Surgical management of mediastinal liposarcoma extending from hypopharynx to carina: Case report
© Gethin-Jones et al; licensee BioMed Central Ltd. 2010
Received: 13 November 2009
Accepted: 2 March 2010
Published: 2 March 2010
We describe the complete resection of a giant, well-differentiated mediastinal liposarcoma extending retropharynx to envelop the aortic arch, trachea and esophagus following preoperative radiotherapy.
Liposarcomas represent only 1% of all malignancies and are commonly found in the lower limbs and retroperitoneum . Rarely are liposarcomas found in the mediastinum and, of all primary mediastinal sarcomas only 9% are liposarcomas . Several reports suggest radiation and chemotherapy without surgical resection are ineffective treatments for mediastinal liposarcoma despite often daunting preoperative imaging [1, 3]. In this case we report on the surgical resection of a large primary mediastinal liposarcoma by sternotomy.
In the literature, less than 150 cases of primary mediastinal liposarcomas have been reported [1, 4] and because of their rarity, there is no consistent approach to management. Warranting further study, radiology and chemotherapy alone seem to be insufficient forms of treatment but are possibly effective as induction or adjuvant therapies [1, 2, 5]. When determining if surgical intervention is feasible, radiographic films, given the complex anatomy of the mediastinum, can be daunting. However, given the often encapsulated nature of the lesions, complete resection is often possible and debulking can lead to symptomatic relief and often a long-term solution in well-differentiated tumors.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Barbetakis N, Samanidis G, Samanidou E, Kirodimos E, Kiziridou A, Bischiniotis T, Tsilikas C: Primary mediastinal liposarcoma: a case report. J of Medical Case Reports. 2007, 1: 161-10.1186/1752-1947-1-161.View ArticleGoogle Scholar
- Burt M, Ihde JK, Hajdu SI, Smith JW, Bains MS, Downey R, Martini N, Rusch VW, Ginsberg RJ: Primary sarcomas of the mediastinum: results of therapy. J Thorac Cardiovasc Surg. 1998, 115 (3): 671-80. 10.1016/S0022-5223(98)70333-2.View ArticlePubMedGoogle Scholar
- Ohta Y, Murata T, Tamura M, Sato H, Kurumaya H, Katayanagi K: Surgical resection of recurrent bilateral mediastinal liposarcoma through the clamshell approach. Ann Thorac Surg. 2004, 77: 1837-1839. 10.1016/S0003-4975(03)01242-6.View ArticlePubMedGoogle Scholar
- Vega AR, Muthuswamy MR: Primary mediastinal liposarcoma: case report and review of the literature. Chest. 2006, 130 (4): 334S-Google Scholar
- Munden RF, Nesbitt JC, Kemp BL, Chasen MH, Whitman GJ: Primary liposarcoma of the mediastinum. AJR Am J Roentgenol. 2000, 175: 1340-View ArticlePubMedGoogle Scholar
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