A review of duodenal metastases from squamous cell carcinoma of the cervix presenting as an upper gastrointestinal bleed
© Kanthan et al; licensee BioMed Central Ltd. 2011
Received: 1 July 2011
Accepted: 29 September 2011
Published: 29 September 2011
Upper gastrointestinal bleeding due to duodenal metastases is extremely uncommon. Extra-pelvic spread of squamous cell carcinoma (SCC) of the cervix to the small bowel is rare with only 6 reported cases in the English literature since 1981(PubMed, Medline).
We report the case of a 49-year-old woman who presented with upper-gastrointestinal bleeding two years after the diagnosis of SCC of the cervix. At esophagogastroduodenoscopy, there was a stricture in the second part of the duodenum which was biopsied for a suspected neoplastic lesion. Histologic and immunohistochemical examination showed a malignant lesion with characteristics identical to her original tumor in the cervix confirming the duodenal metastases.
The clinical presentation of a 'malignant' upper-gastrointestinal bleed due to duodenal metastases from SCC of the cervix is unusual. Awareness of such infrequent patterns of metastases in cervical cancer confirmed by histopathological diagnosis is important for best practice therapeutic decisions in these patients.
Keywordssquamous cell carcinoma of the cervix small bowel metastases duodenal stricture upper gastrointestinal bleed histopathological diagnosis
Histopathology specimens of small bowel lesions are infrequently encountered in surgical pathology. Malignant diagnosis of such lesions accounts for only 0.4% of all cancers and 0.2% of cancer-related deaths . Metastatic lesions are more common in the duodenum, jejunum and ileum than primary lesions. Though malignant melanoma is the most common extra-gastrointestinal primary to metastasize to the small bowel , intestinal metastases are common in end-stage adenocarcinomas of the pancreas, colon, or stomach by intraperitoneal seeding. Squamous cell carcinoma (SCC) of the cervix is the second most common gynecologic malignancy and the majority of patients usually die from local extension rather than distant metastases. It is exceedingly rare for SCC of the cervix to clinically present with symptoms related to small bowel metastases.
We herein report a case of duodenal metastases from SCC of the cervix confirmed by histopathological diagnosis that presented with upper gastrointestinal bleeding. In addition, we have provided a comprehensive review of all reported cases of SCC of the cervix metastasizing to the small bowel in the published English literature by a PubMed and Medline search as available since 1981.
Review and Discussion
Small Bowel Metastases from Squamous Cell Carcinoma of the Cervix as Reported in the Literature (PubMed and Medline available since 1981) - search terms: "squamous cell carcinoma" AND "cervix"/"carcinoma cervix" with "duodenum", "jejunum", "ileum", "small bowel" and/or "small intestine"
Stage of SCC of cervix at diagnosis
Site of Metastasis
Confirmation of Diagnosis
Time interval to metastases
Hematocrit 15% (occult bleeding)
1st part duodenum (gastric outlet)
Biopsy of duodenal lesion
Refused surgical intervention
Small intestinal perforation with panperitonitis
Multiple mets to the small intestine -Jejunum
Jejunal resection -histopathology
1 month h/o intermittent nausea and vomiting, upper abdominal pain (small bowel obstruction)
Single mass-stomach, ileum, omentum, transverse colon
Histopathology of resected 10 × 10 cm mass
Gross hematuria from the conduit
Biopsy of 1 × 1 cm mass about 10 cms from the stoma
Abdominal Pain, persistent vomiting, constipation, (isolated stricture ileum)
Ileum 5 cm proximal to ileo-caecal junction
Histopathology of Rt.Hemicolectomy
2nd part duodenum
Multiple biopsies Ampulla of Vater
Nausea, vomiting, abdominal distension, 50 lb weight loss
Paraaortic LN causing high level duodenal obstruction
Histopathology of paraaortic node
Laparotomy with bypass surgery
Died 12 weeks post-op
Upper gastrointestinal bleeding
2 nd part of duodenum
Biopsy of duodenal lesion
Died within 48 hours of admission
Squamous cell carcinoma (SCC) of the cervix is the second most common gynecologic malignancy [3, 10]. In the cervix, SCC accounts for 80-85% of all cases, with 15-20% being adenocarcinomas . This common neoplasm may occur at any stage of life; however, it is most commonly diagnosed in the fifth decade, with nearly half of the cases being diagnosed before the age of 35 . The decreasing age of occurrence is attributed to the accepted social norms of earlier onset of sexual activity and complemented with earlier detection by active screening programs. In North America, as a result of the implementation of active screening programs, approximately 60% of cases are identified at Stage I, with 25%, 10% and 5% detected in stages II, III and IV respectively . Most cases with Stage IV disease do not die due to distant metastases, but rather as a result of local extension into and around the urinary bladder, causing ureteral obstruction, pyelonephritis and uremia as seen in our index case who also had distant metastases to the duodenum.
Carcinoma of the cervix usually spreads in an orderly and predictable fashion . The earliest and most common metastases are by direct extension to the contiguous structures including the vagina, peritoneum, urinary bladder, ureters, rectum and paracervical tissue ; however, distant metastatic spread with unusual patterns such as pulmonary lymphangitic carcinomatosis have also been reported . Up to 50% of Stage IV patients can present with distant metastases . Common sites of such occurrences are the liver, lungs, and bone marrow. The gastrointestinal tract is involved in approximately 8% of patients with carcinoma of the cervix; these being commonly found in the rectosigmoid as a result of local extension . Gastric lesions are identified in less than 2% of patients with carcinoma of the cervix, and are usually asymptomatic . Isolated metastases to the small bowel are exceedingly rare. Such spread is believed to occur commonly through the lymphatics, usually the para-aortic (as presumed in our case) or mesenteric nodes to the bowel's serosa and less often via the blood stream or by peritoneal seedlings [3, 4, 7].
Neoplasms in the small bowel are rare, with a global incidence of less than 1.0 per 100 000 people . In the USA only 0.4% of all cancers are in the small bowel, making up 0.2% of all cancer-related deaths . Malignant tumors of the small bowel are unusual, and account for only 1-5% of all GI tract malignancies . Metastatic lesions to the small bowel are more common than primary lesions, and most commonly arise from malignant melanoma, carcinoma of the lung, genitourinary cancers, breast cancer, Kaposi's sarcoma, colonic and renal cell carcinomas [2, 14]. Adenocarcinoma is estimated to account for 35-50% of small bowel tumors, with up to 20-40% being carcinoids and 14% being lymphomas . Interestingly, the distribution of the metastases in the small bowel correlates with the histopathological tumour subtype: adenocarcinomas are predominantly located in the duodenum and proximal jejunum while lymphomas and carcinoids are more frequently located in the jejunum or ileum while sarcomas are seen through the entire small bowel [13, 14]. The most common presenting symptom of small bowel lesions is a partial or complete bowel obstruction and less commonly, bowel perforation, persistent abdominal pain, or hemorrhage(overt or occult) [3, 7]. Malignancy only accounts for 1-4% of upper GI bleeds as hemorrhage is more common in benign tumors .
It remains puzzling why small-bowel metastases are such rare events, even though anatomically the small intestine makes up 75% of the length and 90% of the absorptive surface of the esophagogastrointestinal system [1, 13]. Several mechanisms have been identified by which metastases to the small bowel can occur. These include peritoneal dissemination, direct spread from an intra-abdominal malignancy, haematogenous and by lymphatic spread [3, 4, 7]. Recognition of the paucity of neoplasms metastasizing to the small bowel has prompted many theories of antitumor mechanisms that may be involved in the innate local micro-environmental protection in the small intestine [1, 13–16]. These theories include:
A. Motility and Rapid Transit Time
Unlike the solid feces passing through the colon, chyme of the small intestine is liquefied, causing less mucosal irritation and reducing mechanical trauma. Additionally, transit through the small intestine is more rapid than through the large intestine, thereby shortening the exposure of potential carcinogens in the chyme to the mucosal surface.
B. Immune Features
Immune protection is abundant through the small intestine, with numerous lymphoid cells in the mucosa and submucosa. Further, the small bowel is responsible for large secretions of IgA, an antibody intimately involved in mucosal protection. Compared to the rest of the population, patients on immunosuppressive agents have an increased risk of tumorigenesis in the small bowel. Additionally, immunological abnormalities such as IgA deficiency, Crohn's and celiac disease have a greater propensity for the development of small bowel tumors.
C. Intraluminal Microbial Ecosystem
As the bacterial counts in the small bowel are absent or considerably lower than the large bowel, there is minimal exposure to the potentially carcinogenic chemical products of bacterial breakdown. Additionally, the relative intraluminal alkalinity of the small bowel can prevent the formation of potentially carcinogenic nitrosamines. Furthermore, the small bowel contains benzopyrene hydroxylase and other tumor-inhibiting components that may aid in neutralizing carcinogens.
D. Intraluminal environment
It is estimated that every sixteen minutes, one gram of small intestinal mucosa is replaced, and the entire mucosal layer including the absorptive, glandular, and neuroendocrine cells is restored every 4-7 days. Such high turnaround of mucosal cells is probably incompatible with the "critical cell mass" required for tumorigenesis. Liquefied chyme in the small bowel may act as a mucosal barrier to potential carcinogens. Additionally, small bowel stem cells are well protected as they are buried deep within the crypts.
A detailed review of the published English literature yielded only six cases of squamous cell carcinoma of the cervix with documented metastases to the small bowel (Table 1). The most common site of metastases was the ileum (3 cases) followed by the duodenum (2 cases) and the jejunum (1 case). Indirect small bowel involvement was also noted by Ewing et al, who reported metastases to the paraaortic lymph nodes causing a high level complete duodenal obstruction with massive gastric dilatation caused by recurrent cervical cancer . Varied times between the primary and the manifestation of metastatic lesions is reported in the literature ranging from being synchronous [3, 7] to metachronous with a delayed time interval ranging from 2-13 years [4, 5]. Clinical presentations reported, though varied, do not describe overt upper gastrointestinal bleed as seen in our index case. The overall long term prognosis of cases with duodenal metastases is extremely poor as it probably indicates disseminated disease. This is further compounded by delayed diagnosis of these unusual lesions [2, 14].
In conclusion, duodenal metastasis from SCC of the cervix is an extremely uncommon 'malignant' cause of upper gastrointestinal bleeding. Yet, accurate recognition of such unusual patterns of metastases in cervical cancer by histopathology is vital for best practice therapeutic decisions in these patients.
Conflict of interest
The authors declare no conflicts of interest.
- Schottenfeld D, Beebe-Dimmer JL, Vigneau FD: The Epidemiology and Pathogenesis of Neoplasia in the Small Intestine. AEP. 2009, 19 (1): 58-69.PubMed CentralPubMedGoogle Scholar
- Kanthan R, Gomez D, Senger JL, Kanthan SC: Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review. J Clin Pathol. 2010, 63: 921-5. 10.1136/jcp.2010.081000.View ArticlePubMedGoogle Scholar
- Gurian L, Ireland K, Petty W, Katon R: Carcinoma of the Cervix Involving the Duodenum: Case Report and Review of the Literature. J Clin Gastroenterol. 1981, 3: 291-4. 10.1097/00004836-198109000-00015.View ArticlePubMedGoogle Scholar
- Misonou J, Natori T, Aizawa M, Jou B, Tamaki A, Ogasawara M: Stage (Ia) Cervical Cancer Recurring 13 years after hysterectomy and causing small intestinal perforation: a Case Report with a Review of the Literature. Acta Pathol Jpn. 1988, 38 (2): 225-34.PubMedGoogle Scholar
- Christopherson W, Voet R, Buchsbaum HJ: Recurrent Cervical Cancer Presenting as Small Bowel Obstruction. Gynecologic Oncology. 1985, 22: 109-114. 10.1016/0090-8258(85)90014-9.View ArticlePubMedGoogle Scholar
- Hulecki SJ, Klein FA, Davis JE: Squamous Cell Carcinoma of Cervix Metastatic to Ileal Loop. Urology. 1985, 26 (8): 579-60.View ArticlePubMedGoogle Scholar
- Mathur SK, Pandya GP: Solitary metastatic malignant stricture of the ileum: a rare cause of small bowel obstruction (a case report). J Postgrad Med. 1984, 30: 186-PubMedGoogle Scholar
- Lee TH, Park SH, Lee CK, Lee SH, Chung IK, Kim SJ, Kim SW: Ampulla of Vater Metastasis from Recurrent Uterine Cervix Carcinoma Presenting as Groove Pancreatitis. Gastrointestinal Endoscopy. 2011, 73 (2): 362-3. 10.1016/j.gie.2010.08.001.View ArticlePubMedGoogle Scholar
- Ewing TL, Tunca JC: An Unusual Case of Complete Duodenal Obstruction with Massive Stomach Dilatation Caused by Recurrent Cervical Cancer. Gynecologic Oncology. 1981, 11: 126-8. 10.1016/0090-8258(81)90019-6.View ArticlePubMedGoogle Scholar
- Chaturvedi AK, Kleinerman RA, Hidesheim A, Gilbert ES, Storm H, Lynch CF: Second Cancers after Squamous Cell Carcinoma and Adenocarcinoma of the Cervix. Journal of Clinical Oncology. 2009, 27 (6): 967-73. 10.1200/JCO.2008.18.4549.PubMed CentralView ArticlePubMedGoogle Scholar
- Waggoner SE: Cervical cancer. The Lancet. 2003, 361: 2217-25. 10.1016/S0140-6736(03)13778-6.View ArticleGoogle Scholar
- Kanthan R, Senger JLB, Diudea D: Pulmonary Lymphangitic Carcinomatosis from Squamous Cell Carcinoma of the Cervix. WJSO. 2010, 8: 107-Google Scholar
- Torres M, Matta E, Chinea B, Dueno MI, Martinez-Souss J, Ojeda A, Vega W, Toro DH: Malignant Tumors of the Small Intestine. J Clin Gastroenterol. 2003, 37 (5): 372-80. 10.1097/00004836-200311000-00005.View ArticlePubMedGoogle Scholar
- Loualidi A, Spooren PFMJ, Grubben MJAL, Blomjous CEM, Goey SH: Duodenal metastasis: an uncommon cause of occult small intestinal bleeding. The Netherlands Journal of Medicine. 2004, 62 (6): 201-5.PubMedGoogle Scholar
- Kariv R, Arber N: Malignant Tumors of the Small Intestine - New Insights into a Rare Disease. IMAJ. 2003, 5: 188-92.PubMedGoogle Scholar
- Calman KC: Why are small bowel tumours rare? An experimental model. Gut. 1974, 15: 552-4. 10.1136/gut.15.7.552.PubMed CentralView ArticlePubMedGoogle Scholar
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