Table 2 Univariate and multivariate analysis of recurrence survival for adenocarcinoma
Post-recurrence survival variable | Univariate HR1 (95% CI1) | p-value5 | Multivariate HR1 (95% CI1) | p-value5 |
|---|---|---|---|---|
Sex | ||||
Male | 1.0 (reference) | |||
Female | 0.88 (0.66, 1.16) | 0.363 | ||
Age group | ||||
< 60 | 1.0 (reference) | |||
≥ 60 | 0.98 (0.73, 1.30) | 0.884 | ||
BMI1 group | ||||
< 24 | 1.0 (reference) | |||
≥ 24 | 0.74 (0.55, 1.00) | 0.052 | ||
Surgical mode | ||||
Lobectomy | 1.0 (reference) | |||
Segmentectomy | 0.29 (0.04, 2.05) | 0.213 | ||
Wedge resection | 1.44 (0.96, 2.16) | 0.081 | ||
Total pneumonectomy | 1.29 (0.32, 5.20) | 0.722 | ||
Tumor differentiation | ||||
Unknown | 1.0 (reference) | |||
Medium differentiation | 0.85 (0.52, 1.39) | 0.522 | ||
Low differentiation | 1.19 (0.78, 1.80) | 0.420 | ||
Undifferentiation | 0.50 (0.07, 3.57) | 0.488 | ||
Medium–low differentiation | 1.88 (0.60, 5.89) | 0.281 | ||
Vascular cancer thrombus | ||||
No | 1.0 (reference) | 1.0 (reference) | ||
Yes | 1.93 (1.08, 3.47) | 0.027 | 2.00 (1.11, 3.61) | 0.021 |
Bronchial stump | ||||
No | 1.0 (reference) | |||
Yes | 1.62 (0.98, 2.67) | 0.058 | ||
Pleural invasion | ||||
No | 1.0 (reference) | |||
Yes | 0.85 (0.56, 1.28) | 0.427 | ||
AJCC1 8th ed. stage | ||||
AICC < = II stage | 1.0 (reference) | 1.0 (reference) | ||
AICC > II stage | 1.78 (1.34, 2.37) | < 0.001 | 1.70 (1.27, 2.27) | < 0.001 |
Adjuvant chemotherapy | ||||
No | 1.0 (reference) | |||
Yes | 0.87 (0.61, 1.22) | 0.415 | ||
Adjuvant radiation therapy | ||||
No | 1.0 (reference) | |||
Yes | 0.89 (0.65, 1.22) | 0.474 | ||
Postoperative targeted therapy | ||||
No | 1.0 (reference) | |||
Yes | 0.97 (0.61, 1.54) | 0.891 | ||
Two sites | ||||
No | 1.0 (reference) | |||
Yes | 0.96 (0.63, 1.45) | 0.839 | ||
Three or more recurrence sites | ||||
No | 1.0 (reference) | 1.0 (reference) | ||
Yes | 1.80 (1.22, 2.66) | 0.003 | 1.60 (1.07, 2.39) | 0.022 |
Lung recurrence | ||||
No | 1.0 (reference) | 1.0 (reference) | ||
Yes | 0.56 (0.37, 0.84) | 0.005 | 0.62 (0.41, 0.95) | 0.027 |
Brain recurrence | ||||
No | 1.0 (reference) | |||
Yes | 0.96 (0.68, 1.35) | 0.804 | ||
Bone recurrence | ||||
No | 1.0 (reference) | |||
Yes | 1.44 (0.99, 2.09) | 0.058 | ||
Abdominal organs2 recurrence | ||||
No | 1.0 (reference) | |||
Yes | 1.05 (0.49, 2.24) | 0.896 | ||
Pleural recurrence | ||||
No | 1.0 (reference) | 1.0 (reference) | ||
Yes | 1.99 (1.05, 3.77) | 0.034 | 2.18 (1.14, 4.17) | 0.018 |
Lymph node4 recurrence | ||||
No | 1.0 (reference) | |||
Yes | 0.64 (0.38, 1.08) | 0.094 | ||
Multisite3 recurrence | ||||
No | 1.0 (reference) | |||
Yes | 1.35 (0.99, 1.83) | 0.057 | ||