Solitary skull metastasis as initial manifestation of hepatocellular carcinoma
© Shim et al; licensee BioMed Central Ltd. 2008
Received: 10 July 2007
Accepted: 21 June 2008
Published: 21 June 2008
A solitary skull metastasis from hepatocellular carcinoma (HCC) prior to diagnosis of the primary tumor without liver dysfunction is a very rare event.
A 71-year-old male, without known liver disease, presented to our institution with a palpable occipital scalp mass. On brain magnetic resonance imaging (MRI), a highly enhanced and osteolytic skull tumor was observed. The histological diagnosis obtained from the percutaneous needle biopsy was a cranial metastasis from HCC. The metastatic tumor was removed via occipital craniectomy, and the two primary liver mass lesions were subsequently treated by transarterial chemoembolization.
An isolated skull metastasis may be the sole initial presentation of HCC. Early diagnosis is essential in order to treat the primary disease. A skull metastasis from HCC should be considered in the differential diagnosis in patients with subcutaneous scalp mass and osteolytic defects on X-ray.
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and is especially prevalent in African and East Asia . The higher incidence of HCC in Asia is related to the increased prevalence of chronic viral hepatitis B . Late-stage HCC usually metastasizes to the regional lymph nodes and lungs , but less commonly to the skeleton. HCC usually metastasizes preferentially to the vertebral column, pelvis, and ribs, but rarely to the skull .
Although the incidence of bone metastases in HCC has been described as very low in autopsy studies, an increasing trend has been reported recently [4, 5]. In the past, because of its short survival of patients with HCC, their clinical presentations were mostly concerned with the manifestations of the primary cancer itself. However, recent progress in the treatment of HCC has made it possible for the patient to survive longer, and as a result, distant metastasis from HCC, including bone metastasis, has increased and attracted more attention than before .
In this report, we describe a patient without previously known liver disease who presented with metastatic HCC of the skull before the diagnosis of a primary cancer.
The patient was still alive after 9 months of follow-up without hepatic dysfunction due to the progression of primary cancer. He also did not show any evidence of the recurrence of skull metastasis.
The incidence of skeletal metastasis from HCC is estimated to be 2%–16%, depending on the prevalence of the primary disease in the population [4, 6]. The most frequent sites of osseous metastases from HCC are vertebrae, the sternum, ribs, and long bones, although the incidence in the skull is low at 0.5%–1.6% [1, 7–9]. Skull metastases from HCC predominantly affect males in their sixth and seventh decades, with similar age and sex distributions to those with only HCC .
In spite of the low incidence of skull metastases, there have been interesting trends in the reports about skull metastases from HCC. Moreover, in comparison with the incidence of skull metastases before the 1980's, the incidence after the 1990's has clearly increased because of a prolonged survival rate due to recent progress in the diagnosis and treatment of HCC [4, 7]. Therefore, particularly in Asia, patients with HCC should be closely monitored for skull metastases. Plain skull x-ray is the most frequent initial diagnostic step in the patient with clinical suspicion of a bone lesion and bone scan with technetium-99m-methylene diphosphonate is widely used as a screening tool to detect bone metastases. On radiological examination, osteolytic-type behavior with a tendency to be highly enhanced is the most common finding [6, 7]. However these findings are not specific to just HCC: most skull metastases appear as osteolytic, expansile, and hypervascular lesions . Metastases are the most common cranial neoplasms in adults, of which 60% are from breast and lung carcinoma, although hematogenous skull metastases can be caused by nearly all types of tumors .
Because of the wide spectrum of primary cancers causing skull metastases, and because of their indistinguishable radiological findings, pathological confirmation by biopsy is required. Our case also required a biopsy for histopathological confirmation of the skull tumor. Metastases from HCC seldom emerge as a first diagnosis of a solitary skull tumor, because skull metastasis from HCC prior to diagnosis of the primary cancer is very rare . Moreover, our patient had a normal liver function test and a normal alpha-fetoprotein and was asymptomatic from his primary liver cancer. A solitary skull metastasis from HCC is very rare, but this type of metastases could be explained by the osseous route of HCC metastasis.
Metastases in the central nervous system from HCC generally occur through two different kinds of pathways in the advanced stage of HCC [6, 7]. One of them is the hematogenous route via the lung to the brain parenchyma without skull involvement. In this group, the character of HCC is defined as a "neutrophilic" cancer, and the lung is the most common site of extracranial metastases. On the other hand, the second route is the osseous route via Batson's venous plexus to the skull. In this group, bone is the most common site of extracranial metastases, and HCC is characterized as an "osteophilic" cancer. Cancer cells might disseminate within the dipole via the diploic venous channels and expand through the inner and outer table of the skull . Therefore, it is difficult to find the skull metastasis from HCC without the presence of other bone metastases.
This patient initially visited the hospital due to the incidentally discovered scalp mass. In the literature, a subcutaneous mass with occasional pain is the most common clinical presentation (63%), followed by neurological deficits (44%), headache (11%), and seizure . The neurological deficits, such as facial palsy, deafness, visual disturbance, facial numbness, weakness of limbs, and other cranial nerve palsies, are associated with the tumor size and location. Neurological deficits are more frequently present in metastases of the skull base rather than the cranial vault [1, 10].
Several treatment options can be used to treat the skull metastases from HCC, including direct ethanol injection therapy, radiotherapy, surgical resection, and supportive management. Many previous reports suggest that most patients with skull metastases died due to liver failure and that surgical resection of the metastatic lesion could not prolong survival [1, 4, 10]. The stage of the primary cancer is mostly associated with the prognosis. However, surgical resection of the skull metastases is acceptable for preventing intracranial hemorrhage and neurological deterioration. Surgical intervention also allows for biopsy, whereby the tumor can be histologically confirmed; such biopsies are easier to perform in cranial vault-sited cases [1, 3, 12].
Although a solitary skull metastasis prior to the diagnosis of HCC demonstrates rare metastatic behavior for HCC, especially in Asia, skull metastases from HCC should be included in the differential diagnosis of skull tumors, even if the patient is asymptomatic of liver cirrhosis. With the increase of survival in HCC patients, clinically significant bone metastases have also increased, affecting the patients' quality of life. Therefore, early diagnosis and proper management of bone metastasis from HCC is essential to prevent deterioration in the quality of life of HCC patients.
Written consent was obtained from the patient for publication of this case report.
- Hsieh CT, Sun JM, Tsai WC, Tsai TH, Chiang YH, Liu MY: Skull metastasis from hepatocellular carcinoma. Acta Neurochir (Wien). 2007, 149: 185-190. 10.1007/s00701-006-1071-3.View ArticleGoogle Scholar
- Bosch FX, Ribes J, Diaz M, Cleries R: Primary liver cancer; worldwide incidence and trends. Gastroenterology. 2004, 127 (Suppl 1): s5-s16. 10.1053/j.gastro.2004.09.011.View ArticlePubMedGoogle Scholar
- Yoshida D, Chen MN, Awaya S, Nakazawa S: Cranial metastasis of hepatocellular carcinoma in a female – case report. Neurol Med Chir (Tokyo). 1993, 33: 839-844. 10.2176/nmc.33.839.View ArticleGoogle Scholar
- Fukutomi M, Yokota M, Chuman H, Harada H, Zaitsu Y, Funakoshi A, Wakasugi H, Iguchi H: Increased incidence of bone metastases in hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2001, 13: 1083-1088. 10.1097/00042737-200109000-00015.View ArticlePubMedGoogle Scholar
- Nakashima T, Okuda K, Kojiro M, Jimi A, Yamaguchi R, Sakamoto K, Ikari T: Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years. Cancer. 1983, 51: 863-877. 10.1002/1097-0142(19830301)51:5<863::AID-CNCR2820510520>3.0.CO;2-D.View ArticlePubMedGoogle Scholar
- Yen FS, Wu JC, Lai CR, Sheng WY, Kuo BI, Chen TZ, Tsay SH, Lee SD: Clinical and radiological pictures of hepatocellular carcinoma with intracranial metastasis. J Gastroenterol Hepatol. 1995, 10: 413-418. 10.1111/j.1440-1746.1995.tb01593.x.View ArticlePubMedGoogle Scholar
- Chan CH, Trost N, McKelvie P, Rophael JA, Murphy MA: Unusual case of skull metastasis from hepatocellular carcinoma. ANZ J Surg. 2004, 74: 710-713. 10.1111/j.1445-1433.2004.02961.x.View ArticlePubMedGoogle Scholar
- McIver JI, Scheithauer BW, Rydberg CH, Atkinson JL: Metastatic hepatocellular carcinoma presenting as epidural hematoma: case report. Neurosurgery. 2001, 49: 447-449. 10.1097/00006123-200108000-00034.PubMedGoogle Scholar
- Murakami R, Korogi Y, Sakamoto Y, Takhashi M, Okuda T, Yasunaga T, Nishimura R, Yoshimatsu S: Skull metastasis from hepatocellular carcinoma. CT, MR and angiographic findings. Acta Radiol. 1995, 36: 597-602.PubMedGoogle Scholar
- Stark AM, Eichmann T, Mehdorn HM: Skull metastases: clinical features, differential diagnosis, and review of the literature. Surg Neurol. 2003, 60: 219-225. 10.1016/S0090-3019(03)00269-6.View ArticlePubMedGoogle Scholar
- Michael CB, Gokaslan ZL, DeMonte F, McCutcheon IE, Sawaya R, Lang FF: Surgical resection of calvarial metastases overlying dural sinuses. Neurosurgery. 2001, 48: 745-754. 10.1097/00006123-200104000-00009.PubMedGoogle Scholar
- Constans JP, Donzelli R: Surgical features of cranial metastases. Surg Neurol. 1981, 15: 35-38. 10.1016/S0090-3019(81)80087-0.View ArticlePubMedGoogle Scholar
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