Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
© Glockzin et al; licensee BioMed Central Ltd. 2009
Received: 09 October 2008
Accepted: 08 January 2009
Published: 08 January 2009
Peritoneal tumor dissemination arising from colorectal cancer, appendiceal cancer, gastric cancer, gynecologic malignancies or peritoneal mesothelioma is a common sign of advanced tumor stage or disease recurrence and mostly associated with poor prognosis.
Methods and results
In the present review article preoperative workup, surgical technique, postoperative morbidity and mortality rates, oncological outcome and quality of life after CRS and HIPEC are reported regarding the different tumor entities.
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide a promising combined treatment strategy for selected patients with peritoneal carcinomatosis that can improve patient survival and quality of life. The extent of intraperitoneal tumor dissemination and the completeness of cytoreduction are the leading predictors of postoperative patient outcome. Thus, consistent preoperative diagnostics and patient selection are crucial to obtain a complete macroscopic cytoreduction (CCR-0/1).
Peritoneal carcinomatosis is a common sign of advanced tumor stage, disease progression or recurrence in numerous tumor entities of gastrointestinal or gynecological origin. Moreover, there are primary peritoneal malignancies such as malignant peritoneal mesothelioma or primary peritoneal carcinoma. In general, the diagnosis of peritoneal tumor manifestation is associated with poor prognosis. In the European multicenter EVOCAPE I study the median survival rates were 5.2 months for advanced colorectal cancer (CRC, n = 118) and 3.1 months for advanced gastric cancer (GC, n = 125), respectively. The median survival rate in patients with stage IV ovarian cancer (OC) range from 12 to 23 months [2–4]. For diffuse malignant peritoneal mesothelioma (DMPM) median survival rates of less than one year are reported in most existing studies [5–7]. However, in a Phase II trial with systemic application of permetrexed and gemcitabine the median survival rate was 26.8 months in patients with malignant peritoneal mesothelioma . The treatment of choice for patients with peritoneal surface malignancies is palliative systemic chemotherapy. In the past, surgery was performed in palliative intention for prevention or therapy of tumor-related complications such as gastrointestinal obstruction, bleeding or tumor perforation . Solely, in ovarian cancer cytoreductive surgery was already established as an inherent part of the standard treatment regimen . In the early 1990's Sugarbaker et al. introduced cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as a new innovative therapeutic option for selected patients with peritoneal carcinomatosis [11, 12]. Over the years peritoneal carcinomatosis treatment centers were established in the United States, Europe and Japan. Feasibility, efficacy and safety of CRS and HIPEC have been proved in numerous clinical trials. In the present review article patient selection, treatment strategy, mortality and morbidity rates and oncological outcome is reported regarding the different tumor entities.
Hyperthermic intraperitoneal chemotherapy
In case of complete macroscopic cytoreduction (CCR-0/1) CRS is followed by hyperthermic intraperitoneal chemotherapy (HIPEC). The theoretical advantage of the intraperitoneal distribution of cytostatics is a high local concentration of the used agents and reduced systemic toxicity. In vitro studies could show that hyperthermia may potentiate the cytostatic effects. For example an improved tissue penetration could be shown for cisplatin. Moreover, hyperthermia leads to direct cytotoxic effects such as protein denaturation, induction of apoptosis and inhibition of angiogenesis .
Selected studies with CRS and HIPEC in patients with peritoneal carcinomatosis of different origin.
Di Giorgio, 2008
Preoperative diagnostics and patient selection
Preoperative diagnostic workup.
Essential preoperative diagnostics
Laboratory testing incl. tumor markers
Computed tomography (CT) of the chest, abdomen and pelvis with oral, rectal and intravenous contrast
Tumor-specific essential diagnostics
CRC: complete colonoscopy
Useful additional diagnostics (case-dependent)
Magnetic resonance imaging (MRI)
Positron emission tomography (PET)/PET-CT
Morbidity and mortality
In the literature morbidity and mortality rates after CRS and HIPEC range from 25% to 41% and from 0% to 8%, respectively (Table 1) [25–38]. Morbidity can be divided in surgery-related and chemotherapy-related complications. Common surgery-related complications are for example postoperative ileus, anastomotic leakage, wound infection, bleeding, thrombosis and lung embolism. The different cytostatic agents used for HIPEC can lead to leucopenia, anemia, thrombopenia, heart, liver or renal toxicity and other side effects.
In a prospective study of 70 patients with DMPM Yan et al. found primary colonic anastomosis, more than four peritonectomy procedures (total anterior parietal peritonectomy, greater omentectomy/splenectomy, subphrenic peritonectomy, pelvic peritonectomy, lesser omentectomy/cholecystectomy) and operating time greater than 7 hours to be associated with grade IV morbidity . The grade III and IV morbidity rate were 27% and 14%, respectively. The perioperative mortality rate was 3%. Hansson et al. analyzed 123 patients treated with CRS and HIPEC for peritoneal carcinomatosis . The grade III/IV morbidity rate and the treatment-related mortality rate were 41% and 4%, respectively. Bowel morbidity was associated with electroevaporation or excision of tumor nodes on the small bowel surface. In conclusion, morbitity rates after CRS and HIPEC are relatively high but comparable to other major gastrointestinal surgery. However, in the existing studies the assessment of morbidity is not standardized and therefore often not comparable. Thus, following the consensus statement from Milan in further studies the classification system CTCAE version 3.0 should be used. Morbidity is classified in minor complications (grade 0 to 2) and major complications (grade 3 to 5). Moreover, the classification system includes 28 categories leading to an efficient assessment of morbidity .
Several studies have shown that CRS and HIPEC as an integrative part of an interdisciplinary cancer treatment concept may improve survival of patients with peritoneal dissemination of different tumor entities such as colorectal cancer (CRC), gastric cancer (GC), ovarian cancer (OC) and diffuse malignant peritoneal mesothelioma (DMPM) (Table 1).
There are two prospective randomized controlled trials (RCT), one non-randomized comparative study and numerous observational studies regarding clinical and oncologiocal outcome of patients with peritoneal carcinomatosis arising from CRC. Verwaal et al. reported a disease-specific survival of 22.2 months after additional CRS and HIPEC vs. 12.6 months after standard systemic treatment with 5-FU and leucovorin [25, 41]. In patients with complete macroscopic cytoreduction (CCR-0/1) median survival was 48 months and 5-year survival rate was 45%, respectively. The second RCT was closed after inclusion of only 35 patients during a 4 year accrual period. The 2-year survival rates were 60% in both arms . In the comparative study published by Mahteme et al. the median survival in the HIPEC group was 32 months vs. 14 months in the control group. 5-year survival rates were 28% and 5% respectively . In the observational studies the overall median survival ranged from 15 to 32 months and from 28 to 60 months after complete macroscopic cytoreduction (CCR0-1), respectively .
The prognosis of patients with peritoneal tumor dissemination from GC is poor but could be significantly improved by CRS and HIPEC in selected patients. Six observational studies including between 17 and 154 patients showed median survival rates ranging from 10 to 19 months [28–31, 44, 45]. The 5-year survival rates after complete macroscopic cytoreduction (CCR-0/1) were 21%, 27%, 29%, 31% and 32%, respectively. Yonemura et al. could show in a multivariate analysis that the completeness of cytoreduction is a highly significant factor for the prediction of patient survival. Moreover, low PCI as well as P1/P2 using the Japanese classification or stage I/II using the Lyon classification indicating limited extent of peritoneal tumor dissemination were associated with better prognosis .
Cytoreductive surgery has already been shown to improve survival of patients with stage III and IV ovarian cancer previous to introduction of the combined treatment concept with CRS and HIPEC . Nevertheless, further improvement of long-term survival is reported for CRS and HIPEC in selected patients. In several studies the median survival rates range from 28 to 46 months and 5-year survival rates from 15 to 50% .
DMPM is a rare disease with relatively low incidence. Thus, in the systemic review published by Yan et al. survival data of only seven studies including 12 to 100 patients are reported . In these studies median survival ranges between 34 and 92 months and the 5-year survival rates between 33% and 59%, respectively. All studies showed a significant improvement of survival compared to historical controls. Nevertheless, a prospective randomized controlled trial comparing the best available therapy – especially after introduction of permetrexed for the systemic treatment of DMPM – with or without CRS and HIPEC is still not available.
Quality of life after CRS and HIPEC
Despite relatively high morbidity rates and consecutive initial impairment of quality of life (QoL) several studies could show an improvement of QoL after CRS and HIPEC in long-term survivors [48–52]. McQuellon et al. reported an initial decrease of physical, functional and well-being scores with an increase relative to baseline levels during follow-up at 3, 6 and 12 months. One year after surgery 74% of the patients resumed > 50% of their normal activities . In another publication McQuellon et al. concluded that acceptable QoL, return of functional status and reduced pain can be attained 3 to 6 months after CRS and HIPEC. However, a significant number of patients show depressive symptoms at the time of surgery (32%) as well as one year after surgery (24%) . Schmidt et al. evaluated QoL after CRS and HIPEC in 67 patients with peritoneal carcinomatosis using the EORTC QLQ-C30 questionnaire. The mean score for global health status of long-term survivors was significantly decreased compared to the control population (62.6 vs. 73.3) showing particularly an impairment of role and social functioning . Tuttle et al. showed a return of QoL measurements to baseline 4 months after surgery in a prospective analysis of 35 patients. Eight and twelve months after CRS and HIPEC QoL was significantly improved . In conclusion, the existing studies show that CRS and HIPEC can be performed with acceptable postoperative QoL and even may improve QoL in a selected part of long-term survivors.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy provide a promising therapeutic option for highly selected patients with peritoneal carcinomatosis arising from different malignancies such as colorectal cancer, gastric cancer, ovarian cancer or peritoneal mesothelioma. Numerous studies with different levels of evidence have shown that the integration of CRS and HIPEC in an interdisciplinary treatment concept may improve the oncological outcome compared to sole palliative systemic chemotherapy. The completeness of cytoreduction plays a pivotal role for long-term survival. Thus, consequent preoperative diagnostic workup and patient selection is essential. The existing studies also show that the combined treatment concept can be performed with low mortality and acceptable morbidity in specialized centers. The rate of complications is influenced by the extent of surgery and the cytostatic agent used for intraperitoneal application and its concentration. The quality of life is initially impaired by surgery and postoperative complications. Nevertheless, the functional status returns to baseline in most patients during the first 4 moths after surgery. In selected patients QoL may even be improved one year or later after surgery.
However, for most tumor entities prospective randomized controlled trials comparing best available therapy using new therapeutic agents and combined systemic chemotherapy with and without CRS and HIPEC are still not available. Such studies may provide higher levels of evidence in the future and help to determine the significance of CRS and HIPEC as an integrative part of an interdisciplinary cancer treatment strategy in selected patients with peritoneal carcinomatosis.
- Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J, Fontaumard E, Brachet A, Caillot JL, Faure JL, Porcheron J, Peix JL, François Y, Vignal J, Gilly FN: Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000, 88: 358-363. 10.1002/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O.View ArticlePubMedGoogle Scholar
- Hardy JR, Wiltshaw E, Blake PR, Harper P, Slevin M, Perren TJ, Tan S: Cisplatin and carboplatin in combination for the treatment of stage IV ovarian carcinoma. Ann Oncol. 1991, 2: 131-136.View ArticlePubMedGoogle Scholar
- Curtin JP, Malik R, Venkatraman ES, Barakat RR, Hoskins WJ: Stage IV ovarian cancer: impact of surgical debulking. Gynecol Oncol. 1997, 64: 9-12. 10.1006/gyno.1996.4550.View ArticlePubMedGoogle Scholar
- Akahira JI, Yoshikawa H, Shimizu Y, Tsunematsu R, Hirakawa T, Kuramoto H, Shiromizu K, Kuzuya K, Kamura T, Kikuchi Y, Kodama S, Yamamoto K, Sato S: Prognostic factors of stage IV epithelial ovarian cancer: a multicenter retrospective study. Gynecol Oncol. 2001, 81: 398-403. 10.1006/gyno.2001.6172.View ArticlePubMedGoogle Scholar
- Yan TD, Brun EA, Cerruto CA, Haveric N, Chang D, Sugarbaker PH: Prognostic indicators for patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma. Ann Surg Oncol. 2007, 14: 41-49. 10.1245/s10434-006-9169-7.View ArticlePubMedGoogle Scholar
- Eltabbakh GH, Piver MS, Hempling RE, Recio FO, Intengen ME: Clinical picture, response to therapy, and survival of women with diffuse malignant peritoneal mesothelioma. J Surg Oncol. 1999, 70: 6-12. 10.1002/(SICI)1096-9098(199901)70:1<6::AID-JSO2>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Neumann V, Muller KM, Fischer M: [Peritoneal mesothelioma – incidence and etiology]. Pathologe. 1999, 20: 169-176. 10.1007/s002920050340.View ArticlePubMedGoogle Scholar
- Simon GR, Verschraegen CF, Jänne PA, Langer CJ, Dowlati A, Gadgeel SM, Kelly K, Kalemkerian GP, Traynor AM, Peng G, Gill J, Obasaju CK, Kindler HL: Pemetrexed plus gemcitabine as first-line chemotherapy for patients with peritoneal mesothelioma: final report of a phase II trial. J Clin Oncol. 2008, 26: 3567-3572. 10.1200/JCO.2007.15.2868.View ArticlePubMedGoogle Scholar
- Glockzin G, Ghali N, Lang SA, Agha A, Schlitt HJ, Piso P: [Peritoneal carcinomatosis. Surgical treatment, including hyperthermic intraperitoneal chemotherapy]. Chirurg. 2007, 78: 1102-1106. 10.1007/s00104-007-1419-0.View ArticleGoogle Scholar
- Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ: Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 2002, 20: 1248-1259. 10.1200/JCO.20.5.1248.View ArticlePubMedGoogle Scholar
- Sugarbaker PH, Cunliffe WJ, Belliveau J, de Bruijn EA, Graves T, Mullins RE, Schlag P: Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer. Semin Oncol. 1989, 16: 83-97.PubMedGoogle Scholar
- Sugarbaker PH: New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?. Lancet Oncol. 2006, 7: 69-76. 10.1016/S1470-2045(05)70539-8.View ArticlePubMedGoogle Scholar
- Jacquet P, Sugarbaker PH: Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res. 1996, 82: 359-374.View ArticlePubMedGoogle Scholar
- Glehen O, Gilly FN: Quantitative prognostic indicators of peritoneal surface malignancy: carcinomatosis, sarcomatosis, and peritoneal mesothelioma. Surg Oncol Clin N Am. 2003, 12: 649-671. 10.1016/S1055-3207(03)00037-1.View ArticlePubMedGoogle Scholar
- Sugarbaker PH: Laboratory and clinical basis for hyperthermia as a component of intracavitary chemotherapy. Int J Hyperthermia. 2007, 23: 431-442. 10.1080/02656730701455318.View ArticlePubMedGoogle Scholar
- Glehen O, Cotte E, Kusamura S, Deraco M, Baratti D, Passot G, Beaujard AC, Noel GF: Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion. J Surg Oncol. 2008, 98: 242-246. 10.1002/jso.21061.View ArticlePubMedGoogle Scholar
- Yan TD, Morris DL, Shigeki K, Dario B, Marcello D: Preoperative investigations in the management of peritoneal surface malignancy with cytoreductive surgery and perioperative intraperitoneal chemotherapy: Expert consensus statement. J Surg Oncol. 2008, 98: 224-227. 10.1002/jso.21069.View ArticlePubMedGoogle Scholar
- Deraco M, Bartlett D, Kusamura S, Baratti D: Consensus statement on peritoneal mesothelioma. J Surg Oncol. 2008, 98: 268-272. 10.1002/jso.21055.View ArticlePubMedGoogle Scholar
- Sugarbaker PH, Welch LS, Mohamed F, Glehen O: A review of peritoneal mesothelioma at the Washington Cancer Institute. Surg Oncol Clin N Am. 2003, 12: 605-621. 10.1016/S1055-3207(03)00045-0.View ArticlePubMedGoogle Scholar
- Esquivel J, Elias D, Baratti D, Kusamura S, Deraco M: Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination. J Surg Oncol. 2008, 98: 263-267. 10.1002/jso.21053.View ArticlePubMedGoogle Scholar
- Bozzetti F, Yu W, Baratti D, Kusamura S, Deraco M: Locoregional treatment of peritoneal carcinomatosis from gastric cancer. J Surg Oncol. 2008, 98: 273-276. 10.1002/jso.21052.View ArticlePubMedGoogle Scholar
- Moran B, Baratti D, Yan TD, Kusamura S, Deraco M: Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei). J Surg Oncol. 2008, 98: 277-282. 10.1002/jso.21054.View ArticlePubMedGoogle Scholar
- Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, Baratti D, Bartlett D, Barone R, Barrios P, Bieligk S, Bretcha-Boix P, Chang CK, Chu F, Chu Q, Daniel S, de Bree E, Deraco M, Dominguez-Parra L, Elias D, Flynn R, Foster J, Garofalo A, Gilly FN, Glehen O, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Goodman M, Gushchin V, Hanna N, Hartmann J, Harrison L, Hoefer R, Kane J, Kecmanovic D, Kelley S, Kuhn J, Lamont J, Lange J, Li B, Loggie B, Mahteme H, Mann G, Martin R, Misih RA, Moran B, Morris D, Onate-Ocana L, Petrelli N, Philippe G, Pingpank J, Pitroff A, Piso P, Quinones M, Riley L, Rutstein L, Saha S, Alrawi S, Sardi A, Schneebaum S, Shen P, Shibata D, Spellman J, Stojadinovic A, Stewart J, Torres-Melero J, Tuttle T, Verwaal V, Villar J, Wilkinson N, Younan R, Zeh H, Zoetmulder F, Sebbag G, Society of Surgical Oncology Annual Meeting: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007, 14: 128-133.View ArticlePubMedGoogle Scholar
- Helm CW, Bristow RE, Kusamura S, Baratti D, Deraco M: Hyperthermic intraperitoneal chemotherapy with and without cytoreductive surgery for epithelial ovarian cancer. J Surg Oncol. 2008, 98: 283-290. 10.1002/jso.21083.View ArticlePubMedGoogle Scholar
- Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA: Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 2003, 21: 3737-3743. 10.1200/JCO.2003.04.187.View ArticlePubMedGoogle Scholar
- Di Giorgio A, Naticchioni E, Biacchi D, Sibio S, Accarpio F, Rocco M, Tarquini S, Di Seri M, Ciardi A, Montruccoli D, Sammartino P: Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer. Cancer. 2008, 113: 315-325. 10.1002/cncr.23553.View ArticlePubMedGoogle Scholar
- Yan TD, Edwards G, Alderman R, Marquardt CE, Sugarbaker PH: Morbidity and mortality assessment of cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma – a prospective study of 70 consecutive cases. Ann Surg Oncol. 2007, 14: 515-525. 10.1245/s10434-006-9187-5.View ArticlePubMedGoogle Scholar
- Hirose K, Katayama K, Iida A, Yamaguchi A, Nakagawara G, Umeda S, Kusaka Y: Efficacy of continuous hyperthermic peritoneal perfusion for the prophylaxis and treatment of peritoneal metastasis of advanced gastric cancer: evaluation by multivariate regression analysis. Oncology. 1999, 57: 106-114. 10.1159/000012016.View ArticlePubMedGoogle Scholar
- Glehen O, Schreiber V, Cotte E, Sayag-Beaujard AC, Osinsky D, Freyer G, Francois Y, Vignal J, Gilly FN: Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising from gastric cancer. Arch Surg. 2004, 139: 20-26. 10.1001/archsurg.139.1.20.View ArticlePubMedGoogle Scholar
- Yonemura Y, Kawamura T, Bandou E, Takahashi S, Sawa T, Matsuki N: Treatment of peritoneal dissemination from gastric cancer by peritonectomy and chemohyperthermic peritoneal perfusion. Br J Surg. 2005, 92: 370-375. 10.1002/bjs.4695.View ArticlePubMedGoogle Scholar
- Cheong JH, Shen JY, Song CS, Hyung WJ, Shen JG, Choi SH, Noh SH: Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer. Ann Surg Oncol. 2007, 14: 61-68. 10.1245/s10434-006-9205-7.View ArticlePubMedGoogle Scholar
- Culliford AT, Brooks AD, Sharma S, Saltz LB, Schwartz GK, O'Reilly EM, Ilson DH, Kemeny NE, Kelsen DP, Guillem JG, Wong WD, Cohen AM, Paty PB: Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. Ann Surg Oncol. 2001, 8: 787-795. 10.1007/s10434-001-0787-9.View ArticlePubMedGoogle Scholar
- Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, Barone R, Yonemura Y, Cavaliere F, Quenet F, Gutman M, Tentes AA, Lorimier G, Bernard JL, Bereder JM, Porcheron J, Gomez-Portilla A, Shen P, Deraco M, Rat P: Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol. 2004, 22: 3284-3292. 10.1200/JCO.2004.10.012.View ArticlePubMedGoogle Scholar
- Shen P, Hawksworth J, Lovato J, Loggie BW, Geisinger KR, Fleming RA, Levine EA: Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis from nonappendiceal colorectal carcinoma. Ann Surg Oncol. 2004, 11: 178-186. 10.1245/ASO.2004.05.009.View ArticlePubMedGoogle Scholar
- Feldman AL, Libutti SK, Pingpank JF, Bartlett DL, Beresnev TH, Mavroukakis SM, Steinberg SM, Liewehr DJ, Kleiner DE, Alexander HR: Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. J Clin Oncol. 2003, 21: 4560-4567. 10.1200/JCO.2003.04.150.View ArticlePubMedGoogle Scholar
- Deraco M, Nonaka D, Baratti D, Casali P, Rosai J, Younan R, Salvatore A, Cabras Ad AD, Kusamura S: Prognostic analysis of clinicopathologic factors in 49 patients with diffuse malignant peritoneal mesothelioma treated with cytoreductive surgery and intraperitoneal hyperthermic perfusion. Ann Surg Oncol. 2006, 13: 229-237. 10.1245/ASO.2006.03.045.View ArticlePubMedGoogle Scholar
- Piso P, Dahlke MH, Loss M, Schlitt HJ: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from ovarian cancer. World J Surg Oncol. 2004, 2: 21-10.1186/1477-7819-2-21.PubMed CentralView ArticlePubMedGoogle Scholar
- Cotte E, Glehen O, Mohamed F, Lamy F, Falandry C, Golfier F, Gilly FN: Cytoreductive surgery and intraperitoneal chemo-hyperthermia for chemo-resistant and recurrent advanced epithelial ovarian cancer: prospective study of 81 patients. World J Surg. 2007, 31: 1813-1820. 10.1007/s00268-007-9146-8.View ArticlePubMedGoogle Scholar
- Hansson J, Graf W, Pahlman L, Nygren P, Mahteme H: Postoperative adverse events and long-term survival after cytoreductive surgery and intraperitoneal chemotherapy. Eur J Surg Oncol. 2008Google Scholar
- Younan R, Kusamura S, Baratti D, Cloutier AS, Deraco M: Morbidity, toxicity, and mortality classification systems in the local regional treatment of peritoneal surface malignancy. J Surg Oncol. 2008, 98: 253-257. 10.1002/jso.21057.View ArticlePubMedGoogle Scholar
- Verwaal VJ, Bruin S, Boot H, van Slooten G, van Tinteren H: 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008, 15: 2426-2432. 10.1245/s10434-008-9966-2.View ArticlePubMedGoogle Scholar
- Elias D, Delperro JR, Sideris L, Benhamou E, Pocard M, Baton O, Giovannini M, Lasser P: Treatment of peritoneal carcinomatosis from colorectal cancer: impact of complete cytoreductive surgery and difficulties in conducting randomized trials. Ann Surg Oncol. 2004, 11: 518-521. 10.1245/ASO.2004.09.008.View ArticlePubMedGoogle Scholar
- Mahteme H, Hansson J, Berglund A, Pahlman L, Glimelius B, Nygren P, Graf W: Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study. Br J Cancer. 2004, 90: 403-407. 10.1038/sj.bjc.6601586.PubMed CentralView ArticlePubMedGoogle Scholar
- Fujimoto S, Takahashi M, Mutou T, Kobayashi K, Toyosawa T, Isawa E, Sumida M, Ohkubo H: Improved mortality rate of gastric carcinoma patients with peritoneal carcinomatosis treated with intraperitoneal hyperthermic chemoperfusion combined with surgery. Cancer. 1997, 79: 884-891. 10.1002/(SICI)1097-0142(19970301)79:5<884::AID-CNCR3>3.0.CO;2-C.View ArticlePubMedGoogle Scholar
- Hall JJ, Loggie BW, Shen P, Beamer S, Douglas Case L, McQuellon R, Geisinger KR, Levine EA: Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for advanced gastric cancer. J Gastrointest Surg. 2004, 8: 454-463. 10.1016/j.gassur.2003.12.014.View ArticlePubMedGoogle Scholar
- Yonemura Y, Bandou E, Kawamura T, Endou Y, Sasaki T: Quantitative prognostic indicators of peritoneal dissemination of gastric cancer. Eur J Surg Oncol. 2006, 32: 602-606. 10.1016/j.ejso.2006.03.003.View ArticlePubMedGoogle Scholar
- Yan TD, Welch L, Black D, Sugarbaker PH: A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma. Ann Oncol. 2007, 18: 827-834. 10.1093/annonc/mdl428.View ArticlePubMedGoogle Scholar
- Schmidt U, Dahlke MH, Klempnauer J, Schlitt HJ, Piso P: Perioperative morbidity and quality of life in long-term survivors following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Eur J Surg Oncol. 2005, 31: 53-58. 10.1016/j.ejso.2004.09.011.View ArticlePubMedGoogle Scholar
- McQuellon RP, Loggie BW, Fleming RA, Russell GB, Lehman AB, Rambo TD: Quality of life after intraperitoneal hyperthermic chemotherapy (IPHC) for peritoneal carcinomatosis. Eur J Surg Oncol. 2001, 27: 65-73. 10.1053/ejso.2000.1033.View ArticlePubMedGoogle Scholar
- McQuellon RP, Loggie BW, Lehman AB, Russell GB, Fleming RA, Shen P, Levine EA: Long-term survivorship and quality of life after cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2003, 10: 155-162. 10.1245/ASO.2003.03.067.View ArticlePubMedGoogle Scholar
- Tuttle TM, Zhang Y, Greeno E, Knutsen A: Toxicity and quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2006, 13: 1627-1632. 10.1245/s10434-006-9186-6.View ArticlePubMedGoogle Scholar
- McQuellon RP, Danhauer SC, Russell GB, Shen P, Fenstermaker J, Stewart JH, Levine EA: Monitoring health outcomes following cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis. Ann Surg Oncol. 2007, 14: 1105-1113. 10.1245/s10434-006-9304-5.View ArticlePubMedGoogle Scholar
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