From: Apoptosis-related factors are relevant to progression of pancreatic neuroendocrine tumors
Clinicopathological data, n (%) | GLUT1 | SSTR2a | SSTR5 | Survivin | XIAP | Caspase3 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Positive | p value | Positive | p value | Positive | p value | Positive | p value | Positive | p value | Positive | p value | |
Age, years | |||||||||||||
< 62 | 18 | 9 (50.0) | 0.908 | 15 (83.3) | 0.077 | 8 (44.4) | 0.495 | 12 (66.7) | 0.055 | 10 (55.6) | 0.155 | 12 (66.7) | 0.068 |
≥ 62 | 29 | 15 (51.7) | 17 (58.6) | 10 (34.5) | 11 (37.9) | 10 (34.5) | 26 (89.7) | ||||||
Sex | |||||||||||||
Female | 35 | 21 (60.0) | 0.036 | 23 (65.7) | 0.725 | 12 (34.3) | 0.493 | 19 (54.3) | 0.21 | 14 (40.0) | 0.545 | 29 (82.9) | 0.674 |
Male | 12 | 3 (25.0) | 9 (75.0) | 6 (50.0) | 4 (33.3) | 6 (50.0) | 9 (75.0) | ||||||
Functionality | |||||||||||||
Non-functional | 34 | 17 (50.0) | 0.813 | 21 (61.8) | 0.175 | 13 (38.2) | 1 | 16 (47.1) | 0.677 | 15 (44.1) | 0.726 | 27 (79.4) | 1 |
Functional | 13 | 7 (53.8) | 11 (84.6) | 5 (38.5) | 7 (53.8) | 5 (38.5) | 11 (84.6) | ||||||
Tumor size, mm | |||||||||||||
< 21 | 33 | 18 (54.5) | 0.464 | 22 (66.7) | 1 | 12 (36.4) | 0.675 | 12 (36.4) | 0.008 | 10 (30.3) | 0.009 | 30 (90.9) | 0.013 |
≥ 21 | 14 | 6 (42.9) | 10 (71.4) | 6 (42.9) | 11 (78.6) | 10 (71.4) | 8 (57.1) | ||||||
Vascular invasion | |||||||||||||
Negative | 41 | 20 (48.8) | 0.666 | 28 (68.3) | 1 | 16 (39.0) | 1 | 20 (48.8) | 1 | 17 (41.5) | 1 | 33 (80.5) | 1 |
Positive | 6 | 4 (66.7) | 4 (66.7) | 2 (33.3) | 3 (50.0) | 3 (50.0) | 5 (83.3) | ||||||
Extrapancreatic invasion | |||||||||||||
Negative | 42 | 19 (45.2) | 0.05 | 28 (66.7) | 1 | 17 (40.5) | 0.636 | 21 (50.0) | 1 | 18 (42.9) | 1 | 35 (83.3) | 0.24 |
Positive | 5 | 5 (100) | 4 (80.0) | 1 (20.0) | 2 (40.0) | 2 (40.0) | 3 (60.0) | ||||||
T-stage | |||||||||||||
T1 | 33 | 18 (54.5) | 0.245 | 22 (66.7) | 0.408 | 12 (36.4) | 0.895 | 12 (36.4) | 0.014 | 10 (30.3) | 0.009 | 30 (90.9) | 0.012 |
T2 | 10 | 3 (30.0) | 6 (60.0) | 4 (40.0) | 7 (70.0) | 6 (60.0) | 5 (50.0) | ||||||
T3 | 4 | 3 (75.0) | 4 (100) | 2 (50.0) | 4 (100) | 4 (100) | 3 (75.0) | ||||||
N-stage | |||||||||||||
N0 | 42 | 21 (50.0) | 1 | 28 (66.7) | 1 | 16 (38.1) | 1 | 21 (50.0) | 1 | 18 (42.9) | 1 | 34 (81.0) | 1 |
N1 | 5 | 3 (60.0) | 4 (80.0) | 2 (40.0) | 2 (40.0) | 2 (40.0) | 4 (80.0) | ||||||
M-stage | |||||||||||||
M0 | 45 | 22 (48.9) | 0.489 | 30 (66.7) | 1 | 17 (37.8) | 1 | 21 (46.7) | 0.234 | 18 (40.0) | 0.176 | 36 (80.0) | 1 |
M1 | 2 | 2 (100) | 2 (100) | 1 (50.0) | 2 (100) | 2 (100) | 2 (100) | ||||||
p-Stage | |||||||||||||
I | 31 | 17 (54.8) | 0.279 | 21 (67.7) | 0.889 | 12 (38.7) | 1 | 12 (38.7) | 0.028 | 10 (32.3) | 0.045 | 28 (90.3) | 0.031 |
II | 10 | 3 (30.0) | 6 (60.0) | 4 (40.0) | 8 (80.0) | 7 (70.0) | 5 (50.0) | ||||||
III | 4 | 2 (50.0) | 3 (75.0) | 1 (25.0) | 1 (25.0) | 1 (25.0) | 3 (75.0) | ||||||
IV | 2 | 2 (100) | 2 (100) | 1 (50.0) | 2 (100) | 2 (100) | 2 (100) | ||||||
Mitoses / 2mm2 | |||||||||||||
< 2 | 39 | 17 (43.6) | 0.048 | 26 (66.7) | 1 | 15 (38.5) | 1 | 16 (41.0) | 0.023 | 13 (33.3) | 0.007 | 34 (87.2) | 0.033 |
≥ 2 | 8 | 7 (87.5) | 6 (75.0) | 3 (37.5) | 7 (87.5) | 7 (87.5) | 4 (50.0) | ||||||
Ki-67 proliferation index | |||||||||||||
< 3% | 39 | 18 (46.2) | 0.245 | 27 (69.2) | 0.697 | 15 (38.5) | 1 | 18 (46.2) | 0.461 | 15 (38.5) | 0.258 | 33 (84.6) | 0.167 |
≧3% | 8 | 6 (75.0) | 5 (62.5) | 3 (37.5) | 5 (62.5) | 5 (62.5) | 5 (62.5) | ||||||
Grade | |||||||||||||
G1 | 37 | 16 (43.2) | 0.101 | 26 (70.3) | 0.622 | 15 (40.5) | 0.249 | 16 (43.2) | 0.204 | 13 (35.1) | 0.089 | 32 (86.5) | 0.04 |
G2 | 9 | 7 (77.8) | 5 (55.6) | 2 (22.2) | 6 (66.7) | 6 (66.7) | 6 (66.7) | ||||||
G3 | 1 | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 0 (0) | ||||||
Recurrence | |||||||||||||
Negative | 41 | 20 (48.8) | 0.666 | 28 (68.3) | 1 | 17 (41.5) | 0.384 | 19 (46.3) | 0.416 | 16 (39.0) | 0.379 | 33 (80.5) | 1 |
Positive | 6 | 4 (66.7) | 4 (66.7) | 1 (16.7) | 4 (66.7) | 4 (66.7) | 5 (83.3) |