Comparison of laparoscopic peritoneal vaginoplasty and sigmoid colon vaginoplasty performed during radical surgery for primary vaginal carcinoma
© Yao et al.; licensee BioMed Central Ltd. 2014
Received: 3 March 2014
Accepted: 15 September 2014
Published: 30 September 2014
Radical surgery of primary vaginal carcinoma typically involves partial or complete resection of the vagina, and young patients in particular can experience sexual dysfunction after surgery. Vaginoplasty is mandatory for this population, multiple vaginal reconstructive techniques have been reported. Here we attempted to determine whether the peritoneum is a feasible alternative to the sigmoid colon in vaginoplasty performed during radical surgery.
Between February 2005 and July 2009, 12 patients underwent radical surgery for Federation of International Gynecology and Obstetrics Stage I primary vaginal carcinoma in the upper one-third of the vagina. To retain a sex life, the patients received vaginoplasty either with the peritoneum (peritoneal group, 5 patients) or with the sigmoid colon (sigmoid group, 7 patients) during radical surgery. Surgeries were performed at the Anhui Provincial Hospital in China. The data between the two groups was retrospectively analyzed.
The operating time was shorter for the peritoneal group than for the sigmoid group (P < 0.05). There were no significant differences in blood loss as well as in the length or width of the neo-vaginas between the two groups during surgery (P > 0.05). No metastasis or operation-related complications were observed in any of the patients. Six months after surgery, the neo-vaginas of both groups were smooth, soft, and moist. The neo-vaginas in the sigmoid group were similar in size during and 6 months after surgery. The neo-vaginas in the peritoneal group were shorter (although no less wide) 6 months after surgery (P < 0.05); length and width (that admitted two fingers) remained stable thereafter. All patients experienced a satisfactory sex life after surgery. Colposcopy revealed a good vaginal surface covered with squamous epithelium in the neo-vaginas of the peritoneal group, and intestinalization in the neo-vaginas of the sigmoid group. At the 36-month follow-up, all patients were clinically free of disease.
Laparoscopic vaginoplasty using the peritoneum compared with using the sigmoid colon is simpler and more feasible for management of Stage I primary vaginal carcinoma. Its benefits include shorter operating time, no bowel disturbance, and production of a hygienic vaginal environment, as well as a potential sex life and oncologic outcome comparable to that of sigmoid colon vaginoplasty.
Primary vaginal carcinoma is a rare disease, representing 2% to 3% of all gynecological malignancies . Although mainly observed in elderly women, approximately 30% of women with this disease are younger than 60 years of age . Because of its rarity, there is no consensus on the optimum therapy, which must be individualized according to the patient’s medical condition, age, and general health, and the site and stage of the disease . Although the standard treatment for all stages of primary vaginal carcinoma is radiation, some reports have shown better survival outcomes with surgery in patients with early-stage disease, especially young women [4, 5]. Although radical surgery consisting of radical vaginectomy and systematic dissection of lymphatic tumor drainage is a valid option , it typically involves partial or complete resection of the vagina, and young patients in particular can experience severe depression and sexual dysfunction after surgery. Vaginoplasty, particularly the creation of a neo-vagina, is mandatory for this population [6, 7].
Multiple vaginal reconstructive techniques including bowel flaps, skin grafts, peritoneal grafts, and musculofasciocutaneous flaps have been reported . The choice of technique is important for obtaining functional and aesthetic results. Sigmoid colons are routinely used in vaginal reconstructions because of their unique characteristics including their close proximity to the operative site, their morphology, and their capacity to replicate the function of the vagina and early coitus [9, 10]. In 1974, Davydov and Zhvitiashvili  proposed a method for reconstructing the lining of neo-vaginas with the peritoneum from the Douglas pouch. To date, this technique has been used to form neo-vaginas laparoscopically, followed by surgery for congenital vaginal abnormalities [12–15].
In 2003, our department observed favorable survival and quality of life in patients with early-stage primary vaginal cancer who underwent vaginal reconstruction using the sigmoid colon . However, because of bowel disturbance and the risks associated with this procedure (for example, excessive secretion by the neo-vagina, fistula, infection, and development of mucinous adenocarcinoma) , we attempted to determine whether vaginoplasty using the peritoneum is a feasible alternative.
The study was reviewed and approved by the ethics review board of Anhui Provincial Hospital. Written consent was obtained from each patient.
Clinical characteristics of the patients
Peritoneal group (n = 5)
Sigmoid group (n = 7)
49 ± 8
50 ± 11
P > 0.05
Tumor size (cm)
0.8 ± 0.2
0.9 ± 0.2
P > 0.05
Stage (Federation of International Gynecology and Obstetrics)
Routine postoperative care included perineal douching twice a day, treatment with antibiotics to prevent infection, and venous nutrition until the intestinal tract functionally recovered. Five days after surgery, the gauze and suction drains were removed. A special mold (9 cm in length, 3 cm in diameter) was inserted in patients in the peritoneal group for dilation (it was not required in the sigmoid group), and it remained in place for 6 months or until regular twice-weekly sexual intercourse resumed. Patients received a voiding trial approximately 1 week after surgery, and bladder dysfunction was defined as more than 100 ml of residual urine over 14 days.
Intraoperative and postoperative data were collected prospectively. All patients were asked to fill out the Female Sexual Function Index to evaluate sexual function 6 months after surgery; a score ≥24 indicates a satisfactory sex life . All patients were followed-up by our team on a monthly basis for 3 years. Follow-ups included pelvic examination, a vaginal Papanicolaou test, colposcopy, and abdominal and pelvic computed tomography.
Statistical analysis was performed using SPSS software, version 15.0 (SPSS Inc, Chicago, IL). The Student t- test and the Mann-Whitney test were used to examine the differences between the groups. Statistical significance was defined as P < 0.05.
Intraoperative factors between two groups
Peritoneal group (n = 5)
Sigmoid group (n = 7)
Operative time (minutes)
245 ± 46.4
300 ± 26.5
P < 0.05
Blood loss (ml)
320 ± 103.7
340 ± 82.7
P > 0.05
Length of vagina (cm)
12 ± 1.0
13 ± 1.4
P > 0.05
Pathology of surgical margin
Depth of tumor (cm)
0.5 ± 0.2
0.6 ± 0.1
P > 0.05
After 6 months, the neo-vaginal walls of the patients in both groups were smooth, soft, and moist. Comparison of the length and width of the neo-vaginas during surgery and 6 months after surgery showed no change in the sigmoid group, while reduced length but not width was observed in the peritoneal group. The length of the neo-vaginas in the peritoneal group remained stable thereafter; however, the neo-vaginas were shorter in the peritoneal group than in the sigmoid group (P < 0.05). First intercourse after surgery occurred sooner in the sigmoid group than in the peritoneal group (P < 0.05). All patients eventually resumed satisfactory sexual lives, although the patients in the sigmoid group had some complaints of excessive mucus secretion.
Postoperative morbidity and treatment outcomes after 6 months
Peritoneal group (n = 5)
Sigmoid group (n = 7)
Length of vagina (cm)
8.8 ± 0.8
12.5 ± 1.5
P < 0.05
Excessive secretion (n)
P < 0.05
Prolonged dilation (n)
P < 0.05
Time of first intercourse (months)
5.5 ± 0.3
3.5 ± 0.4
P < 0.05
Satisfactory sex life (n)
P > 0.05
Disease-free survival (n)
P = 1.00
Discussion and conclusions
Cutillo and colleagues  described a conservative treatment for retaining sexual function after a vaginectomy (radical tumorectomy with pelvic lymphadenectomy), and Peters and colleagues  proposed a limited treatment (partial or total vaginectomy without dissection of regional lymph nodes). However, the standard treatment favored by gynecologists for lesions limited to the upper one-third of the vagina is vaginectomy and pelvic lymphadenectomy with or without hysterectomy, because it provides adequate margins and sufficient tissue for resection.
For the psychological rehabilitation of women after radical vaginectomy, creation of a neo-vagina is mandatory, especially in young patients who hope to resume sexual activity. In our opinion, the main aims of vaginal reconstruction are to: (1) restore the structure of the vagina such that future sexual activity is possible; (2) rectify vaginal defects with tissues having a good blood supply to promote rapid local healing; and (3) employ a simple, safe, and effective surgical technique. In our series, no intraoperative or postoperative complications were observed. The criterion for anatomic success was a neo-vagina of length 6 cm or greater and allowing easy introduction of two fingers within 6 months after surgery, and functional success was defined as self-reported satisfactory sexual intercourse . Considering these anatomic and functional outcomes, we demonstrated that sigmoidal vaginoplasty and peritoneal vaginoplasty were similarly successful.
The main problem we experienced with peritoneal vaginoplasty was regular shrinkage of the neo-vagina. In addition, two patients experienced small superficial separations 8 days postoperatively, which may reflect the tendency of the peritoneal lining to shrink or indicate the presence of a vaginal mold. Although uncomfortable, placement of a mold in the neo-vagina for 6 months after surgery was deemed critical for maintaining the length and width of the neo-vagina. At the 6-month follow-up, colposcopy revealed a good vaginal surface covered with squamous epithelium in the peritoneal group, and liquid-based cytology detected vaginal squamous cells morphologically similar to those occurring naturally. However, the average length of the neo-vagina in the peritoneal group 6 months after surgery was less (8 to 10 cm) than that during surgery (11 to 13 cm), although the width (that admitted two fingers) was unchanged. Assuming that the peritoneal lining tends to shrink and adhere to itself before squamous metaplasia occurs, we recommend that a mold remain in place for 6 months after surgery, after which intermittent vaginal dilation with regular sexual intercourse is encouraged.
The advantages of sigmoid reconstruction include the sufficient diameter and elasticity of the sigmoid colon, which negate the need for a mold during the postoperative period; because a mold was not inserted, the sigmoid group resumed intercourse sooner than the peritoneal group (P < 0.05). Peritoneal vaginoplasty requires a relatively large amount of the pelvic peritoneum, as well as the pelvic cavity wall. Pelvic adhesion may limit the success of the surgery; therefore, peritoneal vaginoplasty for patients with a history of pelvic surgery is cautioned, and perioperative informed consent should include a discussion of the possible need to convert to a vaginal reconstruction using the sigmoid colon or other graft source.
We believe that lack of complications and postoperative morbidity observed in the peritoneal group may be explained by a number of factors. First, assuming adequate excisional scope of the operation, the round ligaments and the peritoneum covering the roof of the bladder, the lateral pelvic sidewalls, and the Douglas pouch were preserved as much as possible. Moreover, extensive dissection of the pelvic peritoneum with a good blood supply was not crucial. Second, the reserved sections of the two round ligaments were sutured to the corresponding lateral margins of the vagina to provide added support for the neo-vaginal vault. Third, a simple purse-string knot tied to the roof of the bladder, lateral pelvic sidewalls, and the Douglas pouch created a neo-vaginal vault and separated the bottom of the pelvic cavity from the neo-vagina. Fourth, expert identification of the abdominopelvic anatomy and performance of the laparoscopic procedure and open surgery for gynecologic malignancies were not required.
Vaginal reconstruction after radical surgery for primary vaginal carcinoma often includes a high risk of tumor recurrence. In our series, all patients were clinically free of disease at their 36-month follow-up. This finding demonstrates the safety of peritoneal and sigmoid colon vaginoplasty during radical surgery; however, we believe that the number of cases was too small and the follow-up was too short to provide an accurate estimate of the recurrence-free survival rate. We consider our study to be a pilot investigation in which we obtained informed consent for an experimental therapy and strictly adhered to a follow-up program aimed at detecting recurring or additional tumors at early stages. We note that accurate selection of patients is important; patients should be young and have Stage I squamous carcinoma of the upper vagina without involvement of organs outside the vaginal wall or metastasis to the regional lymph nodes.
In our series, peritoneal and sigmoid colon vaginoplasty were similar in terms of allowing a satisfactory sexual life, safety during surgery, and prevention of tumor recurrence during the follow-up period. Laparoscopic vaginoplasty using the peritoneum appears to be an ideal option because it offers the following advantages: (1) relative ease of performance; (2) no bowel disturbance; (3) fewer risks compared with sigmoid colon vaginoplasty (for example, prolapse of the neo-vagina, fistula, infection, and development of a mucinous adenocarcinoma); and (4) satisfactory sexual intercourse, with smooth, soft, moist, and hygienic neo-vaginal walls and no excessive mucus secretion. Its disadvantages include the need a mold for a prolonged period before squamous metaplasia occurs.
We would like to thank Dr. Ying Zhou (Anhui Provincial Hospital Affiliated with Anhui Medical University) for helpful comments during the preparation of this manuscript.
Role of funding sources
This work was supported by the National Natural Science Foundation of China (No. 81072127).
- Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ: Cancer statistics, 2005. CA Cancer J Clin. 2005, 55: 10-30. 10.3322/canjclin.55.1.10.View ArticlePubMedGoogle Scholar
- Creasman WT, Phillips JL, Menck HR: The National Cancer Data Base report on cancer of the vagina. Cancer. 1998, 83: 1033-1040. 10.1002/(SICI)1097-0142(19980901)83:5<1033::AID-CNCR30>3.0.CO;2-6.View ArticlePubMedGoogle Scholar
- Stock RG, Chen AS, Seski J: A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities. Gynecol Oncol. 1995, 56: 45-52. 10.1006/gyno.1995.1008.View ArticlePubMedGoogle Scholar
- Davis KP, Stanhope CR, Garton GR, Atkinson EJ, O’Brien PC: Invasive vaginal carcinoma: analysis of early-stage disease. Gynecol Oncol. 1991, 42: 131-136. 10.1016/0090-8258(91)90332-Y.View ArticlePubMedGoogle Scholar
- Tjalma WA, Monaghan JM, de Barros LA, Naik R, Nordin AJ, Weyler JJ: The role of surgery in invasive squamous carcinoma of the vagina. Gynecol Oncol. 2001, 81: 360-365. 10.1006/gyno.2001.6171.View ArticlePubMedGoogle Scholar
- Mirhashemi R, Averette HE, Lambrou N, Penalver MA, Mendez L, Ghurani G, Salom E: Vaginal reconstruction at the time of pelvic exenteration: a surgical and psychosexual analysis of techniques. Gynecol Oncol. 2002, 87: 39-45. 10.1006/gyno.2002.6780.View ArticlePubMedGoogle Scholar
- Soper JT, Secord AA, Havrilesky LJ, Berchuck A, Clarke-Pearson DL: Comparison of gracilis and rectus abdominis myocutaneous flap neovaginal reconstruction performed during radical pelvic surgery: flap-specific morbidity. Int J Gynecol Cancer. 2007, 17: 298-303. 10.1111/j.1525-1438.2007.00784.x.View ArticlePubMedGoogle Scholar
- Pusic AL, Mehrara BJ: Vaginal reconstruction: an algorithm approach to defect classification and flap reconstruction. J Surg Oncol. 2006, 94: 515-521. 10.1002/jso.20489.View ArticlePubMedGoogle Scholar
- Darai E, Toullalan O, Besse O, Potiron L, Delga P: Anatomic and functional results of laparoscopic-perineal neovagina construction by sigmoid colpoplasty in women with Rokitansky’s syndrome. Hum Reprod. 2003, 18: 2454-2459. 10.1093/humrep/deg443.View ArticlePubMedGoogle Scholar
- Urbanowicz W, Starzyk J, Sulislawski J: Laparoscopic vaginal reconstruction using a sigmoid colon segment: a preliminary report. J Urol. 2004, 171: 2632-2635. 10.1097/01.ju.0000111342.92168.42.View ArticlePubMedGoogle Scholar
- Davydov SN, Zhvitiashvili OD: Formation of vagina (colpopoiesis) from peritoneum of Douglas pouch. Acta Chir Plast. 1974, 16: 35-41.PubMedGoogle Scholar
- Rangaswamy M, Machado NO, Kaur S, Machado L: Laparoscopic vaginoplasty: using a sliding peritoneal flap for correction of complete vaginal agenesis. Eur J Obstet Gynecol Reprod Biol. 2001, 98: 244-248. 10.1016/S0301-2115(01)00313-X.View ArticlePubMedGoogle Scholar
- Ma Y, Qin R, Bi H, Yang X, Zhang J, Yuan J, Li J: The use of peritoneal tissue mobilised with a novel laparoscopic technique to reconstruct a neovagina. J Plast Reconstr Aesthet Surg. 2009, 62: 326-330. 10.1016/j.bjps.2007.11.006.View ArticlePubMedGoogle Scholar
- Fedele L, Frontino G, Restelli E, Ciappina N, Motta F, Bianchi S: Creation of a neovagina by Davydov’s laparoscopic modified technique in patients with Rokitansky syndrome. Am J Obstet Gynecol. 2010, 202: 33. e1-6-View ArticlePubMedGoogle Scholar
- Bianchi F, Frontino G, Ciappina N, Restelli E, Fedele L: Creation of a neovagina in Rokitansky syndrome: comparison between two laparoscopic techniques. Fertil Steril. 2011, 95: 1098-1100. 10.1016/j.fertnstert.2010.11.032.View ArticlePubMedGoogle Scholar
- Ling B, Gao Z, Sun M, Sun F, Zhang A, Zhao W, Hu W: Laparoscopic radical hysterectomy with vaginectomy and reconstruction of vagina in patients with stage I of primary vaginal carcinoma. Gynecol Oncol. 2008, 109: 92-96. 10.1016/j.ygyno.2007.12.012.View ArticlePubMedGoogle Scholar
- Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D’Agostino R: The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000, 26: 191-208. 10.1080/009262300278597.View ArticlePubMedGoogle Scholar
- Cutillo G, Cignini P, Pizzi G, Vizza E, Micheli A, Arcangeli G, Sbiroli C: Conservative treatment of reproductive and sexual function in young woman with squamous carcinoma of the vagina. Gynecol Oncol. 2006, 103: 234-237. 10.1016/j.ygyno.2006.02.032.View ArticlePubMedGoogle Scholar
- Peters WA, Kumar NB, Morley GW: Microinvasive carcinoma of the vagina: a distinct clinical entity?. Am J Obstet Gynecol. 1985, 153: 505-507. 10.1016/0002-9378(85)90462-4.View ArticlePubMedGoogle Scholar
- Fedele L, Bianchi S, Frontino G, Fontana E, Restelli E, Bruni V: The laparoscopic Vecchietti, a modified technique in Rokitansky syndrome: anatomic, functional, and sexual long-term results. Am J Obstet Gynecol. 2008, 198: 377-377.View ArticlePubMedGoogle Scholar
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