Open Access

Eccrine porocarcinoma of the lower extremity: A case report and review of literature

  • Oliver Chang1Email author,
  • Ashraf Elnawawi2,
  • Bernard Rimpel3,
  • Armand Asarian4 and
  • Nadeem Chaudhry5
World Journal of Surgical Oncology20119:94

https://doi.org/10.1186/1477-7819-9-94

Received: 1 March 2011

Accepted: 22 August 2011

Published: 22 August 2011

Abstract

Eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland. It is usually found frequently on the lower extremities, and it affects both sexes equally usually in the sixth to seventh decade. In our case, we present a 42-year-old male patient with a recurring exophytic tumor on the right lower extremity without local extension. The initial tumor was biopsied, excised and diagnosed as an eccrine poroma. The tumor then recurred 6 years later, was re-excised, reconstructed with a soleus muscle flap and diagnosed as an eccrine porocarcinoma.

Keywords

eccrine porocarcinomasweat gland tumormalignant eccrine poroma

Background

Eccrine porocarcinoma (EPC), a rare malignant sweat gland tumor, representing only 0.005% of epithelial cutaneous neoplasms. The first reported case, in 1963, was attributed to Pinkus and Mehregan [1], coined as "epidermotropic eccrine carcinoma", and since then, presentation have been limited due to the rarity of this tumor. It was only a few years later, the term "eccrine porocarcinoma" was introduced by Mishma and Morioka in 1969 [2]. These lesions are most commonly found on the lower extremities, followed by the head, scalp, upper extremities, trunk and abdomen [1, 311]. The tumor can arise from the intraepithelial portion of the eccrine sweat gland, the acrosyringium, being a primary tumor or, even more common, a malignant transformation of an eccrine poroma (EP). In this case, we present a 42-year-old patient with a right lower extremity mass that was previously diagnosed with a benign poroma later, over 6 years, found to have had malignant transformation.

Case Report

A 42-year-old male presented with an exophytic mass on the right lower extremity that had developed over the last 6 years. The patient denied any type of trauma to the area or insect bites. The mass had been previously excised and pathology showed a benign poroma. The laboratory work-up for this patient was within normal limits.

On physical exam, there were no lymphadenopathy in the inguinal, axillary or clavicular areas were noted. The tumor itself measured 3.0 × 2.0 cm with a width of 0.6 cm (Figure 1). Pink exophytic, fungating outgrowths are a signature to this tumor. In combination with the patient's previous history of benign poroma, the treatment of choice was a wide local excision of the mass with 2.5 cm margins - both circumferentially and deep to the level of the periosteum. A soleus muscle flap was then raised and used to reconstruct the defect. The muscle was then covered with a split thickness skin graft.
Figure 1

Preoperative image of the pink exophytic outgrowth - 2.0 × 3.0 cm.

The macroscopic examination of the specimen showed an exophytic mass measuring 3 cm in diameter. Microscopically, the specimen displayed malignant eosinophilic lobular masses with eosinophilic polyhedral fusiform cells that contained variable cytoplasm, hyperchromatic nuclei, distinct nucleoli and indistinct cell boundaries (Figure 2). There was obvious atypia and frequent mitotic figures, epidermotropism, variable squamous differentiation and cell changes with pigmentation in a horizontal nodular pattern. Both carcinoma in situ and invasive components were noted (Figure 3).
Figure 2

The tumor cells are in-situ and invasive. Malignant eosinophilic lobular masses or islands are seen with eosinophilic cells that are polyhedral and fusiform that have variable cytoplasm, hyperchromatic nuclei and indistinct cell boundaries.

Figure 3

High power view show invasive carcinoma cells. There is obvious cell atypia with many mitotic figures seen. The squamous cells have variable differentiation accompanied with changes in pigmentation that are aligned in a horizontal nodular pattern. Both carcinoma in situ and invasive component noted.

The final pathology report stated the specimen was a porocarcinoma in situ with clear surgical margins. During the 6 month and 1 year post-op follow up, the wound had healed without any complications or recurrence (Figure 4). The physical exam remains unchanged with no palpable regional lymph nodes.
Figure 4

Postoperative image of the excised area with a soleus muscle flap reconstruction.

Discussion

Eccrine porocarcinoma (EPC) is more common in elderly patients and most cases occur in the sixth to seventh decade of life. In our case, we presented a male in his early 40 s and with time, has become malignant from a previous benign poroma. Men and women are usually equally affected, and prevalence varies in both sex in diverse studies [1214]. Approximately 50% of EPC appear first in the lower limbs; in that, more than 40% occur below the knees [15]. Less than 5% involve the scalp [16]. Other affected sites are face, ear, eyelids, abdomen, vulva, penis and pubis.

Theorectically, eccrine porocarcinoma progresses from benign to malignant. This is supported clinically by long histories, mean 8.5 years and recent onset of rapid growth in longstanding cases. Only a period of 6 years duration was noted in our case. Histological reports of dysplasia and malignant change in benign variants, including eccrine poroma and hidroacanthoma simplex support this theory [17].

The pathogenesis and roles of possible pre-invasive precursors of this lesion is still unknown [18]. It seems that the upper portion of the dermal eccrine duct could have a role in the oncogenesis. More recently, the p53 gene involved in tumor suppressing, could be involved in EPC carcinogenesis [19]. Throughout the literature search, there is not a definite time line in which a poroma advances and becomes a porocarcinoma.

Treatment of choice for EPC is total surgical excision with broad tumor margins and regional lymph node disection if involved. There is still insufficient literature data on cryosurgery and electrosurgery in order to accurately assess indication and tumor recurrence [18]. Chemotherapy with methotrexate, cisplatin, adriamycin and bleomycin or isotretinoin and interferon alpha have been used with partial or little response. Radiation therapy and chemotherapy seem to be ineffective to control tumor recurrence or metastasis [16]. In our case, post-op chemotherapy or radiation was not given to the patient. There is no effective definitive treatment available for EPC at the moment but surgical excision is still the treatment choice.

It is important to have this diagnosis as a differential for cutaneous lesions due to the malignant nature of the tumor if left unattended. EPC must be considered in the differential diagnosis of patients older than fifty years with long standing tumors in the limbs and head - including basal cell carcinoma, Paget's disease, melanoma and metastatic cancer. EPC has been documented to occur even in the nail fold of the toe mimicking an ingrown toe nail. Biopsy is indicated and, even with a previous diagnosis of EP, one must be attentive to risk of malignancy in the future or if it is a recurrence [20]. EPC is a rare malignancy of the eccrine sweat glands but yet curable if accurately diagnosed and properly treated. Close follow-up to detect local recurrence and lymph node metastasis is recommended since further surgical intervention may be curative.

Conclusion

Eccrine porocarcinoma (EPC), a rare malignant sweat gland tumor, representing only 0.005% of epithelial cutaneous neoplasms. Being only 0.005% of all cutaneous neoplasms makes this diagnosis intricate, but not impractical if more literature is provided of this rare pathology. The treatment is a multidisciplinary effort that consists of a pathologist and surgeon. And if treated in the early stage, surgery can be curative. EPC is a rare malignancy of the eccrine sweat glands but yet curable if accurately diagnosed and properly treated. Due to the limited amount of literature and cases documented, it is important to have a basic knowledge of this disease process as a differential diagnosis when dealing with cutaneous lesions.

Consent

Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Declarations

Authors’ Affiliations

(1)
General Surgery Department, The Brooklyn Hospital
(2)
Chief of the Pathology Department, The Brooklyn Hospital
(3)
Gernal Surgery Department, The Brooklyn Hospital
(4)
Chief of the Colorectal Department, The Brooklyn Hospital
(5)
Chief of the Plastic and Reconstructive Surgery Department, The Brooklyn Hospital

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Copyright

© Chang et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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