Table 1 Univariable and multivariable Cox regression analysis of FOXM1 in hepatocellular carcinoma
| Â | Â | All | HR (univariable) | HR (multivariable) |
|---|---|---|---|---|
FOXM1 | Mean ± SD | 2.7 ± 1.4 | 1.30 (1.15–1.47, p < 0.001) | 1.27 (1.12–1.45, p < 0.001) |
Age | Mean ± SD | 59.6 ± 13.4 | 1.01 (1.00–1.03, p = 0.073) | / |
Sex | Female | 119 (32.7%) | / | / |
Male | 245 (67.3%) | 0.82 (0.57–1.16, p = 0.258) | / | |
AJCC pathologic stage | I | 169 (46.4%) | / | / |
II | 84 (23.1%) | 1.43 (0.87–2.33, p = 0.155) | 1.30 (0.78–2.15, p = 0.313) | |
III | 83 (22.8%) | 2.71 (1.78–4.13, p < 0.001) | 2.48 (1.60–3.85, p < 0.001) | |
IV | 4 (1.1%) | 5.72 (1.76–18.56, p = 0.004) | 0.00 (0.00–Inf, p = 0.997) | |
V | 24 (6.6%) | 2.83 (1.54–5.21, p < 0.001) | 1.72 (0.86–3.44, p = 0.126) | |
T status | T1 | 179 (49.2%) | / | / |
T2 | 91 (25.0%) | / | / | |
T3 | 78 (21.4%) | / | / | |
T4 | 13 (3.6%) | / | / | |
Tx | 1 (0.3%) | / | / | |
Na | 2 (0.5%) | / | / | |
N status | N0 | 247 (67.9%) | / | / |
N1 | 4 (1.1%) | 2.13 (0.52–8.71, p = 0.292) | 1.17 (0.28–4.87, p = 0.830) | |
Nx | 112 (30.8%) | 1.50 (1.03–2.17, p = 0.032) | 1.34 (0.76–2.34, p = 0.309) | |
Na | 1 (0.3%) | 2.33 (0.32–16.83, p = 0.401) | 1.42 (0.18–10.84, p = 0.738) | |
M_status | M0 | 262 (72.0%) | Â | Â |
M1 | 3 (0.8%) | 4.28 (1.34–13.60, p = 0.014) | 242,816.50 (0.00–Inf, p = 0.996) | |
Mx | 99 (27.2%) | 1.61 (1.11–2.33, p = 0.013) | 1.43 (0.83–2.49, p = 0.200) | |
Race | White | 182 (50.0%) | / | / |
Asian | 155 (42.6%) | / | / | |
Black or African American | 16 (4.4%) | / | / | |
American Indian or Alaska Native | 1 (0.3%) | / | / | |
Na | 10 (2.7%) | / | / | |
Ethnicity | Not Hispanic or Latino | 329 (90.4%) | / | / |
Hispanic or Latino | 17 (4.7%) | 0.91 (0.40–2.06, p = 0.814) | / | |
Na | 18 (4.9%) | 1.28 (0.62–2.62, p = 0.506) | / |