Fig. 2

LINC02086 knockdown decreases cell viability, promotes cell apoptosis and inhibits tumor growth. A, LINC02086 knockdown by shRNAs transfection in MCF-7 cells; B, cell viability of MCF-7 cells transfected with shRNA-1, 2 at different time points; C-D, percentages of apoptotic cells detected by flow cytometry; E, tumor volume of mice models at different time points; F, tumor weight of mice models at day 35; G, LINC02086 levels in tumors harvested from mice models; H, TUNEL positive cells on tumor tissue samples harvested from mice models. Scale bar = 50 μm. **P < 0.01, ***P < 0.001 vs. shNC