Table 3 Summary of meta-analysis of association of rs2296241 polymorphism and cancer risk

AA vs. GG+AG

Overall

9

0.99 (0.90, 1.08)

0.30

0.768

1.000

45.2

0.067

Caucasian

6

0.96 (0.86, 1.06)

0.87

0.384

1.000

0

0.700

African

1

1.68 (0.84, 3.37)

1.45

0.146

1.000

-

-

Asian

2

1.06 (0.87, 1.30)

0.61

0.539

1.000

88.2

0.004

Prostate cancer

3

0.94 (0.79, 1.12)

0.66

0.509

1.000

30.5

0.237

Lung cancer

1

0.72 (0.52, 1.01)

1.92

0.055

0.385

-

-

Breast cancer

2

1.01 (0.88, 1.15)

0.11

0.914

1.000

0

0.992

Thyroid carcinoma

2

0.82 (0.58, 1.16)

1.12

0.261

1.000

26.6

0.243

Esophageal squamous cell carcinoma

1

1.34 (1.04, 1.74)

2.27

0.023

0.161

-

-

GG vs. AA+AG

Overall

9

1.06 (0.96, 1.16)

1.13

0.260

1.000

18.1

0.282

Caucasian

6

1.05 (0.94, 1.17)

0.89

0.371

1.000

45.7

0.101

African

1

1.29 (0.60, 2.79)

0.66

0.512

1.000

-

-

Asian

2

1.06 (0.86, 1.31)

0.56

0.579

1.000

0

0.592

Prostate cancer

3

1.20 (1.00, 1.44)

1.93

0.054

0.378

0

0.923

Lung cancer

1

1.13 (0.83, 1.52)

0.77

0.440

1.000

-

--

Breast cancer

3

0.93 (0.80, 1.08)

0.92

0.355

1.000

0

0.607

Thyroid carcinoma

2

1.37 (0.95, 1.96)

1.70

0.089

0.623

57.5

0.125

Esophageal squamous cell carcinoma

1

1.00 (0.75, 1.34)

0.03

0.979

1.000

-

-

AA vs. GG

Overall

9

0.94 (0.84, 1.06)

1.00

0.317

1.000

38.5

0.112

Caucasian

6

0.93 (0.82, 1.06)

1.07

0.285

1.000

40.1

0.138

African

1

1.18 (0.48, 2.95)

0.36

0.717

1.000

0

-

Asian

2

0.97 (0.75, 1.25)

0.23

0.820

1.000

76.9

0.037

Prostate cancer

3

0.83 (0.67, 1.03)

1.67

0.096

0.672

0

0.682

Lung cancer

1

0.71 (0.48, 1.05)

1.72

0.085

0.595

-

-

Breast cancer

2

1.06 (0.89, 1.26)

0.67

0.501

1.000

0

0.735

Thyroid carcinoma

2

0.68 (0.44, 1.05)

1.74

0.082

0.574

61.7

0.106

Esophageal squamous cell carcinoma

1

1.23 (0.88, 1.71)

1.19

0.235

1.000

-

-

AG vs. GG

Overall

9

0.95 (0.85, 1.05)

1.05

0.292

1.000

1.7

0.420

Caucasian

6

0.96 (0.86, 1.08)

0.64

0.521

1.000

25.6

0.243

African

1

0.62 (0.27, 1.38)

1.18

0.238

1.000

-

-

Asian

2

0.92 (0.74, 1.15)

0.72

0.469

1.000

0

0.653

Prostate cancer

3

0.84 (0.69, 1.01)

1.81

0.070

0.490

0

0.718

Lung cancer

1

0.97 (0.71, 1.33)

0.19

0.853

1.000

-

-

Breast cancer

2

1.08 (0.92, 1.26)

0.94

0.346

1.000

0

0.581

Thyroid carcinoma

2

0.76 (0.52, 1.12)

1.39

0.164

1.000

29.7

0.233

Esophageal squamous cell carcinoma

1

0.88 (0.64, 1.19)

0.83

0.405

1.000

-

-

A vs. G

Overall

13

0.96 (0.91, 1.01)

1.49

0.137

0.959

38.9

0.074

Caucasian

8

0.97 (0.91, 1.03)

1.13

0.257

1.000

18.2

0.286

African

2

0.95 (0.70, 1.27)

0.37

0.714

1.000

20.1

0.263

Asian

3

0.95 (0.84, 1.06)

0.96

0.339

1.000

79.4

0.008

Prostate cancer

7

0.91 (0.84, 0.99)

2.29

0.022

0.154

0

0.461

Lung cancer

1

0.86 (0.71, 1.04)

1.59

0.112

0.784

-

-

Breast cancer

2

1.03 (0.94, 1.12)

0.61

0.543

1.000

0

0.762

Thyroid carcinoma

2

0.83 (0.66, 1.03)

1.72

0.085

0.595

65.0

0.091

Esophageal squamous cell carcinoma

1

1.13 (0.96, 1.34)

1.47

0.141

0.987

-

-