Fibromatosis-like carcinoma-an unusual phenotype of a metaplastic breast tumor associated with a micropapilloma
© Rekhi et al; licensee BioMed Central Ltd. 2007
Received: 25 October 2006
Accepted: 27 February 2007
Published: 27 February 2007
Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving.
A 77-year-old lady presented with a 2 × 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC) from the lump was inconclusive. A lumpectomy was performed and sent for frozen section, which revealed presence of spindle cells showing mild atypia in a sclerotic stroma. The tumor cells revealed prominent infiltration into the adjacent fat. A differential diagnosis of a low-grade sarcoma vs. a metaplastic carcinoma, favoring the former, was offered. Final histology sections revealed an infiltrating tumor with predominant spindle cells in a collagenous background, simulating a fibromatosis. Adjacent to the tumor were foci of benign ductal hyperplasia and a micropapilloma. Immunohistochemistry (IHC) showed diffuse co-expression of epithelial markers i.e. cytokeratins (CK, HMWCK, CK7) and EMA along with a mesenchymal marker i.e. vimentin in the tumor cells. Myoepithelial markers (SMA and p63) showed focal positivity. A diagnosis of a low-grade fibromatosis-like carcinoma breast associated with a micropapilloma was formed.
Fibromatosis-like carcinoma is a rare form of a metaplastic breast tumor. This diagnosis requires an index of suspicion while dealing with spindle cell breast tumors. The importance of making this diagnosis to facilitate an intra operative surgical planning is marred by diagnostic difficulties. In such cases, IHC is imperative in forming an objective diagnosis.
Metaplastic breast tumors exhibit a wide morphologic spectrum, ranging from tumors with clearly visualized epithelial elements to heterologous tumors with non-epithelial elements like spindle cells, cartilage and bone [1–4]. With the help of immunohistochemical (IHC) markers, different morphologic entities within the larger group of metaplastic tumors have been identified. Among these is an unusual, "fibromatosis-like" metaplastic carcinoma. Currently, there is a limited understanding for this tumor as a result of its rarity [4, 5]. We present a case of a "fibromatosis-like" metaplastic carcinoma associated with a micropapilloma in an elderly lady. This rare case is discussed to highlight its diagnostic and management issues.
A 77-year-old lady presented with the complaints of a left-sided breast lump of 1-month duration. She had been a heart patient and had been on treatment for the last 4 years. On clinical examination a 3 × 2 cm firm, mobile, non-tender lump was identified in the outer quadrant of her left breast. The overlying skin of the breast along with nipple and areola were unremarkable. There was no significant axillary or cervical lymphadenopathy. The other breast was normal. She underwent a mammographic examination, followed by fine needle aspiration cytology (FNAC) that was essentially inconclusive. Subsequently, she underwent a frozen section for a primary diagnosis.
The lumpectomy specimen on cut surface revealed a firm, grey-white, fibrous, un-encapsulated nodular tumor measuring 2 × 1.2 × 0.8 cm with infiltrative borders. No area of calcification was identified. The closest margin was the base and was found to be 0.5 cm away from the tumor.
Frozen sections revealed a tumor with predominant spindle cells showing mild atypia, amidst a sclerotic stroma and conspicuously infiltrated the adjacent fat. A diagnosis of a low-grade sarcoma was favored over a metaplastic carcinoma. Therefore, a sentinel lymph node biopsy and/or an axillary node dissection (ALND) were not conducted at the time of surgery.
List and details of the IHC antibody markers.
Dako, Glostrup Denmark
High molecular weight (HMWCK)
Epithelial membrane antigen (EMA)
Gross cytic disease fluid protein (GCD-FP)
Estrogen receptor (ER)
Progestrone receptor (PR)
Smooth muscle antigen (SMA)
A portion of fresh tumor tissue fixed in 3% glutaraldehyde was processed for electron microscopy. Ultra thin sections stained with uranyl acetate and lead citrate were observed under an electron microscope model: Zeiss 109, Germany.
After surgery, the patient completed adjuvant radiotherapy (RT). Thereafter, she has been on a regular 2 monthly follow-up; including her metastatic work-up with Positron emission tomography (PET-CT) of the body and bone scan. Due to a high cardiac risk, a second surgery for an ALND was not performed. Nevertheless, till 1 year and 4 months of her follow-up she has not been identified with any lymphadenopathy, recurrent lesion or metastatic lesions in her body.
Spindle cell metaplastic breast tumors display a range of elements, including low-grade tumors to those with areas of high-grade sarcomas like fibrosarcomas and malignant fibrous histiocytomas [2–4]. Among these, a low-grade "fibromatosis-like" variant of a metaplastic carcinoma with only <5% tumor cells showing epithelial traits, has been a recently described entity [4, 5]. Identification of this variant assumes importance as, like fibromatosis, it has more chances for local recurrence than distant metastasis . At the same time its exact diagnosis from this close morphological differential i.e. fibromatosis and other benign and malignant spindle cell tumors has a far-reaching significance and requires application of IHC markers.
The present case observed in an elderly female who underwent a lumpectomy for a painless breast lump, exemplifies the diagnostic and management issues related to this tumor. The relatively bland nature of cells has prompted some authors to label it as a 'tumor' than a carcinoma .
This tumor has predilection for older women. In a classical premier series of 30 exclusive cases by Gobbi et al  and 24 cases by Sneige et al , the average age seen with this tumor was 63.4 years and 66 years respectively. Gobbi et al  identified these cases in women having a single palpable, generally painless, breast mass, more commonly in the left side (62.5%), as seen in our case.
On gross findings, they observed an average size of 2.7 cms with these tumors; mostly associated with unencapsulation and irregular borders . In the present case, the tumor displayed an irregular and an infiltrative growth pattern, both grossly as well as microscopically; thereby closing mimicked an aggressive mesenchymal tumor/sarcoma on the frozen sections. In view of predominantly spindle cells with mild atypia, however, revealing prominent infiltration into the adjacent soft tissues, diagnosis of a low-grade sarcoma was favored over a metaplastic carcinoma that seemed to be the closest differential diagnosis. An exact diagnosis was not offered since multiple section examination and adjunctive IHC application were anticipated for arriving at a final diagnosis. However, in view of a favored diagnosis of a low-grade sarcoma, the patient was spared for an ALND. On histology, the differential diagnoses considered were nodular fasciitis (NF), an inflammatory myofibroblastic tumor, pseudoangiomatous stromal hyperplasia (PASH), a myofibroblastoma, a low-grade fibrosarcoma and of course fibromatosis, which was a very close differential diagnosis. Nodular fasciitis (NF) and an inflammatory myofibroblastic tumor were ruled out based on the lack of conspicuous lymphoplasmacytic infiltrates and myxoid background [7–9]. Absence of slit-like spaces lined by fibroblastic cells made a diagnosis of a pseudoangiomatous stromal hyperplasia (PASH) less likely. Lack of fascicular arrangements and lower cellularity helped to rule out a fibrosarcoma and pleomorphic sarcomas. . The immunoprofile was also helpful in objectively ruling out the other mentioned differential diagnoses, all of which lack epithelial expression. Thus it is imperative to employ a panel of epithelial and myoepithelial markers in spindle cell tumors of breast. Unlike Schafernak et al , who noticed focal positivity for epithelial markers in the spindly cells, we observed a diffuse strong immunoreactivity in spindle and slightly more in plump cells as was observed by Gobbi et al . Among the various cytokeratins, a diffuse strong expression of HMWCK that is believed to be an expression of squamous carcinomas was suggestive for metaplastic traits of the tumor. Similar finding have been noted by others [4, 7]. As in our case, Gobbi et al  demonstrated CK7 positivity, mostly in glandular areas in both their cases of predominantly "fibromatosis-like" carcinomas that were analyzed with IHC. A positive co-expression of epithelial and mesenchymal markers in the spindly cells might be considered as suggestive of 'epithelial-mesenchymal' transition observed with these tumors.
Positive expression for myoepithelial markers in this case is further suggestive that these tumors might constitute as myoepithelial subtypes of a metaplastic carcinoma. A positive p63 expression, like in our case, has been lately identified in 86.3% cases of myoepithelial carcinomas in a study by Koker et al . Ultrastructural findings further confirmed epithelial nature of these tumor cells with the presence of cell junctions and microvilli. Gersel et al  described a series of spindle cell carcinomas of the breast including deceptively bland carcinoma cells.
Micropapillomas and papillomas have been described to be associated with an increased risk for subsequent development of a breast carcinoma and may form its antecedent lesion . Association of a micropapilloma with metaplastic carcinomas was also noted by Gobbi et al . However, the 'fibromatosis-like' pattern was noted in only a few of their cases .
The optimal treatment options for this tumor remain unclear. However, most authors insist on a complete local treatment like lumpectomy with wide margins and adjuvant RT . Rarely, such cases, generally larger sized, with distant metastasis have also been identified by Sneige et al  and Kinkor et al . Though the present case limits an ALND in view of less likeliness for nodal metastasis, currently, given the epithelial nature of this tumor, it would be worthwhile to perform a sentinel lymph node dissection in such cases.
An objective identification of this uncommon tumor with the help of a panel of IHC, along with the presence of a micropapilloma makes this case unique. Further, an uneventful follow-up for more than a year, despite avoidance of an axillary lymph node dissection suggests a relatively lesser metastatic potential of this tumor. A certain degree of index of suspicion in the pathologists' mind while dealing with spindle cell tumors of breast is helpful in making this diagnosis. Documentation of more of such cases with follow-up details would bring new light to the management and biological behavior of this unusual breast tumor.
The written consent was obtained from the patient for publication of this case report.
We would like to thank Mrs. Meena Sawant and Mr. Mahendra Palker from our immunopathology laboratory for carrying out the IHC staining.
- Page DL, Anderson TJ: Uncommon types of invasive carcinoma: Diagnostic histopathology of the breast. 1987, Edinburgh, Scotland: Churchill Livingstone, 236-252.Google Scholar
- Wargotz ES, Deos PH, Norris HJ: Metaplastic carcinomas of the breast. II- Spindle cell carcinoma. Hum Pathol. 1989, 20: 732-740. 10.1016/0046-8177(89)90065-8.View ArticlePubMedGoogle Scholar
- Gersell DJ, Katzenstein ALA: Spindle cell carcinoma of the breast. A clinicopathologic and ultrastructural study. Hum Pathol. 1981, 12: 550-561. 10.1016/S0046-8177(81)80069-X.View ArticlePubMedGoogle Scholar
- Gobbi H, Simpson JF, Borowsky A, Jensen RA, Page DL: Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer. 1999, 85: 2170-2182. 10.1002/(SICI)1097-0142(19990515)85:10<2170::AID-CNCR11>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Gobbi H, Simpson JF, Jensen RA, Olson SJ, Page DL: Metaplastic spindle cell breast tumors arising within papillomas, complex sclerosing lesions and nipple adenomas. Mod Pathol. 2003, 16: 893-901. 10.1097/01.MP.0000085027.75201.B5.View ArticlePubMedGoogle Scholar
- Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonez NG, Gown AM, Ayala A: Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol. 2001, 25: 1009-1016. 10.1097/00000478-200108000-00004.View ArticlePubMedGoogle Scholar
- Kontonegros G, Papamichalis G, Bouropouplou V: Fibroblastic lesion of the breast exhibiting features of nodular fasciitis. Arch Anat Cytol Pathol. 1988, 36: 113-115.Google Scholar
- Torngren S, Frisell J, Nilsson R, Wiege M: Nodular fasciitis and fibromatosis of the female breast simulating breast cancer. Case reports. Eur J Surg. 1991, 157: 155-158.PubMedGoogle Scholar
- Coffin CM, Watterson J, Priest JR, Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995, 19: 859-872.View ArticlePubMedGoogle Scholar
- Damiani S, Miettinen M, Peterse JL, Eusebi V: Solitary fibrous tumor (myofibroblastoma) of the breast. Virchows Arch A. 1994, 425: 89-92.Google Scholar
- Schafernak KT, Policarpio-Nicolas ML, Wiley EL, Laskin WB, Diaz LK: A 59-year-old woman with a spindle cell lesion of the breast. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Arch Pathol Lab Med. 2006, 130: 81-83.Google Scholar
- Koker MM, Kleer CG: p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. Am J Surg Pathol. 2004, 28: 1506-1512. 10.1097/01.pas.0000138183.97366.fd.View ArticlePubMedGoogle Scholar
- Page DL, Salhany KE, Jensen RA, Dupont WD: Subsequent breast carcinoma risk after biopsy with atypia in a breast papilloma. Cancer. 1996, 78: 258-266. 10.1002/(SICI)1097-0142(19960715)78:2<258::AID-CNCR11>3.0.CO;2-V.View ArticlePubMedGoogle Scholar
- Kinkor Z, Svitakova I, Ryska A, Kodet R, Hrabal P: Metaplastic spindle-cell (fibromatosis-like) carcinoma of the breast- report of 4 cases. Cesk Patol. 2002, 38: 164-168.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.