Table 6 Summary of meta-analysis of association of rs6068816 polymorphism and cancer risk

TT vs. CC+CT

Overall

6

0.88 (0.70, 1.10)

1.13

0.259

1.000

22

0.268

Caucasian

4

0.75 (0.47, 1.19)

1.23

0.219

1.000

30

0.232

Asian

2

0.92 (0.71, 1.20)

0.59

0.553

1.000

40.8

0.194

Prostate cancer

2

1.26 (0.61, 2.62)

0.63

0.527

1.000

0

0.947

Breast cancer

2

0.52 (0.27, 0.98)

2.03

0.043

0.301

7.2

0.299

Colorectal cancer

1

1.03 (0.76, 1.41)

0.20

0.845

1.000

-

-

Lung cancer

1

0.70 (0.43, 1.15)

1.41

0.158

1.000

-

-

CC vs. CT+TT

Overall

6

1.03 (0.88, 1.20)

0.32

0.748

1.000

56.8

0.041

Caucasian

4

0.99 (0.76, 1.13)

0.17

0.865

1.000

44.1

0.147

Asian

2

1.45 (0.74, 1.77)

0.61

0.544

1.000

82.9

0.016

Prostate cancer

2

0.85 (0.70, 1.04)

1.57

0.117

0.819

0

0.565

Breast cancer

2

1.10 (0.94, 1.30)

1.18

0.236

1.000

6.9

0.300

Colorectal cancer

1

0.93 (0.76, 1.13)

0.72

0.472

1.000

-

-

Lung cancer

1

1.45 (1.07, 1.97)

2.42

0.016

0.112

-

-

TT vs. CC

Overall

6

0.86 (0.68, 1.09)

1.26

0.209

1.000

42.3

0.123

Caucasian

4

0.75 (0.47, 1.20)

1.20

0.230

1.000

35.9

0.197

Asian

2

0.90 (0.68, 1.19)

0.74

0.461

1.000

72.9

0.055

Prostate cancer

2

1.31 (0.63, 2.71)

0.72

0.473

1.000

0

0.924

Breast cancer

2

0.52 (0.27, 0.97)

2.06

0.039

0.273

13.6

0.282

Colorectal cancer

1

1.07 (0.77, 1.48)

0.41

0.684

1.000

-

-

Lung cancer

1

0.58 (0.35, 0.99)

2.01

0.044

0.308

-

-

CT vs. CC

Overall

6

1.00 (0.90, 1.10)

0.09

0.932

1.000

42.1

0.125

Caucasian

4

1.02 (0.90, 1.16)

0.32

0.748

1.000

17.7

0.302

Asian

2

0.95 (0.80, 1.13)

0.59

0.558

1.000

78

0.033

Prostate cancer

2

1.16 (0.95, 1.42)

1.47

0.142

0.994

0

0.581

Breast cancer

2

0.94 (0.80, 1.10)

0.78

0.435

1.000

0

0.409

Colorectal cancer

1

1.08 (0.87, 1.33)

0.69

0.488

1.000

-

-

Lung cancer

1

0.71 (0.52, 0.98)

2.10

0.036

0.252

-

-

T vs. C

Overall

6

0.97 (0.84, 1.11)

0.49

0.625

1.000

60.8

0.026

Caucasian

4

1.00 (0.84, 1.19)

0.00

0.997

1.000

57.2

0.072

Asian

2

0.90 (0.66, 1.24)

0.64

0.524

1.000

82.1

0.018

Prostate cancer

2

1.16 (0.97, 1.39)

1.60

0.110

0.770

0

0.571

Breast cancer

2

0.88 (0.74, 1.06)

1.36

0.173

1.000

32.1

0.225

Colorectal cancer

1

1.05 (0.90, 1.21)

0.63

0.539

1.000

-

-

Lung cancer

1

0.76 (0.61, 0.95)

2.42

0.016

0.112

-

-