Table 5 Summary of meta-analysis of association of rs2762939 polymorphism and cancer risk
Comparison | Â | Studies | Overall effect | Heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Z score | p value | padjust | I2 (%) | p value | |||
CC vs. GG+GC | Overall | 5 | 1.05 (0.87, 1.27) | 0.51 | 0.609 | 1.000 | 0 | 0.774 |
Caucasian | 3 | 1.02 (0.80, 1.29) | 0.17 | 0.866 | 1.000 | 0 | 0.479 | |
African | 1 | 0.98 (0.52, 1.87) | 0.05 | 0.958 | 1.000 | - | - | |
Asian | 1 | 1.15 (0.80, 1.64) | 0.74 | 0.458 | 1.000 | - | - | |
Prostate cancer | 3 | 0.97 (0.74, 1.29) | 0.18 | 0.857 | 1.000 | 0 | 0.538 | |
Lung cancer | 1 | 1.15 (0.80, 1.64) | 0.74 | 0.458 | 1.000 | - | - | |
Breast cancer | 1 | 1.10 (0.75, 1.60) | 0.48 | 0.631 | 1.000 | Â | Â | |
GG vs. CC+GC | Overall | 4 | 1.02 (0.91, 1.13) | 0.32 | 0.751 | 1.000 | 0 | 0.657 |
Caucasian | 3 | 0.99 (0.88, 1.12) | 0.13 | 0.893 | 1.000 | 0 | 0.588 | |
African | 1 | 1.42 (0.68, 2.96) | 0.93 | 0.354 | 1.000 | - | - | |
Asian | 1 | 1.11 (0.85, 1.47) | 0.77 | 0.443 | 1.000 | - | - | |
Prostate cancer | 3 | 1.06 (0.91, 1.23) | 0.74 | 0.462 | 1.000 | 0 | 0.707 | |
Lung cancer | 1 | 1.11 (0.85, 1.47) | 0.77 | 0.443 | 1.000 | - | - | |
Breast cancer | 1 | 0.92 (0.77, 1.11) | 0.84 | 0.399 | 1.000 | Â | Â | |
CC vs. GG | Overall | 4 | 1.01 (0.83, 1.23) | 0.10 | 0.923 | 1.000 | 0 | 0.767 |
Caucasian | 3 | 1.02 (0.80, 1.0) | 0.17 | 0.862 | 1.000 | 0 | 0.515 | |
African | 1 | 0.75 (0.33, 1.75) | 0.66 | 0.510 | 1.000 | - | - | |
Asian | 1 | 1.05 (0.70, 1.55) | 0.22 | 0.825 | 1.000 | - | - | |
Prostate cancer | 3 | 0.93 (0.69, 1.25) | 0.50 | 0.620 | 1.000 | 0 | 0.557 | |
Lung cancer | 1 | 1.05 (0.70, 1.55) | 0.22 | 0.825 | 1.000 | - | - | |
Breast cancer | 1 | 1.13 (0.77, 1.65) | 0.61 | 0.539 | 1.000 | Â | Â | |
GC vs. GG | Overall | 4 | 0.97 (0.87, 1.09) | 0.48 | 0.634 | 1.000 | 0 | 0.543 |
Caucasian | 2 | 1.01 (0.89, 1.14) | 0.09 | 0.926 | 1.000 | 0 | 0.554 | |
African | 1 | 0.67 (0.30, 1.49) | 1.08 | 0.326 | 1.000 | - | - | |
Asian | 1 | 0.85 (0.63, 1.14) | 6.36 | 0.281 | 1.000 | - | - | |
Prostate cancer | 3 | 0.94 (0.80, 1.11) | 0.70 | 0.481 | 1.000 | 0 | 0.570 | |
Lung cancer | 1 | 0.85 (0.63, 1.14) | 1.08 | 0.281 | 1.000 | - | - | |
Breast cancer | Â | 1.07 (0.89, 1.30) | 0.74 | 0.462 | 1.000 | - | - | |
C vs. G | Overall | 4 | 1.00 (0.92, 1.09) | 0.02 | 0.984 | 1.000 | 0 | 0.834 |
Caucasian | 2 | 1.01 (0.92, 1.11) | 0.18 | 0.860 | 1.000 | 0 | 0.589 | |
African | 1 | 0.88 (0.57, 1.36) | 0.59 | 0.554 | 1.000 | - | - | |
Asian | 1 | 0.99 (0.81, 1.20) | 0.14 | 0.892 | 1.000 | - | - | |
Prostate cancer | 3 | 0.96 (0.85, 1.08) | 0.66 | 0.512 | 1.000 | 0 | 0.884 | |
Lung cancer | 1 | 0.99 (0.81, 1.20) | 0.14 | 0.892 | 1.000 | - | - | |
Breast cancer | 1 | 1.07 (0.92, 1.09) | 0.87 | 0.382 | 1.000 | - | - | |