin’s tumor). The chest radiograph and computed tomography (CT) of the cases revealed the tumor destroyed the rib cage. The patients received polychemotherapy and one of them surgical resection. We agree that Askin’s tumor is very aggressive and need multimodal treatment, because of the poor prognosis with a high recurrent rate. Recently, we encountered a small Askin’s tumor with early-onset chest pain and present herein.

A 14-year-old girl presented with chest pain. Chest radiograph showed a small nodular opacity in the right lung field, suggesting focal pneumonia or mass, and CT scan revealed a small mass with a broad base on the pleura of the right anterior hemithorax and pleural effusion (Figure 1). We resected the mass for the diagnostic and therapeutic purposes. The pathology and immunohistochemistry of the tumor coincided with PNET which was classified as stage IA(T1aN0M0GX). She received six courses of adjuvant chemotherapy including vincristine, etoposide, doxorubicin, cyclophosphamide, and ifosfamide with mesna. She had been tolerable during chemotherapy, achieved complete response, and has been well without recurrence 3 years thereafter.

Figure 1
figure1

CT scan revealing a small mass with a broad base. A small nodular opacity (black arrowheads) in the right chest on chest radiograph (A) revealed a mass (2.7 × 2.2 cm in size) on the pleura of the right anterior hemithorax (white arrowheads) with irregular soft tissue density and inner heterogeneous enhancement on CT scan (B) and (C).

Peripheral PNET outside the central nervous system has an insidious onset of symptoms. Askin’s tumor destroys the rib and often extends into the spinal, retroperitoneal, and intrathoracic compartments, resulting in symptoms and a large-sized tumor (>5 cm on average) [2,3]. In contrast, the presenting case is a small-sized Askin’s tumor presenting with early-onset chest pain, which was thought to be caused by the involvement of the parietal pleura. Unfortunately, there is currently no means to early detect an asymptomatic Askin’s tumor. From our case, even a small-sized PNET might cause symptoms. We believe that meticulous examination with CT and/or positron emission tomography and the suspicion of Askin’s tumor prior to surgery is important.

Consent

Written informed consent was obtained from the patient’s parent for the publication of this report and any accompanying images.

Abbreviations

CT:

computed tomography

PNET:

primitive neuroectodermal tumor

References

  1. 1.

    Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, et al. Askin’s tumor: a case report and literature review. World J Surg Oncol. 2013;11:10–3.

    Article  PubMed Central  PubMed  Google Scholar 

  2. 2.

    Hari S, Jain TP, Thulkar S, Bakhshi S. Imaging features of peripheral primitive neuroectodermal tumours. Br J Radiol. 2008;81:975–83.

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Sallustio G, Pirronti T, Lasorella A, Natale L, Bray A, Marano P. Diagnostic imaging of primitive neuroectodermal tumour of the chest wall (Askin tumour). Pediatr Radiol. 1998;28:697–702.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Linda H who provided English medical writing services on behalf of HARRISCO.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Sang Yong Kim.

Additional information

Competing interest

The authors declare that they have no competing interest. Furthermore, there is no funding for each author and for the manuscript preparation.

Authors’ contributions

All authors carried out this work in collaboration. JYJ and SYK reviewed the medical records and wrote the manuscript. DCJ participated in reviewing the scientific literature and contributed to the final version of the manuscript. KJK have been involved in the acquisition of clinical data. JYJ, SYK, DCJ, and KJK created the study materials or recruited the patient. All authors read and approved the final manuscript.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jeong, J.Y., Kim, S.Y., Jeong, D.C. et al. A small Askin’s tumor presenting with early onset of chest pain. World J Surg Onc 13, 112 (2015). https://doi.org/10.1186/s12957-015-0506-9

Download citation

Keywords

  • Primitive neuroectodermal tumor
  • Askin’s tumor
  • Chest wall