Risk factors for cough after pulmonary resection

Wu, Yongming; Song, Wenpeng; Zhu, Dongmei; Wang, Yan; Che, Guowei

doi:10.1186/s12957-023-03235-y

World Journal of Surgical Oncology

Table 2 Meta-analysis results of risk factors for cough after pulmonary resection

From: Risk factors for cough after pulmonary resection

Risk factor	Operation method	Number of included studies	Heterogeneity		Model	Meta-analysis results
Risk factor	Operation method	Number of included studies	P value	I² (%)	Model	OR (95%CI)	P value
Age	VATS/OPEN	5 [3, 4, 12, 19, 20]	< 0.01	80	random	0.66 [0.46, 0.96]	0.03
Age	VATS	4 [3, 4, 19, 20]	< 0.01	84	random	0.66 [0.44, 1.00]	0.05
gender	VATS/OPEN	5 [3, 9, 12, 16, 18]	0.04	61	random	1.69 [1.07, 2.66]	0.02
gender	VATS	4 [3, 9, 16, 18]	0.07	57	random	1.95 [1.22, 3.11]	< 0.01
BMI	VATS	2 [14, 20]	< 0.01	89	random	0.78 [0.41, 1.47]	0.44
smoking history	VATS/OPEN	9 [3, 4, 10, 12,13,14, 16, 17, 20]	< 0.01	78	random	0.89 [0.56, 1.40]	0.60
smoking history	VATS	6 [3, 4, 14, 16, 17, 20]	< 0.01	68	random	0.62 [0.40, 0.96]	0.03
preoperative cough	VATS	2 [21, 22]	0.44	0	fixed	5.96 [2.58, 13.73]	< 0.01
COPD history	VATS/OPEN	2 [12, 14]	< 0.01	86	random	1.54 [0.19, 12.41]	0.68
upper lobe surgery	VATS	3 [8, 17, 20]	< 0.01	80	random	1.32 [0.45, 3.87]	0.61
right lobe operation	VATS/OPEN	7 [4, 8, 9, 12, 13, 17, 21]	0.09	46	random	2.14 [1.44, 3.19]	< 0.01
right lobe operation	VATS	5 [4, 8, 9, 17, 21]	0.05	59	random	1.91 [1.11, 3.29]	0.02
lobectomy	VATS/OPEN	7 [2, 4, 9, 13, 15, 16, 19]	< 0.01	81	random	3.70 [1.73, 7.90]	< 0.01
lobectomy	VATS	6 [2, 4, 9, 15, 16, 19]	< 0.01	82	random	3.28 [1.48, 7.28]	< 0.01
subcarinal lymph node dissection	VATS/OPEN	3 [2, 9, 20]	0.77	0	fixed	3.45 [1.86, 6.39]	< 0.01
mediastinal lymph node removal	VATS/OPEN	2 [3, 11]	0.45	0	fixed	3.49 [2.07, 5.89]	< 0.01
closure of bronchial stump with stapler	VATS/OPEN	2 [13, 17]	0.93	0	random	5.19 [1.79, 15.07]	< 0.01
peritracheal lymph node resection	VATS/OPEN	6 [4, 13,14,15, 18, 22]	< 0.01	84	random	3.05 [1.40, 6.64]	< 0.01
peritracheal lymph node resection	VATS	5 [4, 14, 15, 18, 22]	< 0.01	86	random	2.75 [1.24, 6.11]	0.01
operation time	VATS	2 [7, 16]	< 0.01	86	random	1.74 [0.50, 6.02]	0.38
drainage time	VATS	2 [7, 15]	< 0.01	92	random	1.60 [0.67, 3.84]	0.29
anesthesia time	VATS	7 [2, 8, 9, 14, 15, 20, 22]	< 0.01	91	random	1.02 [0.99, 1.04]	0.15
tracheal intubation time	VATS	3 [14, 20]	< 0.01	90	random	1.06 [0.97, 1.15]	0.21
postoperative acid reflux	VATS/OPEN	2 [2, 11]	0.72	0	fixed	11.07[4.38, 28.02]	< 0.01

VATS video-assisted thoracoscopic surgery, BMI body mass index, COPD chronic obstructive pulmonary disease, random, random-effects model; fixed, fixed-effects model

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