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Table 2 Univariate and Multivariate analysis for predictors of overall survival

From: Implication of perineural invasion in patients with stage II gastric cancer

Characteristics

Univariate

 

Multivariate

 

HR (95%CI)

p value

HR (95%CI)

p value

Gender (Male)

1.41(0.77–2.57)

0.267

  

Age (≥ 60 years)

1.44(0.84–2.46)

0.180

  

CEA (> 5 ng/ml)

1.93(1.04–3.59)

0.037

2.20(1.17—4.17)

0.015

PNI (Presence)

1.85(1.1–3.13)

0.021

1.76(1.02 – 3.06)

0.044

Vascular invasion (Presence)

1.32(0.73–2.4)

0.352

  

Location (Ref: Lower)

 Middle

2.87(1.48–5.53)

0.002

3.19(1.62 – 6.26)

 < 0.001

 Upper

1.04(0.48–2.25)

0.918

0.97(0.44—2.12)

0.931

 EGJ

1.59(0.76–3.35)

0.221

1.58(0.75—3.33)

0.233

Tumor diameter (> 3 cm)

0.75(0.45–1.27)

0.290

  

Type of gastrectomy (Total)

1.20(0.72–2.03)

0.482

  

Adjuvant chemotherapy (Yes)

0.59(0.35–1.01)

0.055

0.51(0.30—0.88)

0.016

Differentiation type (Poorly differentiated)

1.25(0.66–2.37)

0.490

  

Lauren classification (Ref: Intestinal)

 Diffuse

1.4(0.73–2.68)

0.316

  

 Mix

1.15(0.55–2.41)

0.718

  

 Others

0.5(0.13–1.91)

0.309

  

T Stage (T3/T4a)

2.33(0.93–5.83)

0.072

1.55(0.59 – 4.03)

0.371

Lymph node metastasis (Presence)

1.3(0.77–2.19)

0.329

  
  1. CEA carcinoembryonic antigen, PNI perineural invasion, EGJ esophagogastric junction, HR hazard ratio, CI confidence interval