Table 1 Baseline characteristics before propensity score matching
Covariates | Time interval (TI) after NAC to surgery | P value | |
|---|---|---|---|
4≦TI < 6 (n = 132) | 6≦TI≦8 (n = 123) | ||
Sex (M:F) | 88:44 | 76:47 | 0.417 |
Age (years) | 61.0 (53.3, 65.8) | 59 (54, 67) | 0.386 |
Over weight (BMI > 24) | 34 (25.8) | 28 (22.8) | 0.578 |
Diabetes | 21 (15.9) | 15 (12.2) | 0.395 |
Hypertension | 34 (25.8) | 28 (22.8) | 0.578 |
Coronary heart disease | 5 (3.8) | 7 (5.7) | 0.473 |
Liver cirrhosis | 11 (8.3) | 7 (5.7) | 0.410 |
NAC cycles | 4 (3,5) | 4 (3, 5) | 0.381 |
NAC regimes | 0.261 | ||
FOLFIRI | 44 (33.3) | 30 (24.4) | |
CapeOX | 38 (28.8) | 37 (30.1) | |
FOLFOX | 50 (37.9) | 56 (45.5) | |
Progressive disease during NAC | 18 (13.6) | 12 (9.8) | 0.337 |
Toxic reactions after NAC | 5 (3.8) | 15 (12.2) | 0.013* |
Serum CEA (> 10 ng/mL) | 113 (85.6) | 105 (85.4) | 0.957 |
Hemoglobin (g/L) | 120.2 (96.2, 134.5) | 123.0 (102.0, 135.0) | 0.259 |
WBC (109/L) | 5.9 (4.5, 7.3) | 6.4 (4.7, 7.9) | 0.109 |
PLT (109/L) | 111.6 (76.9, 154.2) | 113.4 (81.9, 155.7) | 0.614 |
Total bilirubin (μmol/L) | 17.9 (12.8, 22.3) | 14.6 (11.6, 19.4) | 0.004* |
Albumin (g/L) | 38.8 (34.4, 43.2) | 38.1 (33.7, 44.2) | 0.659 |
AST (IU/L) | 38.5 (28.3, 54.8) | 40.0 (28.0, 60.0) | 0.513 |
ALT (IU/L) | 33.0 (22.0, 50.8) | 36.0 (23.0, 62.0) | 0.317 |
Primary tumor | |||
Tumor size (cm) | 3.65 (2.7, 4.7) | 3.5 (2.5,4.7) | 0.449 |
Tumor location (left:right) | 66:66 | 64:59 | 0.746 |
Number of tumors | 1 (1, 1) | 1 (1, 1) | 0.909 |
Tumor grade (medium/high:low) | 66:66 | 77:46 | 0.043* |
Nerve invasion | 39 (29.5) | 25 (20.3) | 0.090 |
Cancer nodule | 0.5 (0, 1.75) | 0 (0, 1) | 0.244 |
Lymph node metastasis | 64 (48.5) | 53 (43.1) | 0.388 |
Liver metastases | |||
Tumor size (cm) | 3.7 (2.2, 5.0) | 3.1 (2.1, 4.2) | 0.093 |
Number of tumors | 1 (1, 2) | 1 (1, 2) | 0.685 |
Tumor grade (medium/high:low) | 75:57 | 77:46 | 0.347 |
Liver capsule invasion | 58 (43.9) | 37 (30.1) | 0.022* |
Portal vein tumor thrombus | 21 (15.9) | 7 (5.7) | 0.009* |
Vascular tumor thrombus | 40 (30.3) | 35 (28.5) | 0.746 |
Satellite nodules | 22 (16.7) | 14 (11.4) | 0.226 |
Extrahepatic invasion | 15 (11.4) | 9 (7.3) | 0.269 |
Surgical procedure | |||
ASA grade ≥ 3 | 3 (2.3) | 4 (3.3) | 0.632 |
R0 resection | 125 (94.7) | 110 (89.4) | 0.118 |
Major liver resection | 41 (31.1) | 30 (24.4) | 0.235 |