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Table 3 Univariate analysis of prediction for FTR following highly advanced HBPS

From: Perioperative predictive factors of failure to rescue following highly advanced hepatobiliary-pancreatic surgery: a single-institution retrospective study

 

n

OR

95%CI

p-value

Age (years)

 >75

56

2.86

0.73-12.00

0.13

 <75

121

1

  

Sex

 Male

121

1.66

0.39-11.37

0.52

 Female

56

1

  

BMI (kg/m2)

 >24

46

0.34

0.02-1.94

0.26

 <24

131

1

  

ASA

 3

20

4.44

0.88-18.53

0.07

 1/2

157

1

  

Smoking

 Yes

99

4.18

0.72-79.29

0.12

 No

78

1

  

Past abdominal surgery

 Yes

76

0.65

0.13-2.55

0.55

 No

101

1

  

Preoperative-chemotherapy

 Yes

33

0.53

0.03-3.05

0.53

 No

144

1

  

PNIa

 >40

100

0.35

0.05-1.52

0.17

 <40

77

1

  

Modified GPS

 1/2

49

0.74

0.11-3.17

0.70

 0

128

1

  

SIIb

 >437

88

1.26

0.32-5.27

0.73

 <437

89

1

  

Charlson risk index

 2+

93

1.14

0.29-4.73

0.85

 0/1

84

1

  

History of malignancy

 Yes

56

1.08

0.22-4.28

0.91

 No

121

1

  

Heart-related comorbidity

 Yes

30

1.43

0.21-6.29

0.68

 No

147

1

  

Respiratory-related comorbidity

 Yes

31

1.36

0.20-6.02

0.71

 No

146

1

  

Liver-related comorbidity

 Yes

29

4.58

1.07-18.46

0.04*

 No

148

1

  

Cerebrovascular-related comorbidity

 Yes

15

0.00

-2.59

0.2

 No

162

1

  

Diabetes mellitus

 Yes

58

1.03

0.21-4.05

0.97

 No

119

1

  

Chronic renal dysfunction

 Yes

12

1.78

0.09-11.09

0.62

 No

165

1

  

Type of surgery

 Hepatobiliary

69

2.03

0.52-8.47

0.30

 Pancreas

108

1

  

Operative time (min)

 >420

88

1.28

0.33-5.33

0.72

 <420

89

1

  

Blood loss (ml)

 >1600 

25

71.06

12.02-1359.77

<0.001***

 <1600

152

1

  

Blood transfusion

 Yes

48

10.84

2.51-74.70

<0.01**

 No

129

1

  

Onset time of complication (POD)

 >12

32

3.97

0.93-15.93

0.06

 <12

145

1

  

Pancreatic fistula

 Yes

76

0.36

0.05-1.55

0.18

 No

101

1

  

Bile leakage

 Yes

25

0.00

-0.00

0.09

 No

152

1

  

Liver failure

 Yes

6

66.4

10.6-574.22

<0.001***

 No

171

1

  

Respiratory failure

 Yes

10

82

16.28-530.28

<0.001***

 No

167

1

  

Postoperative bleeding

 Yes

25

5.6

1.30-22.84

0.02*

 No

152

1

  

Re-operation

 Yes

12

1.78

0.09-11.09

0.62

 No

165

1

  

White blood cell on POD3 (×103µl)

 >10000 

73

1.84

0.47-7.66

0.38

 <10000

104

1

  

C-reactive protein on POD3 (mg/dl)

 >15 

93

0.69

0.17-2.71

0.59

 <15

84

1

  

Albumin (g/dl)

 >2.8

70

1.24

0.20-4.85

0.76

 <2.8

107

1

  
  1. OR odds ratio, 95%CI 95% confidence interval, BMI body mass index, ASA American Society of Anesthesiologists physical status classification, GPS Glasgow prognostic score, POD postoperative day
  2. aPrognostic nutritional index = 10 × albumin (g/dl) + 0.005 × the absolute lymphocyte count
  3. bSystemic Inflammation Index = the absolute platelet count × the absolute neutrophil count / the absolute lymphocyte count
  4. *p < 0.05
  5. **p < 0.01
  6. ***p < 0.001