- Case report
- Open Access
Management of a patient with multiple recurrences of fibromatosis (desmoid tumor) of the breast involving the chest wall musculature
© Povoski et al; licensee BioMed Central Ltd. 2006
Received: 05 February 2006
Accepted: 12 June 2006
Published: 12 June 2006
Fibromatosis or desmoid tumor is a rare soft tissue tumor that lacks a metastatic potential, but is characterized by a locally aggressive and infiltrating growth pattern and a high propensity toward local recurrence if incompletely excised.
We report a patient with three post-surgical recurrences of fibromatosis of the breast over a seven year period. The fibromatosis was found to be involving the chest wall musculature and causing persistent and worsening pain. An aggressive operative strategy was undertaken, consisting of mastectomy with en bloc resection of the underlying chest wall musculature, ribs, and parietal pleura.
Aggressive surgical management of fibromatosis of the breast with suspected chest wall involvement is appropriate to attempt to obtain a long-term durable cure.
Fibromatosis (also synonymous with the term desmoid tumor) is a rare soft tissue tumor that is composed of a bland-appearing proliferation of spindle cells [1, 2]. Although fibromatosis is thought to be a benign entity that lacks metastatic potential, it can be characterized by a locally aggressive and infiltrating growth pattern with a high propensity toward local recurrence [3, 4]. Fibromatosis arising from within the breast itself is a rare entity. Over the years, there have been a variety of published case reports [5–23]. In addition, there are a few more comprehensive published series describing this entity within the breast [4, 24–26]. There seems to be generalized agreement that complete wide excision of fibromatosis that is involving the breast alone is the treatment of choice. However, despite what is reported in the literature, there remains a significant lack of agreement amongst surgeons on how to manage fibromatosis of the breast that is suspected to have concomitant involvement of adjacent chest wall structures. This case report specifically describes the clinical, radiographic, and pathologic features of a patient who experienced three post-surgical recurrences of fibromatosis of the breast over a seven-year period of time secondary to previous inadequate excisions. The fibromatosis was found to be involving the chest wall musculature and causing persistent and worsening pain. An aggressive surgical management strategy was successfully undertaken.
A 39 year-old white female presented to The Arthur G. James Cancer Hospital with worsening pain of the left breast and left chest wall region and a recurrent palpable mass within the inferior aspect of her left breast. She reports having had three separate left breast biopsies in the past (seven years, four years, and one year prior to her current presentation) for a recurring left breast palpable mass in this same location.
Seven years prior to her current presentation, she presented to an outside community hospital with a palpable left breast mass in the inferior lateral aspect of her left breast. She underwent a left breast biopsy at that time that was reported as showing dense fibrous stroma with fibrocystic changes.
Three years later (four years prior to her current presentation), she noticed a recurrent enlarging palpable left breast mass. She underwent a repeat left breast biopsy by the same surgeon and this showed hyperplastic fibrosis, consistent with fibromatosis of the breast. The pathology report clearly stated that the tumor involved the surgical margins. The patient reports that the surgeon told her that this was a benign tumor and that nothing further needed to be done.
Three additional years later (one year prior to her current presentation), she again noticed a recurrent enlarging palpable left breast mass. She again underwent a repeat left breast biopsy by the same surgeon and this again showed findings consistent with fibromatosis of the breast. Again, the pathology report clearly stated that the tumor involved the surgical margins. The patient reports that the surgeon again told her that this was a benign tumor and that nothing further needed to be done.
Since the time of her last left breast biopsy (one year prior to her current presentation), the patient reports persistent and worsening pain and palpable tenderness within the inferior aspect of her left breast and left chest wall region, with an associated increasing sized palpable mass within the same region.
The patient is now 22 months out from her previous aggressive operative management of her previous multiple recurrences of her fibromatosis of her left breast and she remains disease free.
In this patient with three post-surgical recurrences of fibromatosis of the breast over a seven year period that were previously inadequately excised and was involving the chest wall musculature and causing persistent and worsening pain, an aggressive surgical resection strategy was undertaken in order to attempt to obtain a long-term durable cure. This aggressive surgical approach has been strongly advocated by some authors for fibromatosis of the breast that involves the chest wall or fibromatosis primarily involving the chest wall [11, 27, 28]. The factors that support this aggressive surgical approach in appropriately selected patients include the potential of fibromatosis to display a locally aggressive and infiltrating growth pattern into surrounding structures, the resultant high propensity for local recurrence when incompletely excised with positive surgical margins, and the lack of convincing evidence for a proven beneficial role of radiation therapy, chemotherapy, or antiestrogen therapy after incomplete excision of breast fibromatosis. However, other authors [16, 19, 23, 24] have been less enthusiastic and have given only more guarded support for an aggressive surgical approach in appropriately selected patients. The factors that these author stress with regards to their hesitation with proceeding with an aggressive surgical approach are the increased potential for a less than optimal cosmetic outcome, the risks for loss of function, the reported lack of any metastatic potential of fibromatosis, rare reported instances of spontaneous regression of fibromatosis, and reports of recurrent fibromatosis after apparent complete excision with negative surgical margins. However, all authors tend to agree that cosmetic breast reconstruction with autologous tissue transfer or expander/implant placement should not be considered at the initial time of aggressive surgical management and should be delayed for several years while close serial surveillance of the resection bed can be maintained to monitor for evidence of recurrent fibromatosis.
Clearly, early recognition and appropriate complete wide local excision of fibromatosis that is confined to the breast and is without concomitant involvement of adjacent chest wall structures is widely advocated in the literature and is fully embraced by the present authors. This local surgical management strategy will prove to be curative in most cases of fibromatosis involving the breast alone, and can avoid the need for more radical resections to obtain clearance of the surgical margins. However, as is apparent from our reported patient who had preoperative suspicion of involvement of the chest wall musculature, the potential of fibromatosis to display a locally aggressive and infiltrating growth pattern and the resultant high propensity for local recurrence when incompletely excised clearly supports the use of a more aggressive resection approach to assure clearance of the surgical margins and should be considered in similarly selected patients.
Written consent was obtained from the patient for permission for the publication of her case report.
- Allen PW: The fibromatoses: a clinicopathologic classification based on 140 cases. Part I. Am J Surg Pathol. 1977, 1: 255-270.View ArticlePubMedGoogle Scholar
- Allen PW: The fibromatoses: a clinicopathologic classification based on 140 cases. Part II. Am J Surg Pathol. 1977, 1: 305-321.View ArticleGoogle Scholar
- Enzinger FM, Weiss SW: Fibromatosis. Soft Tissue Tumors. Edited by: Enzinger FM, Weiss SW. 2001, St. Louis, MO, Mosby, 320-329. 4Google Scholar
- Wargotz ES, Norris HJ, Austin RM, Enzinger FM: Fibromatosis of the breast. A clinical and pathological study of 28 cases. Am J Surg Pathol. 1987, 11: 38-45.View ArticlePubMedGoogle Scholar
- Kalisher L, Long JA, Peyster RG: Extra-abdominal desmoid of the axillary tail mimicking breast carcinoma. Am J Roentgenol. 1976, 126: 903-906.View ArticleGoogle Scholar
- Rosen Y, Papasozomenos SC, Gardner B: Fibromatosis of the breast. Cancer. 1978, 41: 1409-1413. 10.1002/1097-0142(197804)41:4<1409::AID-CNCR2820410428>3.0.CO;2-D.View ArticlePubMedGoogle Scholar
- Ali M, Fayemi AO, Braun EV, Remy R: Fibromatosis of the breast. Am J Surg Pathol. 1979, 3: 501-505.View ArticlePubMedGoogle Scholar
- Jewett ST, Mead JH: Extra-adominal desmoid arising from a capsule around a silicone breast implant. Plast Reconstr Surg. 1979, 63: 577-579.View ArticlePubMedGoogle Scholar
- Bogomoletz WV, Boulenger E, Simatos A: Infiltrating fibromatosis of the breast. J Clin Pathol. 1981, 34: 30-34.PubMed CentralView ArticlePubMedGoogle Scholar
- Cederlund CG, Gustavsson S, Linell F, Moquist-Olsson I, Andersson I: Fibromatosis of the breast mimicking carcinoma at mammography. Br J Radiol. 1984, 57: 98-101.View ArticlePubMedGoogle Scholar
- Thomas T, Lorino C, Ferrara JJ: Fibromatosis of the breast: a case report and literature review. J Surg Oncol. 1987, 35: 70-74.View ArticlePubMedGoogle Scholar
- Leibman AJ, Kossoff MB: Sonographic features of fibromatosis of the breast. J Ultrasound Med. 1991, 10: 43-45.PubMedGoogle Scholar
- Schuh ME, Radford DM: Desmoid tumor of the breast following augmentation mammoplasty. Plast Reconstr Surg. 1994, 93: 603-605.View ArticlePubMedGoogle Scholar
- Hermas S, Soummani A, Boumezgou K, Bennani O, Himmi A, Mansouri A, Aderdour M: Mammary fibromatosis (apropos of one case). Gynecol Obstet Fertil. 2000, 28: 38-43.PubMedGoogle Scholar
- Vandeweyer E, Deraemaecker R: Desmoid tumor of the breast after reconstruction with implant. Plast Reconstr Surg. 2000, 104: 2627-2628.View ArticleGoogle Scholar
- Godwin Y, McCulloch TA, Sully L: Extra-abdominal desmoid tumour of the breast: review of the primary management and implications for breast reconstruction. Br J Plast Surg. 2001, 54: 268-271. 10.1054/bjps.2001.3548.View ArticlePubMedGoogle Scholar
- Greenberg D, McIntyre H, Ramsaroop R, Arthur J, Harman J: Aggressive fibromatosis of the breast: A case report and literature review. Breast J. 2002, 8: 55-57. 10.1046/j.1524-4741.2002.08013.x.View ArticlePubMedGoogle Scholar
- Nakazono T, Satoh T, Hamamoto T, Kudo S: Dynamic MRI of fibromatosis of the breast. Am J Roentgenol. 2003, 181: 1718-1719.View ArticleGoogle Scholar
- Matherne TH, Green A, Tucker JA, Dyess DL: Fibromatosis: the breast cancer imitator. South Med J. 2004, 97: 1100-1103. 10.1097/01.SMJ.0000125109.51375.5C.View ArticlePubMedGoogle Scholar
- Lopez-Ruiz J, Ruiz M, Echevarria JJ, Lopez S, Imaz I: Mammary fibrosmatosis mimicking recurrent breast cancer: radiological findings. Eur Radiol. 2005, 15: 2034-2036. 10.1007/s00330-005-2717-x.View ArticlePubMedGoogle Scholar
- Mesurolle B, Leconte I, Fellah L, Feger C: Dynamic breast MRI in recurrent fibromatosis. Am J Roentgenol. 2005, 184: 696-697.View ArticleGoogle Scholar
- Privette A, Fenton SJ, Mone MC, Kennedy AM, Nelson EW: Desmoid tumor: A case of mistaken identity. Breast J. 2005, 11: 60-64. 10.1111/j.1075-122X.2005.21679.x.View ArticlePubMedGoogle Scholar
- Schwarz GS, Drotman M, Rosenblatt R, Milner L, Shamonki J, Osborne MP: Fibromatosis of the breast: case report and current concepts in the management of an uncommon lesion. Breast J. 2006, 12: 66-71. 10.1111/j.1075-122X.2006.00187.x.View ArticlePubMedGoogle Scholar
- Gump FE, Sternschein MJ, Wolff M: Fibromatosis of the breast. Surg Gynecol Obstet. 1981, 153: 57-60.PubMedGoogle Scholar
- Rosen PP, Ernsberger D: Mammary fibromatosis. A benign spindle-cell tumor with significant risk for local recurrence. Cancer. 1989, 63: 1363-1369. 10.1002/1097-0142(19890401)63:7<1363::AID-CNCR2820630722>3.0.CO;2-B.View ArticlePubMedGoogle Scholar
- Devouassoux-Shisheboran M, Schammel DP, Man YG, Tavassoli FA: Fibromatosis of the breast. Age-correlated morphofunctional features of 33 cases. Arch Pathol Lab Med. 2000, 124: 276-280.PubMedGoogle Scholar
- Abbas AE, Deschamps C, Cassivi SD, Nichols FC, Allen MS, Schleck CD, Pairolero PC: Chest wall desmoid tumors: Results of surgical intervention. Ann Thorac Surg. 2004, 78: 1219-1223. 10.1016/j.athoracsur.2004.03.015.View ArticlePubMedGoogle Scholar
- Pearson GD, Vasko SD: Chest wall reconstruction after desmoid tumor resection. Surg Rounds. 2005, 28: 385-388.Google Scholar
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