- Case report
- Open Access
Mesothelioma as a rapidly developing Giant Abdominal Cyst
© Vyas et al.; licensee BioMed Central Ltd. 2012
- Received: 12 September 2012
- Accepted: 26 November 2012
- Published: 20 December 2012
The benign cystic mesothelioma of the peritoneum is a rare lesion and is known for local recurrence. This is first case report of a rapidly developing massive abdominal tumor with histological finding of benign cystic mesothelioma (BCM). We describe a BCM arising in the retroperitoneal tis[sue on the right side, lifting ascending colon and cecum to the left side of abdomen. Patient was an active 58-year-old man who noticed a rapid abdominal swelling within a two month time period with a weight gain of 40 pounds. Patient had no risk factors including occupational (asbestos, cadmium), family history, social (alcohol, smoking) or history of trauma. We will discuss the clinical, radiologic, intra-operative, immunohistochemical, pathologic findings, and imaging six months after surgery. Patient has no recurrence and no weight gain on follow up visits and imaging.
- Malignant Mesothelioma
- Cavernous Hemangioma
- Bronchogenic Cyst
- Cuboidal Cell
- Cystic Teratoma
Mesothelioma is a rare form of cancer seen in mesothelium, the cellular lining covering many internal organs. The most common site is the pleura, followed by the peritoneum and the pericardium. Retroperitoneal cystic masses are a rare occurrence with a combined incidence of 1:106,400 to 1:250,000 [1–3] when also including mesenteric cystic masses. The differential diagnosis is vast, including cystic lymphangioma, mucinous cystadenoma, cystic teratoma, cystic mesothelioma, mullerian cyst, epidermoid cyst, tailgut cyst, bronchogenic cyst, cystic changes in a solid neoplasm, pseudomyxoma retroperitonei, perianal mucinous carcinoma, pancreatic pseudocyst, lymphocele, urinoma, hematoma , cystadenoma of mesonephric origin, and cavernous hemangioma . Due to the rarity of these conditions, similarity of patient presentation and comparable features on imaging, the correct pre-operative diagnosis may be difficult to attain .
Benign cystic mesothelioma is also a rare entity with most information coming from individual case reports. It was first described by Henke in 1889 as a ‘multiple cystic lymphangioma like tumor , determined to be of mesothelial origin by Mennemeyer and Smith in 1979 , and given the name ‘benign cystic mesothelioma in 1980 by Moore, et al. . The etiology remains unclear and there is no association with asbestos exposure, unlike malignant mesothelioma. There have been rare reports of transformation to low-grade malignant mesothelioma, but it is generally classified as a benign process . There is a 40 to 55% recurrence rate in female patients and a 33% recurrence rate in male patients . The clinical, gross, and histologic findings in our case of BCM were similar to those reported in the literature [11–14].
The common presenting features are those of a massive lesion with effects including abdominal pain, fullness, distention, and intestinal obstruction, and if allowed to enlarge significantly, weight gain. Physical examination may show abdominal tenderness, distention, or a palpable mass. Imaging modalities that can be utilized include ultrasonography (US), CT, or magnetic resonance imaging (MRI). CT is often the most useful as it provides sectional images of the abdominal and retroperitoneal compartments, and gives information in relation to nearby organs, which helps to determine feasibility of resection, and clues to cystic contents . Surgery, with complete enucleation of the cyst to prevent recurrence and possible malignant transformation remains the mainstay of treatment , which can be performed with either a laparotomy or via laparoscopy . Aspiration of the cyst alone may be beneficial to relieve symptoms, but due to high recurrence rates is not a definitive treatment and is rarely beneficial in the pre-operative diagnosis.
Imaging has limitations in diagnosing BCM and the definitive diagnosis is based on histological studies. Pre-operative diagnosis is often incorrect and post-operative diagnosis is made with a combination of microscopy and immunohistochemistry or electron microscopy. Histopathologically, BCM demonstrates a multicystic lesion lined by a single layer of cuboidal cells of mesothelial origin separated by a delicate fibromuscular stroma . Electron microscopy shows characteristic cuboidal cells with innumerable microvilli on the luminal surfaces as well as intercellular bridges with desmosomes distinguishing it from the endothelial cells of lymphangioma . Immunohistochemistry will be positive for cytokeratin and mesothelial origin markers calretinin and D2-40. It will be negative for the lymphoid marker CD34. The mesothelial epithelium can be confirmed by its immunopositivity for calretinin, pancytokeratin, cytokeratin 5/6, HBME1, and EMA and the negativity for CEA, CA-125, factor VIII-related antigen, and CDX-2 .
There is a role for using fine needle aspiration with immunohistochemical stain for definitive diagnosis but there is a concern is some parts of world about hydatid cysts and anaphylaxis from cyst rupture [19, 20]. A cystic lymphatic malformation can be confused with BCM because of the mutually similar gross appearance and the prevalence of lymphatic malformations. Other differential diagnosis can be a well-differentiated papillary mesothelioma with a cystic form of malignant mesothelioma . Complete surgical excision, is the treatment of choice, even though some centers advocate an aggressive surgical treatment including cytoreductive surgery with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy. The jury is divided on the choice of treatment for recurrent disease, from selective and limited surgery for the symptoms of intestinal obstruction or other functional abnormalities and severe abdominal pain, to cytoreductive surgery with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy .
Due to the rarity of BCM there are no established follow-up or post-operative imaging guidelines. With the relatively high recurrence rates of BCM, follow-up is advised, especially if complete enucleation could not be accomplished. We recommend CT scan follow-up at least yearly for 5 years, and we are performing this every 3 months for first year and then yearly due to intra-operative spillage.
- Kurtz RJ, Heimann TM, Holt J, Beck AR: Mesenteric and retroperitoneal cysts. Am Surg. 1986, 203: 109-112.Google Scholar
- Judd ES, Crisp NW: Proc Staff Meet, Mayo Clinic. 1932, Mayo Clinic, 555-7Google Scholar
- Vaughn AM, Lees WM, Henry JW: Mesenteric cysts; a review of the literature and report of a calcified cyst of the mesentery. Surgery. 1948, 23: 306-317.PubMedGoogle Scholar
- Yang DM, Jung DH, Kim H, Kim JH, Hwang HY: Retroperitoneal cystic masses: CT, clinical, and pathologic findings and literature review. RadioGraphics. 2004, 24: 1353-1365. 10.1148/rg.245045017.View ArticlePubMedGoogle Scholar
- Kaliszewski K, Bednarz W, Lukienczuk T, Rzeszutko M, Boryń M, Olewiński R, Dawiskiba T, Spodzieja J, Dawiskiba J: Retroperitoneal tumours - Analysis of own clinical material - A six-year retrospective study. Hepatogastroenterology. 2010, 57: 47-51.PubMedGoogle Scholar
- Baddoura FK, Varma VA: Cytology of multicystic peritoneal mesothelioma. Acta Cytol. 1990, 34: 524-528.PubMedGoogle Scholar
- Mennemeyer R, Smith M: Multicystic peritoneal mesothelioma: a report with electron microscopy of a case mimicking intraabdominal cystic hygroma (lymphangioma). Cancer. 1979, 44: 692-698. 10.1002/1097-0142(197908)44:2<692::AID-CNCR2820440242>3.0.CO;2-6.View ArticlePubMedGoogle Scholar
- Moore JH, Crum CP, Chandler JG, Feldman PS: Benign cystic mesothelioma. Cancer. 1980, 45: 2395-2399. 10.1002/1097-0142(19800501)45:9<2395::AID-CNCR2820450926>3.0.CO;2-5.View ArticlePubMedGoogle Scholar
- Pantanowitz L, Botero M: Giant mesenteric cyst: a case report and review of the literature. The Internet J Pathol. 2001, 1: 2-Google Scholar
- Allam M, Seywright M, Robins JB: The uncertain problem of peritoneal bubblewrap. Br J Obstet Gynaecol. 1998, 105: 1332-1334. 10.1111/j.1471-0528.1998.tb10017.x.View ArticlePubMedGoogle Scholar
- Weiss SW, Goldblum JR, Mesothelioma SW, Weiss JR: Goldblum: Enzinger and Weiss's soft tissue tumors. 2008, St. Louis, Mo: Mosby, 789-824. 5Google Scholar
- Irving JA, Clement PB: Diseases of the peritoneum. Blaustein's pathology of the female genital tract. Edited by: Kurman RJ, Hedrick Ellenson L, Ronnett BM. 2011, New York: Springer, 625-678.View ArticleGoogle Scholar
- Rosai J: Peritoneum, retroperitoneum, and related structures. Rosai and Ackerman's surgical pathology. Edited by: Rosai J. 2011, Edinburgh: Elsevier, 2233-2270.Google Scholar
- Ross MJ, Welch WR, Scully RE: Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer. 1989, 64: 1336-1346. 10.1002/1097-0142(19890915)64:6<1336::AID-CNCR2820640628>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Alzaraa A, Mousa H, Dickens P, Allen J, Benhamida A: Idiopathic benign retroperitoneal cyst: a case report. J Med Case Rep. 2008, 2: 43-10.1186/1752-1947-2-43.PubMed CentralView ArticlePubMedGoogle Scholar
- Burkett JS, Pickleman J: The rationale for surgical treatment of mesenteric and retroperitoneal cysts. Am Surg. 1994, 60: 432-435.PubMedGoogle Scholar
- Vu JH, Thomas EL, Spencer DD: Laparoscopic management of mesenteric cyst. Am Surg. 1999, 65: 264-265.PubMedGoogle Scholar
- Bhandarkar DS, Smith VJ, Evans DA, Taylor TV: Benign cystic peritoneal mesothelioma. J Clin Pathol. 1993, 46: 867-868. 10.1136/jcp.46.9.867.PubMed CentralView ArticlePubMedGoogle Scholar
- Søreide JA, Søreide K, Körner H, Søiland H, Greve OJ, Gudlaugsson E: Benign peritoneal cystic mesothelioma. World J Surg. 2006, 30: 560-566. 10.1007/s00268-005-0639-z.View ArticlePubMedGoogle Scholar
- Assaly M, Bongiovanni M, Kumar N, Egger JF, Pelte MF, Genevay M, Finci V, Tschanz E, Pache JC: Cytology of benign multicystic peritoneal mesothelioma in peritoneal washings. Cytopathology. 2008, 19: 224-228. 10.1111/j.1365-2303.2007.00489.x.View ArticlePubMedGoogle Scholar
- Chua TC, Yan TD, Deraco M: Multi-institutional experience of diffuse intraabdominal multicystic peritoneal mesothelioma. Br J Surg. 2011, 98: 60-64. 10.1002/bjs.7263.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.