Table 4 Summary of meta-analysis of association of rs4809957 polymorphism and cancer risk

AA vs. GG+GA

Overall

4

1.11 (0.90, 1.36)

0.99

0.323

1.000

45.7

0.137

Caucasian

1

0.99 (0.64, 1.53)

0.03

0.974

1.000

-

-

Asian

3

1.14 (0.91, 1.44)

1.13

0.257

1.000

61.7

0.073

Pancreas cancer

1

0.99 (0.64, 1.53)

0.03

0.974

1.000

-

-

Lung cancer

1

0.98 (0.64, 1.49)

0.11

0.911

1.000

-

-

Colorectal cancer

1

0.93 (0.64, 1.35)

0.36

0.715

1.000

-

-

Breast cancer

1

1.70 (1.12, 2.58)

2.51

0.012

0.084

-

-

GG vs. GA+AA

Overall

4

0.90 (0.79, 1.02)

1.70

0.089

0.623

24.6

0.264

Caucasian

1

0.80 (0.66, 0.98)

2.18

0.029

0.203

-

-

Asian

3

0.97 (0.82, 1.13)

0.44

0.663

1.000

0

0.382

Pancreas cancer

1

0.80 (0.66, 0.98)

2.18

0.029

0.203

-

-

Lung cancer

1

1.06 (0.78, 1.43)

0.35

0.729

1.000

-

-

Colorectal cancer

1

1.03 (0.81, 1.31)

0.23

0.822

1.000

-

-

Breast cancer

1

0.81 (0.61, 1.09)

1.39

0.163

1.000

-

-

AA vs. GG

Overall

4

1.13 (0.91, 1.40)

1.11

0.265

1.000

47.4

0.127

Caucasian

1

1.08 (0.70, 1.68)

0.36

0.720

1.000

-

-

Asian

3

1.15 (0.89, 1.47)

1.08

0.282

1.000

64.7

0.059

Pancreas cancer

1

1.08 (0.70, 1.68)

0.36

0.720

1.000

-

-

Lung cancer

1

0.95 (0.60, 1.50)

0.23

0.817

1.000

-

-

Colorectal cancer

1

0.93 (0.62, 1.37)

0.39

0.700

1.000

-

-

Breast cancer

1

1.80 (1.15, 2.82)

2.56

0.010

0.070

-

-

GA vs. GG

Overall

4

1.10 (0.97, 1.26)

1.51

0.132

0.924

14.5

0.320

Caucasian

1

1.27 (1.04, 1.56)

2.30

0.022

0.154

-

-

Asian

3

1.01 (0.85, 1.19)

0.10

0.924

1.000

0

0.770

Pancreas cancer

1

1.27 (1.04, 1.56)

2.30

0.022

0.154

-

-

Lung cancer

1

0.95 (0.69, 1.31)

0.33

0.743

1.000

-

-

Colorectal cancer

1

0.98 (0.77, 1.27)

0.13

0.900

1.000

-

-

Breast cancer

1

1.10 (0.81, 1.50)

0.64

0.523

1.000

-

-

A vs. G

Overall

4

1.09 (0.99, 1.19)

1.73

0.084

0.588

45.7

0.137

Caucasian

1

1.16 (0.89, 1.37)

1.80

0.071

0.497

-

-

Asian

3

1.05 (0.94, 1.18)

0.87

0.387

1.000

55.9

0.104

Pancreas cancer

1

1.16 (0.89, 1.37)

1.80

0.071

0.497

-

-

Lung cancer

1

0.97 (0.78, 1.20)

0.30

0.763

1.000

-

-

Colorectal cancer

1

0.97 (0.82, 1.15)

0.33

0.320

1.000

-

-

Breast cancer

1

1.27 (1.03, 1.55)

2.25

0.024

0.168

-

-