Metastatic renal cell carcinoma to the jaws: report of cases
© Zhang et al.; licensee BioMed Central Ltd. 2014
Received: 3 January 2014
Accepted: 29 June 2014
Published: 11 July 2014
Renal cell carcinoma (RCC) is one of the most frequent urological malignancies in adults. RCC often metastasizes to other organs, but rarely to the oromaxillofacial region. Metastatic tumors to the jaws are also unusual. In this report, we present two cases of RCC metastasis to the jaws. Metastatic RCC is resistant to radiotherapy and chemotherapy, so surgery is the primary therapeutic choice. This report describes the diagnostic procedures utilized and the therapeutic process in the two cases. The differential diagnosis and treatment methods are discussed.
KeywordsMandible Maxilla Metastasis RCC Renal cell carcinoma
Jawbone metastases are rare; they account for less than 1% of oral and maxillofacial malignancies. The most common malignant primary lesions that metastasize to the jawbones arise from the lung, kidney, prostate and rectum in men and from the breast, kidney, uterus and thyroid in women. The mandibular body and ramus are common sites of metastases, and maxillary metastases are uncommon.
Adult renal cell carcinoma (RCC) is a neoplasm of the urinary system that accounts for 3% of adult malignancies and 90% to 95% of kidney tumors . RCC is most common in men ages 50 to 60 years old . Only 10% of the patients exhibit the classic Grawitz triad (flank pain, palpable mass and hematuria) [3–5]. Thirty percent of patients have a distant metastasis [6, 7], most commonly to the lung, followed by bone, liver, brain and regional lymph nodes, but seldom to the mandible or the maxilla. In this report, we describe the cases of two patients,one with maxillary and the other with mandibular metastasis of RCC.
Malignant tumors of the jaw can cause lip paresthesia, numbness, jaw swelling, pain and tooth mobility. These symptoms are often persistent and progressive. X-rays typically show irregular osteolytic destruction.
Oral and maxillofacial surgeons should distinguish jaw metastases of RCC from central mandibular carcinoma, squamous cell cancer, carcinoma arising from salivary glands (such as mucoepidermoid, myoepithelial, epithelial–myoepithelial and acinar cell carcinoma) and benign gum diseases (such as epulis). Metastases also should be differentiated from other primary clear-cell tumors, which are odontogenic or gland-derived. Consequently, the identification of mandibular metastatic RCC is relatively difficult and requires a high index of suspicion by clinicians. A previous history of primary RCC is crucial to making a definitive diagnosis. If the jaw tumor has a rich blood supply and the patienthas a history of RCC, then metastatic RCC should be considered in the differential diagnosis.
A biopsy was performed for patient 1to confirm the diagnosis. The patient had severe bleeding during surgery. Hemorrhage continued despite the use of hemostatic agents, suture hemostasis and adrenaline package oppression. The bleeding was controlled by tightly packing the tumor bone cavity with gauze. The patient required a 1,000-ml whole-blood transfusion. He refused follow-up segmental resection of the mandible after receiving his diagnosis. He was referred to the oncology department for palliative care.
Patient 2 underwent complete curettage of the metastatic tumor with additional resection of the surrounding alveolar process. Although the patient had severe hemorrhage during surgery, the bleeding was relatively easy to control because of the relatively superficial location of the metastasis. The patient’s hemoglobin remained within the normal range following surgery, and he thus did not require transfusion. Follow-up interferon therapy was administered.
RCC has a propensity to metastasize to another organs, including bilateral adrenal glands , skin [9, 10], pancreas and spleen , gastric or duodenal systems , skeleton , pancreas  and bladder [15, 16]. However, metastases from RCC rarely affect the head and neck region .
Metastatic RCC is resistant to radiotherapy and chemotherapy, so supportive care and surgery remain the principal treatments of metastatic disease . If the primary tumor has been or can be excised, then metastatic lesions in the jaws should be resected. The risk of hemorrhage is high in these cases, and preoperative vascular embolization to reduce bleeding is recommended [18–20].
The mandibular metastasis case reported in this article was not considered to be a metastatic cancer at the time of patient admission, because the tumor clinically mimicked other localized hyperplasic lesions of the jaw. Patient 1 underwent biopsy and surgery, with resultant intraoperative bleeding similar to the central hemangioma of the mandible. The tumor in the transferred maxillarycarcinoma patient was initially considered to have a metastatic RCC focus. The location of the tumor was relatively superficial and the operative field broad, so intraoperative bleeding was easy to control.
Metastases from internal neoplasms should be considered among other differential diagnoses in the evaluation of jaw tumors. Especially for patients with a history of RCC, the possibility of metastatic disease should not be ignored. Because jaw metastases of RCC have an extensive supplementary blood supply, appropriate preparation to prevent the risk of bleeding is required prior to biopsy and definitive surgery.
Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We thank Dr. Yin Wang for providing pathology slides.
- Hafez KS, Fergany AF, Novick AC: Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging. J Urol. 1999, 162: 1930-1933. 10.1016/S0022-5347(05)68071-8.View ArticlePubMedGoogle Scholar
- Eble JN, Young RH: Tumors of the urinary tract. Diagnostic Histopathology of Tumors.Volume1. Edited by: Fletcher CDM. 2000, London: Churchill Livingstone, 475-565. 2Google Scholar
- Skinner DG, Vermillion CD, Pfister RC, Leadbetter WF: Renal cell carcinoma. Am Fam Physician. 1971, 4: 89-94.PubMedGoogle Scholar
- Jayson M, Sanders H: Increased incidence of serendipitously discovered renal cell carcinoma. Urology. 1998, 51: 203-205. 10.1016/S0090-4295(97)00506-2.View ArticlePubMedGoogle Scholar
- Sene AP, Hunt L, McMahon RF, Carroll RN: Renal carcinoma in patients undergoing nephrectomy: analysis of survival and prognostic factors. Br J Urol. 1992, 70: 125-134. 10.1111/j.1464-410X.1992.tb15689.x.View ArticlePubMedGoogle Scholar
- Ather MH, Masood N, Siddiqui T: Current management of advanced and metastatic renal cell carcinoma. Urol J. 2010, 7: 1-9.PubMedGoogle Scholar
- Dimanovski J, Popović A: Metastatic renal cell carcinoma. Acta Clin Croat. 2000, 39: 171-174.Google Scholar
- Yamada A, Tanaka M, Yoshikawa M, Nakai Y, Tanaka N, Fujimoto K, Hirao Y, Hirao S: [Bilateral adrenal metastases from renal cell carcinoma: a case report] [Article in Japanese]. Hinyokika Kiyo. 2008, 54: 225-228.PubMedGoogle Scholar
- Martínez Conde R, López Cedrún JL, Aguirre Urízar JM, Rosell Cerro M, Llarena Ibarguren R: [Metastatic hypernephroma in oral soft tissue] [Article in Spanish]. Av Odontoestomatol. 1990, 6: 280-285.PubMedGoogle Scholar
- García Torrelles M, Beltrán Armada JR, Verges Prosper A, Santolaya García JI, Espinosa Ruiz JJ, Tarín Planes M, Sanjuán de Laorden C: [Cutaneous metastases of renal cell carcinoma] [Article in Spanish]. Actas Urol Esp. 2007, 31: 556-558. 10.1016/S0210-4806(07)73682-3.View ArticlePubMedGoogle Scholar
- Showalter SL, Hager E, Yeo CJ: Metastatic disease to the pancreas and spleen. Semin Oncol. 2008, 35: 160-171. 10.1053/j.seminoncol.2007.12.008.View ArticlePubMedGoogle Scholar
- Haffner J, Morel JF, Maunoury V, Caty A, Biserte J, Villers A: [Gastric or duodenal metastases from clear cell renal cell carcinoma:report of two cases and review of the literature] [Article in French]. Prog Urol. 2007, 17: 1305-1309. 10.1016/S1166-7087(07)78566-4.View ArticlePubMedGoogle Scholar
- Weber K, Doucet M, Kominsky S: Renal cell carcinoma bone metastasis—elucidating the molecular targets. Cancer Metastasis Rev. 2007, 26: 691-704. 10.1007/s10555-007-9090-y.View ArticlePubMedGoogle Scholar
- Okamoto K, Kobayashi M, Okabayashi T, Sugimoto T, Nishimori I, Onishi S, Hanazaaki K: Pancreatic metastasis fromrenal cell carcinoma: report of three resected cases and review of Japanese cases. Hepatogastroenterology. 2007, 54: 937-940.PubMedGoogle Scholar
- Nakanishi Y, Arisawa C, Ando M: [Solitary metastasis to the urinary bladder from renal cell carcinoma: a case report] [Article in Japanese]. Hinyokika Kiyo. 2006, 52: 937-939.PubMedGoogle Scholar
- Kato Y, Numata A, Wada N, Iwata T, Saga Y, Hashimoto H, Kakizaki H: A case of metastatic renal cell carcinoma to the ovary. Hinyokika Kiyo. 2006, 52: 923-927.PubMedGoogle Scholar
- Jayasooriya PR, Gunarathna IANS, Attygalla AM, Tilakaratne WM: Metastatic renal cell carcinoma presenting as a clear cell tumour in the head and neck region. Oral Oncol Extra. 2004, 40: 50-53. 10.1016/j.ooe.2003.12.005.View ArticleGoogle Scholar
- Torres Muros B, Solano Romero JR, Baró Rodriguez JG, Bonilla Parrilla R: [Maxillary sinus metastasis of renal cell carcinoma] [Article in Spanish]. Actas Urol Esp. 2006, 30: 954-957. 10.1016/S0210-4806(06)73565-3.View ArticlePubMedGoogle Scholar
- Pereira Arias JG, Ullate Jaime V, Valcárcel Martín F, Onaniel Pérez VJ, Gutiérrez Díez JM, Ateca Díaz-Obregón R, Berreteaga Gallastegui JR: [Epistaxis as initial manifestation of disseminated renal adenocarcinoma] [Article in Spanish]. Actas Urol Esp. 2002, 26: 361-365. 10.1016/S0210-4806(02)72791-5.View ArticlePubMedGoogle Scholar
- Fyrmpas G, Adeniyi A, Baer S: Occult renal cell carcinoma manifesting with epistaxis in a woman: a case report. J Med Case Rep. 2011, 5: 79-10.1186/1752-1947-5-79.PubMed CentralView ArticlePubMedGoogle Scholar
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