- Open Access
Synchronous colorectal neoplasias: our experience about laparoscopic-TEM combined treatment
© Spizzirri et al; licensee BioMed Central Ltd. 2010
Received: 1 March 2009
Accepted: 25 November 2010
Published: 25 November 2010
Synchronous colorectal neoplasias are defined as 2 or more primary tumors identified in the same patient and at the same time. The most voluminous synchronous cancer is called "first primitive" or "index" cancer. The aim of this work is to describe our experience of minimally invasive approach in patients with synchronous colorectal neoplasias.
Since January 2001 till December 2009, 557 patients underwent colectomy for colorectal cancer at the Department of General and Emergency Surgery of the University of Perugia; 128 were right colon cancers, 195 were left colon cancers while 234 patients were affected by rectal cancers. We performed 224 laparoscopic colectomies (112 right, 67 left colectomies and 45 anterior resections of rectum), 91 Transanal Endoscopic Microsurgical Excisions (TEM) and 53 Trans Anal Excisions (TAE). In the same observation period 6 patients, 4 males and 2 females, were diagnosed with synchronous colorectal neoplasias. Minimal invasive treatment of colorectal cancer offers the opportunity to treat two different neoplastic lesions at the same time, with a shorter post-operative hospitalization and minor complications. According to our experience, laparoscopy and TEM may ease the treatment of synchronous diseases with a lower morbidity rate.
Synchronous colorectal neoplasias, defined as 2 or more primary tumors identified in the same patient and at the same time, are caused by common genetic and environmental factors . Since intraoperative palpation can miss up to 69% of the SN , currently, synchronous neoplastic lesions are usually diagnosed at a preoperative staging by colonoscopy or virtual colonoscopy; according to data from literature, 3% of the patients with SN are affected by different types of malignant lesions  while 33-55% show villous adenomas [4, 5]. Literature also confirms the presence of primitive synchronous cancers ; malignant synchronous lesions are very rare, showing the following incidence: between 0,17% and 0,69% in case of 2-3 synchronous lesions, 0,19% in case of 4-5 synchronous lesions .
The most voluminous synchronous cancer is called "first primitive" or "index" cancer. When the index cancer is located in the caecum, the incidence of left colon synchronous cancers is higher than when the index cancer is located in the left colon [8, 9].
Colorectal adenomas standard treatment is usually represented by endoscopic polypectomy; indeed only 5% of synchronous colorectal lesions require a surgical treatment .
When a villous adenoma or a T1 cancer is situated in the middle-lower rectum it is possible to perform a different surgical approach through a transanal endoscopic microsurgery (TEM) followed by a laparoscopic colectomy; this treatment can also be assessed in a reverse order. Firstly it is important to remove the obstructing lesion which can cause intestinal occlusion and later any other lesion, both malignant and benign ones. Multiple cancers patients show a worse prognosis compared to patients affected by single neoplastic lesions (5 year-survival rate incidence of 55%) .
The aim of this work is to describe our experience of minimally invasive approach in patients with synchronous colorectal neoplasias.
Materials and methods
Since January 2001 till December 2009, 557 patients underwent colectomy for colorectal cancer at the Department of General and Emergency Surgery of the University of Perugia; 128 were right colon cancers, 195 were left colon cancers while 234 patients were affected by rectal cancers. We performed 224 laparoscopic colectomies (112 right, 67 left colectomies and 45 anterior resections of rectum), 91 Transanal Endoscopic Microsurgical Excisions (TEM) and 53 Trans Anal Excisions (TAE).
In the same observation period 6 patients, 4 males and 2 females, were diagnosed with synchronous colorectal neoplasias; 3 of them had no comorbility while the others were affected by hypertension (2 males and 1 female). Median age was 67.
1 patient showed a T1 rectal cancer associated with a voluminous sessile right colon adenoma;
3 patients were affected by voluminous rectal adenomas associated with colon cancers (2 right and 1 left colon cancers);
2 patients showed a rectal sessile adenoma associated with a voluminous villous right colon adenoma. (Table 1)
Transmission electron microscopy results
All patients underwent an endoscopic examination with biopsy. Virtual colonoscopy was required just in one case. A voluminous rectal sessile adenoma, whose size was larger than 4 cm, could not be removed by endoscopic excision. All patients underwent abdominal and chest CT scan. All the patients' rectal neoplasias were evaluated through transanal endoscopy and all of them were described as submucosal lesions. Three lesions were located on the posterior rectal wall, 2 on the anterior wall and 1 lesion was located on the left lateral rectal wall.
One patient underwent TEM for the rectal lesion, followed by a laparoscopic right hemicolectomy for the voluminous villous adenoma.
Two patients underwent a laparoscopic right hemicolectomy followed by TEM for a voluminous villous adenoma.
The patient affected by left colon cancer associated with a voluminous villous rectal adenoma, underwent TEM followed by a laparoscopic left hemicolectomy. We decided to perform the endoscopic approach before the left hemicolectomy because of the large rectal tumor size, in order to ease the circular mechanical stapler transit. In this patient we decided to perform a left colectomy instead of an anterior resection of the rectum because the cancer was proximal and we avoided a larger resection.
Two patients with rectal and right colon adenomas underwent TEM and a laparoscopic right hemicolectomy.
Each TEM procedure was performed using the full-thickness-excision technique considering the adenoma as a potential malignant lesion.
Median TEM operating time was 70 minutes, while laparoscopic resection required a mean time of 205 min. Intraoperative blood loss was modest for all patients. The most evident loss was approximately 300 cc in one of the patients undergoing a right hemicolectomy. Postoperative haemoglobin values were constant, ranging between 13,7 g/dl and 12,6 g/dl. We didn't register any complication either during the operative or postoperative time, but only one patient showed a modest hematochezia following a TEM procedure, which stopped spontaneously on the 3rd postoperative day.
The high incidence of colorectal tumors leaded to the need for new surgical approaches. Till the Seventies, a preoperative diagnosis of synchronous colorectal cancers was quite rare (1.6%-4.3%), being mostly assessed by intraoperative bowel manipulation or accidentally [12–16].
* Preoperative examinations of lesions
Rectal cancer (I)
Right emicolectomy for adenoma(II)
Rectal adenoma (II)
Right emicolectomy for cancer(I)
Rectal adenoma (I)
Left emicolectomy for cancer (II)
Rectal adenoma (I)
Right emicolectomy for adenoma (II)
A complete pre-operative study with colonoscopy or virtual colonoscopy is always necessary to perform a diagnostic evaluation of colon-rectum, allowing to detect the presence of synchronous lesions.
Colonoscopy is the most appropriate mean of investigation for colorectal cancer, but it cannot be performed in case of obstructive neoplastic lesions or in case of megacolon. In both cases either a double contrast barium enema, a virtual colonoscopy or an intraoperative colonoscopy [24, 25] can be performed.
The recent employment of virtual colonoscopy has allowed an accurate study of the colonic segments upstream the stenosis . Synchronous colon neoplastic lesions treatment is well known. Preoperative evaluation is very important especially when a laparoscopic approach is going to be performed, as the bowel cannot be palpated [27–29]. The treatment of synchronous colorectal neoplastic lesions can sometimes be complicated; for example, in case of neoplastic lesions in contiguous intestinal segments, such as the right and transverse colon or the left colon and rectum, it is necessary to perform an enlarged right hemicolectomy or an anterior resection of the rectum. In case of neoplastic lesions in distant colic segments, the employment of TEM reduces the probability of an anterior resection of the rectum.
The recent employment of TEM has reduced the need to perform an anterior resection of the rectum when tumors are located in two different and distant colonic segments. In case of right or transverse colon cancers associated with an extraperitoneal rectal cancer, a decrease of both laparoscopic and open total colectomy associated with a right anterior resection of the rectum has been registered [30, 31].
In case of voluminous rectal adenomas or extra peritoneal T1 rectal cancers, a transanal local exeresis could be performed. In 1983 Buess performed TEM for neoplastic lesions whose diameter was smaller than 25% of the entire bowel circumference and without lymphonodal infiltration [32–34].
In literature, a sequential employment of TEM and laparoscopic resection of synchronous colorectal malignant lesions is described by Ikeda . This mini-invasive approach allows a significant rectum sparing.
Results and conclusions
Our experience showed that the combination of TEM and laparoscopic hemicolectomy was characterized by an uncomplicated post-operative time. The current disease free survival is 83% (1/6) as one of the patients with right colon carcinoma was diagnosed with a singular liver metastasis 3 years after the first surgical approach. We also registered no complication compared to the standard transanal resection with a significant reduction of both the hospital stay and the complication rates compared to conventional anterior resection of rectum.
Definitive histological diagnoses
High grade dysplasia
1) Low grade dysplasia
2) Low grade dysplasia
1) B1 (carcinoma)
2) B2 (carcinoma)
Low grade dysplasia
1)Low grade dysplasia
2) Low grade dysplasia
1) High grade dysplasia
2) High grade dysplasia with focus of adenocarcinoma
All the resection margins were disease free.
Minimal invasive treatment of colorectal cancer offers the opportunity to treat two different neoplastic lesions at the same time, with a shorter post-operative hospitalization and minor complications. According to our experience, laparoscopy and TEM may ease the treatment of synchronous diseases with a lower morbidity rate. Our aim is to increase the observed number of cases in order to minimize the complications and obtain better results.
- Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology. 2009, 137 (5): 1609-20. 10.1053/j.gastro.2009.08.002. e1-3. Epub 2009 Aug 14PubMed CentralView ArticlePubMedGoogle Scholar
- Achiam MP, Burgdorf SK, Wilhelmsen M, Alamili M, Rosenberg J: Inadequate preoperative colonic evaluation for synchronous colorectal cancer. Scand J Surg. 2009, 98 (1): 62-7.PubMedGoogle Scholar
- Phillips RKS: Rectal cancer. Colorectal surgery. Edited by: Phillips RKS. 2005, Elsevier Saunders, Philadelphia, 67-82.Google Scholar
- Corman ML: carcinoma of the rectum. Colon & Rectal Surgery. Edited by: Corman ML. 1998, Lippincott-Raven, Philadelphia, 733-862.Google Scholar
- Thorson AG, Christensen MA, Davis SJ: The role of colonoscopy in the assessment of patients with colorectal cancer. Dis Colon Rectum. 1986, 29: 306-11. 10.1007/BF02554117.View ArticlePubMedGoogle Scholar
- Avonts-Avontis K: Multiple colorectal tumors. Surg Clin North Am. 1987, 66: 857-65.Google Scholar
- Lasser A: Synchronous primary adenocarcinomas of the colon and rectum. Dis Colon Rectum. 1978, 21: 20-2. 10.1007/BF02586540.View ArticlePubMedGoogle Scholar
- Kalus R, Welch JP: Quintuple synchronous colon carcinoma: a report of two cases. Jsurg Oncol. 1986, 32: 55-7. 10.1002/jso.2930320115.View ArticleGoogle Scholar
- Chen HS, Sheen-Chen SM: Synchronous and early metachronous colorectal adenocarcinoma:analysis of prognosis and current trends. Dis Colon rectum. 2000, 43: 1093-9. 10.1007/BF02236556.View ArticlePubMedGoogle Scholar
- Nicholls RJ: Surgery for rectal carcinoma. Surgery of the colon & Rectum. Edited by: Nicholls RJ. 1997, Churchill Livingstone, New York, 427-74.Google Scholar
- Moreaux J, Catala M: Multiple cancers of the colon and rectum. Incidence and results of surgical treatment. Gastroenterol Clin Biol. 1985, 9: 336-41.PubMedGoogle Scholar
- Heald RH, Bussey HJR: Clinical experience at St. Mark's Hospital with multiple synchronous cancers of colon and rectum. Dis Colon Rectum. 1975, 18: 6-10. 10.1007/BF02587230.View ArticlePubMedGoogle Scholar
- Travieso CR, Knoepp LF, Hanley PH: Multiple adenocarcinoma of the colon and rectum. Dis Colon Rectum. 1972, 15: 1-6. 10.1007/BF02587659.View ArticlePubMedGoogle Scholar
- Brindley GV, Rice JS: Multiple primary malignancies of the large intestine. Surg Clin North Am. 1952, 32: 1399-1509.Google Scholar
- Moertel CG, Bargen A, Dockerty MB: Multiple carcinoma of the large intestine. Gastroenterology. 1958, 34: 85-98.PubMedGoogle Scholar
- Welch JP: Multiple colorectal tumors. Am Jsurg. 1981, 142: 274-80. 10.1016/0002-9610(81)90292-0.View ArticleGoogle Scholar
- Rielly JC, Rusin LC, Theuerkauf FJ: Colonscopy: its role in cancer of colon and rectum. Dis Colon Rectum. 1982, 25: 532-8. 10.1007/BF02564161.View ArticleGoogle Scholar
- Cunliffe WJ, Halsleton PS, Tweedle DEF: Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg. 1984, 71: 941-3. 10.1002/bjs.1800711210.View ArticlePubMedGoogle Scholar
- Langevin JM, Nivatvongs S: The true incidence of synchronous cancer of the large bowel. Am J Surg. 1984, 147: 330-3. 10.1016/0002-9610(84)90161-2.View ArticlePubMedGoogle Scholar
- Evers BM, Mullins RJ, Mathewes TH, Broghamer WL, Polk HC: Multiple adenocarcinomas of the colon and rectum. An analysis of incidences and current trends. Dis Colon Rectum. 1988, 31: 518-22. 10.1007/BF02553724.View ArticlePubMedGoogle Scholar
- Fegiz G, Ramacciato G, Indinnimeo M, Gozzo P, Valabrega S, De Angelis R, Barillari P: Synchronous large bowel cancer: a series of 47 cases. Ital J Surg Sci. 1989, 19: 23-8.PubMedGoogle Scholar
- Nikoloudis N, Saliangas K, Economou A, Andreadis E, Siminou S, Manna l, Georgakis K, Chrissidis T: Synchronous colorectal cancer. Tech Coloproctol. 2004, 177-9. 10.1007/s10151-004-0149-2. Suppl 1Google Scholar
- Takeuchi H, Toda T, Nagasaki S, Kawano T, Minamisono Y, Maehara Y, Sugimachi K: Synchronous multiple colorectal adenocarcinomas. J Surg Oncol. 1997, 64: 304-7. 10.1002/(SICI)1096-9098(199704)64:4<304::AID-JSO10>3.0.CO;2-2.View ArticlePubMedGoogle Scholar
- Kuramoto S, Ihara O, Sakai S, Tsuchiya T, Oohara T: Intraoperative colonoscopy in the detection of non palpable colonic lesions -how to identify the affected bowel segment. Surg Endosc. 1988, 2: 76-80. 10.1007/BF00704357.View ArticlePubMedGoogle Scholar
- Kaibara N, Kimura O, Nishidoi H, Miyano Y, Koga S: Intraoperative colonoscopy for the diagnosis of multiple cancers of the large intestine. Jpn J Surg. 1982, 12: 117-21. 10.1007/BF02469378.View ArticlePubMedGoogle Scholar
- Fenlon HM, McAneny DB, Nunes DP, Clarke PD, Ferrucci JT: Occlusive colon carcinoma: virtual colonoscopy in the preoperative evaluation of the proximal colon. Radiol. 1999, 210: 423-8.View ArticleGoogle Scholar
- McDermott JP, Devereaux DA, Caushaj PF: Pitfall of laparoscopic colectomy. An unrecognized synchronous cancer. Dis Colon Rectum. 1994, 37: 602-3. 10.1007/BF02050997.View ArticlePubMedGoogle Scholar
- Hojman D, Garriz RA, Markman I: Multiple malignant tumors of the colon and rectum. Dis Colon Rectum. 1966, 9: 121-6. 10.1007/BF02617314.View ArticlePubMedGoogle Scholar
- Caracino AM, Antonucci S, Tarone F: Synchronous carcinomas of the large intestine. Ann Ital Chir. 1994, 65: 229-31.PubMedGoogle Scholar
- Ng SS, Li JC, Lee JF, Yiu RY, Leung KL: Laparoscopic total colectomy for colorectal cancers: a comparative study. Surg Endosc. 2006, 20: 1193-6. 10.1007/s00464-005-0330-3.View ArticlePubMedGoogle Scholar
- Lacy AM, Garcia-valdecasas JC, Taura P, Bordas JM, Grande L, Fuster J, Cugat E, Visa J: Is laparoscopic colectomy a safe procedure in synchronous colorectal carcinoma? Report of a case. Surg Laparosc Endosc. 1995, 5: 75-6.PubMedGoogle Scholar
- Lauter DM, Lau ST, Lanzafame K: Combined laparoscopic assisted right hemicolectomy and low anterior resection for synchronous colorectal carcinomas. Surg Endosc. 2003, 17: 1498-10.1007/s00464-002-4534-5.View ArticlePubMedGoogle Scholar
- Stipa F, Stipa S: Microchirugia endoscopica transanale. Encycl Méd Chir, Tecniche Chirurgiche -addominali. 2002, 40-706. 1-9Google Scholar
- Guerrieri M, Baldarelli M, Morino M, Trompetto M, Da Rold A, Selmi I, Allaix ME, Lezoche G, Lezoche E: Transanal endoscopic microsurgery in rectal adenomas: experience of six italian centers. Dig Liver Dis. 2006, 38: 202-7. 10.1016/j.dld.2005.11.014.View ArticlePubMedGoogle Scholar
- Ikeda Y, Koyanagi N, Mori M, Akahoshi K, Ueyama T, Sugimachi K: Transanal endoscopic microsurgery for T1 rectal cancer in patients with synchronous colorectal cancer. Surg End. 1999, 13: 710-12. 10.1007/s004649901078.View ArticleGoogle Scholar
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