Skip to main content

Pure nongestational choriocarcinoma of the ovary: a case report

Abstract

Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational choriocarcinoma of the ovary is extremely rare, and its diagnosis is very difficult during the reproductive years. We present a case of a 33-year-old woman diagnosed with pure nongestational ovarian choriocarcinoma. Following surgery, multiple courses of a chemotherapy regimen of etoposide, methotrexate, and actinomycin-D (EMA) were effective.

Background

Choriocarcinoma of the ovary is a rare aggressive tumor, which may be either gestational or nongestational in origin. Most occurrences are gestational in origin and usually metastasize to the ovary from a uterine or tubal choriocarcinoma. In contrast, pure nongestational choriocarcinoma of the ovary (NGCO) is extremely rare, and diagnosis is very difficult in women of reproductive age[1, 2]. We present a case of pure NGCO occurring in a 33-year-old woman with a brief review of the literature.

Case presentation

A 33-year-old woman (gravida 4, para 2) presented to our hospital with complaints of lower abdominal pain and vaginal bleeding for several days. Her last menstrual period occurred three weeks before her presentation, and previous menstrual cycles were regular. Her husband had undergone vasectomy several years ago. Her medical history and family history were unremarkable. The general condition of the patient appeared to be good; however, pelvic examination revealed a mass in the left ovary. Chest radiograph was normal. The urine test result for human chorionic gonadotropin (hCG) was positive, and serum β-hCG level was 74,612 mIU/ml. Transvaginal ultrasound (TVS) revealed a left adnexal mass of 5 × 4 cm with profuse abdominal fluid accumulation.

According to a diagnosis of left tubal pregnancy, laparoscopic exploration was performed. The left ovary was as large as a tennis ball and was ruptured and surrounded by a hematoma. A cystic mass of 2 × 2 cm was found on the right ovary and both fallopian tubes were intact. A 3-cm white-yellow mass and a 1-cm nodule were scattered in the peritoneal cavity. Approximately 500 ml of intraperitoneal blood was noted. Left oophorectomy, right ovarian cystectomy, and peritoneal mass biopsies were performed. On the second and fifth postoperative day, serum β-hCG levels were 17,963 mIU/ml and 10,172 mIU/ml, respectively. Histological examination showed a choriocarcinoma of the left ovary and corpus luteal cyst of the right ovary. Peritoneal biopsies showed ovarian tissue with marked central change of the corpus albicans and partial covering of choriocarcinomatous nests. The tumor cells were composed of cytotrophoblastic cells forming clusters of cytotrophoblast separated by streaming masses of syncytiotrophoblasts (Figure1). The tumor mass was diffusely hemorrhagic and necrotic. Tumor cells were found to infiltrate the stroma, but the external capsule was free from malignant invasion. One week after surgery, the levels of tumor markers, including alpha-fetoprotein and cancer antigen 125, were within normal limits. Chest computed tomography and pelvic magnetic resonance imaging showed no evidence of lung metastasis or lesion remnants.

Figure 1
figure1

Histological stain of the left ovary with plexiform pattern of triphasic differentiation into cytotrophoblast, syncytiotrophoblast, and intermediate trophoblast and marked cytologic atypia and hemorrhage with intracytoplasmic hyaline material. Hematoxylin and eosin (H&E) stain. (a) 200×. (b) 400×.

Endometrial biopsy was performed to rule out gestational origin. Histological examination of the endometrium revealed few fragments of basal endometrium with focal, early proliferative-phase regions without trophoblastic lesions. The patient received nine courses of EMA chemotherapy, including etoposide (100 mg/m2), methotrexate (100 mg/m2), and actinomycin-D (0.5 mg), at seven-day intervals without major complications. After six courses of chemotherapy, the β-hCG level decreased to normal (2.74 mIU/ml) and remained normal thereafter. A further three courses were completed for consolidation. The patient remains without evidence of disease five years after initial diagnosis.

Choriocarcinoma arises in the ovary and may be of either gestational or nongestational origin. Gestational choriocarcinoma of the ovary (GCO) can occur following pregnancy and is characterized by presentation in the uterine cavity[3]. NGCO most commonly arises from ovarian germ cell tumors but can originate from any epithelial cancer, including cancer of the lung, stomach, and bowel[4]. It is important to distinguish between these types because NGCO is generally believed to have a poor prognosis. However, no distinctive ultrastructural or immunohistochemical differences have been reported between choriocarcinomas of gestational and nongestational origin[1]. Clinical diagnosis of NGCO is often difficult, not solely owing to its rarity. Pure NGCO is pathologically indistinguishable from GCO, except in patients who are unable to conceive or who have never had sexual intercourse[5]. Moreover, the symptoms are often nonspecific and can mimic other more common conditions that occur in young women, such as a hemorrhagic ovarian cyst, tuboovarian abscess, ovarian cyst torsion, and ectopic pregnancy[6]. The symptoms of vaginal bleeding, elevated hCG level, pelvic pain, and an adnexal mass often lead to incorrect diagnosis of ectopic pregnancy, threatenedor incomplete abortion, cervical polyp, or other types of malignancy[7]. In this case, the ultrasonographic findings, clinical symptoms and signs, and rarity of choriocarcinoma mistakenly led to the initial diagnosis of ectopic pregnancy.

Saito et al. first described the diagnostic criteria for NGCO in 1963. These include absence of disease in the uterine cavity, pathological confirmation of disease, and exclusion of molar pregnancy and of intrauterine pregnancy[8]. All the criteria were fulfilled in this case. Owing to the rarity of the condition, little information on clinicopathological features and therapeutic options is available. GCO has been treated by methotrexate-based chemotherapy, but some studies showed that NGCO may be resistant to this chemotherapy, requiring more aggressive combination chemotherapy[9]. We began adjuvant chemotherapy with the EMA (etoposide, methotrexate, actinomycin-D) regimen. After six courses of chemotherapy, the serum β-hCG level was normalized.

A comparison of case reports of ovarian choriocarcinoma is presented in Table1. The summarized cases show limitations in that they are not all fully staged and the chemotherapy protocols are diverse. Analysis of the seven cases documented thus far suggests that the disease responds well to the combination of surgery and postoperative adjuvant chemotherapy. However, long-term effects of such therapy should be further studied with more cases.

Table 1 Nongestational choriocarcinoma of the ovary: a summary of cases

Conclusions

Because of the small number of patients with pure ovarian choriocarcinoma, a consensus on the treatment regimen including surgery and chemotherapy is lacking. Our report adds data that can be helpful in both diagnosis and treatment of this rare disease.

Consent

Written informed consent was obtained from the patient for publication of this report and accompanying images. A copy of this written consent is available for review by the Editor-in Chief of this journal.

Abbreviations

EMA:

etoposide, methotrexate, and actinomycin-D

GCO:

gestational choriocarcinoma of the ovary

hCG:

human chorionic gonadotropin

NGCO:

nongestational choriocarcinoma of the ovary

TVS:

transvaginal ultrasound.

References

  1. 1.

    Vance RP, Geisinger KR: Pure nongestational choriocarcinoma of the ovary: report of a case. Cancer. 1985, 56: 2321-2325. 10.1002/1097-0142(19851101)56:9<2321::AID-CNCR2820560931>3.0.CO;2-Q.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Jacobs AJ, Newland JR, Green RK: Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 1982, 37: 603-609. 10.1097/00006254-198210000-00001.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Park SH, Park A, Kim JY, Kwon JH, Koh SB: A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. J, Gynecol Oncol. 2009, 20: 192-194. 10.3802/jgo.2009.20.3.192.

    Article  Google Scholar 

  4. 4.

    Oladipo A, Mathew J, Oriolowo A, Lindsay I, Fisher R, Seckl M, Yiannakis D: Nongestational choriocarcinoma arising from a primary ovarian tumour. BJOG. 2007, 114: 1298-1300. 10.1111/j.1471-0528.2007.01486.x.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Kong B, Tian YJ, Zhu WW, Qin YJ: A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review. J Obstet Gynaecol Res. 2009, 35: 574-578. 10.1111/j.1447-0756.2008.00973.x.

    Article  PubMed  Google Scholar 

  6. 6.

    Chen MJ, Yang JH, Lin MC, Ho HN, Yang YS: An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. BJOG. 2004, 111: 188-190. 10.1046/j.1471-0528.2003.00048.x.

    Article  PubMed  Google Scholar 

  7. 7.

    Imai A, Furui T, Iida K, Tamaya T: Gynecologic tumors and symptoms in childhood and adolescence. Curr Opin Obstet Gynecol. 2001, 13: 469-473. 10.1097/00001703-200110000-00005.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Saito M, Azuma T, Nakamura K: On ectopic choriocarcinoma. World, Obstet Gynecol. 1963, 17: 459-484.

    Google Scholar 

  9. 9.

    Balat O, Kutlar I, Ozkur A, Bakir K, Aksoy F, Ugur MG: Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. Tumori. 2004, 90: 136-138.

    PubMed  Google Scholar 

  10. 10.

    Gerson RF, Lee EY, Gorman E: Primary extrauterine ovarian choriocarcinoma mistaken for ectopic pregnancy: sonographic imaging findings. AJR Am J Roentgenol. 2007, 189: W280-W283. 10.2214/AJR.05.0814.

    Article  PubMed  Google Scholar 

  11. 11.

    Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, Kikkawa F: A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Int J Gynecol Cancer. 2007, 17: 254-258. 10.1111/j.1525-1438.2006.00764.x.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Roghaei MA, Mahzuni P, Rezaei F: A pure nongestational choriocarcinoma of the ovary. J Res, Med Sci. 2007, 12: 269-270.

    Google Scholar 

  13. 13.

    Byeun TS, Byeun C, Chung DY, Park DC, Ahn WS, Lee JW, Namkoong SE, Kim SP: A case of primary ovarian carcinoma. Korean J, Obstet Gynecol. 1995, 38: 1713-1717.

    Google Scholar 

  14. 14.

    Corakci A, Ozeren S, Ozkan S, Gurbuz Y, Ustun H, Yucesoy I: Pure nongestational choriocarcinoma of ovary. Gynecol Obstet. 2005, 271: 176-177.

    Google Scholar 

  15. 15.

    Lyn LV, Yang K, Wu H, Lou J, Peng Z: Pure choriocarcinoma of the ovary: a case report. J, Gynecol Oncol. 2011, 22: 135-139. 10.3802/jgo.2011.22.2.135.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Duck Yeong Ro.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YJC made substantial contributions to conception and design, and acquisition of data. She also drafted the manuscript and revised its final form. KYC and YWK were involved in analysis and interpretation of data. DYR contributed to interpreting the data and gave final approval of the version to be published. All authors read and approved the final manuscript.

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Authors’ original file for figure 2

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Choi, Y.J., Chun, K.Y., Kim, Y.W. et al. Pure nongestational choriocarcinoma of the ovary: a case report. World J Surg Onc 11, 7 (2013). https://doi.org/10.1186/1477-7819-11-7

Download citation

Keywords

  • Chemotherapy
  • Nongestational choriocarcinoma
  • Ovary