Male breast cancer: is the scenario changing
World Journal of Surgical Oncology volume 6, Article number: 58 (2008)
The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects of male breast cancer with particular emphasis on incidence, risk factors, patho-physiology, treatment, prognostic factors, and outcome.
Information on all aspects of male breast cancer was gathered from available relevant literature on male breast cancer from the MEDLINE database over the past 32 years from 1975 to 2007. Various reported studies were scrutinized for emerging evidence. Incidence data were also obtained from the IARC, Cancer Mondial database.
There is a scenario of rising incidence, particularly in urban US, Canada and UK. Even though more data on risk factors is emerging about this disease, more multi-institutional efforts to pool data with large randomized trials to show treatment and survival benefits are needed to support the existing vast emerging knowledge about the disease.
Male breast cancer (MBC) comprises about 1% of all breast cancers but is found to be on the rise with the increasing incidence of female breast cancer . The rarity of this condition precludes large randomized trials. Most of the information is therefore based on small single institution retrospective studies or by extrapolation from breast cancer trials in females. In this review we have tried to describe all the available information on male breast cancer with particular emphasis on incidence, etiology, patho-physiology, clinical features, treatment, prognosis and survival to find out if any changing trends are emerging about the disease.
An online search was made in Pubmed and MEDLINE databases to find all published studies of interest on male breast cancer. Searches were performed using the terms "breast cancer" and "male". The online cancer incidence database – Cancer Mondial (International Agency for Research on Cancer, Lyon, France) was also searched to provide incidence trends of male breast cancer from 1960–2000. Literature was meticulously reviewed and collated to obtain evidence about various aspects of the disease reviewed under the following sections.
Though MBC is rare, a geographic variation in its incidence has been reported. It is higher in USA and UK than in Finland and Japan . National Cancer Institute data on cancer survival in the US shows increase in the incidence of MBC from 0.86 to 1.08 per 100,000 men . An alarming increasing incidence has been seen in the US and Canada whereas it is increasing gradually in other parts of the world as well  (Table 1). In the US the highest areas were New York State and California where the incidence has been rising since the 1960s. From data on incidence trends, it seems to be an urban disease in men with high prevalence in these areas. Data from Africa is scanty. In Tanzania, it accounts for 6% while in Zambia it is 15% of all cases of breast cancer [4, 5]. Uganda has seen a rising trend in incidence. In Europe, Scandinavian countries like Sweden, Denmark and Finland have been seeing increasing incidences as well. About 240 men are diagnosed in UK each year compared to 40,400 women. There is a documented increase in the incidence of female breast cancer [6, 7] over the years as well, the rate of rise faster than male breast cancer. Some studies have even indicated a stable incidence of MBC [8–11]. The prevalence of MBC increases with age. Age frequency distribution for males is unimodal with peak incidence in the late sixth and early seventh decade. By comparison, females have bimodal age frequency distribution with early onset incidence at 50 and late at 70 years. The average age of diagnosis in males is 60 years, which is ten years older than that noticed in female patients with the disease [8, 12]. A large database review showed differing trends in age based incidences between male and female breast cancers  (Figure 1).
Etiology and risk factors
The definite etiology of MBC is unknown. Factors such as alteration in hormonal milieu, family history and genetic alterations are known to influence its occurrence. Various studies have shown that conditions that alter the estrogen-testosterone ratio in males predispose to breast cancer [14, 15]. Among these conditions the strongest association is with Klinefelter's syndrome. Males with this condition have a fifty times increased risk and accounts for 3% of all MBC . Conditions, which are associated with increased estrogen levels, like cirrhosis [17, 18] and exogenous administration of estrogen (either in transsexuals or as therapy for prostate cancer) have been implicated as causative factors [19–22]. Also, androgen deficiency due to testicular disease like mumps, undescended testes, or testicular injury, has been linked to the occurrence of breast cancer in men [23, 24]. Occupational exposure to heat and electromagnetic radiation, causing testicular damage and further leading to the development of MBC is also postulated [25, 26]. An inherited predisposition for breast cancer is noticed in males-analogous to that in females [27–31]. A positive family history of a first-degree female relative having breast cancer is seen in up to 15–20% patients . This increased risk is conferred by mutations in the breast cancer susceptibility genes (BRCA1 and BRCA2). Mutations in both the BRCA1 and BRCA2 genes are linked to female breast cancer. Genetic studies in males however, have shown that germline mutations in BRCA2 alone account for the majority of hereditary breast cancer [33–36]. No link between BRCA1 and familial breast cancer has been noticed in one study , whereas other studies have suggested a possible link [38, 39]. The Cambridge study showed that 8% of patients had BRCA2 mutations and all the carriers had a family history of breast, ovarian, prostate or pancreatic cancer . The highest prevalence of BRCA2 mutation in MBC has been noted in Iceland where 40% have the mutation . Several case reports have linked MBC with other genetic disorders like Cowden syndrome  and Hereditary Non-Polyposis Colonic Cancer (HNPCC) . It has been recently reported that male breast cancer may also predispose to increased risk of developing a second cancer of the stomach, skin and breast .
A strong racial predilection is noted in MBC, with studies establishing a high-risk for Jews. Among them, the Sephardic Jews present at a younger age with advanced stage disease whereas the Ashkenazi Jews have an increased lifetime risk of suffering from the disease [45, 46]. Gynecomastia, present in 6–38% of MBC patients has also been implicated as a risk factor [47, 48] and some studies have shown positive correlation between the two . An interesting study in the US comparing incidence, pathology and outcomes in male and female breast cancer in a defined population showed more black males than white males to be affected. Also black men with breast cancer had more involved axillary lymph nodes and higher stage than whites at presentation . This is in stark contrast to the high incidence of male breast cancer preponderance in whites as shown in another recently reported study in the US which showed higher incidence in white males, although black males were more not likely to see an oncologist for consideration of chemotherapy and had higher mortality associated with the disease (hazard ratio = 3.29; 95% CI, 1.10 to 9.86) . Reports have shown that an association of MBC and gynecomastia could also represent a chance occurrence as 35–40% of healthy men have clinical or histological gynecomastia .
Alcohol has been variably linked as a causative factor in the genesis of MBC. A large Swedish study has not shown any such correlation , although it has been implicated as a causal agent in other studies . A case control study conducted in Europe has shown that for alcohol intakes of less than 60 grams per day, the relative risk of MBC is comparable to that in females, and it continues to increase at high consumption levels . Other risk factors mentioned in various studies are low socioeconomic status, obesity, pacemakers, tuberculosis and hyperthyroidism [56, 57]. A meta analysis of 7 case-control studies revealed that the risk of MBC to be significantly increased in males with the following characteristics; never married, benign breast disease, gynecomastia, Jewish or history of breast cancer in a first-degree relative [58–61].
The entire spectrum of histological variants of breast cancer has been noted in men. Infiltrating ductal carcinoma is the most predominant subtype with an incidence ranging from 64–93%. The second commonest variant is papillary type seen in 2.6–5% [59–61]. Since the lobular system is not well developed in men, lobular carcinoma is uncommon, although, some cases have been reported in literature . Medullary, tubular, small cell and mucinous carcinoma constitute less than 15% of the cases . Rare tumors like inflammatory carcinomas and sarcomas have also been described [64, 65]. Metastasis to breast from tumors of prostate and lung is known [66, 67]. In some series most of the tumors were noted to be of high-grade  whereas other series have shown predominance of grade 1 and grade 2 tumours . In another study 94% of the tumors were noted to be of grade 1 and 2 [70, 71].
Several molecular markers have been identified and studied in MBC patients and include ER (estrogen receptor), PR (progesterone receptor), AR (androgen receptor), p53 gene, Her2neu (Human Epidermal Growth factor-2) expression, gelatinases, p27 gene, MIB-1 (Ki67) index, and Bcl-2 (B-cell lymphoma-2) gene. A high ER positivity as compared to female breast cancer has been noticed consistently in studies on MBC. Approximately 64–85% of cancers in men are ER positive and more than 70% are PR positive [72–74]. Such high levels of positivity may be due to low estrogen levels leaving receptors available for binding and is probably responsible for good hormonal control . A recent study has however shown that like females, the ER positive status does increase with age . Androgen receptor status has been variably reported as being from negative to 95% positive, and its correlation with clinico-pathological factors and survival is not well defined . It has been shown to both stimulate and inhibit growth of AR positive breast cancer lines in vitro . One study proposed that decrease of AR action in the breast might predispose to earlier development of MBC . p53 has been reported to be positive in 21–95% of MBC [80–82]. It is a tumor suppressor gene that regulates cell growth by inducing blockage in the cell cycle. Its over expression has been correlated with recurrence and poorer prognosis in some patients  whereas no such correlation has been found in others [84, 85]. Levels of ER, PR and AR among MBC patients have been summarized in various studies [1, 77, 80–82, 86, 87] (Table 2).
This is a proto-oncogene, which codes for a tyrosine-kinase transmembrane receptor. Its expression in women is seen in 20–30% of breast cancers and indicates a poor prognosis. In MBC over-expression of Her2-neu correlates significantly with probability of relapse, increased staging, and higher grades of the carcinoma [88–90].
Increased gelatinolytic activity of these enzymes (MMP-2, MMP-9) in MBC patients has been reported in a study to be related to increased tendency to metastasis and poor prognosis .
p27 and MIB-1
Tumour expression of proliferation marker (MIB-1) and cell cycle related protein (p27) have shown to be good predictors of lymph node metastasis in MBC .
Is a proto-oncogene that inhibits apoptosis and helps promote cell growth. In women with breast cancer, studies have shown it to be associated with a favourable prognosis [93, 94] but its role in MBC is yet to be defined.
A recent study has evaluated the role of new protein markers p21Waf1 and p27Kip1 as predictors of the most efficient endocrine response .
The typical clinical presentation of breast cancer in 75%–95% of men is a hard eccentric non-tender mass . The mean diameter is reported as 3–3.5 cm but can range from 0.5–12.5 cm. Skin ulceration may be present in a significant number of patients . Collective reviews have shown predilection for the left side in a ratio of 1.07:1. Nipple involvement manifesting as retraction, nipple discharge, fixation or eczema is seen in 40–50% patients. This early presentation of late stage disease is attributed to the small bulk of breast tissue and the central location of these tumours. Paget's disease has been reported in up o 5% of cases. Less common presentations are breast tenderness, itching or symptoms of distant metastasis . Bilateral MBC has been reported in 1.9% patients . Axillary lymph node involvement is very common and clinically suspicious adenopathy has been seen in 40–55% patients. This is explained on the basis of lack of awareness and delayed diagnosis as compared to females. Biologically however, MBC is less aggressive than that in women .
A population-based study has shown lymphadenopathy in 37.7% male and 29.2% female patients. Men are 1.6 times more likely to have axillary involvement as compared to females. This study also showed that 6.9% males presented with distant metastasis unlike 5.6% females . The mean duration of symptoms before diagnosis has been reported to be 14–21 months in older studies and 1–8 months in more recent ones [102, 103].
The paucity of breast tissue in males makes it difficult to perform and interpret imaging techniques like ultrasound (US) and mammography as compared to females. US has not been shown to be useful in diagnosing MBC . Mammography has however shown to be useful in diagnosing breast cancer in most studies. It forms less than 1% of mammographic examinations done in breast imaging centres . A study of 100 mammograms from Dallas, Texas concluded that sensitivity of mammography was 92%, specificity 90%, positive predictive value 55% and negative predictive value 99% and accuracy of 90% . Mammography can also help to distinguish between benign and malignant lesions of the male breast. The mammographic characteristics in male breast cancer are more likely to show a mass lesion, rather than micro calcifications . Fine needle aspiration cytology (FNAC) is a reliable investigation modality in MBC and helps to differentiate benign from malignant lesions. In a large study (614 cases of males with breast lesions) conducted by John Hopkins Institute USA showed a sensitivity of 95.3%, specificity of 100% and diagnostic accuracy of 98% for FNAC . Other techniques like TC-99m Sestamibi uptake scan have been tried for the diagnosis of malignant masses in males .
A number of variables have been reported to affect prognosis in MBC patients. Among these, tumour stage [1, 109–111] (Figure 2) and axillary nodal status [77, 108, 112] have consistently been shown to be the most important independent predictors of overall survival. Giordano et al., showed  five year overall survival rates to be 78% for patients with stage I, 67% with stage II, 40% with stage III, and 19% with stage IV MBC. The five-year survival for patients with node negative disease has been shown in another series to be approximately 70% and that for node positive disease ranging from 37% to 54% .
The grade of the tumour has been shown to affect prognosis significantly in univariate analysis. However, the significance of this association is not noted in multivariate analysis . In non-disseminated cases, tumour size and the nodal status were the most important prognostic indicators. Five-year survivals range from 74% for tumours less than 2 cm to 37% for those more than 5 cm in size . One study of 65 MBC cases reported the clinical stage to be the single most significant factor-affecting prognosis irrespective of tumour size or lymph node metastasis . Another study however showed that axillary lymph node status on multivariate analysis was the only prognostic parameter of statistical significance . Though recent studies have provided prognostic information of molecular markers in MBC, the comparative results from these studies are conflicting.
ER and PR positivity is believed to be prognostically favourable in MBC similar to breast cancer in females . However several studies have found that though ER positivity predicted better overall survival in univariate analysis, this difference was no longer significant after adjustments for tumour size, lymph node status and age were made [1, 32, 83, 117]. The role of AR as a prognostic factor is also controversial and most studies have shown a lack of association between AR and survival . In contrast, a recent study has demonstrated that AR expression significantly predicts shorter disease free and overall survival rates . Over expression of c-erbB2 has been associated with shortened survival for patients in some studies  whereas others have failed to demonstrate a similar correlation [118–120]. Similarly, p53 mutation has been linked to poor survival and increased local recurrence in some series unlike others where no such link could be shown [83, 119]. Similar inconsistent results have also been demonstrated for a variety of other molecular markers like c-myc, MIB-1 DNA ploidy and Her2 neu. BRCA2 associated tumours have been significantly associated with poorer disease free and overall survival rates as was shown in a study where the disease free survival and overall survival for BRCA2 positive patients was 28% and 25% respectively whereas that for controls was 86% and 68% .
MBC has traditionally been associated with dismal survival rates as compared to females [27, 121]. This is attributed to the late age of presentation and also to delayed detection. In studies where male patients were matched with female patients by stage and age, equivalent overall survival rates have been shown [1, 106, 122]. Comparison of disease specific survival was shown to have statistically better significant results in males as compared to female breast cancer patients . The disease free, overall and relapse free survival rates in MBC patients is seen to be variable in studies [1, 32, 60, 61, 63, 109, 124–128] (Table 3).
There are no prospective randomised trials validating the efficacy of various treatment options in MBC. Management of these patients is based largely on evidence obtained from studies in female breast cancer patients. A literature review shows that there have been marked changes in the treatment protocols for MBC, which mirrors the changes seen in female breast cancer management.
Although radical mastectomy was the treatment of choice in earlier years, less invasive procedures like modified radical mastectomy (MRM) or simple mastectomy are now the standard procedure. A number of series have not shown improvement in survival or local recurrence for male patients who underwent more radical procedures [106, 129, 130]. Conservative breast surgery in the form of lumpectomy has been reported for Stage-I and ductal carcinoma in-situ (DCIS). As in female breast cancer series, lumpectomy alone results in unacceptably high rates of local recurrence, which is reduced upon addition of local radiotherapy (RT) . There is a lack of uniformity in literature regarding the indications and role of postoperative RT in MBC. Interpretation of results from the literature is difficult because most of the studies do not have matched controls for tumour size, nodal status or stage. There have been recommendations for its routine use as it is felt that lack of sufficient breast tissue prevents wide clearance margins on surgery [131, 132]. Some studies have even suggested routine inclusion of the internal mammary chain in the radiation field . This approach has however been challenged by others who have shown low local recurrence rates in patients who underwent surgery alone without RT [134, 135]. Historically no survival advantage has been noted with the use of adjuvant radiotherapy. Its value is however similar to female situations where a survival benefit has been demonstrated for high-risk patients [136, 137].
In an Austrian study, 31 males were irradiated postoperatively to the chest wall and 16 patients to the axilla. Nine patients also received hormone and chemotherapy. 32.2% were Stage II and 35.5% Stage III. Five-year disease free survival was 100% for Stage I, 56.3% for Stage II and 67.3% for Stage III disease. Local relapse occurred in only one patient . Another large German study showed a five-year survival of 59% and 10-year survival of 46% . However no data suggests which patients should receive irradiation to the axilla and which to the chest wall. Therefore a general trend is now noticed towards limiting post mastectomy RT to high-risk patients with advanced T stage and or limited nodal involvement.
The concepts in the management of axillary disease in MBC have changed significantly over the past decade. The standard of care for axillary treatment till now has been axillary lymph node dissection. This is however associated with the attendant risk of significant morbidity. The validation of sentinel lymph node biopsy (SLNB) as an accurate procedure in female patients has prompted similar procedure in men. All of these studies have findings, which compare favourably with the findings of SLNB in females and hence it is being advocated now as the standard surgical procedure in male patients [139, 140].
Due to the high positivity of ER in MBC (75–80%), most cases have an excellent response to hormonal manipulation. Although various methods like orchidectomy, hypophysectomy and adrenalectomy have been described, tamoxifen has shown to have equivalent results as in females. No randomised control trials have been done in male patients and most results have been interpreted using data from female breast cancer patients. No data is available to suggest the duration of treatment in males but one large study showed a 56% disease free survival versus 28% at 5 years in patients of MBC in Stage I and operable Stage 3 disease who were given tamoxifen for 2 years . All these patients were node positive. We feel that more studies need to be done to show whether tamoxifen should be given for 5 years like in women.
Although no definite data or trials exist about the role and efficacy of adjuvant chemotherapy in MBC, various studies and centre reviews have shown a benefit in survival and prevention of recurrence . A large study involving 24 node positive patients treated with cyclophosphamide, 5-flourouracil and methotrexate showed a five-year actuarial survival of 80% with a median follow up of 46 months  and hence it is obvious that chemotherapy is efficacious in node positive men. In a retrospective analysis of therapy in MBC, it was noticed that the median survival of patients who underwent surgery alone was 33 months. However, for those patients who received additional adjuvant therapy in the form of radiation, hormones and chemotherapy, either alone or in combination, the median survival rose to 86 months (p < 0.003). Adjuvant therapy was most effective in large size, node positive and poorly differentiated tumours .
Therapy for metastatic disease
As in females, MBC can spread to the liver, lungs, brain and bones. Rare sites like the choroids plexus and orbit have been documented . There have been cases of metastasis to the breast from a primary in the colon, nasal cavity and from a bronchogenic carcinoma .
Hormonal therapy has been proven to help in metastatic disease. Past therapies included orchiectomy, hypophysectomy and adrenalectomy. However these radical and disfiguring procedures have been given up for medications like tamoxifen. A study has mentioned response rates of 32% to 50% for orchiectomy, 17% to estrogens, 43% to steroids, 25% to tamoxifen and 60% to androgens [146, 147]. Tamoxifen has shown its beneficial effect in visceral dominant, bone dominant and soft tissue dominant metastasis and the response depends on the degree of ER positivity .
Diethylstilbestrol has also been prescribed to patients having soft tissue disease (breast, chest wall and/or lymph nodes) with an overall response rate of 38% . Systemic chemotherapy can be used as a second line of therapy in failed hormonal therapy or in ER negative patients. A study reported response rates of 67% for 5-Flourouracil, doxorubicin and cyclophosphamide, 55% for doxorubicin and vincristine, 53% for cyclophosphamide, 33% for cyclophosphamide, methotrexate and 5-flourouracil, and 13% for 5-flourouracil . Not much has been reported about definitive regimens due to small number of cases.
MBC is a rare disease, which presents mostly in the latter decades of life. It behaves similar to female breast cancer in most ways. There are important risk factors shown like family history and Klinefelter's syndrome. Genetically BRCA-2 mutations are also linked to MBC. 80% of the carcinomas are of the infiltrative ductal variety. Lobular carcinoma is extremely rare although other pathological varieties may be seen. Men have a higher rate of ER positivity, which accounts for good responses with hormonal agents like tamoxifen. They also express markers like Her2-neu, p53 and Cyclin-D1 in similar percentages as females.
Most males present with advanced clinical stage of the disease due to a lack of awareness. Diagnosis is with a mammogram and fine needle aspiration cytology (FNAC) or core biopsy. All patients should be staged completely to exclude metastasis. The treatment of localised disease is by performing a modified radical mastectomy. Adjuvant therapy is mainly tamoxifen as most are strongly ER positive. Chemotherapy may be useful in node positive and locally advanced disease although more evidence is needed for appropriate regimens. The use of adjuvant RT has not been conclusively proven to reduce local recurrence. The treatment of metastatic disease is mainly hormonal which has shown good survival in some studies versus a poor outlook in others. More research and trials have to be conducted to find out the effect of hormonal agents like aromatase inhibitors.
The scenario in male breast cancer has been changing with respect to its rising incidence-particularly in urban US, Canada and in Uganda. No particular reason for this has been found. Better understanding of the patho-physiology could be possible from emerging data on etiological factors and molecular markers. It is an acceptable fact that the phenotype, pathology, treatment, prognosis and survival of male breast cancer differ in some aspects with that of female breast cancer. Certain impediments like inability to perform randomised trials in male breast cancer due to low incidence of the disease should prompt efforts at setting up large multi-institutional, worldwide studies, so data could be shared and pooled together to enable emergence of meaningful therapies to treat and improve survival. One of the ways forwards may be by setting up a worldwide database of all prevalent cases (a task not difficult in this day and age).
Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN: Breast carcinoma in men: a population-based study. Cancer. 2004, 101: 51-57. 10.1002/cncr.20312.
O'Malley CD, Prehn AW, Shema SJ, Glaser SL: Racial/ethnic differences in survival rates in a population-based series of men with breast carcinoma. Cancer. 2002, 94: 2836-2843. 10.1002/cncr.10521.
International Agency for Research in Cancer – CancerMondial database, Cancer Incidence in 5 Continents (CI5, Vol 1–9).
Ihekwaba FN: Breast cancer in men in black Africa: a report of 73 cases. J R Coll Surg Edinb. 1994, 39 (6): 344-347.
Smigal C, Jemal A, Ward E, Cokkinides V, Smith R, Howe HL, Thun M: Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin. 2006, 56: 168-183.
Ewertz M: Epidemiology of breast cancer: the Nordic contribution. Eur J Surg. 1996, 162: 97-99.
Shavers VL, Harlan LC, Stevens JL: Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer. 2003, 97: 134-147. 10.1002/cncr.11051.
Devesa SS, Blot WJ, Stone BJ, Miller BA, Tarone RE, Fraumeni JF: Recent cancer trends in the United States. J Natl Cancer Inst. 1995, 87: 175-182. 10.1093/jnci/87.3.175.
Levi F, Lucchini F, LaVecchia C: Epidemiology of male breast cancer. Eur J Cancer Prev. 2002, 11: 315-318. 10.1097/00008469-200208000-00001.
Devesa SS, Silverman DT, Young JL, Pollack ES, Brown CC, Horm JW, Percy CL, Myers MH, McKay FW, Fraumeni JF: Cancer incidence and mortality trends among men in the United States, 1947–84. J Natl Cancer Inst. 1987, 79: 701-770.
LaVecchia C, Levi F, Lucchini F: Descriptive epidemiology of male breast cancer in Europe. Int J Cancer. 1992, 51: 62-66. 10.1002/ijc.2910510113.
Hill TD, Khamis HJ, Tyczynski JE, Berkel HJ: Comparison of male and female breast cancer incidence trends, tumour characteristics, and survival. Ann Epidemiol. 2005, 15: 773-780. 10.1016/j.annepidem.2005.01.001.
Anderson WF, Althuis MD, Brinton LA, Devesa SS: Is male breast cancer similar or different than female breast cancer?. Breast Cancer Res Treat. 2004, 83: 77-86. 10.1023/B:BREA.0000010701.08825.2d.
Ballerini P, Recchione C, Cavalleri A, Moneta R, Saccozzi R, Secreto G: Hormones in male breast cancer. Tumori. 1990, 76: 26-28.
Casagrande JT, Hanisch R, Pike MC, Ross RK, Brown JB, Henderson BE: A case-control study of male breast cancer. Cancer Res. 1988, 48: 1326-1330.
Hultborn R, Hanson C, Kopf I, Verbiene I, Warnhammar E, Weimarck A: Prevalence of Klinefelter's syndrome in male breast cancer patients. Anticancer Res. 1997, 17: 4293-297.
Sørensen HT, Friis S, Olsen JH, Thulstrup AM, Mellemkjaer L, Linet M, Trichopoulos D, Vilstrup H, Olsen J: Risk of breast cancer in men with liver cirrhosis. Am J Gastroenterol. 1998, 93: 231-233.
Misra SP, Misra V, Dwivedi M: Cancer of the breast in a male cirrhotic: is there an association between the two?. Am J Gastroenterol. 1996, 91: 380-382.
Symmers WS: Carcinoma of the breast in transsexual individuals after surgical and hormonal interference with the primary and secondary sexual characteristics. Br Med J. 1968, 2: 83-87.
Pritchard TJ, Pankowsky DA, Crowe JP, Abdul-Karim FW: Breast cancer in male-to-female transsexual: A case report. JAMA. 1988, 259: 2278-2280. 10.1001/jama.259.15.2278.
O'Grady WP, McPivin RW: Breast cancer in a man treated with ethyl stilbesterol. Arch Path. 1969, 88: 162-165.
Schlappack OK, Braun O, Maier U: Report of two cases of male breast cancer after prolonged estrogen treatment for prostatic carcinoma. Cancer Detect Prev. 1986, 9: 319-322.
Thomas DB, Jimenez LM, McTiernan A, Rosenblatt K, Stalsberg H, Stemhagen A, Thompson WD, Curnen MG, Satariano W, Austin DF, Greenberg RS, Key C, Kolonel LN, West DW: Breast cancer in men, risk factors with hormonal implications. Am J Epidemiol. 1992, 135: 734-748.
Mabuchi K, Bross DS, Kessler II: Risk factors for male breast cancer. J Natl Cancer Inst. 1985, 74: 371-375.
Stenlund C, Floderus B: Occupational exposure to magnetic fields in relation to male breast cancer and testicular cancer: a Swedish case-control study. Cancer Causes Control. 1997, 8: 184-191. 10.1023/A:1018468112964.
Rosenbaum PF, Vena JE, Zielezny MA, Michalek AM: Occupational exposures associated with male breast cancer. Am J Epidemiol. 1994, 139: 30-36.
Rosenblatt KA, Thomas DB, McTiernan A, Austin MA, Stalsberg H, Stemhagen A, Thompson WD, Curnen MG, Satariano W, Austin DF, Isacson P, Greenberg RS, Key C, Kolonel L, West D: Breast cancer in men: aspects of familial aggregation. J Natl Cancer Inst. 1991, 83: 849-854. 10.1093/jnci/83.12.849.
Anderson DE, Badzioch MD: Breast cancer risks in relatives of male breast cancer patients. J Natl Cancer Inst. 1992, 84: 1114-1117. 10.1093/jnci/84.14.1114.
Demeter JG, Waterman NG, Verdi GD: Familial male breast carcinoma. Cancer. 1990, 65: 2342-2343. 10.1002/1097-0142(19900515)65:10<2342::AID-CNCR2820651029>3.0.CO;2-Y.
Everson RB, Li FP, Fraumeni JF, Fishman J, Wilson RE, Stout D, Norris HJ: Familial male breast cancer. Lancet. 1976, 1: 9-12. 10.1016/S0140-6736(76)92907-X.
Marger D, Urdaneta N, Fischer JJ: Breast cancer in brothers: case reports and a review of 30 cases of male breast cancer. Cancer. 1975, 36: 458-461. 10.1002/1097-0142(197508)36:2<458::AID-CNCR2820360222>3.0.CO;2-V.
Goss PE, Reid C, Pintilie M, Lim R, Miller N: Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years; 1955–1996. Cancer. 1999, 85: 629-639. 10.1002/(SICI)1097-0142(19990201)85:3<629::AID-CNCR13>3.0.CO;2-V.
Pages S, Caux V, Stoppa-Lyonnet D, Tosi M: Screening of male breast cancer and of breast-ovarian cancer families for BRCA2 mutations using large bifluorescent amplicons. Br J Cancer. 2001, 84: 482-488. 10.1054/bjoc.2000.1627.
Diez O, Cortes J, Domenech M, Pericay C, Brunet J, Alonso C, Baiget M: BRCA2 germ-line mutations in Spanish male breast cancer patients. Ann Oncol. 2000, 11: 81-84. 10.1023/A:1008339009528.
Friedman LS, Gayther SA, Kurosaki T, Gordon D, Noble B, Casey G, Ponder BA, Anton-Culver H: Mutation analysis of BRCA1 and BRCA2 in male breast cancer population. Am J Hum Genet. 1997, 60: 313-319.
Haraldsson K, Loman L, Zhang Q, Johannsson O, Olsson H, Borg A: BRCA2 germline mutations are frequent in male breast cancer patients without a family history of the disease. Cancer Res. 1998, 58: 1367-1371.
Stratton MR, Ford D, Neuhasen S, Seal S, Wooster R, Friedman LS, King MC, Egilsson V, Devilee P, McManus R, Daly PA, Smyth E, Ponder BAJ, Peto J, Cannon-Albright L, Easton DF, Goldgar DE: Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q. Nature Genetics. 1994, 7: 103-107. 10.1038/ng0594-103.
Sun X, Gong Y, Rao MS, Badve S: Loss of BRCA1 expression in sporadic male breast carcinoma. Breast Cancer Res Treat. 2002, 71: 1-7. 10.1023/A:1013317909431.
Borg A, Isola J, Chen J, Rubio C, Johansson U, Werelius B, Lindblom A: Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. Int J Cancer. 2000, 85: 796-800. 10.1002/(SICI)1097-0215(20000315)85:6<796::AID-IJC10>3.0.CO;2-L.
Basham VM, Lipscombe JM, Ward JM, Gayther SA, Ponder BA, Easton DF, Pharoah PD: BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. Breast Cancer Res. 2002, 4: R2-10.1186/bcr419.
Thorlacius S, Olafsdottir G, Tryggvadottir L, Neuhausen S, Jonasson JG, Tavtigian SV, Tulinius H, Ogmundsdottir HM, Eyfjörd JE: A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat Genet. 1996, 13: 117-119. 10.1038/ng0596-117.
Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI: Male breast cancer in Cowden syndrome patients with germline PTEN mutations. J Med Genet. 2001, 38: 159-164. 10.1136/jmg.38.3.159.
Chakraborty R, Little MP, Sankaranarayanan K: Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. III. Effects of incomplete penetrance and dose-dependent radiosensitivity on cancer risks in populations. Radiat Res. 1997, 147: 309-320. 10.2307/3579338.
Bagchi S: Men with breast cancer have high risk of second cancer. Lancet Oncol. 2007, 8 (3): 198-10.1016/S1470-2045(07)70067-0.
Brenner B, Fried G, Levitzki P, Rakowsky E, Lurie H, Idelevich E, Neuman A, Kaufman B, Sulkes J, Sulkes A: Male breast carcinoma in Israel: higher incident but possibly prognosis in Ashkenazi Jews. Cancer. 2002, 94: 2128-2133. 10.1002/cncr.10449.
Steinitz R, Katz L, Ben-Hur M: Male breast cancer in Israel: selected epidemiological aspects. Isr J Med Sci. 1981, 17: 816-821.
Braunstein GD: Gynaecomastia. N Engl J Med. 1993, 328: 490-495. 10.1056/NEJM199302183280708.
Colombo-Benkmann M, Stern J, Herfarth C: On the neglected entity of unilateral gynecomastia. Ann Plast Surg. 2006, 56: 346-10.1097/01.sap.0000197867.08217.bb.
de Bree E, Tsagkatakis T, Kafousi M, Tsiftsis DD: Breast enlargement in young men not always gynaecomastia: breast cancer in a 22-year-old man. ANZ J Surg. 2005, 75: 914-916. 10.1111/j.1445-2197.2005.03572.x.
Nahleh Z, Srikantiah R, Safa M, Jazieh AR, Muhleman A, Komrokji R: Male breast cancer in the veteren affairs population: a comparative analysis. Cancer. 2007, 109: 1471-7. 10.1002/cncr.22589.
Crew KD, Neugut KI, Wang X, Jacobson JS, Gran VR, Raptis G, Hershman DL: Racial disparities in treatment and survival of male breast cancer. J Clin Oncol. 2007, 25: 1089-98. 10.1200/JCO.2006.09.1710.
Prasad V, M King J, McLeay W, Raymond W, Cooter RD: Bilateral atypical ductal hyperplasia, an incidental finding in gynaecomastia-case report and literature review. Breast. 2005, 14: 317-321. 10.1016/j.breast.2005.04.010.
Casagrande JT, Hanisch R, Pike MC, Ross RK, Brown JB, Henderson BE: A case-control study of male breast cancer. Cancer Res. 1988, 48: 1326-1330.
Koc M, Polat P: Epidemiology and aetiological factors of male breast cancer: a ten years retrospective study in eastern Turkey. Eur J Cancer Prev. 2001, 10: 531-534. 10.1097/00008469-200112000-00008.
Guenel P, Cyr D, Sabroe S, Lynge E, Merletti F, Ahrens W, Baumgardt-Elms C, Menegoz F, Olsson H, Paulsen S, Simonato L, Wingren G: Alcohol drinking may increase risk of breast cancer in men: a European population-based case control study. Cancer Causes Control. 2004, 15: 571-580. 10.1023/B:CACO.0000036154.18162.43.
Hsing AW, McLaughlin JK, Cocco P, Co Chien HT, Fraumeni JF: Risk factors for male breast cancer (United States). Cancer Causes Control. 1998, 9: 269-275. 10.1023/A:1008869003012.
Knez I, Cerwenka H, Moinfar F, Hoff M, Machler H, Anelli-Monti M, Radner H, Rigler B: Invasive ductal carcinoma of the male breast expanding from pacemaker pocket decubitus. Pacing Clin Electrophysiol. 1999, 22: 531-533. 10.1111/j.1540-8159.1999.tb00484.x.
Sasco AJ, Lowenfels AB, Pasker de Jonc P: Epidemiology of male breast cancer. A meta analysis of published case control studies and discussion of selected aetiological factors. Int J Cancer. 1993, 53: 538-549. 10.1002/ijc.2910530403.
Ribeiro G, Swindell R, Harris M, Banerjee S, Cramer A: A review of the management of the male breast carcinoma based on an analysis of 420 treated cases. The Breast. 1996, 5: 141-146. 10.1016/S0960-9776(96)90058-2.
Cutuli B, Lacroze M, Dilhuydy JM, Velten M, De Lafontan B, Marchal C, Resbeut M, Graic Y, Campana F, Moncho-Bernier V, De Gislain C, Tortochaux J, Cuillere JC, Reme-Saumon M, N'Guyen TD, Lesaunier F, Le Simple T, Gamelin E, Hery M, Berlie J: Male breast cancer: results of the treatments and prognostic factors in 397 cases. Eur J Cancer. 1995, 31A: 1960-1964. 10.1016/0959-8049(95)00366-5.
Donegan WL, Redlich PN, Lang PJ, Gall MT: Carcinoma of the breast in males: a multi-institutional survey. Cancer. 1998, 83: 498-509. 10.1002/(SICI)1097-0142(19980801)83:3<498::AID-CNCR19>3.0.CO;2-R.
Koc M, Oztas S, Erem MT, Ciftcioglu MA, Onuk MD: Invasive lobular carcinoma of the male breast: a case report. Jpn J Clin Oncol. 2001, 31: 444-446. 10.1093/jjco/hye099.
Borgen PI, Wong GY, Vlamis V, Potter C, Hoffmann B, Kinne DW, Osborne MP, McKinnon WM: Current management of male breast cancer. A review of 104 cases. Ann Surg. 1992, 215: 451-457. 10.1097/00000658-199205000-00007.
Sina B, Samorodin CS: Bilateral inflammatory carcinoma of the male breast. Cutis. 1984, 33: 501-502.
Jimenez-Ayala M, Diez-Nau MD, Larrad A, Ferrer-Vergara L, Rodriguez-Costa J, Lacruz C, Escalona-Zapata J: Hemangiopericytoma of the male breast. Report of a case with cytological, immunological and histological studies. Acta Cytol. 1991, 35: 234-238.
Allen FJ, Van Velden DJ: Prostate carcinoma metastatic to male breast. Br J Urol. 1991, 67: 434-435.
Verger E, Conzill C, Velasco M, Sole M: Metastasis in the male breast from a lung adenocarcinoma. Acta Oncol. 1992, 31: 479-10.3109/02841869209088294.
Heinig J, Jackish C, Rody A, Koch O, Buechter D, Schneider HP: Clinical management of breast cancer in males, a report of four cases. Eur J of Obstet Gynecol Reprod Biol. 2002, 102: 67-73. 10.1016/S0301-2115(01)00551-6.
Ravandi-Kashani F, Hayes TG: Male breast cancer: A review of the literature. Eur J Cancer. 1998, 34: 1341-1347. 10.1016/S0959-8049(98)00028-8.
Morimoto T, Komaki K, Yamakawa T, Tanaka T, Oomine Y, Konishi Y, Mori T, Monden Y: Cancer of the male breast. J Surg Oncol. 1990, 44: 180-184. 10.1002/jso.2930440311.
Giordano SH, Buzdar AU, Hortobagyi GN: Breast cancer in men. Ann Intern Med. 2002, 137: 678-687.
Olsson H: Estrogen receptor content in malignant breast tumours in men-a review. J Mammary Gland Biol Neoplasia. 2000, 5: 283-287. 10.1023/A:1009546811429.
Freidman MA, Hoffman PG, Dandolos EM, Lagios MD, Johnston WH, Siiteri PK: Estrogen receptors in male breast cancer: Clinical and pathological correlations. Cancer. 1981, 47: 134-137. 10.1002/1097-0142(19810101)47:1<134::AID-CNCR2820470122>3.0.CO;2-M.
Stalsberg H, Thomas DB, Rosenblatt KA, Jimenez LM, McTiernan A, Stemhagen A, Thompson WD, Curnen MG, Satariano W, Austin DF, Greenberg RS, Key C, Kolonel L, West D: Histologic types and hormone receptors in breast cancer in men: a population-based study in 282 United States men. Cancer Causes Control. 1993, 4: 143-151. 10.1007/BF00053155.
Tarone RE, Chu KC: The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States). Cancer Causes Control. 2002, 13: 7-14. 10.1023/A:1013960609008.
Pachecho MM, Oshima CF, Lopes MO, Widman A, Franco EL, Brentani MM: Steroid hormone receptors in male breast diseases. Anticancer Res. 1986, 6: 1013-1017.
Pich A, Margaria E, Chiusa L, Candelaresi G, Dal Canton O: Androgen receptor expression in male breast carcinoma: lack of clinicopathological association. Br J Cancer. 1999, 79: 959-964. 10.1038/sj.bjc.6690153.
Bentel JM, Berrel SN, Pickering MA, Holds DJ, Horsfall DJ, Tilley WD: Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate in human breast cancer cells. Mol Cell Endocrinol. 1999, 154: 11-20. 10.1016/S0303-7207(99)00109-4.
Birrell SN, Bental JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD: Androgens induce divergent proliferative response in human breast cancer cell lines. J Steroid Biochem Mol Biol. 1995, 52: 459-467. 10.1016/0960-0760(95)00005-K.
Andre S, Fonseca I, Pinto AE, Cardoso P, Pereira T, Soares J: Male breast cancer-a reappraisal of clinical and biologic indicators of prognosis. Acta Oncol. 2001, 40: 472-478. 10.1080/028418601750288190.
Mourao Netto M, Logullo AF, Nonogaki S, Brentani RR, Brentani MM: Expression of c-erbB-2, p53 and c-myc proteins in male breast carcinoma: Comparison with traditional prognostic factors and survival. Braz J Med Biol Res. 2001, 34: 887-894. 10.1590/S0100-879X2001000700008.
Shpitz B, Bomstein Y, Sternberg A, Klein E, Liverant S, Groisman G, Bernheim J: Angiogenesis, p53 and c-erbB-2 immunoreactivity and clinicopathological features in male breast cancer. J Surg Oncol. 2000, 75: 252-257. 10.1002/1096-9098(200012)75:4<252::AID-JSO5>3.0.CO;2-2.
Wang-Rodriguez J, Cross K, Gallagher S, Djahanban M, Armstrong JM, Wiedner N, Shapiro DH: Male breast cancer: correlation of ER, PR Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 cases. Mod Pathol. 2002, 15: 853-861. 10.1097/01.MP.0000022251.61944.1D.
Dawson PJ, Schroer KR, Wolman SR: ras and p53 genes in male breast cancer. Mod Pathol. 1996, 9: 367-370.
Jaiyesimi IA, Buzdar AU, Sahin AA, Ross MA: Carcinoma of the male breast. Ann Intern Med. 1992, 117: 771-777.
Kwiatkowska E, Teresiak M, Filas V, Karczewska A, Breborowicz D, Mackiewicz A: BRCA2 mutations and androgen receptor expressions as independent predictors of outcome of male breast cancer patients. Clin Cancer Res. 2003, 9: 4452-4459.
Rayson D, Erlichman C, Suman VJ, Roche PC, Wold LE, Ingle JN, Donohue JH: Molecular markers in male breast carcinoma. Cancer. 1998, 83: 1947-1955. 10.1002/(SICI)1097-0142(19981101)83:9<1947::AID-CNCR10>3.0.CO;2-J.
Bloom KJ, Govil H, Gattuso P, Reddy V, Francescatti D: Status of HER-2 in male and female breast carcinoma. Am J Surg. 2001, 182: 389-392. 10.1016/S0002-9610(01)00733-4.
Giannelli G, Fransvea E, Marinosci F, Bergamini C, Daniele A, Colucci S, Paradiso A, Quaranta M, Antonaci S: Gelatinase levels in male and female breast cancer. Biochem Biophys Res Commun. 2002, 292: 161-166. 10.1006/bbrc.2002.6599.
Reed W, Hannisdal E, Boehler PJ, Klein E, Liverant S, Groisman G, Bernheim J: The prognostic value of p53 and c-erb B-2 immunostaining is overrated for patients with lymph node negative breast carcinoma: a multivariate analysis of prognostic factors in 613 patients with a follow-up of 14–30 years. Cancer. 2000, 88: 804-813. 10.1002/(SICI)1097-0142(20000215)88:4<804::AID-CNCR11>3.0.CO;2-Y.
Erdem O, Dursun A, Coşkun U, Günel N: The prognostic value of p53 and c-erbB-2 expression, proliferative activity and angiogenesis in node-negative breast carcinoma. Tumori. 2005, 91: 46-52.
Anderson J, Reddy VB, Green L, Bitterman P, Borok R, Maggi-Galluzzi C, Montironi R, Wick M, Gould VE, Gattuso P: Role of expression of cell cycle inhibitor p27 and MIB-1 in predicting lymph node metastasis in male breast carcinoma. Breast J. 2002, 8: 101-107. 10.1046/j.1524-4741.2002.08206.x.
Joensuu H, Pylkkanen L, Toikkanen S: Bcl-2 protein expression and long term survival in breast cancer. Am J Pathol. 1994, 145: 1191-1198.
Hu SW, Chuang JH, Tsai KB: Immunohistochemical expression in male breast cancer: two case reports. Kaohsiung J Med Sci. 2006, 22: 235-242.
Curigliano G, Colleoni M, Renne G, Mazzarol G, Gennari R, Peruzzotti G, de Braud E, Robertson C, Maiorano E, Veronesi P, Nole F, Mandala M, Ferretti G, Viale G, Goldhirsch A: Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay. Ann Oncol. 2002, 13: 895-902. 10.1093/annonc/mdf166.
Gennari R, Curigliano G, Jereczek-Fossa BA, Zurrida S, Renne G, Intra M, Galimberti V, Luini A, Orecchia R, Viale G, Goldhrisch A, Veronesi U: Male breast cancer: A special therapeutic problem. Anything new? (Review). Int J Oncol. 2004, 24: 663-670.
Wagner JL, Thomas CR, Koh WJ, Rudolph RH: Carcinoma of the male breast: update 1994. Med Pediatr Oncol. 1995, 24: 123-132. 10.1002/mpo.2950240213.
Malani AK: Male breast cancer: a different disease than female breast cancer?. South Med J. 2007, 100: 197-
Sosnovskikh I, Naninato P, Gatti G, Caldarella P, Masullo M, De Brito LL, Luini A: Synchronous bilateral breast cancer in men: a case report and review of the literature. Tumori. 2007, 93: 225-227.
Lefor AT, Numann PJ: Carcinoma of the breast in men. N Y State J Med. 1988, 88: 293-296.
Gentilini O, Chagas E, Zurrida S, Intra M, De Cicco C, Gatti G, Silva L, Renne G, Cassano E, Veronesi U: Sentinel lymph node biopsy in male patients with early breast cancer. Oncologist. 2007, 12: 512-515. 10.1634/theoncologist.12-5-512.
Scheike O: Male breast cancer: Clinical manifestations in 257 cases in Denmark. Br J Cancer. 1973, 28: 552-562.
Vazquez B, Rousseau D, Hurd TC: Surgical management of breast cancer. Semin Oncol. 2007, 34: 234-240. 10.1053/j.seminoncol.2007.03.013.
Ahmed R, Ali SM: Role of imaging in diagnosis of carcinoma of breast. J Coll Physicians Surg Pak. 2005, 15: 238-241.
Hines SL, Tan WW, Yasrebi M, DePeri ER, Perez EA: The role of mammography in male patients with breast symptoms. Mayo Clin Proc. 2007, 82: 297-300.
Evans GF, Anthony T, Turnage RH, Schumpert TD, Levy KR, Amirkhan RH, Campbell TJ, Lopez J, Appelbaum AH: The diagnostic accuracy of mammography in the evaluation of male breast disease. Am J Surg. 2001, 181: 96-100. 10.1016/S0002-9610(00)00571-7.
Siddiqui MT, Zakowski MF, Ashfaq R, Ali SZ: Breast masses in males: multi-institutional experience on fine-needle aspiration. Diagn Cytopathol. 2002, 26: 87-91. 10.1002/dc.10066.
Hibbeln JF, Blend MJ, Wood DK: Tc-99m sestamibi uptake in infiltrating ductal carcinoma of the breast in a male patient. Clin Nucl Med. 1996, 21: 469-470. 10.1097/00003072-199606000-00008.
de Perrot M, Deleaval J, Robert J, Spiliopoulos A: Thirty-year experience of surgery for breast carcinoma in men. Eur J Surg. 2000, 166: 929-31. 10.1080/110241500447074.
Vaizey C, Burke M, Lange M: Carcinoma of the male breast – a review of 91 patients from the Johannesburg Hospital breast clinics. S Afr J Surg. 1999, 37: 6-8.
Rudan I, Rudan N, Basic N, Basic V, Rudan D: Differences between male and female breast cancer. II. Clinicopathological features. Acta Med Croatica. 1997, 51: 129-133.
Guinee VF, Olsson H, Moller T, Shallenberger RC, Blink van den JW, Peter Z, Durand M, Dische S, Cleton FJ, Zewuster R, Fang Cui M, Lane W, Richter R: The prognosis of breast cancer in males. A report of 335 cases. Cancer. 1993, 71: 154-161. 10.1002/1097-0142(19930101)71:1<154::AID-CNCR2820710125>3.0.CO;2-#.
Yildirim E, Berberoğlu U: Male breast cancer: a 22-year experience. Eur J Surg Oncol. 1998, 24: 548-552. 10.1016/S0748-7983(98)93608-3.
Salvadori B, Saccozzi R, Manzari A, Andreola S, Conti RA, Cusumano F, Grassi M: Prognosis of breast cancer in males: an analysis of 170 cases. Eur J Cancer. 1994, 30A (7): 930-935. 10.1016/0959-8049(94)90117-1.
Mustafa IA, Cole B, Wanebo HJ, Bland KI, Chang HR: Prognostic analysis of survival in small breast cancers. J Am Coll Surg. 1998, 186: 562-569. 10.1016/S1072-7515(98)00076-3.
Berg JW, Hutter RV: Breast cancer. Cancer. 1995, 75: 257-69. 10.1002/1097-0142(19950101)75:1+<257::AID-CNCR2820751311>3.0.CO;2-Y.
Truong PT, Berthelet E, Lee J, Kader HA, Olivotto IA: The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer. 2005, 103: 2006-2014. 10.1002/cncr.20969.
Joshi MG, Lee AKC, Loda M, Camus MG, Pedersen C, Heatley GJ, Hughes KS: Male breast carcinoma: an evaluation of the prognostic factors contributing to a poorer outcome. Cancer. 1996, 77: 490-498. 10.1002/(SICI)1097-0142(19960201)77:3<490::AID-CNCR10>3.0.CO;2-#.
Willsher PC, Leach IH, Ellis IO, Bell JA, Elston CW, Bourke JB, Blamey RW, Robertson JF: Male breast cancer: pathological and immunohistochemical features. Anticancer Res. 1997, 17: 2335-2338.
Bines J, Goss B, Hussong J: C-erbB2 and p53 overexpression as predictors of survival in patients with male breast cancer (Abstract). Proceedings of ASCO. 1997, 16: 558-
Bruce DM, Heyes SD, Payne S: Male breast cancer: clinicopathological features, immunocytochemical characteristics and prognosis. Eur J Surg Oncol. 1996, 22: 42-46. 10.1016/S0748-7983(96)91418-3.
Adami HO, Holmberg L, Malker B, Ries L: Long-term survival in 406 men with breast cancer. Br J Cancer. 1985, 52: 99-103.
Scott-Conner CE, Jochimsen PR, Menck HR, Winchester DJ: An analysis of male and female breast cancer treatment and survival among demographically identical pairs of patients. Surgery. 1999, 126: 775-781. 10.1067/msy.2099.99953.
Herman K, Lobaziewicz W, Skotnicki P, Fortuna J, Kusy T, Lesniak T: Male breast cancer. Does the prognosis differ compared to female?. Neoplasma. 2000, 47: 191-5.
Hill A, Yagmur Y, Tran KN, Bolton JS, Robson M, Borgen PI: Localized male breast carcinoma and family history. An analysis of 142 patients. Cancer. 1999, 86: 821-5. 10.1002/(SICI)1097-0142(19990901)86:5<821::AID-CNCR18>3.0.CO;2-I.
Vinod SK, Pendlebury SC: Cancer of the male breast: a review of adjuvant therapy. Australas Radiol. 1999, 43: 69-72. 10.1046/j.1440-1673.1999.00601.x.
Leivonen MK, Peltokallio P, Kalima TV: Long term survival in male breast cancer. Ann Chir Gynaecol. 1989, 78: 146-8.
Carmalt HL, Mann LJ, Kennedy CW, Fletcher JM, Gillett DJ: Carcinoma of the male breast: a review and recommendations for management. Aust NZ J Surg. 1998, 68: 712-5. 10.1111/j.1445-2197.1998.tb04657.x.
El-Tamer MB, Komenaka IA, Troxel A, Li H, Joseph KA, Ditkoff BA, Schnabel FR, Kinne DW: Men with breast cancer have better disease-specific survival than women. Arch Surg. 2004, 139: 1079-1082. 10.1001/archsurg.139.10.1079.
Margaria E, Chiusa L, Ferrari L, Dal Canton O, Pich A: Therapy and survival in male breast carcinoma: A retrospective analysis of 50 cases. Oncol Rep. 2000, 7: 1035-1039.
Vetto J, Jun SY, Paduch D, Eppich H, Shih R, Padduch D: Stages at presentation, prognostic factors and outcome of breast cancer in males. Am J Surg. 1999, 177: 379-383. 10.1016/S0002-9610(99)00067-7.
Robison R, Montague ED: Treatment results in men with breast cancer. Cancer. 1982, 49: 403-406. 10.1002/1097-0142(19820115)49:2<403::AID-CNCR2820490232>3.0.CO;2-T.
Stranzl H, Mayer R, Quehenberger F, Prettenhofer U, Willfurth P, Stöger H, Hackl A: Adjuvant radiotherapy in male breast cancer. Radiother Oncol. 1999, 53: 29-35. 10.1016/S0167-8140(99)00122-X.
Chung HC, Koh EH, Roh JK, Min JS, Lee KS, Suh CO, Kim KE, Loh JJ, Lee KB, Kim BS: Male breast cancer-a 20-year review of 16 cases at Yonsei University. Yonsei Med J. 1990, 31: 242-250.
Chakravarthy A, Kim CR: Post-mastectomy radiation in male breast cancer. Radiother Oncol. 2002, 65: 99-103. 10.1016/S0167-8140(02)00210-4.
Hultborn R, Friberg S, Hultborn KA: Male breast carcinoma. I. A study of the total material reported to the Swedish Cancer Registry 1958–1967 with respect to clinical and histopathological parameters. Acta Oncol. 1987, 26: 241-256. 10.3109/02841868709089970.
Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, Zedeler K: Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997, 337: 949-955. 10.1056/NEJM199710023371401.
Stranzl H, Mayer R, Quehenberger F, Prettenhofer U, Willfurth P, Stöger H, Hackl A: Adjuvant radiotherapy in male breast cancer. Radiother Oncol. 1999, 53: 29-35. 10.1016/S0167-8140(99)00122-X.
Schuchardt U, Seegenschmiedt MH, Kirschner MJ, Renner H, Sauer R: Adjuvant radiotherapy for breast carcinoma in men: a 20-year clinical experience. Am J Clin Oncol. 1996, 19: 330-336. 10.1097/00000421-199608000-00002.
Cimmino VM, Degnim AC, Sabel MS, Diehl KM, Newman LA, Chang AE: Efficacy of sentinel lymph node biopsy in male breast cancer. J Surg Oncol. 2004, 86: 74-77. 10.1002/jso.20045.
Goyal A, Horgan K, Kissin M, Yiangou C, Sibbering M, Lansdown M, Newcombe RG, Mansel RE, Chetty U, Ell P, Fallowfield L, Kissin M, ALMANAC Trialists Group: Sentinel lymph node biopsy in male breast cancer patients. Eur J Surg Oncol. 2004, 30: 480-483. 10.1016/j.ejso.2004.02.006.
Ribeiro G, Swindell R: Adjuvant tamoxifen for male breast cancer (MBC). Br J Cancer. 1992, 65: 252-254.
Patel HZ, Buzdar AU, Hortobagyi GN: Role of adjuvant chemotherapy in male breast cancer. Cancer. 1989, 64: 1583-1585. 10.1002/1097-0142(19891015)64:8<1583::AID-CNCR2820640804>3.0.CO;2-Q.
Bagley CS, Wesley MN, Young RC, Lippman ME: Adjuvant chemotherapy in males with cancer of the breast. Am J Clin Oncol. 1987, 10: 55-60. 10.1097/00000421-198702000-00013.
Kreusel KM, Heimann H, Wiegel T, Bornfeld N, Foerster MH: Choroidal metastasis in men with metastatic breast cancer. Am J Ophthalmol. 1999, 128: 253-255. 10.1016/S0002-9394(99)00062-8.
Muttarak M, Nimmonrat A, Chaiwun B: Metastatic carcinoma to the male and female breast. Australas Radiol. 1998, 42: 16-19. 10.1111/j.1440-1673.1998.tb00556.x.
Kantarjian H, Yap HY, Hortobagyi G, Buzdar A, Blumenschein G: Hormonal therapy for metastatic male breast cancer. Arch Intern Med. 1983, 143: 237-240. 10.1001/archinte.143.2.237.
Neifeld JP, Meyskens F, Tormey DC, Javadpour N: The role of orchiectomy in the management of advanced male breast cancer. Cancer. 1976, 37: 992-995. 10.1002/1097-0142(197602)37:2<992::AID-CNCR2820370257>3.0.CO;2-B.
Arriola E, Hui E, Dowsett M, Smith IE: Aromatase inhibitors and male breast cancer. Clin Transl Oncol. 2007, 9: 192-194. 10.1007/s12094-007-0034-3.
Kraybill WG, Kaufman R, Kinne D: Treatment of advanced male breast cancer. Cancer. 1981, 47: 2185-2189. 10.1002/1097-0142(19810501)47:9<2185::AID-CNCR2820470913>3.0.CO;2-B.
The authors declare that they have no competing interests.
KC and KK contributed equally to writing the entire manuscript, KC also did database searches, retrieved relevant references and designed various tables and figures.
GR and DK helped in editing the manuscript.
HS helped in the final review and editing of the manuscript.
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Contractor, K.B., Kaur, K., Rodrigues, G.S. et al. Male breast cancer: is the scenario changing. World J Surg Onc 6, 58 (2008). https://doi.org/10.1186/1477-7819-6-58