Primary thyroid angiosarcoma: an unusual localization
© Petronella et al.; licensee BioMed Central Ltd. 2012
Received: 29 September 2011
Accepted: 3 May 2012
Published: 3 May 2012
The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas. In particular, angiosarcoma of the thyroid gland is a rare, highly aggressive malignant vascular tumor and in Italy the greatest geographical incidence of this lesion is witnessed near the Alps. Here, a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for about 20 years is described. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.
The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. The most common causes are benign conditions (colloid cysts and thyroiditis 80% of cases), followed by benign follicular neoplasias (10% to 15%) and carcinomas (5%) [1, 2]. The majority of clinically apparent thyroid neoplasms are primary and epithelial, while mesenchymal tumors, which are commonly seen in other parts of the body, are rare in the thyroid [3, 4].
Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas .
Angiosarcoma is, in general, an uncommon soft tissue sarcoma. This lesion mainly affects the skin and deep soft tissue but the involvement of the head and neck region is therefore usually reported in the literature, mainly in patients with a history of long-standing multinodular goiter. Location in the thyroid gland is nevertheless quite exceptional.
In particular, angiosarcoma of the thyroid gland is a rare and highly aggressive malignant vascular tumor [3, 6–11]. The greatest incidence of this lesion is witnessed near the Alps. It constitutes only 2% to 10% of malignant thyroid tumors in Switzerland, Austria and Northern Italy [3, 7, 9].
The prevalence of this lesion in Alpine regions may be due to iodine deficiency with a long history of endemic goiter . It has a female predilection (female to male ratio of 9:3) and arises in old age, most commonly during the fifth to eighth decades of life (median age 65 years) [7–9]. There are cases in which the tumor occurs without a history of goiter, and it is very unusual in non-Alpine areas, therefore it seemed prudent to present a case involving this type.
Most of these tumors appear as poorly encapsulated and infiltrating masses, which tend to grow in the absence of pain. Local recurrences and metastases are common, even after complete excision [6, 12–14].
The prognosis of this tumor is not favorable because it tends to spread rapidly and most patients develop postoperative early systemic metastasis. In fact, this type of cancer typically metastasizes in the first instance at the level of regional lymph nodes and the lungs, and in the late stages in the bone marrow . A very wide surgical excision is the management of choice in cases of radically removable tumor. Radiation therapy may be effective in some patients and can be completed using chemotherapy with adriamicina .
We describe a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for 20 years, who decided to undergo operation for worsening dyspnea. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in the thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.
A 71-year-old man was referred to our department complaining of dyspnea, hypoventilation and dysphonia, determined by swelling in the neck region and related to a considerable increase in size of the thyroid gland.
On clinical examination, the thyroid gland appeared firm during the acts of deglutition. The patient reported that he had a goiter for more than 20 years and he had never undergone any drug therapy.
An ultrasound examination dating back to 1997 documented a complete subversion of the echotexture of the whole gland and the presence of a large nodule in the right lobe displaying a complex echotexture. A further ecography in 2000 documented an increase in volume of the thyroid, which was also the cause of the right carotid bulb dislocation.
Laboratory investigations revealed significantly elevated thyroglobulin values. A preoperative fine needle aspiration was not significant; it consisted of an acellular smear within a background of inflammatory and necrotic cells without any cytologic specification.
Consequently, we decided not to repeat this procedure because of the worsening of the patient’s dyspnea, for which a surgical management for liberation of the airways was planned.
As regards adjuvant therapy, our patient has not been subjected to any kind of special treatment because, even today, there are no guidelines and there are various schools of thought as to the best treatment options.
The prognosis was not favorable. The postoperative course was not simple: it was decided to admit the patient to our intensive coronary unit for precautionary reasons. After 3 days, due to an atelectasis of the left lung, intubation and subsequently tracheostomy were needed. Breathing difficulties continued for a long time (about 60 days after surgery). Our patient was monitored and follow-up was started but it was too short to be meaningful because unfortunately, our patient died about 3 months later as a result of of cardiac and respiratory complications related to his oncologic condition.
Due to the cytologic and histologic presentation diagnosis of angiosarcoma of the thyroid gland is often difficult and requires an expert pathologist. Sometimes, on fine needle aspiration cytology (FNAC) samples, these vascular neoplasms yield a final report of ‘inadequate’ material or may closely mimic a number of different lesions, potentially causing an erroneous cytopathologic diagnosis [15, 16]. For this reason, a definitive diagnosis of the angiosarcoma is based mainly on characteristic histopathological features of a malignant vascular tumor and must be supported by detailed investigations (immunopositivity for vascular markers for example, CD31, CD34, factor VIII related antigen, and absence of epithelial markers). However, care should be taken to distinguish a reactive process from vascular neoplasms such as hemangioma or angiosarcoma, because an exuberant endothelial cell proliferation may be a potential manifestation of a thyroid hematoma . Cases, as in our patient, of long-standing nodular goiter with complete infarction are a real challenge for both the pathologist and the clinician/radiologist .
Some authors controversially considered whether the thyroid angiosarcoma truly exists, because they are of the opinion that the reported cases were being classified as anaplastic carcinomas with angiomatoid features [5, 18]. It may be that the angiosarcomas are ‘transitional’ tumors, that can show a variable appearance of mesenchymal metaplasia with both epithelial and endothelial differentiation. ‘Angiosarcoma’ may represent the extreme in the spectrum of endothelial differentiation. In fact, the WHO classification of thyroid tumors, published in 2004, has added to the four traditional major tumor groups (papillary, follicular, medullary, and anaplastic carcinoma) the entity of poorly differentiated carcinoma and a variety of rare thyroid malignancies, such as angiosarcoma . At present, it must be acknowledged that the distinction between undifferentiated angiomatoid thyroid carcinomas and ‘true’ thyroid angiosarcomas is an academic one, because the prognoses and treatments for these lesions are essentially identical .
Their etiology remains unknown even though endothelial proliferations after recurrent intranodular hemorrhages occurring in a long-standing nodular goiter have been considered to initiate neoplastic transformation [3, 19]. Immunohistochemical confirmation of the diagnosis of angiosarcoma, even those that are poorly differentiated, can usually be obtained using a panel of vascular markers. Antibody directed against CD31 is still considered the most sensitive and specific marker for endothelial differentiation, being expressed in 90% of angiosarcomas and in slightly more than 1% of carcinomas; the endothelial marker CD34 and the antigen related to factor VIII should also be added to the panel [10, 20].
Immunonegativity for thyroglobulin supports a diagnosis of angiosarcoma. In fact, a weak signal for this antibody is seen in all anaplastic carcinomas, confirming that these lesions are unrelated malignant tumors . The lack of staining with Pan-CK argues against an endothelial differentiation but there are cases reported in the literature that are interpreted as epithelioid angiosarcomas even in the presence of keratin positivity, a marker traditionally regarded as indicative of epithelial differentiation . Finally, when faced with these lesions it is important to exclude metastasis from a more common primary site. Treatment is difficult because of its locally aggressive and destructive behavior, with a high recurrence rate. As regards adjuvant therapy, nowadays there exist various schools of thought. There are those who say that, after the radical excision of the tumor, radiotherapy and then chemotherapy are indicated [6, 22]; others claim that, if the tumor is not corroded surgically, if the patient is subjected to radiotherapy and chemotherapy it represents only a palliative treatment because the first step of choice is radical surgical excision of the neoplasm, as seen in our patient [6, 8].
The features that have been correlated with poor outcome include extracapsular tumor spread and distant metastasis [5–10]. Data on survival are sparse. With regard to prognosis, Goh et al. showed a 5-year survival rate of 33.3%. Most patients die in less than 6 months regardless of the treatment with a few surviving up to 5 years [5, 9, 13, 14]. Entirely intrathyroid tumors generally have a longer survival than those with extrathyroidal extension [3, 6–9]. However, cases of long survival have been reported, especially from non-mountainous, non-endemic goiter areas [3, 9, 23].
In conclusion, we present a rare case of primary thyroid angiosarcoma in a patient from a non-Alpine area with a history of long-standing goiter in the absence of pain and without evident signs of rapid growth, but with worsening dyspnea.
Despite a wide surgical excision and the lesion being limited to the thyroid gland, our patient died a few months after surgery; therefore the follow-up was not contributory to establishing the rate of disease-free survival.
We report and confirm the diagnosis even though the cytological and histopathological examination presented some difficulties in distinguishing it from other malignant tumor such as undifferentiated angiosarcomatoid carcinoma. Initial evaluation of hematoxylin and eosin stained sections and appropriate immunohistochemical panel for endothelial markers (CD31, CD34 and factor VIII) can usually provide a definitive diagnosis.
Written informed consent was obtained from the patient for publication of this report and any accompanying images.
- Coltrera MD: Evaluation and imaging of a thyroid nodule. Surg Oncol Clin N Am. 2008, 17: 37-56. 10.1016/j.soc.2007.10.006.View ArticlePubMedGoogle Scholar
- Gharib H, Papini E: Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol Metab Clin North Am. 2007, 36: 707-735. 10.1016/j.ecl.2007.04.009.View ArticlePubMedGoogle Scholar
- De Lellis, Ronald ADL, Ricardo VL, Philipp UH, Charis E: Tumours of endocrine organs. WHO Classification of Tumours. 2004, Geneva, Switzerland: WHO, 113-114.Google Scholar
- Sniezek JC, Holten M: Rare tumors of the thyroid gland. Otolaryngol Clin N Am. 2003, 36: 107-115. 10.1016/S0030-6665(02)00134-2.View ArticleGoogle Scholar
- Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M: Diagnostic controversies in vascular proliferations of the thyroid gland. Endocr Pathol. 2008, 19: 175-183. 10.1007/s12022-008-9039-x.View ArticlePubMedGoogle Scholar
- Astl J, Duskova J, Limanova Z, Povysil C, Kuchynkova Z: Hemangiosarcoma of the thyroid gland. A case report. Neuro Endocrinol Lett. 2000, 21: 213-216.PubMedGoogle Scholar
- Goh SG, Chuah KL, Goh HK, Chen YY: Two cases of epithelioid angiosarcoma involving the thyroid and a brief review of non-Alpine epithelioid angiosarcoma of the thyroid. Arch Pathol Lab Med. 2003, 127: 70-73.Google Scholar
- Kalitova P, Plzak J, Kodet R, Astl J: Angiosarcoma of the thyroid. Eur Arch Otorhinolaryngol. 2009, 266: 903-905. 10.1007/s00405-008-0820-8.View ArticlePubMedGoogle Scholar
- Maiorana A, Collina G, Cesinaro AM, Fano RA, Eusebi V: Angiomatoid carcinoma of the thyroid: clinicopathological analysis of seven cases from non-Alpine areas. Virchows Arch. 1996, 429: 131-137.PubMedGoogle Scholar
- Weiss SW, Goldblum JR: Malignant vascular tumors. Enzinger and Weiss’s Soft Tissue Tumors. Edited by: Weiss SW, Goldblum JR. 2008, Maryland Heights, MI, USA: Mosby, 703-732. 5Google Scholar
- Del Rio P, Cataldo S, Sommaruga L, Corcione L, Guazzi A, Sianesi M: A rare case of thyroid haemangiosarcoma. Chir Ital. 2007, 59: 747-749.PubMedGoogle Scholar
- Yilmazlar T, Kirdak T, Adim S, Ozturk E, Yerci O: A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis. Endocr J. 2005, 52: 57-59. 10.1507/endocrj.52.57.View ArticlePubMedGoogle Scholar
- Rhomberg W, Böhler FK, Eiter H, Fritzsche H, Breitfellner G: Malignant hemangioendothelioma of the thyroid gland: new results on pathogenesis, therapy and prognosis. Wien Klin Wochenschr. 1998, 110: 479-484.PubMedGoogle Scholar
- Rhomberg W, Gruber-Mösenbacher U, Eiter H, Fritzsche H, Breitfellner G: Prognosis and epidemiology of malignant hemangioendotheliomas of the thyroid gland. Schweiz Med Wochenschr. 1993, 123: 1640-1644.PubMedGoogle Scholar
- Fulciniti F, Di Mattia D, Bove P, Mastro AA, De Chiara A, Botti G, Petrillo A, Apice G: Fine needle aspiration of metastatic epithelioid angiosarcoma: a report of 2 cases. Acta Cytol. 2008, 52: 612-618. 10.1159/000325607.View ArticlePubMedGoogle Scholar
- Isa NM, James DT, Saw TH, Pennisi R, Gough I: Primary angiosarcoma of the thyroid gland with recurrence diagnosed by fine needle aspiration: a case report. Diagn Cytopathol. 2009, 37: 427-432. 10.1002/dc.21065.View ArticlePubMedGoogle Scholar
- Aulicino MR, Kaneko M, Uinger PD: Excessive endothelial cell proliferation occurring in an organizing thyroid hematoma: report of a case and review of the literature. Endocr Pathol. 1995, 6: 153-158. 10.1007/BF02739878.View ArticlePubMedGoogle Scholar
- Ritter JH, Mills SE, Nappi O, Wick MR: Angiosarcoma-like neoplasms of epithelial organs: true endothelial tumors or variants of carcinoma?. Semin Diagn Pathol. 1995, 12: 270-282.PubMedGoogle Scholar
- Eusebi V, Carcangiu ML, Dina R, Rosai J: Keratin-positive epithelioid angiosarcoma of thyroid. A report of four cases. Am J Surg Pathol. 1990, 14: 737-747. 10.1097/00000478-199008000-00004.View ArticlePubMedGoogle Scholar
- Cutlan RT, Greer JE, Wong FS, Eltorky M: Immunohistochemical characterization of thyroid gland tumors. Exp Mol Pathol. 2000, 69: 159-164. 10.1006/exmp.2000.2323.View ArticlePubMedGoogle Scholar
- Papotti M, Volante M, Negro F, Eusebi V, Bussolati G: Thyroglobulin mRNA expression helps to distinguish anaplastic carcinoma from angiosarcoma of the thyroid. Virchows Arch. 2000, 437: 635-642. 10.1007/s004280000308.View ArticlePubMedGoogle Scholar
- Lamovec J, Zidar A, Zidanik B: Epithelioid angiosarcoma of the thyroid gland. Report of two cases. Arch Pathol Lab Med. 1994, 118: 642-646.PubMedGoogle Scholar
- Ryska A, Ludvikova M, Szepe P, Boor A: Epithelioid haemangiosarcoma of thyroid gland. Report of six cases of non-alpine region. Histopathology. 2004, 44: 40-46. 10.1111/j.1365-2559.2004.01772.x.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.