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Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized

Abstract

Background

Improvement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC.

Methods

We reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs.

As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC.

Results

Multiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients.

By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001).

Conclusion

Patients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC.

Background

Colorectal cancer (CRC) is a common form of cancer in developed countries, being the second and third leading cause of cancer death in men and women, respectively [1], and has become an important issue in Asian countries [2,3]. Reports from the World Health Organization show that the incidence of CRC is rapidly rising in Asian countries [2,4,5], which have experienced a two- to four-fold increase in the incidence of CRC during the last few decades [6]. Patients with CRC also frequently develop multiple primary malignancies (MPMs) [7,8]. The prognosis for CRC patients has steadily improved, owing to both increased detection of early CRC and development of new chemotherapeutic agents. The improvement in the prognosis for CRC patients has led to an increased incidence of MPMs [9]. It is important to understand the characteristics of MPMs, in order to administer appropriate treatment and to determine suitable follow-up plans in CRC patients. This study was undertaken to review the clinical and pathological features of MPMs, especially those of extracolonic sites, in CRC patients.

Methods

Between April 2007 and March 2012, 1,111 patients underwent surgery for primary sporadic CRC in Saitama Medical Center, Jichi Medical University. From our database of CRC patients, we extracted details of patients who had developed at least one MPM in an extracolonic site while having synchronous or metachronous CRC. Synchronous MPMs were defined as malignancies detected within 6-month interval before and after the detection of CRC [9,10].

All the MPMs were pathologically or cytologically confirmed as malignancies. Any metastasis to extracolonic sites from the CRC was excluded.

Two patients with familiar adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, and two with ulcerative colitis associated colorectal cancer were also excluded. The tumor locations of CRC were divided into two groups: colon and rectum (portions below the level of the sacral promontory) [11]. We reviewed clinicopathological parameters, such as age, sex, location of tumor, differentiation of tumor, stage according to the tumor, node, and metastasis (TNM) classification, of the American Joint Committee on Cancer (6th edition) [12], and occurrence of MPMs at extracolonic sites.

It is not known whether the incidence of gastric cancer (GC) is higher or not in CRC patients. We performed gastroscopy for CRC patients as screening because the incidence of GC is high in Japan [13]; if GC was discovered in CRC patients before surgery, we could treat them by simultaneous operation. Of 1,111 patients, 832 underwent gastroscopy. These features in patients with CRC harboring simultaneous GC were compared with those in patients with GC that was detected by mass screening. Screening for GC is widely spread in Japan, a nation afflicted by high GC mortality [14]. In 1983, a national law was enacted that stipulated that each municipality should provide annual GC screening for inhabitants aged 40 or older, by either gastroscopy or barium meal. In 2010, 200,007 residents (6.0% of the target population) participated in this mass screening in the Saitama Prefecture and GC was detected in 225 patients (0.01%).

Statistical analysis

Clinical and pathological factors related to the presence of MPMs were compared by the Mann-Whitney U test and the χ 2 test. To enable the incidence of synchronous GC in patients with CRC to be compared, allowing for the differences in age distributions between patients with CRC and people who underwent screening for stomach abnormalities, as described, an age-adjusted odds ratio was calculated, comparing the rate in patients with synchronous GC with that in patients whose GC was diagnosed after screening. Statistical significance was indicated for P < 0.05.

The odds ratio was presented with 95% confidence intervals. SPSS version 17 (IBM, Tokyo, Japan) was used for statistical analyses.

In this study retrospective anonymized clinical information from patients from the Saitama Medical Center, Jichi Medical University were employed. The study has been approved by the Research Ethics Committee at Jichi Medical University.

Results and discussion

Among the 1,111 patients with primary CRC, there were 117 patients (10.5%) with MPMs. Table 1 shows the clinicopathological relationship between CRC patients with and without MPMs. Patients with CRC and MPMs were older than patients without MPMs (P < 0.001). All patients with CRC and MPMs were 50 years old or older.

Table 1 Comparison of clinical and pathological features between colorectal cancer patients with and without multiple primary malignancies

There were no statistical differences between sexes, tumor location, or differentiation of tumor. Early CRC tended to be more associated with MPMs than advanced CRC (P = 0.034) (Table 1 and Figure 1). Nine patients had triple primary malignancies.

Figure 1
figure 1

Incidence of multiple primary malignancies according to colorectal cancer stage. 37 of 284 patients with colorectal cancer (13%) with stage I had multiple primary malignancies, 47 of 330 patients with colorectal cancer (12.4%) had stage II, 26 of 321 patients with colorectal cancer (8.1%) had stage III and 7 of 126 patients with colorectal cancer (5.6%) had stage IV. The incidence of multiple primary malignancies decreased with colorectal cancer stage. MPM, multiple primary malignancy.

Table 2 shows the sites of the MPMs. Of 18 organs noted to have MPMs in this study, malignancies in the stomach were most frequently associated with CRC, both synchronously and metachronously, followed by lung or breast cancer.

Table 2 Extracolonic site distribution of multiple primary malignancies in patients with colorectal cancer

Patients with CRC and synchronous GCs were compared with GC patients detected by mass screening carried out in the Saitama Prefecture in 2010 (Tables 3 and 4). The incidence of synchronous GC in patients with CRC was significantly higher than that of GC in the mass-screened group: 2.34% versus 0.11% (Table 3 and Figure 2). The age-adjusted odds ratio for incidence of GC in the mass-screened group was 18.8 (95% confidence interval, 18.6 to 19; P < 0.001) (Tables 3 and 4 and Figure 2). All patients with CRC with synchronous GC were 55 years old or older. The age distribution of all CRC patients peaked in the 70s. Conversely, that of CRC patients with synchronous GCs formed two peaks; one for individuals in their 60s and one for individuals who were 80 years old or older (Figure 3).

Table 3 Comparison of clinical features between synchronous gastric cancer with colorectal cancer patients and gastric cancer among screened group
Table 4 Comparison of the incidence of gastric cancer between colorectal cancer patients and screened patients
Figure 2
figure 2

Comparison of the incidence between synchronous gastric cancer in patients with colorectal cancer and gastric cancer among screened patients according to age subgroups. In those older than 54 years, the incidence of synchronous gastric cancer in patients with colorectal cancer was significantly higher than that of gastric cancer among the mass-screened group. GC, gastric cancer.

Figure 3
figure 3

Comparison of the age distributions between all patients with colorectal cancer (top panel) and patients with colorectal cancer with synchronous gastric cancer (bottom panel). The age distribution of all patients with colorectal cancer peaked in the 70 to 74 years age range (211 of 1,111 patients). By contrast, that of patients with colorectal cancer with synchronous gastric cancer formed two peaks; among individuals 60 to 64 years old (7 of 152 patients) and among those 80 years or older (6 of 157 patients). CRC, colorectal cancer; GC, gastric cancer.

This study demonstrates that patients with CRC are likely to develop MPMs in extracolonic sites, the occurrence of which accounted for 10.5% (117/ 1,111) in our analyses. This result is congruent with previous reports showing the occurrence of MPMs in extracolonic sites among CRC patients, which ranged from 2.4% to 17% [14-17]. Moreover, our data suggest that patients with early-stage CRC are more likely to exhibit MPMs than those with advanced stages of CRC; this might be because the prognosis in early CRC patients is favorable, and thus the follow-up time becomes longer than that for advanced CRC patients. Therefore, the MPMs might occur more often in patients with early-stage CRC than in those with advanced CRC.

Our data showed that GC was the most frequently associated cancer in patients with CRC both synchronously and metachronously, consistent with previous reports [9,10,15-19].

Note that increased surveillance for GC might appear to increase its incidence as a result of increased detection. Patients with CRC do seem to undergo far more testing than the general population, including gastroscopy and computed tomography, accounting for the high detection rate of GC in patients with CRC [20]. As we have mentioned before, annual GC screening for inhabitants was undertaken not only by gastroscopy but also by barium meal. In some areas of the Saitama Prefecture, individuals can choose between barium meal and gastroscopy for the screening of GC. Out of 200,007 screened people, 56,036 people (28.0%) underwent gastroscopy in 2010. We should agree on the difficulty of comparison between the incidence of synchronous GC and that of screen-detected GC. In addition, 2 of 52 patients with GC were diagnosed with stomach cancer first. After that, the two patients were diagnosed with CRC by screening colonoscopy. So, the present study has some selection bias, increasing the incidence of GC with CRC. Consequently, it is hard to determine precisely the real magnitude of the correlation between CRC and GC. There are few reports of MPMs in CRC patients with comparative data [10,17], and even then, the existing data were calculated from a population that included unscreened people; hence, it is far from accurate. After calculation of prevalence using populations that consist of screened subjects, we should employ this as comparative data. Allowing for this point, we used a database of patients with GC that was detected by screening carried out in the Saitama Prefecture in Japan in 2010 as comparative data, to highlight a characteristic of synchronous GC with CRC. Some researchers reported that screend groups were likely to differ from unscreened groups in certain characteristics, such as familial history, diet, or smoking habits [21]. Though we could not dispute this bias, we viewed the GC data from screened individuals as a preferable comparison because the population included many unscreened people. From these results, the prevalence of synchronous GC in patients with CRC (2.6%) was found to be extremely high, which implies that patients with CRC are at increased risk of synchronous GC. In addition, all patients with CRC who had synchronous GC were older than 50 years. Based on these data, careful perioperative screening is necessary for the detection of GC in patients with sporadic CRC who are older than 50 years.

In addition to the finding that the most common site of a metachronous MPM in CRC patients is the stomach [22], one of the most common MPMs in patients with GC is CRC [23,24]. These facts seem to suggest that GC and CRC share the same risk factors. In a previous study, microsatellite instability [19], translocation of TP53 [25,26] and ageing [22,27,28] were regarded as shared risk factors between GC and CRC. In terms of ageing, the median age of CRC patients with MPMs was significantly higher than that of CRC patients without MPMs, which agrees with those reports. Intriguingly, the age distribution of CRC patients with synchronous GC formed two characteristic peaks; not only was there a peak at 80 years old or older, but there was also a peak for people in their 60s. Familiar adenomatous polyposis or hereditary non-polyposis colorectal cancer are given as hereditary diseases to be complicated with GC and CRC. We excluded patients with these diseases from our cohort of patients with CRC by checking patients’ familial histories. Additionally, in hereditary non-polyposis colorectal cancer, the mean age at diagnosis as CRC is 42 to 50.4 years [29,30]. In familiar adenomatous polyposis, without surgical intervention, patients almost inevitably develop CRC by a mean age of 40 or 50 years [31]. We concluded that these hereditary diseases were less likely to be included. It is thought that there are some factors that are not due to ageing or known hereditary disease.

In the 18 organs that had MPMs, the lung was the second most frequently associated with CRC, followed by the stomach, and then the breast. In Japan, the organ with the highest incidence of MPMs in Japan is the stomach, followed by the colon and rectum, and then the lung and breast [13]. This sequence matches precisely with that of MPMs in our cohort of patients with CRC.

There are some limitations to this study. First, this research was performed retrospectively. Second, our data did not include information regarding Helicobacter pylori infection status. It is believed that 70 to 80% of people over 40 years of age in Japan are infected with H. pylori [32]. H. pylori infection is an important factor that has been associated with the development of GC [33]. The incidence of H. pylori infection of the stomach in European countries is less than that in Japan [34]. In a European study of MPMs with CRC, cancer in the stomach is far from frequent [35]. In this study, H. pylori might contribute to the high incidence of GC with CRC.

Finally, our data did not include any information regarding atrophic gastritis; a previous study revealed that atrophic gastritis might be a major cause of GC [36]. For these reasons, additional studies are required for further evaluation.

Conclusions

Gastric cancer was the most common synchronous or metachronous MPM in patients with CRC. Careful perioperative screening is necessary for the detection of MPMs in patients with CRC. However, screening for GC is not always necessary in sporadic CRC patients younger than 50 years.

Abbreviations

CRC:

colorectal cancer

GC:

gastric cancer

MPM:

multiple primary malignancy

TNM:

tumor, node, and metastasis

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90

    Article  PubMed  Google Scholar 

  2. Yiu HY, Whittemore AS, Shibata A (2004) Increasing colorectal cancer incidence rates in Japan. Int J Cancer 109:777–81

    Article  CAS  PubMed  Google Scholar 

  3. Yee YK, Tan VP, Chan P, Hung IF, Pang R, Wong BC (2009) Epidemiology of colorectal cancer in Asia. J Gastroenterol Hepatol 24:1810–6

    Article  PubMed  Google Scholar 

  4. Lu JB, Sun XB, Dai DX, Zhu SK, Chang QL, Liu SZ et al. (2003) Epidemiology of gastroenterologic cancer in Henan Province. China World J Gastroenterol 9:2400–3

    Google Scholar 

  5. Yang L, Parkin DM, Li LD, Chen YD, Bray F (2004) Estimation and projection of the national profile of cancer mortality in China: 1991–2005. Br J Cancer 90:2157–66

    PubMed Central  CAS  PubMed  Google Scholar 

  6. Sung JJ, Lau JY, Goh KL, Leung WK (2005) Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 6:871–6

    Article  PubMed  Google Scholar 

  7. Kobayashi Y, Arimoto H, Watanabe S (1991) Occurrence of multiple primary cancer at the National Cancer Center Hospital, 1962–1989. Jpn J Clin Oncol 21:233–51

    CAS  PubMed  Google Scholar 

  8. Tsukuma H, Fujimoto I, Hanai A, Hiyama T, Kitagawa T, Kinoshita N (1994) Incidence of second primary cancers in Osaka residents, Japan, with special reference to cumulative and relative risks. Jpn J Cancer Res 85:339–45

    Article  CAS  PubMed  Google Scholar 

  9. Lee WS, Lee JN, Choi S, Jung M, Baek JH, Lee WK (2010) Multiple primary malignancies involving colorectal cancer–clinical characteristics and prognosis with reference to surveillance. Langenbecks Arch Surg 395:359–64

    Article  PubMed  Google Scholar 

  10. Lee SH, Ahn BK, Baek SU (2009) Multiple primary cancers in extracolonic sites with colorectal cancer. Int J Color Dis 24:301–4

    Article  Google Scholar 

  11. Oya M, Takahashi S, Okuyama T, Yamaguchi M, Ueda Y (2003) Synchronous colorectal carcinoma: clinico-pathological features and prognosis. Jpn J Clin Oncol 33:38–43

    Article  PubMed  Google Scholar 

  12. Greene F, Page D, Fleming I, Fritz A, Balch C, Haller D et al. (2002) AJCC Cancer Staging Manual, 6th edn. Springer, New York

    Book  Google Scholar 

  13. Matsuda A, Matsuda T, Shibata A, Katanoda K, Sobue T, Nishimoto H (2013) Cancer incidence and incidence rates in Japan in 2007: a study of 21 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol 43:328–36

    Article  PubMed  Google Scholar 

  14. Hisamichi S (1989) Screening for gastric cancer. World J Surg 13:31–7

    Article  CAS  PubMed  Google Scholar 

  15. Maruyama H, Hasuike Y, Furukawa J, Naoi M, Takata N, Yayoi E et al. (1992) Multiple colorectal carcinomas and colorectal carcinoma associated with extracolonic malignancies. Surg Today 22:99–104

    Article  CAS  PubMed  Google Scholar 

  16. Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T (2003) Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol 8:162–7

    Article  PubMed  Google Scholar 

  17. Yamamoto S, Yoshimura K, Ri S, Fujita S, Akasu T, Moriya Y (2006) The risk of multiple primary malignancies with colorectal carcinoma. Dis Colon Rectum 49:S30–6

    Article  PubMed  Google Scholar 

  18. Lim SB, Jeong SY, Choi HS, Sohn DK, Hong CW, Jung KH et al. (2008) Synchronous gastric cancer in primary sporadic colorectal cancer patients in Korea. Int J Color Dis 23:61–5

    Article  CAS  Google Scholar 

  19. Yun HR, Yi LJ, Cho YK, Park JH, Cho YB, Yun SH et al. (2009) Double primary malignancy in colorectal cancer patients - MSI is the useful marker for predicting double primary tumors. Int J Color Dis 24:369–75

    Article  CAS  Google Scholar 

  20. Yoon SN, Oh ST, Lim SB, Kim TW, Kim JH, Yu CS et al. (2010) Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer. World J Surg 34:2168–76

    Article  PubMed  Google Scholar 

  21. Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K et al. (2003) Prospective study of screening for stomach cancer in Japan. Int J Cancer 106:103–7

    Article  CAS  PubMed  Google Scholar 

  22. Schatzkin A, Baranovsky A, Kessler LG (1988) Diet and cancer. Evidence from associations of multiple primary cancers in the SEER program. Cancer 62:1451–7

    Article  CAS  PubMed  Google Scholar 

  23. Ha TK, An JY, Youn HG, Noh JH, Sohn TS, Kim S (2007) Surgical outcome of synchronous second primary cancer in patients with gastric cancer. Yonsei Med J 48:981–7

    Article  PubMed Central  PubMed  Google Scholar 

  24. Eom BW, Lee HJ, Yoo MW, Cho JJ, Kim WH, Yang HK et al. (2008) Synchronous and metachronous cancers in patients with gastric cancer. J Surg Oncol 98:106–10

    Article  PubMed  Google Scholar 

  25. Uchino S, Noguchi M, Ochiai A, Saito T, Kobayashi M, Hirohashi S (1993) p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. Int J Cancer 54:759–64

    Article  CAS  PubMed  Google Scholar 

  26. Sawai T, Nanashima A, Tsuji T, Yamaguchi H, Yasutake T, Nakagoe T et al. (2001) Instability of chromosome 17 and the p53 locus in non-familial colorectal cancer with multiple primary malignancies. J Exp Clin Cancer Res 20:401–5

    CAS  PubMed  Google Scholar 

  27. Wynder EL, Mushinski MH, Spivak JC (1977) Tobacco and alcohol consumption in relation to the development of multiple primary cancers. Cancer 40:1872–8

    Article  CAS  PubMed  Google Scholar 

  28. Saito S, Hosoya Y, Togashi K, Kurashina K, Haruta H, Hyodo M et al. (2008) Prevalence of synchronous colorectal neoplasms detected by colonoscopy in patients with gastric cancer. Surg Today 38:20–5

    Article  PubMed  Google Scholar 

  29. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P et al. (2005) Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 352:1851–60

    Article  CAS  PubMed  Google Scholar 

  30. Stoffel E, Mukherjee B, Raymond VM, Tayob N, Kastrinos F, Sparr J et al. (2009) Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology 137:1621–7

    Article  PubMed Central  PubMed  Google Scholar 

  31. Vasen HF, Moslein G, Alonso A, Aretz S, Bernstein I, Bertario L et al. (2008) Guidelines for the clinical management of familial adenomatous polyposis (FAP). Gut 57:704–13

    Article  CAS  PubMed  Google Scholar 

  32. Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T et al. (1992) Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 102:760–6

    CAS  PubMed  Google Scholar 

  33. The EUROGAST Study Group (1993) An international association between Helicobacter pylori infection and gastric cancer. Lancet 341:1359–62

    Article  Google Scholar 

  34. Graham DY, Adam E, Klein PD, Evans DJ Jr, Evans DG, Hazell SL et al. (1989) Epidemiology of Campylobacter pylori infection. Gastroenterol Clin Biol 13:84B–8

    CAS  PubMed  Google Scholar 

  35. Evans HS, Moller H, Robinson D, Lewis CM, Bell CM, Hodgson SV (2002) The risk of subsequent primary cancers after colorectal cancer in southeast England. Gut 50:647–52

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  36. Derakhshan MH, Malekzadeh R, Watabe H, Yazdanbod A, Fyfe V, Kazemi A et al. (2008) Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut 57:298–305

    Article  CAS  PubMed  Google Scholar 

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Acknowledgement

The authors thank Saitama Prefecture for providing the data on the screening of gastric cancer.

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Correspondence to Takaharu Kato.

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The authors declare that they have no competing interests.

Authors’ contributions

TK participated in designing the study, performed the statistical analysis and wrote the manuscript. KS participated in designing the study. YM, JS, ST, YJK, HN, and HH participated in the acquisition of data. FK and TR conceived the study and participated in its design and coordination. All authors read and approved the final manuscript.

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Kato, T., Suzuki, K., Muto, Y. et al. Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized. World J Surg Onc 13, 23 (2015). https://doi.org/10.1186/s12957-014-0432-2

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