- Case report
- Open Access
Synchronous sebaceous lymphadenoma with squamous cell carcinoma – case report
© Shukla and Panicker; licensee BioMed Central Ltd. 2003
Received: 25 August 2003
Accepted: 24 December 2003
Published: 24 December 2003
Sebaceous lymphadenoma is a rare benign salivary gland tumour of uncertain histogenesis. So is synchronous occurrence of two benign or malignant neoplasms.
68-year-old female presented with right side parotid swelling associated with pain and gradual increase is size. Fine needle aspiration cytology of parotid swelling was suggestive of pleomorphic adenoma. Total conservative parotidectomy was performed and histopathology of the specimen revealed sebaceous lymphadenoma with squamous cell carcinoma.
Sebaceous lymphadenoma and squamous cell carcinoma are two rare benign and malignant neoplasms arising in parotid gland. Synchronous occurrence of these two entities has not been reported.
Synchronous occurrence of two or more pathologically distinct benign and malignant neoplasm in a single organ is rare and accounts for < 0.1% of all salivary gland neoplasms. We report here a rare case of synchronous occurrence of sebaceous lymphadenoma, a rare benign salivary gland neoplasm predominantly seen in elderly females  and primary squamous cell carcinoma too is of rare occurrence in parotid glad. The limited number of reported cases of synchronous carcinoma in the salivary glands makes clinical management of these lesions difficult.
A 68-year-old woman presented with swelling in the right parotid region of 8 years duration with history of gradual increase in size over last 1 year with pain and tinnitus for past 2 months. There was no difficulty in opening the mouth and no history suggestive of facial nerve palsy. Medical or family history was not contributory.
Examination showed a non tender swelling with variegated consistency in parotid region raising the ear lobule. Overlying skin showed dilated veins. The swelling was partly fixed to underlying structures and clinically there was no evidence of facial nerve involvement. There were no palpable cervical lymph nodes and haematological and biochemical investigation were within normal limits. A fine needle aspiration cytology (FNAC) was carried out which was suggestive of pleomorphic adenoma. With a diagnosis of pleomorphic adenoma patient underwent parotidectomy.
Sebaceous lymphadenoma is rare benign salivary gland neoplasm . There have been several care reports describing the tumour and its association with other salivary gland neoplasm. Sebaceous lymphadenoma is predominantly seen in elderly females and age at presentation ranges between 25 to 89 years.
Microscopy in sebaceous lymphadenoma show variable sized sebaceous glands admixed with salivary ducts surrounded by dense lymphoid stroma. Lymphoid background has well developed germinal centres. Histiocytes, foreign body giant cell and inflammatory reaction are seen. Focal necrosis can be observed occasionally [2, 3]
Histogenesis of Sebaceous lymphadenoma is unclear. Possible theories are that it develops within the ectopic salivary gland in intraparotid lymph node  or may arise due to sebaceous differentiation in other tumours [1, 4]. Other tumours to consider with similar histological characteristic include tumours with focal sebaceous differentiation, Warthin's tumour, mucoepidermoid carcinoma, pleomorphic adenoma (malignant), adenoid cystic carcinoma, benign oncocytoma and basal cell adenoma. [5, 6]
Malignant transformation of the sebaceous lymphadenoma, although rare, should be considered along with possibility of a synchronous second primary malignant neoplasm in enlarging, locally invasive parotid lesions, considering that clinical behaviour and prognosis will be determined by the nature of the malignant component [7–9].
Parotidectomy is the treatment of choice in sebaceous lymphadenoma, however in presence of synchronous squamous cell carcinoma neck dissection should also be carried out if cervical lymph nodes are involved and we feel that postoperative adjuvant radiotherapy should improve the survival.
Conflict of interest
- Chen K, Chan JKC: Salivary gland tumours. In Diagnostic Histopathology of Tumours. Edited by: Fletcher CDM. 2000, Hong Kong Churchill Livingstone, 1: 259-2Google Scholar
- Auclair PL, Ellis GL, Gnepp DR: Other benign epithelial neoplasms. Surgical Pathology of Salivary Gland. Edited by: Ellis GL, Auclair PL, Gnepp DR. 1991, Philadelphia, WB Saunders Company, 252-268.Google Scholar
- Firat P, Hosal S, Tutar E, Ruacan S: Sebaceous lymphadenoma of the parotid gland. J Otolaryngol. 2000, 29: 114-116.PubMedGoogle Scholar
- Gnepp DR, Brannon R: Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer. 1984, 53: 2155-2170.View ArticlePubMedGoogle Scholar
- Kwon GY, Kim EJ, Go JH: Lymphadenoma arising in the parotid gland: a case report. Yonsei Med J. 2002, 43: 536-538.View ArticlePubMedGoogle Scholar
- Gnepp DR: Sebaceous neoplasms of salivary gland origin: a review. Pathol Annu. 1983, 18 (Pt 1): 71-102.PubMedGoogle Scholar
- Croitoru CM, Mooney JE, Luna MA: Sebaceous lymphadenocarcinoma of salivary glands. Ann Diagn Pathol. 2003, 7: 236-239. 10.1016/S1092-9134(03)00052-2.View ArticlePubMedGoogle Scholar
- Mayorga M, Fernandez N, Val-Bernal JF: Synchronous ipsilateral sebaceous lymphadenoma and acinic cell adenocarcinoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999, 88: 593-596.View ArticlePubMedGoogle Scholar
- Dreyer T, Battmann A, Silberzahn J, Glanz H, Schulz A: Unusual differentiation of a combination tumour of the parotid gland. A case report. Pathol Res Pract. 1993, 189: 577-581. discussion 581–585View ArticlePubMedGoogle Scholar
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