Primary presacral neuroendocrine tumor associated with imperforate anus
© Kim et al; licensee BioMed Central Ltd. 2007
Received: 27 April 2007
Accepted: 11 October 2007
Published: 11 October 2007
Presacral masses are unusual growths that have a limited differential diagnosis, typically not including neuroendocrine tumors (NETs). Classically, NETs are well-differentiated gastroenteropancreatic tumors of probable benign behavior. These tumors are associated with a typical morphologic pattern and involve the distal colon, rectum, and genitourinary tract; they are considered less aggressive, frequently asymptomatic, and rarely cause carcinoid syndrome, even when metastatic. Neuroendocrine tumors of the presacral region are extremely rare and few have been described in the literature. They have not been previously reported as being associated with imperforate anus.
We present an interesting case of a woman with a history of imperforate anus that was found to have a primary neuroendocrine tumor of the presacral region with no rectal wall involvement.
We argue that this is a primary gastroenteropancreatic neuroendocrine tumor which likely originated from cells of hindgut origin that underwent an abnormal migration during embryonic development.
Neuroendocrine tumors are rare with an incidence rate of two to five per 100,000, with a higher incidence rate for African-American men and women. The age distribution ranges from the second to the ninth decade, with peak incidence between the ages of 50 and 70. They are the most common neuroendocrine tumor of the gastrointestinal tract. Around 55% are located in the gastrointestinal tract and 30% in the bronchopulmonary system. In the gastrointestinal tract, they tend to arise most commonly in the small intestine (45%), followed by rectum (20%), appendix (16%), colon (11%), and stomach (7%) .
Neuroendocrine tumors of the presacral region are rare and usually represent direct extension or metastasis from primary rectal tumors. Only a handful of primary presacral NETs have been reported in the literature and are felt presumably to derive from hindgut rests, especially given their histopathologic similarity with primary rectal NETs . We report a rare case of a primary presacral NET in a patient with a history of imperforate anus, which is associated with abnormalities in hindgut cell migration and explains the predisposition to develop a classic hindgut-like gastroenteropancreatic NET in this region.
Postoperatively, the patient did well and was discharged without complications. She had no new symptoms of incontinence, rectal, or back pain. Her bowel habits and loose stools remained at her pre-operative baseline. There was no evidence of recurrence of disease after 10 months of follow up.
All of these features confirmed this tumor to be a well differentiated neuroendocrine tumor according to the WHO classification.
The presacral space is a region bounded by the rectum anteriorly, sacrum posteriorly, peritoneal reflection superiorly and perineal muscles inferiorly. The differential diagnosis of lesions arising in this area include solid tumors such as teratomas, chordomas, paragangliomas and ependymomas, or cystic lesions, such as tailgut cysts, duplication cysts, and dermoid cysts, thought to arise from the embryological tailgut or neurenteric canal. An association between tailgut cysts and presacral NETs is described in the literature. Furthermore, NETs of the presacral space are histopathologically similar to rectal NETs. The theory is that the presence of remnant hindgut cells may be the basis for development of neuroendocrine tumors in this region.
Previous case reports describing the presence of a presacral carcinoid
Incomplete migration and/or fusion of the urorectal septum with the cloacal membrane lead to persistence of the cloaca and/or fistulae. Imperforate anus results from persistence of the dorsal cloacal membrane [15, 16] and ventral persistence causes absent urethral and vaginal openings. There appears to be a 'malfunctioning of cells ingressing from an end-stage primitive streak' that leads to defective development of the dorsal cloaca . Our postulate is that incomplete or impaired migration of hindgut cells led to both our patient's imperforate anus, and the predisposition to develop a primary neuroendocrine tumor from persistent hindgut rests in the presacral region. In fact, there was no evidence suggesting that the tumor emanated from the rectal wall. Colonoscopy failed to show a primary rectal tumor. EUS and CT images clearly demonstrate the tumor location outside the rectal wall. At surgery, the tumor was found to not involve the rectal wall. A somatostatin receptor scintography scan ruled out the chance that this tumor was metastatic from elsewhere as primary uptake was found in the presacral mass with no uptake in other sites. While carcinoid tumors can arise from other pelvic organs, besides the rectum, there was no evidence of primary tumors in the vagina, cervix or ovaries.
Our patient presented initially with abdominal pain and diarrhea, and was found to have an incidental presacral mass on CT scan. It was determined that her presenting symptoms were not related to the presence of this tumor but to a brief episode of nonspecific colitis. The neuroendocrine tumor was diagnosed after an appropriate diagnostic work-up following the most current guidelines [18, 19]. Classically, gastroenteropancreatic neuroendocrine tumors are indolent and do not manifest symptoms unless they are either secretory tumors or are locally advanced to cause obstructive symptoms or have metastasized. The carcinoid syndrome, characterized by such symptoms as flushing, diarrhea, and wheezing, usually results from liver metastasis and subsequent release of vasoactive compounds such as serotonin . The somatostatin receptor scintigraphy scan demonstrated no metastasis, nor did our patient exhibit a constellation of symptoms to suggest an actual carcinoid syndrome. Furthermore, she did not present with obstructive-type symptoms secondary to the mass. The histopathologic findings were of a well-delineated mass composed of highly differentiated neuroendocrine cells, displaying no angioinvasion and with a low mitotic index. The tumor cells were positive for chromogranin, synaptophysin, cytokeratin and negative for S-100. A paraganglioma was ruled out based on these findings and the lack of the typical histologic appearance. Our patient's clinical picture and above histopathologic findings are all consistent with the standard World Health Organization (WHO) classification of a well-differentiated gastroenteropancreatic neuroendocrine tumor of probable benign behavior [18, 20, 21].
In conclusion, we report the first case of primary presacral neuroendocrine tumor, of likely gastroenteropancreatic and, more specifically, originating from abnormal migration of hindgut cells in a patient with imperforate anus. There was no tumor involvement of the rectal wall on preop EUS or CT imaging or during surgical resection. The presence of previous surgery in the pelvis to create a neoanus resulted in increased complexity when determining the treatment options for this patient. However, as demonstrated by this case for tumors below the S3 level, despite previous surgery in the low pelvis, a transsacral approach for resection should be feasible, with careful preservation of the rectal wall .
Written informed consent was obtained from the patient for publication of this case report.
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