Tuberculosis and metastatic carcinoma coexistence in axillary lymph node: A case report
© Pandey et al; licensee BioMed Central Ltd. 2003
Received: 12 January 2003
Accepted: 7 April 2003
Published: 7 April 2003
Coexistence of cancer and tuberculosis in axillary lymph nodes is rare. Only seven cases have been reported in the literature.
We report here a case of infiltrating ductal carcinoma breast metastasizing to the axillary lymph node along with tubercular granuloma in the same lymph node without primary mammary or pulmonary tuberculosis.
Primary tuberculosis coexisting with carcinoma is of rare occurrence. A possibility should always be borne in mind especially in patients from endemic areas.
The synchronous occurrence of tuberculosis and carcinoma is unusual and association of the two has baffled surgeons and physicians for over two centuries. Coexistence of tuberculosis and metastatic carcinoma in axillary lymph nodes, without pulmonary or mammary tuberculosis is even rare. Warthin (1899) first described the coexistence of tuberculosis and cancer in axillary node , five other cases have been reported between 1902 and 1992 [2–4].
A 52-year-old postmenopausal lady presented to the out patient clinic at Regional Cancer Centre, Trivandrum with a breast lump of 8 months duration. Examination revealed a 3 × 2.5-cm well-defined hard mass in the upper inner quadrant of left breast. There were no palpable nodes in the left axilla. Contralateral breast and axilla were normal. There were no supraclavicular nodes. Biochemical parameters and chest roentgenogram were normal and metastatic work-up was negative.
The association of tuberculosis and cancer has been recorded in most of the organs and has been described and explained by many authors in many diverse ways. Kaplan et al. (1974) reviewed 58,245 patients with cancer and identified 201 cases of coexisting tuberculosis . Highest prevalence was seen in patients with Hodgkin's disease (96/10,000 cases) followed by lung cancer (92/10,000), lymphosarcoma (88/10,000) and reticulum cell sarcoma (78/10,000) . Among 14,742 cases of breast reviewed by them, only 28 had coexisting tuberculosis in breast, a prevalence of 19/10,000. No case of axillary nodal coexistence was identified in their series .
Bayle first described the association of tuberculosis and carcinoma in 1810. He described "cavitation cancereuse" as one of the six types of tuberculosis, which appears to be the first published description of coexistence of the two . The coexistence of breast cancer and tuberculosis has been described in over 100 cases [7, 8], however its coexistence in the axillary node is rare. Only seven cases have been reported in the literature so far [2–4]. Majority of these cases reported breast cancer with axillary node showing tubercular foci, while our patient had a metastatic carcinoma and tubercular granulomatous foci in the same lymph node in the same high power field (figure 1) with the absence of tubercular foci elsewhere. The case is being reported for its rarity.
- Warthin AS: The coexistence of tuberculosis and carcinoma of the mammary gland. Am J Med Sci. 1899, 118: 25-View ArticleGoogle Scholar
- Miller RE, Solomen PF, West JP: The coexistence of carcinoma and tuberculosis of the breast and axillary lymph nodes. Am J Surg. 1971, 121: 338-340.View ArticlePubMedGoogle Scholar
- Grege A, Kienle J: Association of tuberculosis with carcinoma breast. Radiol. 1969, 93: 1107-1108.View ArticleGoogle Scholar
- Das DK, Mohil RS, Kashyap V, Khan IV, Mandal AK, Gulati SM: Colloid carcinoma of the breast with concomitant metastasis and a tubercular lesion in the axillary lymph nodes: a case report. Acta Cytol. 1992, 36: 399-403.PubMedGoogle Scholar
- Kaplan MH, Armstrong D, Rosen P: Tuberculosis complicating neoplastic disease: a review of 201 cases. Cancer. 1974, 33: 850-858.View ArticlePubMedGoogle Scholar
- Bayle GI: Recherches sur la phthisie pulmonaire. Gabon Paris. 1810Google Scholar
- Brammo-Cook F, O'Brian DS, Daly PA: Unusual breast masses. The sequential development of mammary tuberculosis and Hodgkin's disease in a young woman. Cancer. 1988, 61: 1457-1459.View ArticleGoogle Scholar
- Cheng W, Alagaratnam TT, Leung CY, Chen ACL: Tuberculosis and lymphoma of the breast in a patient with dermatomyositis. Aust NZ J Surg. 1993, 63: 660-661.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.