- Case report
- Open Access
A role of 18F-fluorodeoxyglucose positron emission/computed tomography in a strategy for abdominal wall metastasis of colorectal mucinous adenocarcinoma developed after laparoscopic surgery
World Journal of Surgical Oncology volume 9, Article number: 28 (2011)
Metastasis to the abdominal wall including port sites after laparoscopic surgery for colorectal cancer is rare. Resection of metastatic lesions may lead to greater survival benefit if the abdominal wall metastasis is the only manifestation of recurrent disease. A 57-year-old man, who underwent laparoscopic surgery for advanced mucinous adenocarcinoma of the cecum 6 years prior, developed a nodule in the surgical wound at the lower right abdomen. Although tumor markers were within normal limits, the metastasis to the abdominal wall and abdominal cavity from the previous cecal cancer was suspected. An abdominal computed tomography scan did not provide detective evidence of metastasis. 18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) was therefore performed, which demonstrated increased 18F-fluorodeoxyglucose uptake (maximum standardized uptake value: 3.1) in the small abdominal wall nodule alone. Histopathological examination of the resected nodule confirmed the diagnosis of metastatic mucinous adenocarcinoma. Prognosis of intestinal mucinous adenocarcinoma is reported to be poorer than that of non-mucinous adenocarcinoma. In conclusion, this case suggests an important role of 18F-FDG PET/CT in early diagnosis and decision-making regarding therapy for recurrent disease in cases where a firm diagnosis of recurrent colorectal cancer is difficult to make.
Metastasis to the abdominal wall including port sites after laparoscopic surgery for colorectal carcinoma (CRC) is rare. Recently the rate was reported as 1.3% in a randomized clinical trial by the Colon Cancer Laparoscopic or Open Resection Study Group  and 2.4% in the CLASSIC trial . Although the prognosis is not clearly defined in the literature, resection of metastatic lesions may lead to greater survival benefit if the abdominal wall metastasis is the only manifestation of recurrent disease. However, it can be difficult to diagnose a lesion in the abdominal wall as recurrence of disease on the basis of clinical characteristics alone. Approximately between 5% to 15% of CRCs are mucinous adenocarcinomas [3–7]. Patients with colorectal mucinous adenocarcinoma are reported to have a poorer prognosis compared to patients with non-mucinous adenocarcinoma because the greater frequency of lymph node involvement and peritoneal dissemination seen with mucinous adenocarcinoma [7–10]. Therefore, Patients with mucinous adenocarcinoma should be followed carefully after surgery, and receive rapid diagnosis and treatment if recurrence is suspected. We report a case in which 18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) was very useful for early diagnosis and planning a theraupetic strategy for a case of mucinous adenocarcinoma metastasis at a laparoscopic port site.
A 57-year-old man received curative laparoscopic ileocecal resection and lymph node dissection for carcinoma of the cecum in May 2004. Morphologically, the tumor was type I (45 mm by 30 mm). The histological examination revealed a mucinous adenocarcinoma which invaded the cecal subserosa. Tumor cells were not identified histologically in the 20 regional lymph nodes, surgical margins, lymph vessels, or veins of the surgical specimens (pT3 N0 M0). The patient was subsequently followed at our hospital and treated with oral 5-fluorouracil. In February 2008, the patient discovered a nodule in the incision site in the lower right abdomen. A 2-cm, firm, ill-defined, tender mass was palpable in the incision site, and was suspected to be a recurrence of the cecal mucinous adenocarcinoma. However, the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were within normal limits (CEA: 4.7 ng/dl, CA19-9: 16.2 U/ml). In November 2008, an abdominal computed tomography (CT) scan revealed a small nodule in the abdominal wall, which was difficult to interpret as metastasis of the cecal cancer (Figure 1). 18F-fluorodeoxyglucose (18F-FDG) positron emission/computed tomography (PET/CT) was performed in January 2009. The CT scan was performed first, from head to pelvic floor using 3.3-mm section thickness. Immediately after the CT scan, a PET scan was performed using the identical transverse field of view and section thickness as that of the CT scan. For the PET scan, the patient, whose blood glucose level was 103 mg/dl, received 181.8 MBq of 18F-FDG intraverously. Data acquisition was performed within 20 min after injection using an integrated PET/CT system (Eminence SOPHIA; Shimadzu Corporation, Kyoto, Japan). PET image data sets were reconstructed by 137caesium for attenuation correction, and coregistered images were displayed. The PET/CT scan demonstrated increased 18F-FDG uptake (maximum standardized uptake value: 3.1) in the small abdominal nodule, but no further metastases in distant organs, peritoneum, or lymph nodes. The small nodule was diagnosed as a solitary metastasis of the cecal cancer at the previous port site (Figure 2). The nodule was resected in February 2009. The tumor was located in the abdominal wall, slightly exposed to the abdominal cavity. There was no gross evidence of metastasis in the abdominal cavity and cytological examination identified no tumor cells in the ascitic fluid. The tumor was identified as a metastatic lesion on the basis of histological findings (Figures 3, 4 and 5). No recurrence developed during 24-months postsurgical follow up.
Port site metastasis after laparoscopic surgery for CRC is rare, reported as 0.71-1% in the literature [11–16]. Recently the rate was reported as 1.3% in a randomized clinical trial by the Colon Cancer Laparoscopic or Open Resection Study Group  and 2.4% in the CLASSIC trial . Several factors that may contribute to abdominal wall metastasis have been proposed , but it was impossible to identify a cause in this case. The operating record indicated that a wound drape had been used to prevent the implantation of tumor cells during surgery; clinico-pathologically, the depth of invasion of the primary tumor was confined to the intestinal wall and no vascular invasion was identified, and there were no postoperative complications.
Early resection of the metastatic lesion may lead to greater survival benefit, but early confirmation of metastatic disease on the basis of clinical characteristics alone is challenging. 18F-FDG PET/CT imaging, which both structural and functional information provide, is used to identify and stage various types of tumors because of its superiority to traditional imaging for diagnosing recurrent disease. In a retrospective comparison of PET versus PET/CT for the detection of CRC recurrence, the sensitivity, specificity and overall accuracy of PET were 80%, 69% and 75% respectively, compared with 89%, 92% and 90%, respectively, for PET/CT . Goshen et al  reported 18F-FDG PET/CT was a sensitive tool for the diagnosis of 16 abdominal wall lesions in 12 CRC patients, who had moderately or well-differentiated adenocarcinoma. Kozugi et al reported that 18F-FDG PET was an important tool for the detection of port site recurrence of colon cancer in a patient who had elevated serum CEA levels but no metastases detected using routine radiographic examinations . In addition, Sarikaya et al retrospectively analyzed the usefulness of PET for patients with CRC and suspected tumor recurrence, but normal CEA levels, and found that the overall accuracy of PET was 76.9%, and the positive predictive value was 84.6%. They concluded that PET yielded high positive predictive value for recurrence CRC despite normal CEA levels, and should be considered early in the evaluation of patients with suspected tumor recurrence . 18F-FDG PET/CT is useful tool to help interpret potential malignancies when routine radiographic examinations are inconclusive. In addition, we consider that 18F-FDG PET/CT should be a prerequisite examination in patients with suspected recurrence of CRC who have normal CEA levels.
18F-FDG PET/CT imaging, however, does have some disadvantages. False-negative findings can occur for several reasons, including inflammation, small lesions size and diabetes. Mucinous adenocarcinoma as a histological type, regardless of the organs, may result in more false negatives as well. Sarikaya et al  reported that 3 of 5 patients (60%) with false-negative PET findings had mucinous adenocarcinoma diagnosed histologically. Rodriguez-Fernandez et al  and Sun L et al  reported false-negative results in patients with mucinous adenocarcinoma of the gallbladder and gastric cancer, respectively. For detection of gallbladder recurrence 18F-FDG PET scan showed a sensitivity of 80%, a specificity of 82%, and positive and negative predictive values of 67% and 90%, respectively. The single false-negative result was a patient with mucinous adenocarcinoma. For detection of gastric cancer recurrence, the accuracy of 18F-FDG PET/CT scan was 82.6%, and positive and negative predictive values were 85.7% and 77.7%, respectively. The two false-negative in patients with mucinous adenocarcinoma as shown in these reports, and in our case study it can be difficult to detect lesions of mucinous adenocarcinoma by PET scan and 18F-FDGPET/CT scan can be very useful in early diagnosis and therapeutic management.
Mucinous adenocarcinomas have a biological behavior that involves more lymph nodes at diagnosis and the greater frequency of peritoneal dissemination when compared to non-mucinous adenocarcinomas [7–10]. Recently, treatment with FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin) or FOLFIRI (Folinic acid + Fluorouracil + Irinotecan) has been considered useful to obtain better progression-free survival for unresectable colorectal recurrence. However, there is no doubt that early complete resection of the metastatic lesion could lead to even greater survival benefit. 18F-FDG PET/CT scan can play an important role in selecting among patients with recurrence those who may obtain greater survival benefit.
In the case we presented 18F-FDG PET/CT scan was very useful in early diagnosis and therapeutic management for recurrence of mucinous adenocarcinoma after laparoscopic surgery for CRC. Mucinous adenocarcinomas may contribute to a higher rate of false-negative results, but does not decrease the usefulness of this diagnostic tool. 18F-FDG PET/CT imaging, which provide both functional and anatomical information and correctly stages recurrence disease should be considered early in the evaluation of patients with suspected recurrence of CRC.
Written informed consent was obtained from the patient for publication of this case report and any accompanying image. A copy of the written consent is available for review by the Editor-in Chief of this journal.
- 18F-FDG PET/CT:
18F-fluorodeoxyglucose positron emission/computed tomography
positron emission/computed tomography
carbohydrate antigen 19-9
positron emission tomography
Folinic acid + Fluorouracil + Oxaliplatin
Folinic acid + Fluorouracil + Irinotecan
The Colon Cancer Laparoscopic or Open resection Study Group, Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy A, Bonjer HJ: Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randmised cilinical trial. Lancet Oncol. 2009, 10: 44-52. 10.1016/S1470-2045(08)70310-3.
Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ: Five-year follow -up of the medical research council CLASSIC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg. 2010, 97: 1638-1645. 10.1002/bjs.7160.
Symonds DA, Vickery AL: Mucinous carcinoma of the colon and rectum. Cancer. 1976, 37: 1891-1900. 10.1002/1097-0142(197604)37:4<1891::AID-CNCR2820370439>3.0.CO;2-Z.
Fante R, Benatti P, di Gregorio C, De Pietri S, Pedroni M, Tamassia MG, Percesepe A, Rossi G, Losi L, Roncucci L, Ponz de Leon M: Colorectal carcinoma in different age groups. A population-based investigation. Am J Gastroenterol. 1997, 92: 1505-1509.
Yamamoto S, Mochizuki H, Hase K, Yamamoto T, Ohkusa Y, Yokoyama S, Ushitani Y, Tamakuma S: Assessment of clinicopathologic features of colorectal mucinous adenocarcinoma. Am J Surg. 1993, 166: 257-261. 10.1016/S0002-9610(05)80969-9.
Wu CS, Tung S, Chen Pc, Kuo YC: Clinicopathological study of colorectal mucinous carcinoma in Taiwan: A multivariate study. J Gastroenterol Hepatol. 1996, 11: 77-81. 10.1111/j.1440-1746.1996.tb00014.x.
Nozoe T, Anai H, Nasu S, Sugimachi K: Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. J Surg oncol. 2000, 75: 103-107. 10.1002/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C.
Maksimovic S: Survival rates of patients with mucinous adenocarcinoma of the colorectum. Med Arh. 2007, 61: 26-29.
Kanemitsu Y, Kato T, Yasui K, Morimoto T, Shimizu Y, Kodera Y, Yamamura Y: Survival after curative resection for mucinous adenocarcinoma of the colorectum. Dis Colon Rectum. 2003, 46: 160-167. 10.1007/s10350-004-6518-0.
Green JB, Timmcke AE, Mitchell WT, Hicks TC, Gathright JB, Ray JE: Mucinous carcinoma -just another colon cancer?. Dis Colon Rectum. 1993, 36: 49-54. 10.1007/BF02050301.
Ziprin P, Ridgway PF, Peck DH, Darzi AW: The theories and realities of port-site metastases: a critical appraisal. J Am Coll Surg. 2002, 195: 395-408. 10.1016/S1072-7515(02)01249-8.
Zmora O, Gervaz P, Wexner SD: Trocar site recurrence in laparoscopic surgery for colorectal cancer. Surg Endosc. 2001, 15: 788-793. 10.1007/s004640080151.
Lacy AM, Delgado S, Garcia-Valdecasas JC, Castells A, Pique JM, Grande L, Fuster J, Targarona EM, Pera M, Visa J: Port site metastases and recurrence after laparoscopic colectomy; a randomized trial. Surg Endosc. 1998, 12: 1039-1042. 10.1007/s004649900776.
Milsom JW, Böhm B, Hammerhofer KA, Fazio V, Steiger E, Elson P: A prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report. J Am Coll Surg. 1998, 187: 46-54. 10.1016/S1072-7515(98)00132-X.
Franklin ME, Rosenthal D, Abrego-Medina D, Dorman JP, Glass JL, Norem R, Diaz A: Prospective comparison of open vs laparoscopic colon surgery for carcinoma: five-year results. Dis Colon Rectum. 1996, 39 (10 suppl): s35-46. 10.1007/BF02053804.
Fleshman JW, Nelson H, Peters WR, Kim HC, Larach S, Boorse RR, Ambroze W, Leggett P, Bleday R, Stryker S, Christenson B, Wexner S, Senagore A, Rattner D, Sutton J, Fine AP: Early results of laparoscopic surgery for colorectal cancer; retrospective analysis of 372 patients treated by Clinical Outcomes of Surgical Therapy (COST) Study Group. Dis Colon Rectum. 1996, 39 (10 suppl): s53-58. 10.1007/BF02053806.
Curet MJ: Port site metastases. Am J Surg. 2004, 187: 705-712. 10.1016/j.amjsurg.2003.10.015.
Votrubova J, Belohlavek O, Jaruskova M, Oliverius M, Lohynska R, Trskova K, Sedlackova E, Lipska L, Stahalova V: The role of FDG-PET/CT in the detection of recurrence colorectal cancer. Eur J Nucl med Mol Imaging. 2006, 33: 779-784. 10.1007/s00259-006-0072-z.
Goshen E, Davidson T, Aderka D, Zwas ST: PET/CT detects abdominal wall and port site metastases of colorectal carcinoma. Br J Radiol. 2006, 79: 572-577. 10.1259/bjr/25287790.
Kosugi K, Ono M, Saito N, Sugito M, Ito M, Murakami K, Sato K, Kotaka M, Nomura S, Arai M, Kobatake T: Port site recurrence diagnosed by positoron emission tomography after laparoscopic surgery for colon cancer. Hepatogastroenterology. 2005, 52: 1440-1443.
Sarikaya I, Bloomston M, Povoski ST, Zhang J, Hall NC, Knopp MV, Martin EW: FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA. World J Surg Oncol. 2007, 5: 64-10.1186/1477-7819-5-64.
Rodriguez-Fernandez A, Gomez-Rio M, Llamas-Elvira JM, Ortega-Lozano S, Ferron-Orihuela JA, Ramia-Angel JM, Mansilla-Rosello A, Martinez-del-Valle MD, Ramos-Font C: Positron-emission tomography with fluorine-18-fluoro-2- deoxy-D-glucose for gallbladder cancer diagnosis. Am J Surg. 2004, 188: 171-175. 10.1016/j.amjsurg.2003.12.070.
Sun L, Su XH, Guan YS, Pan WM, Luo ZM, Wei JH, Wu H: Clinical role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative follow up of gastric cancer: initial results. World J Gastroenterol. 2008, 14: 4627-4632. 10.3748/wjg.14.4627.
The authors declare that they have no competing interests.
MU was an assistant of the operation. HK is a chairman of the department of gastroenterological surgery, Toho University Medical Center, Omori Hospital. All authors read and approved the final manuscript.
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Funahashi, K., Ushigome, M. & Kaneko, H. A role of 18F-fluorodeoxyglucose positron emission/computed tomography in a strategy for abdominal wall metastasis of colorectal mucinous adenocarcinoma developed after laparoscopic surgery. World J Surg Onc 9, 28 (2011). https://doi.org/10.1186/1477-7819-9-28
- Port Site
- Mucinous Adenocarcinoma
- Suspected Recurrence
- Classic Trial
- Cecal Cancer