Table 2 Summary of meta-analysis of association of rs4809960 polymorphism and cancer risk

CC vs. TC+TT

Overall

7

0.94 (0.71, 1.24)

0.43

0.667

1.000

51.6

0.054

Caucasian

5

0.85 (0.65, 1.12)

1.14

0.255

1.000

43.9

0.129

African

1

1.71 (0.07, 42.57)

0.33

0.744

1.000

-

-

Asian

1

1.52 (1.01, 2.28)

2.01

0.044

0.308

-

-

Prostate cancer

3

0.84 (0.60, 1.16)

1.08

0.280

1.000

0

0.480

Breast cancer

2

1.01 (0.79, 1.30)

0.11

0.911

1.000

0

0.560

Colorectal cancer

2

0.75 (0.17, 3.34)

0.37

0.708

1.000

88.4

0.003

TT vs. TC+CC

Overall

7

1.13 (0.94, 1.36)

1.30

0.192

1.000

74.3

0.001

Caucasian

5

1.18 (1.01, 1.37)

2.10

0.035

0.245

57.4

0.052

African

1

1.81 (0.86, 3.81)

1.56

0.118

0.826

-

-

Asian

1

0.79 (0.65, 0.97)

2.31

0.021

0.147

-

-

Prostate cancer

3

1.16 (0.81, 1.65)

0.82

0.415

1.000

72.9

0.025

Breast cancer

2

1.19 (1.05, 1.36)

2.70

0.007

0.049

0

0.479

Colorectal cancer

2

1.09 (0.56, 2.10)

0.25

0.804

1.000

89.9

0.002

CC vs. TT

Overall

7

0.90 (0.66, 1.23)

0.68

0.498

1.000

59.2

0.023

Caucasian

5

0.81 (0.62, 1.06)

1.55

0.121

0.847

40.2

0.153

African

1

1.49 (0.06, 37.34)

0.24

0.808

1.000

-

-

Asian

1

1.64 (1.08, 2.48)

2.33

0.020

0.140

-

-

Prostate cancer

3

0.81 (0.58, 1.13)

1.23

0.218

1.000

0

0.787

Breast cancer

2

0.94 (0.73, 1.22)

0.45

0.650

1.000

0

0.538

Colorectal cancer

2

0.71 (0.13, 4.05)

0.38

0.703

1.000

91.1

0.001

TC vs. TC+TT

Overall

7

0.89 (0.74, 1.07)

1.29

0.197

1.000

72.4

0.001

Caucasian

5

0.86 (0.72, 1.02)

1.76

0.079

0.553

63.5

0.027

African

1

0.52 (0.25, 1.11)

1.69

0.091

0.637

-

-

Asian

1

1.21 (0.98, 1.49)

1.80

0.073

0.511

-

-

Prostate cancer

3

0.86 (0.56, 1.32)

0.71

0.479

3.353

80.4

0.006

Breast cancer

2

0.82 (0.72, 0.94)

2.87

0.004

0.028

0

0.602

Colorectal cancer

2

0.95 (0.56, 1.60)

0.21

0.834

1.000

83.5

0.014

C vs. T

Overall

7

0.91 (0.79, 1.06)

1.24

0.217

1.000

73.3

0.001

Caucasian

5

0.88 (0.79, 0.98)

2.40

0.016

0.112

43.1

0.135

African

1

0.63 (0.32, 1.25)

1.32

0.185

1.000

-

-

Asian

1

1.24 (1.06, 1.46)

2.67

0.008

0.056

-

-

Prostate cancer

3

0.90 (0.74, 1.09)

1.07

0.284

1.000

42.3

0.177

Breast cancer

2

0.89 (0.80, 0.99)

2.14

0.033

0.231

0

0.344

Colorectal cancer

2

0.93 (0.51, 1.69)

0.25

0.804

1.000

92.5

<0.001