- Case report
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Malignant glomus tumor of the lung with multiple metastasis: a rare case report
World Journal of Surgical Oncology volume 13, Article number: 22 (2015)
Malignant glomus tumor, or glomangiosarcoma, is a very rare mesenchymal neoplasm that, when seen, occurs in visceral organs. Despite having histologic features of malignancy, these tumors usually do not metastasize. However, when metastasis occurs, this disease is often fatal. Our report presents the case of a 59-year-old female patient with a highly aggressive and widely metastatic glomus tumor of the lung.
Glomus tumors are uncommon benign neoplasms that customarily originate from glomus bodies in the dermis or subcutis of the extremities. Extracutaneous glomus tumors occur but are very rare, especially in visceral organs such as the stomach, mediastinum, trachea, lung, ileum, and kidney [1-5]. A few cases of glomangiosarcoma in visceral organs have been reported; nevertheless, these all involved local invasion and metastasis occurred scarcely . Herein, we report a case with a highly aggressive and widely metastatic malignant glomus tumor of the lung.
A 59-year-old female patient (living in eastern China, at an altitude of 550 m) presented to our hospital complaining of an ongoing cough and hemoptysis for 4 months and melena for 1 week. The patient’s medical history was unremarkable. The auscultation revealed attenuated respiratory sound in bilateral lungs and no rales or wheezing were noted. There was no superficial node enlargement. Laboratory investigations showed normocytic anemia (hemoglobin level 58 g/L) and a platelet count of 294 × 109 /L. The computed tomography (CT) scan of the chest showed multiple masses in bilateral lungs with the largest measuring 25 mm in diameter in the left upper lobe (Figure 1A,B) and an irregularly protruding edge, lobulated mass was abutting the left cardiac border in the left inferior lobe (Figure 1D–E). Also noted were mildly enlarged mediastinal nodes. Enhanced CT scans of the abdomen demonstrated gastrointestinal lumen multiple clumps, with the upper right jejunum intussusception, incomplete obstruction by tumor, and multiple mass in spleen and ileum considering tumor metastasis (Figure 1F–H). To make a definite diagnosis of tumor, an endoscopic study was performed. Bronchoscopy revealed new features in the left lung lingual lobe cavity, the lumen was completely blocked. Gastroscopy revealed stomach multiple clumps. Pathology and immunohistochemistry were subsequently performed. Immunohistochemically, tumor cells from the lung were positive for SMA (Figure 2A), CD163, F8, vimentin (Figure 2E), and collagen IV (Figure 2C), whereas they were negative for CD21, CD31, CD34, CD35, CD117, Bcl-2, CK7, CKlow, EMA, HMB45, desmin, myosin, s-100, and TTF-1 (Table 1). Tumor cells from stomach were positive for SMA (Figure 2B) and collagen IV (Figure 2D), and F8 was rare weakly positive, whereas they were negative for CD31, CD117, CK, dog-1, HMB45, desmin, and s-100. Ki-67 labeling index reached about 60% (Figure 2F) from lung specimen and about 40% from stomach (Table 1). The histopathological findings were consistent with malignant glomus tumor . With deteriorating medical conditions and widespread metastasis, the patient was submitted to a palliative therapy. Bronchial artery embolization was given for hemostasis. The patient developed more generalized weakness and eventually died within 20 weeks of diagnosis.
Glomus tumors typically present as solitary or multicentric lesions in the dermis or subcutis, with characteristic subungual location. Extracutaneous presentations occur but are rare, especially in the visceral organs, where glomus bodies are sparse or even absent, including the respiratory tract, gastrointestinal tract, and mediastinum. Within the respiratory tract, the trachea is the most frequent site of involvement. Primary glomus tumors of the lung, especially with metastasis, are extremely rare. To the best of our knowledge, only three cases have been reported in the English literature. The first case of a glomangiomyoma of the lung with widespread metastasis was reported by Gaertner et al.  in 2000, in which the patient developed widespread metastatic disease to the lungs, upper mediastinum, brain, liver, and subcutaneous tissue of the lower limb after surgery, then she received chemotherapy and ultimately died 68 weeks after surgery. A decade later, Liu et al.  reported another case of primary malignant glomus tumor in the lung with multiple metastasis to the left lung, visceral pleura, adjacent bronchi, and the vessel walls. The patient also underwent surgery and chemotherapy, but died 4 days after surgery due to pulmonary failure. This was followed by Hohenforst-Schmidt et al. , who reported a case of glomus tumor in the left hilum of the lung, but multiple lung metastasis were evident at the 6-year follow-up visit; the patient was submitted to a pneumonectomy of the left lung and was disease free within in the surgical limits.
Folpe et al.  proposed the following criteria for malignant glomus tumor: tumors with a deep location and a size of more than 20 mm, or atypical mitotic figures, or moderate to high nuclear grade and ≥5 mitotic figures per 50 high power fields. In our case, the diameter of the largest mass was 25 mm in the left upper lobe (Figure 1A). Microscopically, nuclear atypia of tumor cells with high mitotic activity was evident (Figure 3), fulfilling the criteria for malignancy. Given the rarity of reported cases of malignant glomus tumor of the lung, these patients can be misdiagnosed easily with other pulmonary disorders. Malignant glomus tumors have to be differentiated from other lesions such as Ewing’s tumors/primitive neurectodermal tumors, carcinoid tumors, neuroendocrine carcinoma, sclerosing hemangioma, malignant melanoma, synovial sarcoma, malignant mesothelioma, hemangiopericytoma, and metastatic tumors. Histologic and immunohistochemical features are fundamental in establishing the diagnosis of malignant glomus tumors, the clinicopathologic features and immunohistochemical profiles of which were summarized initially by Khoury et al. . In this case, it was slightly difficult to differentiate from a multiple gastrointestinal glomus tumor with lung metastasis; however, the possibility of metastatic malignant glomus tumors from other organs to the lung was obviated in light of the clinical and radiological evidence. The patient was referred to hospital due to long term pulmonary symptoms rather than gastrointestinal discomfort. However, and even more importantly, the irregularly protruding edge, lobulated mass in the left inferior lobe (Figure 1D–E), considered a primary lesion, did not meet the characteristics of metastasis in radiology.
Surgical resection is curative and remains the mainstay of treatment in reported cases of malignant glomus tumor diagnosed with or without local metastasis , and long term follow-up is greatly recommended. Milia et al.  reported a successful outcome with combined radiotherapy and chemotherapy in a case of malignant glomus tumor in a 40-year-old man presenting with a lesion in the upper cervical region. In our case, the patient lost the opportunity for surgery given the widespread metastasis and did not undergo radiotherapy or chemotherapy because of asthenia, resulting in fatality.
Malignant glomus tumor of the lung, particularly with multiple metastasis, is exceedingly rare. The cornerstone of diagnosis is pathological features and immunostaining. This case, combined with the other three cases mentioned above (Table 2), indicate that a case of malignant glomus tumor with widespread metastasis is often fatal. Diagnosis before metastasis and effortlessly aggressive surgical treatment is essential of excellent prognosis in this disease.
Written informed consent was obtained for publication of this report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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The authors declare that they have no competing interests.
CD took part in the care of the patient and the clinical follow-up of the patient. SW was responsible for the literature review, design, and writing of the manuscript. JT revised the manuscript. All authors read and approved the final manuscript.
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Wang, S., Ding, C. & Tu, J. Malignant glomus tumor of the lung with multiple metastasis: a rare case report. World J Surg Onc 13, 22 (2015). https://doi.org/10.1186/s12957-014-0423-3
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