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Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case
World Journal of Surgical Oncology volume 4, Article number: 66 (2006)
Adenoid Cystic Carcinoma of the lacrimal gland is a rare tumour. Their aggressive behaviour, with a high-risk of local recurrence, and late distant spread of the tumour even after aggressive management has been reported. Metastasis to the liver is rare and when it occurs, it is usually part of widespread metastasis, and therefore surgical treatment is seldom considered.
We report a rare case of an isolated liver metastasis from a lacrimal gland adenoid cystic carcinoma 20 years after resection of the primary tumour. The patient presented with right upper quadrant pain radiating to the back and shortness of breath of 3 months duration. No local recurrence was detected during a 15 year follow-up with computerized tomography (CT) of the head. Abdominal CT scan demonstrated a solitary liver tumour with no other primary source, and the bone scan was normal. The patient was treated with an extended right hemihepatectomy. The histology revealed a predominantly cribriform tumour with focal areas of basaloid type metastatic lacrimal gland adenoid cystic carcinoma.
This case illustrates the unpredictable behaviour of adenoid cystic carcinoma and the need for a life long follow up for these patients after treatment. The possibility of surgical resection for liver metastasis from adenoid cystic carcinoma should always be considered.
Adenoid cystic carcinomas (ACC) of the lacrimal gland are rare malignant tumours accounting for 1.6% of all orbital tumours [1–3]. Despite their rarity they are the second most frequent epithelial neoplasms occurring in the lacrimal gland after pleomorphic adenomas .
There are few studies and reports on lacrimal gland ACC describing time interval to presentation of metastases and length of follow-up required [9, 10]. The liver is considered a rare site of distant metastasis and when it is involved is usually as part of disseminated disease . To our knowledge, neither solitary liver metastasis, nor metastatic liver resection from a lacrimal gland ACC has been reported.
We present a case of an isolated liver metastasis occurring 20 years after initial surgery for lacrimal gland ACC, with no evidence of loco regional, synchronous or metachronous distant metastasis.
In 1985, a 51-year-old male, underwent a radical craniofacial resection for a left lacrimal gland adenoid cystic carcinoma, followed by postoperative radiotherapy. He was followed-up with annual head and orbital CT scans for 15 years with no signs of loco-regional recurrence. Five years after discharge from follow-up, he presented with a 3-month history of right upper quadrant pain, radiating to his back, associated with shortness of breath and reduced exercise tolerance.
Physical examination revealed hepatomegaly and right upper quadrant tenderness, but no stigmata of chronic liver disease. Head and neck examination revealed no sign of local recurrence. LFT, inflammatory markers, coagulation profile, CEA, CA 19-9, and AFP were all normal. An abdominal ultrasound (USS) examination and subsequent chest and abdominal CT scan showed a large 15 × 17 × 20 cm heterogeneous mass with a central area of low attenuation suggesting necrosis involving segments 4 to 8 of the liver (Figure 1), partially occluding the right portal vein. No lung or bone metastases were identified.
The patient was otherwise fit with no other significant past medical history. After discussion at our multidisciplinary meeting the patient was offered surgery. At operation, the tumour was found to infiltrate the right hemi diaphragm, which was locally excised en bloc with the extended right hemihepatectomy. The postoperative course was unremarkable and he was discharged 7 days after surgery. The histology revealed a metastatic adenoid cystic carcinoma identical to his primary lacrimal gland tumour 20 years earlier, with prominent cribriform and focal basaloid type areas (Figures 2 and 3).
ACC in general has a slow biological growth and tends to have a protracted course with a poor outcome, with a reported survival rate of less than 50% at 5 years and 20% at 10 years [11–14]. Lacrimal gland ACC displays a similarly aggressive behavior with an overall survival of 20% at 10 years [15, 16]. Local recurrence risk was shown to be higher than distant recurrence in 8 different studies [8, 17], suggesting local recurrence as the commonest cause of disease progression and death.
In 23 years retrospective study, Ramon et al, reviewed the outcome of 12 patients with low grade ACC, showing that all patients had local recurrence with a mean interval of 3.25 years, and a mean survival of 5 years . In the Bayler series of patients with lacrimal gland ACC, the longest survivors lived 13 and 16 years respectively after exenteration and radiotherapy . In this case our patient is still alive 21 years after the primary resection.
Late presentation of distant metastases is a recognised feature of ACC with reported distant metastasis rates of 19–24%, and a mean time to presentation of 7.6 years . Recurrence after 16 years has been reported ; with bone and lungs as the commonest sites for distant metastases [5, 8, 11, 20].
Metastasis to the liver is rare and usually only occurs in conjunction with more widespread metastatic disease . Reported rates of liver metastases in ACC are between 2–20%, with the longest reported period to presentation of only 36 months [10, 21]. No isolated hepatic metastases from lacrimal gland ACC were recorded in these series.
This patient had liver metastasis as the sole presentation of secondary disease 20 years following treatment for his primary with no evidence of local recurrence. Surgical resection of liver metastasis from lacrimal gland ACC has never been reported before.
There is no proven effective chemotherapy for the treatment of metastatic lacrimal gland ACC; however some studies suggested benefit from neoadjuvant and adjuvant chemotherapy in the treatment of primary lacrimal gland ACC, in terms of improving local disease control and overall disease free survival .
This case highlights new aspects on ACC of the lacrimal glands, and a new evidence of the unpredictability of ACC behaviour in general.
Solitary hepatic metastasis can occur extremely late after resection of lacrimal gland ACC. Life long follow-up of patients with ACC is mandatory as treatable single organ recurrence may occur decades after resection of the primary. Resection of such liver metastasis is possible and should be considered.
Font RL, Smith SL, Bryan RG: Malignant epithelial tumours of the lacrimal gland: a clinicopathologic study of 21 cases. Arch Ophthalmol. 1998, 116: 613-616.
Henderson JW, Farrow GM: Adenoid cystic carcinoma. Orbital tumours. Edited by: John W Henderson. 1980, New York: Decker; Stuttgart; Thieme, 414-418. 2
Font RL, Gamel JW: Epithelial tumours of the lacrimal gland: an analysis of 265 cases. Ocular and adnexal Tumors. Edited by: Jakobiec FA. 1978, Birmingham, Ala: Aesculapius, 787-805.
Zimmerman LE, Sanders TE, Ackerman LV: Epithelial tumours of the lacrimal gland: prognostic and therapeutic significance of histologic types. Int Ophthalmic Clin. 1962, 2: 337-367. 10.1097/00004397-196206000-00005.
Spiro RH, Huvos AG: Stage means more than grade in adenoidcystic carcinoma. Am J Surg. 1992, 164: 623-628. 10.1016/S0002-9610(05)80721-4.
Spiro RH: Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg. 1997, 174: 495-498. 10.1016/S0002-9610(97)00153-0.
Qureshi SS, Nadkarni MS, Shrikhande SV, Desai S, Deodhar K, Ramadwar M, Shukla PJ: Hepatic resection from metastatic adenoid cystic carcinoma of parotid gland. Indian J Gastroenterol. 2005, 24: 29-30.
Khan AJ, DiGiovanna MP, Ross DA, Sasaki CT, Carter D, Son YH, Haffty BG: Adenoid cystic carcinoma: A retrospective clinical review. Int J Cancer. 2001, 96: 149-158. 10.1002/ijc.1013.
Bartley GB, Harris GJ: Adenoid cystic carcinoma of the lacrimal gland: Is there a cure... yet?. Ophthal Plast Reconstruct Surg. 2002, 18: 315-318. 10.1097/00002341-200209000-00001.
Esmaeli B, Ahmadi MA, Youssef A, Diba R, Amato M, Myers JN, Kies M, El-Naggar A: Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstruct Surg. 2004, 20: 22-26. 10.1097/01.IOP.0000105518.72611.4F.
Meldrum ML, Tse DT, Benedetto P: Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol. 1998, 116: 315-321.
Spiro RH: The controversial adenoid cystic carcinoma. Clinical considerations. Controversies in the Management of Salivary Gland Disease. Edited by: McGurk M, Renehan AG. 2001, Oxford, UK: Oxford University Press, 207-211.
Speight PM, Barret AW: Salivary gland tumours. Oral Dis. 2002, 8: 229-240. 10.1034/j.1601-0825.2002.02870.x.
Font RL, Gamel JW: Adenoid cystic carcinoma of the lacrimal gland: a clinico-pathologic study of 79 cases. Ocular Pathology Update. Edited by: Nichols DH. 1980, New York, NY: Masson Publishing USA, 277-283.
Spencer WH: Ophthalmic Pathology: an Atlas and Textbook. 1996, Philadelphia, PA: WB Saunders Co, 2494-2509.
Gamel JW, Font RL: Adenoid cystic carcinoma of the lacrimal gland: the clinical significance of a basiloid histologic pattern. Hum Pathol. 1982, 13: 219-225.
Wright JE, Rose GE, Garner A: Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol. 1992, 76: 401-407.
Remon Font, Shannon Smith, Richard Bryan: Malignant epithelial tumours of the lacrimal gland. A clinicaopathologic study of 21 Cases. Arch Ophthalmol. 1998, 116: 613-616.
Friedrich RE, Bleckmann V: Adenoid cystic carcinoma of salivary gland origin: localization, classification, clinical pathological correlation. treatment results and long-term follow-up control in 84 patients. Anticancer Res. 2003, 23: 931-940.
Sugarbaker EV: Patterns of metastasis in human malignancies. Cancer Biol Rev. 1981, 2: 235-278.
Sung MW, Kim KH, Kim JW, Min YG, Seong WJ, Roh JL, Lee SJ, Kwon TK, Park SW: Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2003, 129: 1193-1197. 10.1001/archotol.129.11.1193.
Tse DT, Benedetto P, Dubovy S, Schiffman JC, Feuer WJ: Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. Am J Ophthalmol. 2006, 141: 46-53.
The written consent was obtained from the patient for publication of this case report.
The authors thank Dr. A Bateman from the Histopathology Department and Dr. D Breen from the Radiology Department in Southampton General Hospital for their help in interpretation of the histological features of the tumour and providing detailed reports on the CT films.
The author(s) declare that they have no competing interests.
BAZ, MAH the main operators in charge of the idea, literature search, the manuscript, article drafting and formatting.
MAG literature search and figures preparation.
HEM histological examination.
NWP performed surgical operation, critical revision of the article.
JNP critical revision and final approval of the version.
All Authors read and approved the final version of the manuscript
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Zeidan, B.A., Hilal, M.A., Al-Gholmy, M. et al. Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case. World J Surg Onc 4, 66 (2006). https://doi.org/10.1186/1477-7819-4-66
- Liver Metastasis
- Adenoid Cystic Carcinoma
- Pleomorphic Adenoma
- Lacrimal Gland
- Orbital Tumour