Table 3 Sensitivity analysis of the influence of surgery on OS of stage T4N0-3M0 EC

Surgery vs. no surgery in T4

0.435 (0.382–0.496)

 < 0.001

0.492 (0.427–0.567)

 < 0.001

0.493 (0.417–0.582)

 < 0.001

Surgery vs. no surgery in T4a

0.377 (0.289–0.493)

 < 0.001

0.471 (0.354–0.627)

 < 0.001

0.391 (0.282–0.543)

 < 0.001

Surgery vs. no surgery in T4b

0.423 (0.297–0.603)

 < 0.001

0.480 (0.335–0.689)

 < 0.001

0.434 (0.282–0.67)

 < 0.001

Neo + surgery vs. no surgery in T4

0.373 (0.319–0.437)

 < 0.001

0.548 (0.461–0.650)

 < 0.001

0.448 (0.367–0.548)

 < 0.001

Surgery without neo vs. no surgery in T4

0.628 (0.512–0.769)

 < 0.001

0.464 (0.375–0.574)

 < 0.001

0.587 (0.435–0.792)

 < 0.001

Neo + surgery vs. surgery without neo in T4

0.586 (0.459–0.748)

 < 0.001

0.966 (0.686–1.360)

0.843

0.892 (0.58–1.372)

0.603

Surgery vs. no surgery in adenocarcinoma

0.373 (0.289–0.481)

 < 0.001

0.432 (0.331–0.565)

 < 0.001

0.435 (0.33–0.574)

 < 0.001

Surgery vs. no surgery in squamous cell carcinoma

0.511 (0.349–0.749)

0.001

0.388 (0.26–0.579)

 < 0.001

0.536 (0.335–0.859)

0.01